A naturally occurring nucleotide polymorphism in the orf2/folc promoter is associated with Streptococcus suis virulence

A. de Greeff, H. Buys, J.M. Wells, H.E. Smith

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Streptococcus suis is a major problem in the swine industry causing meningitis, arthritis and pericarditis in piglets. Pathogenesis of S. suis is poorly understood. We previously showed that introduction of a 3 kb genomic fragment from virulent serotype 2 strain 10 into a weakly virulent serotype 2 strain S735, generated a hypervirulent isolate. The 3 kb genomic fragment contained two complete open reading frames (ORF) in an operon-structure of which one ORF showed similarity to folylpolyglutamate synthetase, whereas the function of the second ORF could not be predicted based on database searches for protein similarity.
Original languageEnglish
Article number264
JournalBMC Microbiology
Volume14
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • germ-free pigs
  • serotype-2
  • strains
  • identification
  • cytokine
  • pathogen
  • suilysin
  • release
  • type-2
  • cells

Fingerprint Dive into the research topics of 'A naturally occurring nucleotide polymorphism in the orf2/folc promoter is associated with Streptococcus suis virulence'. Together they form a unique fingerprint.

Cite this