High throughput cellulair assays (KB-23-002-009, KB-15-003-023)

Project: EZproject

Project Details

Description

The Adverse Outcome Pathway (AOP) concept is a new way of thinking within the toxicology and chemical risk assessment and is considered to be the basis for new mechanism-based toxicity testing and a framework for the development of alternative methods for animal experimentation. This project aims to construct a panel of fluorescence-based bioassays representing different cellular processes that upon perturbation can result in toxicity. The fluorescence is measured through (real-time) cell imaging. Various fluorophores can be applied allowing to study the effects of compounds on different processes and pathways at the same time. The assays, together with a cell imager, will be used for hazard identification of (new) compounds, in particular those related to food.

StatusFinished
Effective start/end date1/01/1331/12/19

Research Output

Phenolic compounds of Triplaris gardneriana can protect cells against oxidative stress and restore oxidative balance

de Almeida, T. S., Neto, J. J. L., de Sousa, N. M., Pessoa, I. P., Vieira, L. R., De Medeiros, J. L., Boligon, A. A., Hamers, A. R. M., Farias, D. F., Peijnenburg, A. & Carvalho, A. F. U., 2017, In : Biomedicine and Pharmacotherapy. 93, p. 1261-1268

Research output: Contribution to journalArticleAcademicpeer-review

  • 6 Citations (Scopus)