Functionele interpretatie van metabolomics en transcriptomics data (KB-17-003.01-004)

  • Hendriksen, Peter (Project Leader)

Project: EZproject

Research Output

  • 29 Article
  • 1 Chapter
  • 1 Comment/Letter to the editor
2015

Characterization of the modes of action of deoxynivalenol (DON) in the human Jurkat T-cell line

Katika, M. R., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2015, In : Journal of Immunotoxicology. 12, 3, p. 206-216

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models

Schmeits, P. C. J., Schaap, M. M., Luijten, M., van Someren, E., Boorsma, A., van Loveren, H., Peijnenburg, A. A. C. M. & Hendriksen, P. J. M., 2015, In : Archives of Toxicology. 89, 12, p. 2325-2337

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro

Schmeits, P. C. J., Shao, J., van der Krieken, D. A., Volger, O. L., van Loveren, H., Peijnenburg, A. A. C. M. & Hendriksen, P. J. M., 2015, In : Journal of Applied Toxicology. 35, 7, p. 831-841

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)
2014

DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer Thapsigargin based on comparative gene expression profiling in Jurkat T cells

Schmeits, P. C. J., Katika, M. R., Peijnenburg, A. A. C. M., van Loveren, H. & Hendriksen, P. J. M., 2014, In : Toxicology Letters. 224, 3, p. 395-406

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices

Szalowska, E., van der Burg, B., Man, H. Y., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2014, In : PLoS ONE. 9, 1, 15 p., e86795.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

Transcriptome-based functional classifiers for direct immunotoxicity

Shao, J., Berger, L. F., Hendriksen, P. J. M., Peijnenburg, A. A. C. M., van Loveren, H. & Volger, O. L., 2014, In : Archives of Toxicology. 88, 3, p. 673-689

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)
2013

Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics

Schmeits, P. C., Volger, O. L., Zandvliet, E. T., van Loveren, H., Peijnenburg, A. & Hendriksen, P. J., 2013, In : Toxicology Letters. 217, 1, p. 1-13

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Endocrine disrupting effects of thioxanthone photoinitiators

Reitsma, M., Bovee, T. F. H., Peijnenburg, A. A. C. M., Hendriksen, P. J. M., Hoogenboom, L. A. P. & Rijk, J. C. W., 2013, In : Toxicological sciences. 132, 1, p. 64-74

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Toxicogenomics-Based Identification of Mechanisms for Direct Immunitoxicity

Shao, J., Katika, M. R., Schmeits, P. C., Hendriksen, P. J. M., van Loveren, H., Peijnenburg, A. A. C. M. & Volger, O. L., 2013, In : Toxicological sciences. 135, 2, p. 328-346 19 p.

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

Szalowska, E., Stoopen, G. M., Groot, M. J., Hendriksen, P. J. M. & Peijnenburg, A. A. C. M., 2013, In : BMC Medical Genomics. 6, 18 p., 39.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)
2012

Data (pre-)processing of nominal and accurate mass LC-MS or GC-MS data using MetAlign

Lommen, A., 2012, Plant Metabolomics . Hardy, N. W. & Hall, R. D. (eds.). Totowa: Humana Press, Vol. 860. p. 229-253 (Methods in molecular biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Distribution, Elimination and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-day Oral Exposure

van der Zande, M., Vandebriel, R. J., Doren, E., Kramer, E. H. M., Herrera-Rivera, Z., serrano-Rojero, C. S., Gremmer, E. R., Mast, J., Peters, R. J. B., Hollman, P. C. H., Hendriksen, P. J. M., Marvin, H. J. P., Peijnenburg, A. A. C. M. & Bouwmeester, H., 2012, In : ACS Nano. 6, 8, p. 7427-7442

Research output: Contribution to journalArticleAcademicpeer-review

409 Citations (Scopus)

Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells

Katika, M. R., Hendriksen, P. J. M., de Ruijter, N. C. A., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology Letters. 212, 2, p. 126-136

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

MetAlign 3.0: performance enhancement by efficient use of advances in computer hardware

