A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous

A. Liakopoulos, D.J. Mevius, Daniela Ceccarelli

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Abstract

β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the Twentieth century, and they are now observed in isolates in different epidemiological settings both in human, animal and the environment. Likely originated from a chromosomal penicillinase of Klebsiella pneumoniae, SHV β-lactamases currently encompass a large number of allelic variants including extended-spectrum β-lactamases (ESBL), non-ESBL and several not classified variants. SHV enzymes have evolved from a narrow- to an extended-spectrum of hydrolyzing activity, including monobactams and carbapenems, as a result of amino acid changes that altered the configuration around the active site of the β -lactamases. SHV-ESBLs are usually encoded by self-transmissible plasmids that frequently carry resistance genes to other drug classes and have become widespread throughout the world in several Enterobacteriaceae, emphasizing their clinical significance.
Original languageEnglish
Article number1374
Number of pages27
JournalFrontiers in Microbiology
Volume7
DOIs
Publication statusPublished - 2016

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