A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers

L. Grievink; H.A. Smit; P. van 't Veer; B. Brunekreef; D. Kromhout

doi:10.1097/00001648-200001000-00013

A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers

L. Grievink, H.A. Smit, P. van 't Veer, B. Brunekreef, D. Kromhout

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Abstract

The aim of this study was to investigate the relations between plasma levels of antioxidants, [beta]-carotene and [alpha]-tocopherol, and chronic respiratory symptoms in Dutch adults who never smoked or were long-term former smokers. Cases (who reported one or more respiratory symptoms) and controls were selected from a population-based cross-sectional study. Plasma concentrations of antioxidants were determined in 491 cases and 496 controls. ORs for the presence of chronic respiratory symptoms were estimated for quintiles of plasma antioxidant concentration after adjustment for age, gender, and body mass index. The OR of respiratory symptoms in all but the highest quintile of plasma [beta]-carotene decreased and were slightly below one. We saw no meaningful relation with plasma [alpha]-tocopherol.

Original language	English
Pages (from-to)	59-63
Journal	Epidemiology
Volume	11
DOIs	https://doi.org/10.1097/00001648-200001000-00013
Publication status	Published - 2000

Keywords

α-tocopherol
β-carotene
Antioxidants
Case- control studies
Plasma
Respiratory symptoms

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10.1097/00001648-200001000-00013

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title = "A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers",

abstract = "The aim of this study was to investigate the relations between plasma levels of antioxidants, [beta]-carotene and [alpha]-tocopherol, and chronic respiratory symptoms in Dutch adults who never smoked or were long-term former smokers. Cases (who reported one or more respiratory symptoms) and controls were selected from a population-based cross-sectional study. Plasma concentrations of antioxidants were determined in 491 cases and 496 controls. ORs for the presence of chronic respiratory symptoms were estimated for quintiles of plasma antioxidant concentration after adjustment for age, gender, and body mass index. The OR of respiratory symptoms in all but the highest quintile of plasma [beta]-carotene decreased and were slightly below one. We saw no meaningful relation with plasma [alpha]-tocopherol.",

keywords = "α-tocopherol, β-carotene, Antioxidants, Case- control studies, Plasma, Respiratory symptoms",

author = "L. Grievink and H.A. Smit and {van 't Veer}, P. and B. Brunekreef and D. Kromhout",

year = "2000",

doi = "10.1097/00001648-200001000-00013",

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T1 - A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers

AU - Grievink, L.

AU - Smit, H.A.

AU - van 't Veer, P.

AU - Brunekreef, B.

AU - Kromhout, D.

PY - 2000

Y1 - 2000

N2 - The aim of this study was to investigate the relations between plasma levels of antioxidants, [beta]-carotene and [alpha]-tocopherol, and chronic respiratory symptoms in Dutch adults who never smoked or were long-term former smokers. Cases (who reported one or more respiratory symptoms) and controls were selected from a population-based cross-sectional study. Plasma concentrations of antioxidants were determined in 491 cases and 496 controls. ORs for the presence of chronic respiratory symptoms were estimated for quintiles of plasma antioxidant concentration after adjustment for age, gender, and body mass index. The OR of respiratory symptoms in all but the highest quintile of plasma [beta]-carotene decreased and were slightly below one. We saw no meaningful relation with plasma [alpha]-tocopherol.

AB - The aim of this study was to investigate the relations between plasma levels of antioxidants, [beta]-carotene and [alpha]-tocopherol, and chronic respiratory symptoms in Dutch adults who never smoked or were long-term former smokers. Cases (who reported one or more respiratory symptoms) and controls were selected from a population-based cross-sectional study. Plasma concentrations of antioxidants were determined in 491 cases and 496 controls. ORs for the presence of chronic respiratory symptoms were estimated for quintiles of plasma antioxidant concentration after adjustment for age, gender, and body mass index. The OR of respiratory symptoms in all but the highest quintile of plasma [beta]-carotene decreased and were slightly below one. We saw no meaningful relation with plasma [alpha]-tocopherol.

KW - α-tocopherol

KW - β-carotene

KW - Antioxidants

KW - Case- control studies

KW - Plasma

KW - Respiratory symptoms

U2 - 10.1097/00001648-200001000-00013

DO - 10.1097/00001648-200001000-00013

M3 - Article

SN - 1044-3983

VL - 11

SP - 59

EP - 63

JO - Epidemiology

JF - Epidemiology

ER -

A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers

Abstract

Keywords

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