A metabolic profile is associated with the risk of incident coronary heart disease

A. Vaarhorst, A. Verhoeven, C.M. Weller, S. Bohringer, P.A. van den Brandt, M.M. Greevenbroek, A.H. Merry, W.M.M. Verschuren, J.M.A. Boer, E.J.M. Feskens, B.T. Heijmans, P.E. Slagboom

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Abstract

Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.
Original languageEnglish
Pages (from-to)45-52.e7
JournalAmerican Heart Journal
Volume168
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Metabolome
Coronary Disease
Metabolomics

Keywords

  • artery-disease
  • cardiovascular events
  • population
  • prediction
  • plasma
  • phosphatidylcholine
  • metabonomics
  • netherlands
  • mortality
  • cohort

Cite this

Vaarhorst, A., Verhoeven, A., Weller, C. M., Bohringer, S., van den Brandt, P. A., Greevenbroek, M. M., ... Slagboom, P. E. (2014). A metabolic profile is associated with the risk of incident coronary heart disease. American Heart Journal, 168(1), 45-52.e7. https://doi.org/10.1016/j.ahj.2014.01.019
Vaarhorst, A. ; Verhoeven, A. ; Weller, C.M. ; Bohringer, S. ; van den Brandt, P.A. ; Greevenbroek, M.M. ; Merry, A.H. ; Verschuren, W.M.M. ; Boer, J.M.A. ; Feskens, E.J.M. ; Heijmans, B.T. ; Slagboom, P.E. / A metabolic profile is associated with the risk of incident coronary heart disease. In: American Heart Journal. 2014 ; Vol. 168, No. 1. pp. 45-52.e7.
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Vaarhorst, A, Verhoeven, A, Weller, CM, Bohringer, S, van den Brandt, PA, Greevenbroek, MM, Merry, AH, Verschuren, WMM, Boer, JMA, Feskens, EJM, Heijmans, BT & Slagboom, PE 2014, 'A metabolic profile is associated with the risk of incident coronary heart disease', American Heart Journal, vol. 168, no. 1, pp. 45-52.e7. https://doi.org/10.1016/j.ahj.2014.01.019

A metabolic profile is associated with the risk of incident coronary heart disease. / Vaarhorst, A.; Verhoeven, A.; Weller, C.M.; Bohringer, S.; van den Brandt, P.A.; Greevenbroek, M.M.; Merry, A.H.; Verschuren, W.M.M.; Boer, J.M.A.; Feskens, E.J.M.; Heijmans, B.T.; Slagboom, P.E.

In: American Heart Journal, Vol. 168, No. 1, 2014, p. 45-52.e7.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A metabolic profile is associated with the risk of incident coronary heart disease

AU - Vaarhorst, A.

AU - Verhoeven, A.

AU - Weller, C.M.

AU - Bohringer, S.

AU - van den Brandt, P.A.

AU - Greevenbroek, M.M.

AU - Merry, A.H.

AU - Verschuren, W.M.M.

AU - Boer, J.M.A.

AU - Feskens, E.J.M.

AU - Heijmans, B.T.

AU - Slagboom, P.E.

PY - 2014

Y1 - 2014

N2 - Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.

AB - Background Metabolomics, defined as the comprehensive identification and quantification of low-molecular-weight metabolites to be found in a biological sample, has been put forward as a potential tool for classifying individuals according to their risk of coronary heart disease (CHD). Here, we investigated whether a single-point blood measurement of the metabolome is associated with and predictive for the risk of CHD.

KW - artery-disease

KW - cardiovascular events

KW - population

KW - prediction

KW - plasma

KW - phosphatidylcholine

KW - metabonomics

KW - netherlands

KW - mortality

KW - cohort

U2 - 10.1016/j.ahj.2014.01.019

DO - 10.1016/j.ahj.2014.01.019

M3 - Article

VL - 168

SP - 45-52.e7

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

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Vaarhorst A, Verhoeven A, Weller CM, Bohringer S, van den Brandt PA, Greevenbroek MM et al. A metabolic profile is associated with the risk of incident coronary heart disease. American Heart Journal. 2014;168(1):45-52.e7. https://doi.org/10.1016/j.ahj.2014.01.019