A common genetic mechanism underlies morphological diversity in fruits and other plant organs

Shan Wu, Biyao Zhang, Neda Keyhaninejad, Gustavo R. Rodríguez, Hyun Jung Kim, Manohar Chakrabarti, Eudald Illa-Berenguer, Nathan K. Taitano, M.J. Gonzalo, Aurora Díaz, Yupeng Pan, Courtney P. Leisner, Dennis Halterman, C.R. Buell, Yiqun Weng, Shelley H. Jansky, Herman van Eck, Johan Willemsen, Antonio J. Monforte, Tea Meulia & 1 others Esther van der Knaap

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Shapes of edible plant organs vary dramatically among and within crop plants. To explain and ultimately employ this variation towards crop improvement, we determined the genetic, molecular and cellular bases of fruit shape diversity in tomato. Through positional cloning, protein interaction studies, and genome editing, we report that OVATE Family Proteins and TONNEAU1 Recruiting Motif proteins regulate cell division patterns in ovary development to alter final fruit shape. The physical interactions between the members of these two families are necessary for dynamic relocalization of the protein complexes to different cellular compartments when expressed in tobacco leaf cells. Together with data from other domesticated crops and model plant species, the protein interaction studies provide possible mechanistic insights into the regulation of morphological variation in plants and a framework that may apply to organ growth in all plant species.

LanguageEnglish
Article number4734
JournalNature Communications
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

fruits
Fruits
organs
Fruit
proteins
crops
Crops
Plant Proteins
Edible Plants
Amino Acid Motifs
Proteins
Family Relations
Lycopersicon esculentum
Cell Division
Tobacco
Organism Cloning
Molecular Biology
Ovary
tomatoes
cell division

Cite this

Wu, S., Zhang, B., Keyhaninejad, N., Rodríguez, G. R., Kim, H. J., Chakrabarti, M., ... van der Knaap, E. (2018). A common genetic mechanism underlies morphological diversity in fruits and other plant organs. Nature Communications, 9(1), [4734]. https://doi.org/10.1038/s41467-018-07216-8
Wu, Shan ; Zhang, Biyao ; Keyhaninejad, Neda ; Rodríguez, Gustavo R. ; Kim, Hyun Jung ; Chakrabarti, Manohar ; Illa-Berenguer, Eudald ; Taitano, Nathan K. ; Gonzalo, M.J. ; Díaz, Aurora ; Pan, Yupeng ; Leisner, Courtney P. ; Halterman, Dennis ; Buell, C.R. ; Weng, Yiqun ; Jansky, Shelley H. ; van Eck, Herman ; Willemsen, Johan ; Monforte, Antonio J. ; Meulia, Tea ; van der Knaap, Esther. / A common genetic mechanism underlies morphological diversity in fruits and other plant organs. In: Nature Communications. 2018 ; Vol. 9, No. 1.
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abstract = "Shapes of edible plant organs vary dramatically among and within crop plants. To explain and ultimately employ this variation towards crop improvement, we determined the genetic, molecular and cellular bases of fruit shape diversity in tomato. Through positional cloning, protein interaction studies, and genome editing, we report that OVATE Family Proteins and TONNEAU1 Recruiting Motif proteins regulate cell division patterns in ovary development to alter final fruit shape. The physical interactions between the members of these two families are necessary for dynamic relocalization of the protein complexes to different cellular compartments when expressed in tobacco leaf cells. Together with data from other domesticated crops and model plant species, the protein interaction studies provide possible mechanistic insights into the regulation of morphological variation in plants and a framework that may apply to organ growth in all plant species.",
author = "Shan Wu and Biyao Zhang and Neda Keyhaninejad and Rodr{\'i}guez, {Gustavo R.} and Kim, {Hyun Jung} and Manohar Chakrabarti and Eudald Illa-Berenguer and Taitano, {Nathan K.} and M.J. Gonzalo and Aurora D{\'i}az and Yupeng Pan and Leisner, {Courtney P.} and Dennis Halterman and C.R. Buell and Yiqun Weng and Jansky, {Shelley H.} and {van Eck}, Herman and Johan Willemsen and Monforte, {Antonio J.} and Tea Meulia and {van der Knaap}, Esther",
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Wu, S, Zhang, B, Keyhaninejad, N, Rodríguez, GR, Kim, HJ, Chakrabarti, M, Illa-Berenguer, E, Taitano, NK, Gonzalo, MJ, Díaz, A, Pan, Y, Leisner, CP, Halterman, D, Buell, CR, Weng, Y, Jansky, SH, van Eck, H, Willemsen, J, Monforte, AJ, Meulia, T & van der Knaap, E 2018, 'A common genetic mechanism underlies morphological diversity in fruits and other plant organs', Nature Communications, vol. 9, no. 1, 4734. https://doi.org/10.1038/s41467-018-07216-8

