A controlled human intervention trial to study protein quality by amino acid uptake kinetics with the novel Lemna protein concentrate as case study

Jurriaan J. Mes*, Diederik Esser, Els Oosterink, Ronald T.M. van den Dool, Jasper Engel, Govardus A.H. de Jong, Ron Wehrens, Ingrid M. van der Meer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A human intervention trial was conducted to study amino acid uptake of the novel Lemna protein concentrate (LPC) in comparison to whey (WPC). The study was a cross-over, double-blind, controlled trial in which 12 healthy participants received 20 grams of LPC and WPC in randomised order. The LPC consumption resulted in a significant lower postprandial increase in almost all individual amino acids, total amino acid (TAA) and total essential amino acids (TEAA) compared to WPC based on area under the curve (AUC) calculations. When the AUC after WPC consumption was set at 100%, LPC showed a relative AUC of 60.4% for TAA and 66.3% for the TEAA. Interindividual variation for LPC was high with an uptake of TEAA of LPC compared to WPC ranging from 18.2 to 94.2%. Human intervention trials can partly replace animal trials as they fully reflect the human situation and provide estimates on individual variations.

Original languageEnglish
JournalInternational Journal of Food Sciences and Nutrition
DOIs
Publication statusE-pub ahead of print - 18 Aug 2021

Keywords

  • 3Rs
  • amino acid uptake
  • duckweed
  • in vivo protein digestibility
  • Lemna
  • protein concentrate

Fingerprint

Dive into the research topics of 'A controlled human intervention trial to study protein quality by amino acid uptake kinetics with the novel Lemna protein concentrate as case study'. Together they form a unique fingerprint.

Cite this