A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

Aurelia Santoro, Alberto Bazzocchi, Giulia Guidarelli, Rita Ostan, Enrico Giampieri, Daniele Mercatelli, M. Scurti, A.M. Berendsen, Olga Surala, Amy Jennings, Nathalie Meunier, Elodie Caumon, Rachel Gillings, Fawzi Kadi, Frederic Capel, Kevin D. Cashman, Barbara Pietruszka, E.J.M. Feskens, C.P.G.M. de Groot, Giuseppe Battista & 2 others Stefano Salvioli, Claudio Franceschi

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Abstract

Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65–79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.
LanguageEnglish
Article number1693
Number of pages16
JournalFrontiers in Physiology
Volume9
DOIs
Publication statusPublished - 30 Nov 2018

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Body Composition
Cross-Sectional Studies
Fats
Photon Absorptiometry
Physical Phenomena
Endocrine System Diseases
Poland
Human Body
Sex Characteristics
Netherlands
Bone Density
Italy
Population
France
Cluster Analysis
Healthy Volunteers
Obesity
Technology
Growth

Cite this

Santoro, Aurelia ; Bazzocchi, Alberto ; Guidarelli, Giulia ; Ostan, Rita ; Giampieri, Enrico ; Mercatelli, Daniele ; Scurti, M. ; Berendsen, A.M. ; Surala, Olga ; Jennings, Amy ; Meunier, Nathalie ; Caumon, Elodie ; Gillings, Rachel ; Kadi, Fawzi ; Capel, Frederic ; Cashman, Kevin D. ; Pietruszka, Barbara ; Feskens, E.J.M. ; de Groot, C.P.G.M. ; Battista, Giuseppe ; Salvioli, Stefano ; Franceschi, Claudio. / A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features. In: Frontiers in Physiology. 2018 ; Vol. 9.
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title = "A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features",
abstract = "Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65–79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67{\%}, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18{\%}, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56{\%}, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52{\%}, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23{\%}, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34{\%}, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18{\%}, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.",
author = "Aurelia Santoro and Alberto Bazzocchi and Giulia Guidarelli and Rita Ostan and Enrico Giampieri and Daniele Mercatelli and M. Scurti and A.M. Berendsen and Olga Surala and Amy Jennings and Nathalie Meunier and Elodie Caumon and Rachel Gillings and Fawzi Kadi and Frederic Capel and Cashman, {Kevin D.} and Barbara Pietruszka and E.J.M. Feskens and {de Groot}, C.P.G.M. and Giuseppe Battista and Stefano Salvioli and Claudio Franceschi",
year = "2018",
month = "11",
day = "30",
doi = "10.3389/fphys.2018.01693",
language = "English",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers",

}

Santoro, A, Bazzocchi, A, Guidarelli, G, Ostan, R, Giampieri, E, Mercatelli, D, Scurti, M, Berendsen, AM, Surala, O, Jennings, A, Meunier, N, Caumon, E, Gillings, R, Kadi, F, Capel, F, Cashman, KD, Pietruszka, B, Feskens, EJM, de Groot, CPGM, Battista, G, Salvioli, S & Franceschi, C 2018, 'A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features', Frontiers in Physiology, vol. 9, 1693. https://doi.org/10.3389/fphys.2018.01693

A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features. / Santoro, Aurelia; Bazzocchi, Alberto; Guidarelli, Giulia; Ostan, Rita; Giampieri, Enrico; Mercatelli, Daniele; Scurti, M.; Berendsen, A.M.; Surala, Olga; Jennings, Amy; Meunier, Nathalie; Caumon, Elodie; Gillings, Rachel; Kadi, Fawzi; Capel, Frederic; Cashman, Kevin D.; Pietruszka, Barbara; Feskens, E.J.M.; de Groot, C.P.G.M.; Battista, Giuseppe; Salvioli, Stefano; Franceschi, Claudio.

In: Frontiers in Physiology, Vol. 9, 1693, 30.11.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

AU - Santoro, Aurelia

AU - Bazzocchi, Alberto

AU - Guidarelli, Giulia

AU - Ostan, Rita

AU - Giampieri, Enrico

AU - Mercatelli, Daniele

AU - Scurti, M.

AU - Berendsen, A.M.

AU - Surala, Olga

AU - Jennings, Amy

AU - Meunier, Nathalie

AU - Caumon, Elodie

AU - Gillings, Rachel

AU - Kadi, Fawzi

AU - Capel, Frederic

AU - Cashman, Kevin D.

AU - Pietruszka, Barbara

AU - Feskens, E.J.M.

AU - de Groot, C.P.G.M.

AU - Battista, Giuseppe

AU - Salvioli, Stefano

AU - Franceschi, Claudio

PY - 2018/11/30

Y1 - 2018/11/30

N2 - Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65–79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.

AB - Body composition (BC) is an emerging important factor for the characterization of metabolic status. The assessment of BC has been studied in various populations and diseases such as obesity, diabetes, endocrine diseases as well as physiological and paraphysiological conditions such as growth and aging processes, and physical training. A gold standard technique for the assessment of human BC at molecular level is represented by dual-energy X-ray absorptiometry (DXA), which is able to precisely assess the body mass (and areal bone mineral density-aBMD) on a regional and whole-body basis. For the first time, within the framework of the NU-AGE project, BC has been assessed by means of a whole-body DXA scan in 1121 sex-balanced free-living, apparently healthy older adults aged 65–79 years enrolled in 5 European countries (Italy, France, United Kingdom, Netherlands, and Poland). The aim of this analysis is to provide a complete profile of BC in healthy elderly participants from five European countries and to investigate country- and sex-related differences by state-of-the-art DXA technology. To compare BC data collected in different centers, specific indexes and ratios have been used. Non-parametric statistical tests showed sex-specific significant differences in certain BC parameters. In particular, women have higher fat mass (FM) (Fat/Lean mass ratio: by 67%, p < 2.2e-16) and lower lean mass (Lean Mass index: by -18%, p < 2.2e-16) than men. On the other hand, men have higher android FM than women (Android/gynoid FM ratio: by 56%, p < 2.2e-16). Interesting differences also emerged among countries. Polish elderly have higher FM (Fat/Lean mass ratio: by 52%, p < 2.2e-16) and lower lean mass (Skeletal Mass index: by -23%, p < 2.2e-16) than elderly from the other four countries. At variance, French elderly show lower FM (Fat/Lean mass ratio: by -34%, p < 2.2e-16) and higher lean mass (Skeletal Mass index: by 18%, p < 2.2e-16). Moreover, five BC profiles in women and six in men have been identified by a cluster analysis based on BC parameters. Finally, these data can serve as reference for normative average and variability of BC in the elderly populations across Europe.

U2 - 10.3389/fphys.2018.01693

DO - 10.3389/fphys.2018.01693

M3 - Article

VL - 9

JO - Frontiers in Physiology

T2 - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 1693

ER -