A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration

Wenkun Zhou, Jose L. Lozano-Torres, Ikram Blilou, Xiaoyue Zhang, Qingzhe Zhai, Geert Smant, Chuanyou Li, Ben Scheres*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. JA also affects growth, which is hitherto interpreted as a trade-off between growth and defense. Here, we describe a molecular network triggered by wound-induced JA that promotes stem cell activation and regeneration. JA regulates organizer cell activity in the root stem cell niche through the RBR-SCR network and stress response protein ERF115. Moreover, JA-induced ERF109 transcription stimulates CYCD6;1 expression, functions upstream of ERF115, and promotes regeneration. Soil penetration and response to nematode herbivory induce and require this JA-mediated regeneration response. Therefore, the JA tissue damage response pathway induces stem cell activation and regeneration and activates growth after environmental stress.
Original languageEnglish
Pages (from-to)942-956
JournalCell
Volume177
Issue number4
Early online date4 Apr 2019
DOIs
Publication statusPublished - 2 May 2019

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Stem cells
Regeneration
Stem Cells
Chemical activation
Growth
Stem Cell Niche
Tissue regeneration
Herbivory
Transcription
Heat-Shock Proteins
jasmonic acid
Thyristors
Soil
Hormones
Tissue
Soils
Wounds and Injuries
Proteins

Cite this

Zhou, Wenkun ; Lozano-Torres, Jose L. ; Blilou, Ikram ; Zhang, Xiaoyue ; Zhai, Qingzhe ; Smant, Geert ; Li, Chuanyou ; Scheres, Ben. / A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration. In: Cell. 2019 ; Vol. 177, No. 4. pp. 942-956.
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title = "A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration",
abstract = "Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. JA also affects growth, which is hitherto interpreted as a trade-off between growth and defense. Here, we describe a molecular network triggered by wound-induced JA that promotes stem cell activation and regeneration. JA regulates organizer cell activity in the root stem cell niche through the RBR-SCR network and stress response protein ERF115. Moreover, JA-induced ERF109 transcription stimulates CYCD6;1 expression, functions upstream of ERF115, and promotes regeneration. Soil penetration and response to nematode herbivory induce and require this JA-mediated regeneration response. Therefore, the JA tissue damage response pathway induces stem cell activation and regeneration and activates growth after environmental stress.",
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A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration. / Zhou, Wenkun; Lozano-Torres, Jose L.; Blilou, Ikram; Zhang, Xiaoyue; Zhai, Qingzhe; Smant, Geert; Li, Chuanyou; Scheres, Ben.

In: Cell, Vol. 177, No. 4, 02.05.2019, p. 942-956.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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AU - Zhou, Wenkun

AU - Lozano-Torres, Jose L.

AU - Blilou, Ikram

AU - Zhang, Xiaoyue

AU - Zhai, Qingzhe

AU - Smant, Geert

AU - Li, Chuanyou

AU - Scheres, Ben

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AB - Plants are sessile and have to cope with environmentally induced damage through modification of growth and defense pathways. How tissue regeneration is triggered in such responses and whether this involves stem cell activation is an open question. The stress hormone jasmonate (JA) plays well-established roles in wounding and defense responses. JA also affects growth, which is hitherto interpreted as a trade-off between growth and defense. Here, we describe a molecular network triggered by wound-induced JA that promotes stem cell activation and regeneration. JA regulates organizer cell activity in the root stem cell niche through the RBR-SCR network and stress response protein ERF115. Moreover, JA-induced ERF109 transcription stimulates CYCD6;1 expression, functions upstream of ERF115, and promotes regeneration. Soil penetration and response to nematode herbivory induce and require this JA-mediated regeneration response. Therefore, the JA tissue damage response pathway induces stem cell activation and regeneration and activates growth after environmental stress.

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