A role for CXC chemokines and their receptors in stress axis regulation of common carp

Lukasz Pijanowski, Lidy Verburg-van Kemenade, Magdalena Chadzinska

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Although chemokines mainly function to activate leukocytes and to direct their migration, novel evidence indicates non-immune functions for chemokines within the nervous and endocrine systems. These include development of the nervous system, neuromodulation, neuroendocrine regulation and direct neurotransmitter-like actions. In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the expression patterns of CXC ligands and their receptors in the stress axis organs of carp, during a restraint stress procedure. We showed that stress down-regulated the gene expression of CXCL9-11 (CXCb1 and CXCb2)in stress axis organs and up-regulated expression of CXCR4 chemokine receptor in NPO and pituitary. Moreover, upon stress, reduced gene expression of CXCL12a and CXCL14 was observed in the head kidney. Our results imply that in teleost fish, CXC chemokines and their receptors are involved in neuroendocrine regulation. The active regulation of their expression in stress axis organs during periods of restraint indicates a significant role in the stress response.

LanguageEnglish
Pages194-199
JournalGeneral and Comparative Endocrinology
Volume280
Early online date8 May 2019
DOIs
Publication statusPublished - 1 Sep 2019

Fingerprint

CXCR Receptors
Carps
Chemokine Receptors
chemokines
Cyprinus carpio
Chemokines
Nervous System
Fishes
Head Kidney
CXCR4 Receptors
Gene Expression
receptors
Endocrine System
stress response
Neurotransmitter Agents
gene expression
endocrine system
Leukocytes
neurodevelopment
neurotransmitters

Keywords

  • Carp
  • CXC chemokines
  • CXC receptors
  • Stress

Cite this

Pijanowski, Lukasz ; Verburg-van Kemenade, Lidy ; Chadzinska, Magdalena. / A role for CXC chemokines and their receptors in stress axis regulation of common carp. In: General and Comparative Endocrinology. 2019 ; Vol. 280. pp. 194-199.
@article{cdd9802651874a77aab06e02c57dcd63,
title = "A role for CXC chemokines and their receptors in stress axis regulation of common carp",
abstract = "Although chemokines mainly function to activate leukocytes and to direct their migration, novel evidence indicates non-immune functions for chemokines within the nervous and endocrine systems. These include development of the nervous system, neuromodulation, neuroendocrine regulation and direct neurotransmitter-like actions. In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the expression patterns of CXC ligands and their receptors in the stress axis organs of carp, during a restraint stress procedure. We showed that stress down-regulated the gene expression of CXCL9-11 (CXCb1 and CXCb2)in stress axis organs and up-regulated expression of CXCR4 chemokine receptor in NPO and pituitary. Moreover, upon stress, reduced gene expression of CXCL12a and CXCL14 was observed in the head kidney. Our results imply that in teleost fish, CXC chemokines and their receptors are involved in neuroendocrine regulation. The active regulation of their expression in stress axis organs during periods of restraint indicates a significant role in the stress response.",
keywords = "Carp, CXC chemokines, CXC receptors, Stress",
author = "Lukasz Pijanowski and {Verburg-van Kemenade}, Lidy and Magdalena Chadzinska",
year = "2019",
month = "9",
day = "1",
doi = "10.1016/j.ygcen.2019.05.004",
language = "English",
volume = "280",
pages = "194--199",
journal = "General and Comparative Endocrinology",
issn = "0016-6480",
publisher = "Elsevier",

}

A role for CXC chemokines and their receptors in stress axis regulation of common carp. / Pijanowski, Lukasz; Verburg-van Kemenade, Lidy; Chadzinska, Magdalena.

In: General and Comparative Endocrinology, Vol. 280, 01.09.2019, p. 194-199.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A role for CXC chemokines and their receptors in stress axis regulation of common carp

AU - Pijanowski, Lukasz

AU - Verburg-van Kemenade, Lidy

AU - Chadzinska, Magdalena

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Although chemokines mainly function to activate leukocytes and to direct their migration, novel evidence indicates non-immune functions for chemokines within the nervous and endocrine systems. These include development of the nervous system, neuromodulation, neuroendocrine regulation and direct neurotransmitter-like actions. In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the expression patterns of CXC ligands and their receptors in the stress axis organs of carp, during a restraint stress procedure. We showed that stress down-regulated the gene expression of CXCL9-11 (CXCb1 and CXCb2)in stress axis organs and up-regulated expression of CXCR4 chemokine receptor in NPO and pituitary. Moreover, upon stress, reduced gene expression of CXCL12a and CXCL14 was observed in the head kidney. Our results imply that in teleost fish, CXC chemokines and their receptors are involved in neuroendocrine regulation. The active regulation of their expression in stress axis organs during periods of restraint indicates a significant role in the stress response.

AB - Although chemokines mainly function to activate leukocytes and to direct their migration, novel evidence indicates non-immune functions for chemokines within the nervous and endocrine systems. These include development of the nervous system, neuromodulation, neuroendocrine regulation and direct neurotransmitter-like actions. In order to clarify a potential role for chemokines and their receptors in the stress response of fish, we studied changes in the expression patterns of CXC ligands and their receptors in the stress axis organs of carp, during a restraint stress procedure. We showed that stress down-regulated the gene expression of CXCL9-11 (CXCb1 and CXCb2)in stress axis organs and up-regulated expression of CXCR4 chemokine receptor in NPO and pituitary. Moreover, upon stress, reduced gene expression of CXCL12a and CXCL14 was observed in the head kidney. Our results imply that in teleost fish, CXC chemokines and their receptors are involved in neuroendocrine regulation. The active regulation of their expression in stress axis organs during periods of restraint indicates a significant role in the stress response.

KW - Carp

KW - CXC chemokines

KW - CXC receptors

KW - Stress

U2 - 10.1016/j.ygcen.2019.05.004

DO - 10.1016/j.ygcen.2019.05.004

M3 - Article

VL - 280

SP - 194

EP - 199

JO - General and Comparative Endocrinology

T2 - General and Comparative Endocrinology

JF - General and Comparative Endocrinology

SN - 0016-6480

ER -