A molecular framework for plant regeneration

Jian Xu, Hugo Hofhuis, Renze Heidstra, Michael Sauer, Jiři Friml, Ben Scheres*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

221 Citations (Scopus)

Abstract

Plants and some animals have a profound capacity to regenerate organs from adult tissues. Molecular mechanisms for regeneration have, however, been largely unexplored. Here we investigate a local regeneration response in Arabidopsis roots. Laser-induced wounding disrupts the flow of auxin-a cell-fate-instructive plant hormone-in root tips, and we demonstrate that resulting cell-fate changes require the PLETHORA, SHORTROOT, and SCARECROW transcription factors. These transcription factors regulate the expression and polar position of PIN auxin efflux-facilitating membrane proteins to reconstitute auxin transport in renewed root tips. Thus, a regeneration mechanism using embryonic root stem-cell patterning factors first responds to and subsequently stabilizes a new hormone distribution.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalScience
Volume311
Issue number5759
DOIs
Publication statusPublished - 20 Jan 2006
Externally publishedYes

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