A multi-module, microfluidic gastrointestinal tract for testing food and drugs

Pim de Haan*, Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester, Michel W.F. Nielen, Elisabeth Verpoorte

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademicpeer-review

Abstract

This work describes our efforts to date to realize a miniaturized gastrointestinal (GI) tract total analysis system (gut-µTAS) for nutrients or drugs upon ingestion. A multi-module flow system is being developed that seeks to combine all processes of the GI tract, including enzymatic digestion, absorption, and metabolism together with online mass spectrometry analysis. When exposing cells to digested materials (chyme), we found that the cells tolerate up to ~15% of chyme in the cellular matrix. Finally, we monitored the absorption of model drug, verapamil, in the gut-on-a-chip device by online mass spectrometry (MS) analysis.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages378-379
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference/symposium

Conference/symposium23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Digestion
  • Gut-on-a-chip
  • Mass spectrometry
  • Oral bioavailability

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