Netherlands Toxicogenomics Center (KB-15-003-016, KB-06-003-002)

Peijnenburg, Ad (Project Leader)

Project: LVVN project

32 Article
3 Chapter
1 promoter, other
1 internal PhD, WU

32 results

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2014
DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer Thapsigargin based on comparative gene expression profiling in Jurkat T cells
Schmeits, P. C. J., Katika, M. R., Peijnenburg, A. A. C. M., van Loveren, H. & Hendriksen, P. J. M., 2014, In: Toxicology Letters. 224, 3, p. 395-406
Research output: Contribution to journal › Article › Academic › peer-review
32 Link opens in a new tab Citations (Scopus)
Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices
Szalowska, E., van der Burg, B., Man, H. Y., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2014, In: PLoS ONE. 9, 1, 15 p., e86795.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
52 Link opens in a new tab Citations (Scopus)
The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4
Schmeits, P. J. M., Kol, S., van Loveren, H., Peijnenburg, A. A. C. M. & Hendriksen, P. J. M., 2014, In: Toxicology Research. 3, 4, p. 254-265
Research output: Contribution to journal › Article › Academic › peer-review
7 Link opens in a new tab Citations (Scopus)
Towards an integrated in vitro strategy for estrogenicity testing
Wang, S., Aarts, H. J. M., de Haan, L. H. J., Argyriou, D., Peijnenburg, A. A. C. M., Rietjens, I. M. C. M. & Bovee, T. F. H., 2014, In: Journal of Applied Toxicology. 34, 9, p. 1031-1040
Research output: Contribution to journal › Article › Academic › peer-review
15 Link opens in a new tab Citations (Scopus)
Transcriptome-based functional classifiers for direct immunotoxicity
Shao, J., Berger, L. F., Hendriksen, P. J. M., Peijnenburg, A. A. C. M., van Loveren, H. & Volger, O. L., 2014, In: Archives of Toxicology. 88, 3, p. 673-689
Research output: Contribution to journal › Article › Academic › peer-review
24 Link opens in a new tab Citations (Scopus)
Transcriptomic signatures of peroxisome proliferator-activated receptor a (PPARa) in different mouse liver models identify novel aspects of its biology
Szalowska, E., Tesfay, H. A., van Hijum, S. A. F. T. & Kersten, A. H., 2014, In: BMC Genomics. 15, 14 p., 1106.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
20 Link opens in a new tab Citations (Scopus)
2013
A 155-plex High-Throughput In Vitro Coregulator Binding Assay for (Anti-) Estrogenicity Testing Evaluated with 23 Reference Compounds
Wang, S., Houtman, R., Melchers, D., Aarts, J., Peijnenburg, A. A. C. M., van Beuningen, R., Rietjens, I. M. C. M. & Bovee, T. F. H., 2013, In: Altex. 30, 2/13, p. 145-157
Research output: Contribution to journal › Article › Academic › peer-review
23 Link opens in a new tab Citations (Scopus)
A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies
Wang, S., Rijk, J. C. W., Pen, M. J., Aarts, J. M., Peijnenburg, A. A. C. M., Rietjens, I. & Bovee, T. F. H., 2013, In: Analytical Biochemistry. 435, 1, p. 83-92
Research output: Contribution to journal › Article › Academic › peer-review
5 Link opens in a new tab Citations (Scopus)
Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics
Schmeits, P. C., Volger, O. L., Zandvliet, E. T., van Loveren, H., Peijnenburg, A. & Hendriksen, P. J., 2013, In: Toxicology Letters. 217, 1, p. 1-13
Research output: Contribution to journal › Article › Academic › peer-review
16 Link opens in a new tab Citations (Scopus)
Effect of oxygen concentration and selected protocol factors on viability and gene expression of mouse liver slices
Szalowska, E., Stoopen, G. M., Rijk, J. C. W., Wang, S., Hendriksen, P. J. M., Groot, M. J., Ossenkoppele, J. S. & Peijnenburg, A. A. C. M., 2013, In: Toxicology in Vitro. 27, 5, p. 1513-1524
Research output: Contribution to journal › Article › Academic › peer-review
10 Link opens in a new tab Citations (Scopus)
Endocrine disrupting effects of thioxanthone photoinitiators
Reitsma, M., Bovee, T. F. H., Peijnenburg, A. A. C. M., Hendriksen, P. J. M., Hoogenboom, L. A. P. & Rijk, J. C. W., 2013, In: Toxicological sciences. 132, 1, p. 64-74
