Abstract
Streptococcus suis is a major problem in the swine industry causing meningitis, arthritis and pericarditis in piglets. Pathogenesis of S. suis is poorly understood. We previously showed that introduction of a 3 kb genomic fragment from virulent serotype 2 strain 10 into a weakly virulent serotype 2 strain S735, generated a hypervirulent isolate. The 3 kb genomic fragment contained two complete open reading frames (ORF) in an operon-structure of which one ORF showed similarity to folylpolyglutamate synthetase, whereas the function of the second ORF could not be predicted based on database searches for protein similarity.
Original language | English |
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Article number | 264 |
Journal | BMC Microbiology |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- germ-free pigs
- serotype-2
- strains
- identification
- cytokine
- pathogen
- suilysin
- release
- type-2
- cells