A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening

H.J. Wisselink, M. Swanenburg, Jose Gonzales Rojas, M.A.P.M. van Asseldonk, Coen van Wagenberg, J. van der Giessen, B.G. Meerburg, Inge Krijger, D.M. Eppink, M. Bouwknegt, D. Oorburg

Research output: Contribution to conferenceAbstractAcademic

Abstract

Toxoplasma gondii is recognized as one of the major foodborne pathogens with a high human disease burden. In the Netherlands, pork contributes to about 11 % of the meatborne T. gondii infections. To control T. gondii infections in pigs, EFSA has advised to perform serological testing of pigs and audits of pig farms on risk factors for T. gondii infection. In the Netherlands, a program was started to translate the EFSA advice into a practical risk based surveillance system. In first instance, a large scale serological monitoring of fattening pigs was started and seroprevalence over time was determined. Next, the association between within-herd seroprevalence and risk factors for T. gondii on fattening pig farms in the Netherlands was determined. For this, a questionnaire for auditing farms for the presence of risk factors of T. gondii was developed and used on 25 case and 50 control farms. Results show that there is a significant association between seroprevalence and risk factors as cats present on farms, use of unheated feed products and feeding wet feed. Moreover, on-farm presence of rats and mice also increases Toxoplasma transmission risks. Subsequently, a study was started on farms to quantify the effectiveness of interventions on farms. A cross-over clinical trial was set up in which case farms were their own control and the cross-over moment is the implementation of interventions on risk factors to change farm management. Farms with a high within-herd seroprevalence were followed for at least during a year and monitored periodically for seroprevalence and implementation of interventions to eventually reduce the disease burden. The break-even point was calculated for which the intervention cost at fattening pig farms equal averted human disease burden and averted cost-of-illness minus cost of the surveillance program. The results shows favourable economic perspectives for interventions to control pig meat-born transmission of T. gondii.
Original languageEnglish
Publication statusPublished - 2 Oct 2019
Event5th Internation Meeting on Apicomplexan Parasites in Farm Animals - Berlin, Germany
Duration: 2 Oct 20194 Oct 2019

Conference

Conference5th Internation Meeting on Apicomplexan Parasites in Farm Animals
CountryGermany
CityBerlin
Period2/10/194/10/19

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Toxoplasma gondii
screening
farms
swine
monitoring
seroprevalence
risk factors
burden of disease
finishing
Netherlands
human diseases
cost of illness analysis
herds
infection
Toxoplasma
audits
farm management
food pathogens
pork
clinical trials

Cite this

Wisselink, H. J., Swanenburg, M., Gonzales Rojas, J., van Asseldonk, M. A. P. M., van Wagenberg, C., van der Giessen, J., ... Oorburg, D. (2019). A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening. Abstract from 5th Internation Meeting on Apicomplexan Parasites in Farm Animals, Berlin, Germany.
Wisselink, H.J. ; Swanenburg, M. ; Gonzales Rojas, Jose ; van Asseldonk, M.A.P.M. ; van Wagenberg, Coen ; van der Giessen, J. ; Meerburg, B.G. ; Krijger, Inge ; Eppink, D.M. ; Bouwknegt, M. ; Oorburg, D. / A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening. Abstract from 5th Internation Meeting on Apicomplexan Parasites in Farm Animals, Berlin, Germany.
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title = "A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening",
abstract = "Toxoplasma gondii is recognized as one of the major foodborne pathogens with a high human disease burden. In the Netherlands, pork contributes to about 11 {\%} of the meatborne T. gondii infections. To control T. gondii infections in pigs, EFSA has advised to perform serological testing of pigs and audits of pig farms on risk factors for T. gondii infection. In the Netherlands, a program was started to translate the EFSA advice into a practical risk based surveillance system. In first instance, a large scale serological monitoring of fattening pigs was started and seroprevalence over time was determined. Next, the association between within-herd seroprevalence and risk factors for T. gondii on fattening pig farms in the Netherlands was determined. For this, a questionnaire for auditing farms for the presence of risk factors of T. gondii was developed and used on 25 case and 50 control farms. Results show that there is a significant association between seroprevalence and risk factors as cats present on farms, use of unheated feed products and feeding wet feed. Moreover, on-farm presence of rats and mice also increases Toxoplasma transmission risks. Subsequently, a study was started on farms to quantify the effectiveness of interventions on farms. A cross-over clinical trial was set up in which case farms were their own control and the cross-over moment is the implementation of interventions on risk factors to change farm management. Farms with a high within-herd seroprevalence were followed for at least during a year and monitored periodically for seroprevalence and implementation of interventions to eventually reduce the disease burden. The break-even point was calculated for which the intervention cost at fattening pig farms equal averted human disease burden and averted cost-of-illness minus cost of the surveillance program. The results shows favourable economic perspectives for interventions to control pig meat-born transmission of T. gondii.",
author = "H.J. Wisselink and M. Swanenburg and {Gonzales Rojas}, Jose and {van Asseldonk}, M.A.P.M. and {van Wagenberg}, Coen and {van der Giessen}, J. and B.G. Meerburg and Inge Krijger and D.M. Eppink and M. Bouwknegt and D. Oorburg",
year = "2019",
month = "10",
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language = "English",
note = "5th Internation Meeting on Apicomplexan Parasites in Farm Animals ; Conference date: 02-10-2019 Through 04-10-2019",

}

Wisselink, HJ, Swanenburg, M, Gonzales Rojas, J, van Asseldonk, MAPM, van Wagenberg, C, van der Giessen, J, Meerburg, BG, Krijger, I, Eppink, DM, Bouwknegt, M & Oorburg, D 2019, 'A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening' 5th Internation Meeting on Apicomplexan Parasites in Farm Animals, Berlin, Germany, 2/10/19 - 4/10/19, .

