Netherlands Toxicogenomics Center (KB-15-003-016, KB-06-003-002)

Project: EZproject

Research Output

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Article
2014

DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer Thapsigargin based on comparative gene expression profiling in Jurkat T cells

Schmeits, P. C. J., Katika, M. R., Peijnenburg, A. A. C. M., van Loveren, H. & Hendriksen, P. J. M., 2014, In : Toxicology Letters. 224, 3, p. 395-406

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices

Szalowska, E., van der Burg, B., Man, H. Y., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2014, In : PLoS ONE. 9, 1, 15 p., e86795.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

The effects of tributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4

Schmeits, P. J. M., Kol, S., van Loveren, H., Peijnenburg, A. A. C. M. & Hendriksen, P. J. M., 2014, In : Toxicology Research. 3, 4, p. 254-265

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Towards an integrated in vitro strategy for estrogenicity testing

Wang, S., Aarts, H. J. M., de Haan, L. H. J., Argyriou, D., Peijnenburg, A. A. C. M., Rietjens, I. M. C. M. & Bovee, T. F. H., 2014, In : Journal of Applied Toxicology. 34, 9, p. 1031-1040

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Transcriptome-based functional classifiers for direct immunotoxicity

Shao, J., Berger, L. F., Hendriksen, P. J. M., Peijnenburg, A. A. C. M., van Loveren, H. & Volger, O. L., 2014, In : Archives of Toxicology. 88, 3, p. 673-689

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Transcriptomic signatures of peroxisome proliferator-activated receptor a (PPARa) in different mouse liver models identify novel aspects of its biology

Szalowska, E., Tesfay, H. A., van Hijum, S. A. F. T. & Kersten, A. H., 2014, In : BMC Genomics. 15, 14 p., 1106.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)
2013

A 155-plex High-Throughput In Vitro Coregulator Binding Assay for (Anti-) Estrogenicity Testing Evaluated with 23 Reference Compounds

Wang, S., Houtman, R., Melchers, D., Aarts, J., Peijnenburg, A. A. C. M., van Beuningen, R., Rietjens, I. M. C. M. & Bovee, T. F. H., 2013, In : Altex. 30, 2/13, p. 145-157

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies

Wang, S., Rijk, J. C. W., Pen, M. J., Aarts, J. M., Peijnenburg, A. A. C. M., Rietjens, I. & Bovee, T. F. H., 2013, In : Analytical Biochemistry. 435, 1, p. 83-92

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics

Schmeits, P. C., Volger, O. L., Zandvliet, E. T., van Loveren, H., Peijnenburg, A. & Hendriksen, P. J., 2013, In : Toxicology Letters. 217, 1, p. 1-13

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Effect of oxygen concentration and selected protocol factors on viability and gene expression of mouse liver slices

Szalowska, E., Stoopen, G. M., Rijk, J. C. W., Wang, S., Hendriksen, P. J. M., Groot, M. J., Ossenkoppele, J. S. & Peijnenburg, A. A. C. M., 2013, In : Toxicology in Vitro. 27, 5, p. 1513-1524

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)

Endocrine disrupting effects of thioxanthone photoinitiators

Reitsma, M., Bovee, T. F. H., Peijnenburg, A. A. C. M., Hendriksen, P. J. M., Hoogenboom, L. A. P. & Rijk, J. C. W., 2013, In : Toxicological sciences. 132, 1, p. 64-74

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Identification of Cisplatin-Regulated Metabolic Pathways in Pluripotent Stem Cells

von Stechow, L., Ruiz-Aracama, A., Water, B., Peijnenburg, A., Danen, E. & Lommen, A., 2013, In : PLoS ONE. 8, 10, 13 p., e76476.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

Robust Array-Based Coregulator Binding Assay Predicting ERa-Agonist Potency and Generating Binding Profiles Reflecting Ligand Structure

Aarts, J. M. M. J. G., Wang, S., Houtman, R., van Beuningen, R. M. G. J., Westerink, W. M. A., van de Waart, B. J., Rietjens, I. M. C. M. & Bovee, T. F. H., 2013, In : Chemical Research in Toxicology. 26, 3, p. 336-346 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Short chain fatty acids stimulate Angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating PPARy