Research output: Contribution to journal › Article › Academic › peer-review
36 Link opens in a new tab Citations (Scopus)
Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells
von Stechow, L., Ruiz-Aracama, A., Water, B., Peijnenburg, A., Danen, E. & Lommen, A., 2013, In: PLoS ONE. 8, 10, 13 p., e76476.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
42 Link opens in a new tab Citations (Scopus)
Robust Array-Based Coregulator Binding Assay Predicting ERa-Agonist Potency and Generating Binding Profiles Reflecting Ligand Structure
Aarts, J. M. M. J. G., Wang, S., Houtman, R., van Beuningen, R. M. G. J., Westerink, W. M. A., van de Waart, B. J., Rietjens, I. M. C. M. & Bovee, T. F. H., 2013, In: Chemical Research in Toxicology. 26, 3, p. 336-346 11 p.
Research output: Contribution to journal › Article › Academic › peer-review
27 Link opens in a new tab Citations (Scopus)
Short chain fatty acids stimulate Angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating PPARy
Alex, S., Lange, K., Amolo, T., Grinstead, J. S., Haakonsson, A. K., Szalowska, E., Koppen, A., Mudde, C. M., Haenen, D., Al-Lahham, S., Roelofsen, H., Houtman, R., van der Burg, B., Mandrup, S., Bonvin, A. M. J. J., Kalkhoven, E., Muller, M. R., Hooiveld, G. J. E. J. & Kersten, A. H., 2013, In: Molecular and Cellular Biology. 33, 7, p. 1303-1316
Research output: Contribution to journal › Article › Academic › peer-review
267 Link opens in a new tab Citations (Scopus)
Toxicogenomics-Based Identification of Mechanisms for Direct Immunitoxicity
Shao, J., Katika, M. R., Schmeits, P. C., Hendriksen, P. J. M., van Loveren, H., Peijnenburg, A. A. C. M. & Volger, O. L., 2013, In: Toxicological sciences. 135, 2, p. 328-346 19 p.
Research output: Contribution to journal › Article › Academic › peer-review
41 Link opens in a new tab Citations (Scopus)
Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes
Szalowska, E., Stoopen, G. M., Groot, M. J., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2013, In: BMC Medical Genomics. 6, 18 p., 39.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
30 Link opens in a new tab Citations (Scopus)
2012
Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells
Katika, M. R., Hendriksen, P. J. M., de Ruijter, N. C. A., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In: Toxicology Letters. 212, 2, p. 126-136
Research output: Contribution to journal › Article › Academic › peer-review
19 Link opens in a new tab Citations (Scopus)
MetAlign 3.0: performance enhancement by efficient use of advances in computer hardware
Lommen, A. & Kools, H. J., 2012, In: Metabolomics. 8, 4, p. 719-726 8 p.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
157 Link opens in a new tab Citations (Scopus)
metAlignID: A high-throughout sofware tool set for automated detection of trace level contaminants in comprehensive LECO two-dimensional gas chromatography time-of-flight mass spectrometry data
Lommen, A., van der Kamp, H. J., Kools, H. J., van der Lee, M. K. & van der Weg, G., 2012, In: Journal of Chromatography. A, Including electrophoresis and other separation methods. 1263, p. 169-178
Research output: Contribution to journal › Article › Academic › peer-review
21 Link opens in a new tab Citations (Scopus)
'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans
Jetten, M. J. A., Gaj, S., Ruiz Aracama, A., de Kok, T. M., van Delft, J. H. M., Lommen, A., van Someren, E. P., Jennen, D., Claessen, S. M., Peijnenburg, A. A. C. M., Stierum, R. & Kleinjans, J. C. S., 2012, In: Toxicology and Applied Pharmacology. 259, 3, p. 320-328
Research output: Contribution to journal › Article › Academic › peer-review
45 Link opens in a new tab Citations (Scopus)
Proliferation assays for estrogenicity testing with high predictive value for the in vivo uterotrophic effect
Wang, S., Aarts, J. M. M. J. G., Evers, N. M., Peijnenburg, A. A. C. M., Rietjens, I. & Bovee, T. F. H., 2012, In: Journal of Steroid Biochemistry and Molecular Biology. 128, 3-5, p. 98-106
