A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

Rosa van den Berg, Sander Kooijman*, Raymond Noordam, Ashna Ramkisoensing, Gustavo Abreu-Vieira, Lauren L. Tambyrajah, Wieneke Dijk, Philip Ruppert, Isabel M. Mol, Barbara Kramar, Rosanna Caputo, Laura Sardón Puig, Evelien M. de Ruiter, Jan Kroon, Menno Hoekstra, Ronald J. van der Sluis, Onno C. Meijer, Ko Willems van Dijk, Linda W.M. van Kerkhof, Constantinos ChristodoulidesFredrik Karpe, Zachary Gerhart-Hines, Sander Kersten, Johanna H. Meijer, Claudia P. Coomans, Diana van Heemst, Nienke R. Biermasz, Patrick C.N. Rensen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Abstract

Many favorable metabolic effects have been attributed to thermogenic activity of brown adipose tissue (BAT). Yet, time of day has rarely been considered in this field of research. Here, we show that a diurnal rhythm in BAT activity regulates plasma lipid metabolism. We observed a high-amplitude rhythm in fatty acid uptake by BAT that synchronized with the light/dark cycle. Highest uptake was found at the onset of the active period, which coincided with high lipoprotein lipase expression and low angiopoietin-like 4 expression by BAT. Diurnal rhythmicity in BAT activity determined the rate at which lipids were cleared from the circulation, thereby imposing the daily rhythm in plasma lipid concentrations. In mice as well as humans, postprandial lipid excursions were nearly absent at waking. We anticipate that diurnal BAT activity is an important factor to consider when studying the therapeutic potential of promoting BAT activity. van den Berg et al. show a strong circadian rhythm in fatty acid uptake by brown adipose tissue that peaks at wakening regardless of the light exposure period. Consequently, postprandial lipid handling by brown adipose tissue is highest at wakening, resulting in the lowest postprandial plasma lipid excursions.
Original languageEnglish
Pages (from-to)3521-3533
JournalCell Reports
Volume22
Issue number13
DOIs
Publication statusPublished - 27 Mar 2018

Keywords

  • angiopoietin-like 4
  • APOE3-Leiden.CETP mice
  • brown adipose tissue
  • circadian rhythm
  • diurnal rhythm
  • fatty acids
  • lipoprotein lipase
  • postprandial lipid response
  • triglycerides

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