Speerpunt 1 - Opkomende risico's (KB-37-002-036)

Project: EZproject

Project Details


New tools will be developed and existing tools improved with the aim of detecting chemical food safety risks at an early stage. The food chain is complex and influenced by a variety of factors, this issue will be approached from different angles. For this reason, 3 main projects have been defined from different fields, namely 'in vitro bioassays', 'in silico tools' and 'non-target screening with molecular networking'. In vitro bioassays are suitable tools for effect-based screening of foods for the presence of undesirable substances. For sub-project 1 we will first make an inventory of which package of available in vitro bioassays is needed to cover the most relevant endpoints. The missing in vitro bioassays will be implemented at WFSR. In addition, it is investigated how RNA sequencing can be used in recent and new developments in toxicology. Both the toxicity of individual substances and mixtures of pesticides will be investigated with this technique, in order to gain a picture of the whole range of possible effects and interactions on the expression of genes (the transcriptome) after exposure. In the main project in silico tools methods will be developed with which on the one hand signals for emerging risks can be picked up in the literature using text mining. On the other hand, a prioritization tool will be designed which can identify and prioritize potential emerging chemical risks from databases, based on physico-chemical properties (with AI) and structure-activity relationships (OECD QSAR toolbox), for further research. In main project 3, in collaboration with the Bioinformatics group of Plant Sciences, a workflow will be set up to mine high resolution MS data to (1) start characterizing matrices and (2) identify changes over time. Together, these tools will help WFSR to identify emerging risks in a timely manner in order to guarantee food safety.

Effective start/end date1/01/2231/12/22


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