Research output: Contribution to journal › Article › Academic › peer-review
22 Link opens in a new tab Citations (Scopus)
Screening for Modulatory Effects on Steroidogenesis Using the Human H295R Adrenocortical Cell Line: A Metabolomics Approach
Rijk, J. C. W., Peijnenburg, A. A. C. M., Blokland, M. H., Lommen, A., Hoogenboom, L. A. P. & Bovee, T. F. H., 2012, In: Chemical Research in Toxicology. 25, 8, p. 1720-1731
Research output: Contribution to journal › Article › Academic › peer-review
52 Link opens in a new tab Citations (Scopus)
Transcriptome analysis of the human T Lymphocyte cell line Jurkat and human periheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights
Katika, M. R., Hendriksen, P. J. M., Shao, J., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In: Toxicology and Applied Pharmacology. 264, 1, p. 51-64
Research output: Contribution to journal › Article › Academic › peer-review
51 Link opens in a new tab Citations (Scopus)
Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO)
Kol, S. W. M., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In: Toxicology. 296, 1-3, p. 37-47
Research output: Contribution to journal › Article › Academic › peer-review
16 Link opens in a new tab Citations (Scopus)
2011
An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
Ruiz-Aracama, A., Peijnenburg, A. A. C. M., Kleinjans, J., Jennen, D., van Delft, J., Hellfrisch, C. & Lommen, A., 2011, In: BMC Genomics. 12, 251.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
75 Link opens in a new tab Citations (Scopus)
Application of toxicogenomics in hepatic systems toxicology for risk assessment: Acetaminophen as a case study
Kienhuis, A. S., Bessems, J. G. M., Pennings, J. L. A., Driessen, M., Luijten, M., van Delft, J. H. M. & van der Ven, L. T. M., 2011, In: Toxicology and Applied Pharmacology. 250, p. 96-107 12 p.
Research output: Contribution to journal › Article › Academic › peer-review
40 Link opens in a new tab Citations (Scopus)
Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis
Madhumohan, R. K., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In: Toxicology and Applied Pharmacology. 254, p. 311-322
Research output: Contribution to journal › Article › Academic › peer-review
48 Link opens in a new tab Citations (Scopus)
Identification by Gene Coregulation Mapping of Novel Genes involved in Embryonic Stem Cell Differentiation
Pennings, J. L. A., van Dartel, D. A. M., Pronk, T. E., Hendriksen, P. J. M. & Piersma, A. H., 2011, In: Stem cells and development. 20, 1, p. 115-126
Research output: Contribution to journal › Article › Academic › peer-review
11 Link opens in a new tab Citations (Scopus)
Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells
Jennen, D. G. J., Ruiz-Aracama, A., Magkoufopoulou, C., Peijnenburg, A. A. C. M., Lommen, A., van Delft, J. & Kleinjans, J. C. S., 2011, In: BMC Systems Biology. 5, 14 p., 139.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
37 Link opens in a new tab Citations (Scopus)
MADMAX - Management and analysis database for multiple ~omics experiments
Lin, K., Kools, H. J., de Groot, P. J., Gavai, A. K., Basnet, R. K., Bonnema, A. B., Visser, R. G. F. & Leunissen, J., 2011, In: Journal of integrative bioinformatics. 8, 2, 16 p., 160.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
The effects of deoxynivalenol on gene expression in the murine thymus
Kol, S., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In: Toxicology and Applied Pharmacology. 250, 3, p. 299-311
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
28 Link opens in a new tab Citations (Scopus)
Ultra-fast searching assists in evaluating sub-ppm mass accuracy enhancement in U-HPLC/Orbitrap MS data
Lommen, A., Gerssen, A., Oosterink, J. E., Kools, H. J., Ruiz-Arcama, A., Peters, R. J. B. & Mol, J. G. J., 2011, In: Metabolomics. 7, 1, p. 15-24
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
38 Link opens in a new tab Citations (Scopus)

Netherlands Toxicogenomics Center (KB-15-003-016, KB-06-003-002)

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