High throughput cellulair assays (KB-23-002-009, KB-15-003-023)

  • Peijnenburg, Ad (Project Leader)

Project: LNV project

Project Details


The Adverse Outcome Pathway (AOP) concept is a new way of thinking within the toxicology and chemical risk assessment and is considered to be the basis for new mechanism-based toxicity testing and a framework for the development of alternative methods for animal experimentation. This project aims to construct a panel of fluorescence-based bioassays representing different cellular processes that upon perturbation can result in toxicity. The fluorescence is measured through (real-time) cell imaging. Various fluorophores can be applied allowing to study the effects of compounds on different processes and pathways at the same time. The assays, together with a cell imager, will be used for hazard identification of (new) compounds, in particular those related to food.

Effective start/end date1/01/1331/12/19


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