Modulation of the intestinal microenvironment:a strategy against enteric coronavirus infection in pigs

Project: PhD

Project Details

Description

PED remains a major threat to the global pig industry. However, appropriate prevention and control measures, whether vaccines or antiviral drugs, are still urgently needed. I aim to present some new insights into anti-coronavirus strategies (not limited to PEDV) via modulation of intestinal microbiota. Previous studies have shown that PEDV infection can reshape the intestinal microbiota. This inspired me to hypothesize that intestinal microbiota may also influence PEDV infection. In recent years, several studies indicated that intestinal microbiota affects virus infection directly or indirectly. However, the mechanisms underlying the regulation of the intestinal microbiota to inhibit viral infection are still largely unknown. So far, many research are confined to many antiviral drugs, which can be successful in in vitro experiments but these cannot be applied to clinical treatment. Based on the background knowledge provided, novel antiviral medicines should focus on enteric viruses, the intestinal tract and should also include the exploration of the intestinal microbiota and their metabolites. Because intestinal microbiota or metabolites can theoretically be taken orally without the risk of degradation by proteases, also because they can act on virus-prone sites and stimulate mucosal immune responses, they are promising candidates to fight enteric viral infections. Therefore, I hypothesize that these are key substances that can resist PEDV infection in the intestinal microenvironment.
StatusFinished
Effective start/end date11/06/1930/09/22

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