ß-carotene conversion products and their effects on adipose tissue

F. Tourniaire, E. Gouranton, J. von Lintig, J. Keijer, M.L. Bonet, J. Amengual, G. Lietz, J.F. Landrier

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Abstract

Recent epidemiological data suggest that ß-carotene may be protective against metabolic diseases in which adipose tissue plays a key role. Adipose tissue constitutes the major ß-carotene storage tissue and its functions have been shown to be modulated in response to ß-carotene breakdown products, especially retinal produced after cleavage by ß-carotene 15,15'-monooxygenase (BCMO1), and retinoic acid arising from oxidation of retinal. However, the possibility exists that ß-carotene in its intact form can also affect adipocyte function. Development of a knock out model and identification of a loss-of-function mutation have pointed out BCMO1 as being probably the sole enzyme responsible for provitamin A conversion into retinal in mammals. The utilisation of BCMO1-/-mice should provide insights on ß-carotene effect on its own in the future. In humans, intervention studies have highlighted the huge interindividual variation of ß-carotene conversion efficiency, possibly due to genetic polymorphisms, which might impact on response to ß-carotene. This brief review discusses the processes involved in ß-carotene conversion and the effect of cleavage products on body fat and adipose tissue function
Original languageEnglish
Pages (from-to)179-187
JournalGenes & Nutrition
Volume4
Issue number3
DOIs
Publication statusPublished - 2009

Keywords

  • dietary vitamin-a
  • trans-retinoic acid
  • nutrition examination survey
  • 3rd national-health
  • diabetes-mellitus
  • in-vivo
  • plasma-concentrations
  • serum carotenoids
  • intestinal-absorption
  • insulin-resistance

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