Glucose control in relation to Mental And Physical Performance and well-beING

    Project: NWO project

    Project Details

    Description

    A healthy lifestyle is able to reverse the epidemic development of overweight, and cardio-metabolic disease. Unfortunately, most people do not manage to incorporate or to maintain the recommended changes in their daily lifestyle. This may be due to the fact that people do not perceive the benefits of a healthy lifestyle in the short term. There is evidence that a well-controlled blood glucose level—by boosting physical and mental energy—may also be an important determinant of wellbeing, mental and physical performance. The link between blood glucose and the latter factors has hardly been studied. Moreover, it is not known to what extent these relationships differ in healthy subjects and subjects with an impaired glucose metabolism.

    On the other hand, despite being compliant to lifestyle advices, the metabolic flexibility to respond to lifestyle intervention may vary between individuals. Recent evidence indicates that insulin resistance and metabolic inflexibility may develop separately in different organs, representing different etiologies towards cardio-metabolic diseases. Interestingly, these tissue-specific sub-phenotypes may have a differential response to diet, suggesting that successful lifestyle interventions may require a more personalised approach. The present proposal intends to (1) unravel the metabolic and dietary/lifestyle determinants of blood glucose control and mental and physical performance and well-being (2) study the impact of tailored dietary and/or physical activity interventions on these parameters (3) develop and test multi-scale tissue dynamic and mathematical models on diet and lifestyle in relation to blood glucose homeostasis and mental and physical performance and well-being in overweight subjects.
    StatusFinished
    Effective start/end date1/02/1731/12/21

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