A common genetic mechanism underlies morphological diversity in fruits and other plant organs. / Wu, Shan; Zhang, Biyao; Keyhaninejad, Neda; Rodríguez, Gustavo R.; Kim, Hyun Jung; Chakrabarti, Manohar; Illa-Berenguer, Eudald; Taitano, Nathan K.; Gonzalo, M.J.; Díaz, Aurora; Pan, Yupeng; Leisner, Courtney P.; Halterman, Dennis; Buell, C.R.; Weng, Yiqun; Jansky, Shelley H.; van Eck, Herman; Willemsen, Johan; Monforte, Antonio J.; Meulia, Tea; van der Knaap, Esther.

In: Nature Communications, Vol. 9, No. 1, 4734, 01.12.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - A common genetic mechanism underlies morphological diversity in fruits and other plant organs

AU - Wu, Shan

AU - Zhang, Biyao

AU - Keyhaninejad, Neda

AU - Rodríguez, Gustavo R.

AU - Kim, Hyun Jung

AU - Chakrabarti, Manohar

AU - Illa-Berenguer, Eudald

AU - Taitano, Nathan K.

AU - Gonzalo, M.J.

AU - Díaz, Aurora

AU - Pan, Yupeng

AU - Leisner, Courtney P.

AU - Halterman, Dennis

AU - Buell, C.R.

AU - Weng, Yiqun

AU - Jansky, Shelley H.

AU - van Eck, Herman

AU - Willemsen, Johan

AU - Monforte, Antonio J.

AU - Meulia, Tea

AU - van der Knaap, Esther

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Shapes of edible plant organs vary dramatically among and within crop plants. To explain and ultimately employ this variation towards crop improvement, we determined the genetic, molecular and cellular bases of fruit shape diversity in tomato. Through positional cloning, protein interaction studies, and genome editing, we report that OVATE Family Proteins and TONNEAU1 Recruiting Motif proteins regulate cell division patterns in ovary development to alter final fruit shape. The physical interactions between the members of these two families are necessary for dynamic relocalization of the protein complexes to different cellular compartments when expressed in tobacco leaf cells. Together with data from other domesticated crops and model plant species, the protein interaction studies provide possible mechanistic insights into the regulation of morphological variation in plants and a framework that may apply to organ growth in all plant species.

AB - Shapes of edible plant organs vary dramatically among and within crop plants. To explain and ultimately employ this variation towards crop improvement, we determined the genetic, molecular and cellular bases of fruit shape diversity in tomato. Through positional cloning, protein interaction studies, and genome editing, we report that OVATE Family Proteins and TONNEAU1 Recruiting Motif proteins regulate cell division patterns in ovary development to alter final fruit shape. The physical interactions between the members of these two families are necessary for dynamic relocalization of the protein complexes to different cellular compartments when expressed in tobacco leaf cells. Together with data from other domesticated crops and model plant species, the protein interaction studies provide possible mechanistic insights into the regulation of morphological variation in plants and a framework that may apply to organ growth in all plant species.

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DO - 10.1038/s41467-018-07216-8

M3 - Article

VL - 9

JO - Nature Communications

T2 - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4734

ER -