Alex, S., Lange, K., Amolo, T., Grinstead, J. S., Haakonsson, A. K., Szalowska, E., Koppen, A., Mudde, C. M., Haenen, D., Al-Lahham, S., Roelofsen, H., Houtman, R., van der Burg, B., Mandrup, S., Bonvin, A. M. J. J., Kalkhoven, E., Muller, M. R., Hooiveld, G. J. E. J. & Kersten, A. H., 2013, In : Molecular and Cellular Biology. 33, 7, p. 1303-1316

Research output: Contribution to journalArticleAcademicpeer-review

99 Citations (Scopus)

Toxicogenomics-Based Identification of Mechanisms for Direct Immunitoxicity

Shao, J., Katika, M. R., Schmeits, P. C., Hendriksen, P. J. M., van Loveren, H., Peijnenburg, A. A. C. M. & Volger, O. L., 2013, In : Toxicological sciences. 135, 2, p. 328-346 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

Szalowska, E., Stoopen, G. M., Groot, M. J., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2013, In : BMC Medical Genomics. 6, 18 p., 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)
2012

Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells

Katika, M. R., Hendriksen, P. J. M., de Ruijter, N. C. A., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology Letters. 212, 2, p. 126-136

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

MetAlign 3.0: performance enhancement by efficient use of advances in computer hardware

Lommen, A. & Kools, H. J., 2012, In : Metabolomics. 8, 4, p. 719-726 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
98 Citations (Scopus)
18 Citations (Scopus)

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

Jetten, M. J. A., Gaj, S., Ruiz Aracama, A., de Kok, T. M., van Delft, J. H. M., Lommen, A., van Someren, E. P., Jennen, D., Claessen, S. M., Peijnenburg, A. A. C. M., Stierum, R. & Kleinjans, J. C. S., 2012, In : Toxicology and Applied Pharmacology. 259, 3, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)
18 Citations (Scopus)
40 Citations (Scopus)

Transcriptome analysis of the human T Lymphocyte cell line Jurkat and human periheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

Katika, M. R., Hendriksen, P. J. M., Shao, J., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology and Applied Pharmacology. 264, 1, p. 51-64

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO)

Kol, S. W. M., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology. 296, 1-3, p. 37-47

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
2011

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Ruiz-Aracama, A., Peijnenburg, A. A. C. M., Kleinjans, J., Jennen, D., van Delft, J., Hellfrisch, C. & Lommen, A., 2011, In : BMC Genomics. 12, 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
60 Citations (Scopus)

Application of toxicogenomics in hepatic systems toxicology for risk assessment: Acetaminophen as a case study

Kienhuis, A. S., Bessems, J. G. M., Pennings, J. L. A., Driessen, M., Luijten, M., van Delft, J. H. M. & van der Ven, L. T. M., 2011, In : Toxicology and Applied Pharmacology. 250, p. 96-107 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis

Madhumohan, R. K., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In : Toxicology and Applied Pharmacology. 254, p. 311-322

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Identification by Gene Coregulation Mapping of Novel Genes involved in Embryonic Stem Cell Differentiation

Pennings, J. L. A., van Dartel, D. A. M., Pronk, T. E., Hendriksen, P. J. M. & Piersma, A. H., 2011, In : Stem cells and development. 20, 1, p. 115-126

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Jennen, D. G. J., Ruiz-Aracama, A., Magkoufopoulou, C., Peijnenburg, A. A. C. M., Lommen, A., van Delft, J. & Kleinjans, J. C. S., 2011, In : BMC Systems Biology. 5, 14 p., 139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

MADMAX - Management and analysis database for multiple ~omics experiments

Lin, K., Kools, H. J., de Groot, P. J., Gavai, A. K., Basnet, R. K., Bonnema, A. B., Visser, R. G. F. & Leunissen, J., 2011, In : Journal of integrative bioinformatics. 8, 2, 16 p., 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effects of deoxynivalenol on gene expression in the murine thymus

Kol, S., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In : Toxicology and Applied Pharmacology. 250, 3, p. 299-311

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
19 Citations (Scopus)

Ultra-fast searching assists in evaluating sub-ppm mass accuracy enhancement in U-HPLC/Orbitrap MS data

Lommen, A., Gerssen, A., Oosterink, J. E., Kools, H. J., Ruiz-Arcama, A., Peters, R. J. B. & Mol, J. G. J., 2011, In : Metabolomics. 7, 1, p. 15-24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)