TY - GEN
T1 - A multi-module, microfluidic gastrointestinal tract for testing food and drugs
AU - de Haan, Pim
AU - Santbergen, Milou J.C.
AU - van der Zande, Meike
AU - Bouwmeester, Hans
AU - Nielen, Michel W.F.
AU - Verpoorte, Elisabeth
PY - 2019
Y1 - 2019
N2 - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-µTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
AB - This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-µTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.
KW - Digestion
KW - Gut-on-a-chip
KW - Mass spectrometry
KW - Oral bioavailability
M3 - Conference paper
AN - SCOPUS:85094964555
T3 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
SP - 378
EP - 379
BT - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PB - Chemical and Biological Microsystems Society
T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Y2 - 27 October 2019 through 31 October 2019
ER -