A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening. / Wisselink, H.J.; Swanenburg, M.; Gonzales Rojas, Jose; van Asseldonk, M.A.P.M.; van Wagenberg, Coen; van der Giessen, J. ; Meerburg, B.G.; Krijger, Inge; Eppink, D.M.; Bouwknegt, M.; Oorburg, D.

2019. Abstract from 5th Internation Meeting on Apicomplexan Parasites in Farm Animals, Berlin, Germany.

Research output: Contribution to conferenceAbstractAcademic

TY - CONF

T1 - A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening

AU - Wisselink, H.J.

AU - Swanenburg, M.

AU - Gonzales Rojas, Jose

AU - van Asseldonk, M.A.P.M.

AU - van Wagenberg, Coen

AU - van der Giessen, J.

AU - Meerburg, B.G.

AU - Krijger, Inge

AU - Eppink, D.M.

AU - Bouwknegt, M.

AU - Oorburg, D.

PY - 2019/10/2

Y1 - 2019/10/2

N2 - Toxoplasma gondii is recognized as one of the major foodborne pathogens with a high human disease burden. In the Netherlands, pork contributes to about 11 % of the meatborne T. gondii infections. To control T. gondii infections in pigs, EFSA has advised to perform serological testing of pigs and audits of pig farms on risk factors for T. gondii infection. In the Netherlands, a program was started to translate the EFSA advice into a practical risk based surveillance system. In first instance, a large scale serological monitoring of fattening pigs was started and seroprevalence over time was determined. Next, the association between within-herd seroprevalence and risk factors for T. gondii on fattening pig farms in the Netherlands was determined. For this, a questionnaire for auditing farms for the presence of risk factors of T. gondii was developed and used on 25 case and 50 control farms. Results show that there is a significant association between seroprevalence and risk factors as cats present on farms, use of unheated feed products and feeding wet feed. Moreover, on-farm presence of rats and mice also increases Toxoplasma transmission risks. Subsequently, a study was started on farms to quantify the effectiveness of interventions on farms. A cross-over clinical trial was set up in which case farms were their own control and the cross-over moment is the implementation of interventions on risk factors to change farm management. Farms with a high within-herd seroprevalence were followed for at least during a year and monitored periodically for seroprevalence and implementation of interventions to eventually reduce the disease burden. The break-even point was calculated for which the intervention cost at fattening pig farms equal averted human disease burden and averted cost-of-illness minus cost of the surveillance program. The results shows favourable economic perspectives for interventions to control pig meat-born transmission of T. gondii.

AB - Toxoplasma gondii is recognized as one of the major foodborne pathogens with a high human disease burden. In the Netherlands, pork contributes to about 11 % of the meatborne T. gondii infections. To control T. gondii infections in pigs, EFSA has advised to perform serological testing of pigs and audits of pig farms on risk factors for T. gondii infection. In the Netherlands, a program was started to translate the EFSA advice into a practical risk based surveillance system. In first instance, a large scale serological monitoring of fattening pigs was started and seroprevalence over time was determined. Next, the association between within-herd seroprevalence and risk factors for T. gondii on fattening pig farms in the Netherlands was determined. For this, a questionnaire for auditing farms for the presence of risk factors of T. gondii was developed and used on 25 case and 50 control farms. Results show that there is a significant association between seroprevalence and risk factors as cats present on farms, use of unheated feed products and feeding wet feed. Moreover, on-farm presence of rats and mice also increases Toxoplasma transmission risks. Subsequently, a study was started on farms to quantify the effectiveness of interventions on farms. A cross-over clinical trial was set up in which case farms were their own control and the cross-over moment is the implementation of interventions on risk factors to change farm management. Farms with a high within-herd seroprevalence were followed for at least during a year and monitored periodically for seroprevalence and implementation of interventions to eventually reduce the disease burden. The break-even point was calculated for which the intervention cost at fattening pig farms equal averted human disease burden and averted cost-of-illness minus cost of the surveillance program. The results shows favourable economic perspectives for interventions to control pig meat-born transmission of T. gondii.

M3 - Abstract

ER -

Wisselink HJ, Swanenburg M, Gonzales Rojas J, van Asseldonk MAPM, van Wagenberg C, van der Giessen J et al. A risk based surveillance programme for Toxoplasma gondii in pigs using a combination of farm auditing and serological screening. 2019. Abstract from 5th Internation Meeting on Apicomplexan Parasites in Farm Animals, Berlin, Germany.