A Review of Patents on "Mozafari Method" as a Green Technology for Manufacturing Bioactive Carriers

Gisoo Maleki, Zeinab Bahrami, Ernst J. Woltering, Sepideh Khorasani, M.R. Mozafari*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)


Encapsulation and controlled release of bioactive compounds is now an established protocol to enhance the bioavailability and long-lasting efficacy of therapeutic and disease-preventive agents while minimizing or eliminating side effects. Currently, there are a number of products approved by the regulatory authorities for Human or animal use, which contain encapsulated drugs, nutraceuticals, diagnostic agents, cosmetics, or even vaccines. Manufacturing the encapsulation/carrier systems requires special considerations with respect to scalability, environmental issues, and cost-effectiveness. Among the many available procedures for large-scale preparation of micro-and nanocarriers, the "Mozafari method" has proven to be simple to implement and reproducible technique that does not require sophisticated equipment or use of potentially toxic solvents. The mentioned proprietary method and patents in which this method is utilized or incorporated is the focus of the present review article.

Original languageEnglish
Article number34
JournalBiointerface Research in Applied Chemistry
Issue number1
Early online date23 Jan 2022
Publication statusPublished - 15 Feb 2023


  • bioactive agents
  • carrier vehicle
  • drug delivery
  • liposome
  • nanoliposome
  • solid lipid nanoparticle
  • tocosome


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