A metabolic profile is associated with the risk of incident coronary heart disease

A. Vaarhorst; A. Verhoeven; C.M. Weller; S. Bohringer; P.A. van den Brandt; M.M. Greevenbroek; A.H. Merry; W.M.M. Verschuren; J.M.A. Boer; E.J.M. Feskens; B.T. Heijmans; P.E. Slagboom

doi:10.1016/j.ahj.2014.01.019

A metabolic profile is associated with the risk of incident coronary heart disease

A. Vaarhorst, A. Verhoeven, C.M. Weller, S. Bohringer, P.A. van den Brandt, M.M. Greevenbroek, A.H. Merry, W.M.M. Verschuren, J.M.A. Boer, E.J.M. Feskens, B.T. Heijmans, P.E. Slagboom

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Abstract

Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.

Original language	English
Pages (from-to)	45-52.e7
Journal	American Heart Journal
Volume	168
Issue number	1
DOIs	https://doi.org/10.1016/j.ahj.2014.01.019
Publication status	Published - 2014

Keywords

artery-disease
cardiovascular events
population
prediction
plasma
phosphatidylcholine
metabonomics
netherlands
mortality
cohort

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10.1016/j.ahj.2014.01.019

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Vaarhorst, A., Verhoeven, A., Weller, C. M., Bohringer, S., van den Brandt, P. A., Greevenbroek, M. M., Merry, A. H., Verschuren, W. M. M., Boer, J. M. A., Feskens, E. J. M., Heijmans, B. T., & Slagboom, P. E. (2014). A metabolic profile is associated with the risk of incident coronary heart disease. American Heart Journal, 168(1), 45-52.e7. https://doi.org/10.1016/j.ahj.2014.01.019

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AU - Vaarhorst, A.

AU - Verhoeven, A.

AU - Weller, C.M.

AU - Bohringer, S.

AU - van den Brandt, P.A.

AU - Greevenbroek, M.M.

AU - Merry, A.H.

AU - Verschuren, W.M.M.

AU - Boer, J.M.A.

AU - Feskens, E.J.M.

AU - Heijmans, B.T.

AU - Slagboom, P.E.

PY - 2014

Y1 - 2014

N2 - Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.

AB - Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.

KW - artery-disease

KW - cardiovascular events

KW - population

KW - prediction

KW - plasma

KW - phosphatidylcholine

KW - metabonomics

KW - netherlands

KW - mortality

KW - cohort

U2 - 10.1016/j.ahj.2014.01.019

DO - 10.1016/j.ahj.2014.01.019

M3 - Article

SN - 0002-8703

VL - 168

SP - 45-52.e7

JO - American Heart Journal

JF - American Heart Journal

IS - 1

ER -

A metabolic profile is associated with the risk of incident coronary heart disease

Abstract

Keywords

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