Lommen, A. & Kools, H. J., 2012, In : Metabolomics. 8, 4, p. 719-726 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
98 Citations (Scopus)
18 Citations (Scopus)
40 Citations (Scopus)

The Identification and Interpretation of Differences in the Transcriptomes of Organically and Conventionally Grown Potato Tubers

van Dijk, J. P., Cankar, K., Hendriksen, P. J. M., Beenen, H. G., Zhu, M., Scheffer, S. J., Shepherd, L. V. T., Steward, D., Davies, H. V., Leifert, C., Wilkockson, S. J., Gruden, K. & Kok, E. J., 2012, In : Journal of Agricultural and Food Chemistry. 60, 9, p. 2090-2101

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Transcriptome analysis of the human T Lymphocyte cell line Jurkat and human periheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights

Katika, M. R., Hendriksen, P. J. M., Shao, J., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology and Applied Pharmacology. 264, 1, p. 51-64

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO)

Kol, S. W. M., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2012, In : Toxicology. 296, 1-3, p. 37-47

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
2011

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Ruiz-Aracama, A., Peijnenburg, A. A. C. M., Kleinjans, J., Jennen, D., van Delft, J., Hellfrisch, C. & Lommen, A., 2011, In : BMC Genomics. 12, 251.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
60 Citations (Scopus)

Assessment of two complementary liquid chromatography coupled to high resolution mass spectrometry metabolomics strategies for the screening of anabolic steroid treatment in calves

Dervilly-Pinel, G., Weigel, S., Lommen, A., Chereau, S., Rambaud, L., Essers, M. L., Antignac, J. P., Nielen, M. W. F. & Le Bizec, B., 2011, In : Analytica Chimica Acta. 700, 1-2, p. 144-154

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Characterization of Translocation of Silver Nanoparticles and Effects on Whole-Genome Gene Expression Using an In Vitro Intestinal Epithelium Coculture Model

Bouwmeester, H., Poortman, J. H., Peters, R. J. B., Wijma, E., Kramer, E. H. M., Makama, S., Puspitaninganindita, K., Marvin, H. J. P., Peijnenburg, A. A. C. M. & Hendriksen, P. J. M., 2011, In : ACS Nano. 5, 5, p. 4091-4103 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

168 Citations (Scopus)

Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis

Madhumohan, R. K., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In : Toxicology and Applied Pharmacology. 254, p. 311-322

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Identification by Gene Coregulation Mapping of Novel Genes involved in Embryonic Stem Cell Differentiation

Pennings, J. L. A., van Dartel, D. A. M., Pronk, T. E., Hendriksen, P. J. M. & Piersma, A. H., 2011, In : Stem cells and development. 20, 1, p. 115-126

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

Jennen, D. G. J., Ruiz-Aracama, A., Magkoufopoulou, C., Peijnenburg, A. A. C. M., Lommen, A., van Delft, J. & Kleinjans, J. C. S., 2011, In : BMC Systems Biology. 5, 14 p., 139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
29 Citations (Scopus)

Safety Assessment of GMO-derived Foods

Kok, E. J., van Dijk, J. P., Prins, T. W. & Kleter, G. A., 2011, In : Collection of Biosafety Reviews. 5, p. 82-111

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

Tailored Microarray Platform for the Detection of Marine Toxins

Bovee, T. F. H., Hendriksen, P. J. M., Portier, L., Wang, S., Elliott, C. T., van Egmond, H. P., Nielen, M. W. F., Peijnenburg, A. A. C. M. & Hoogenboom, L. A. P., 2011, In : Environmental Science and Technology. 45, 20, p. 8965-8973

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

The effects of deoxynivalenol on gene expression in the murine thymus

Kol, S., Hendriksen, P. J. M., van Loveren, H. & Peijnenburg, A. A. C. M., 2011, In : Toxicology and Applied Pharmacology. 250, 3, p. 299-311

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
19 Citations (Scopus)

Ultra-fast searching assists in evaluating sub-ppm mass accuracy enhancement in U-HPLC/Orbitrap MS data

Lommen, A., Gerssen, A., Oosterink, J. E., Kools, H. J., Ruiz-Arcama, A., Peters, R. J. B. & Mol, J. G. J., 2011, In : Metabolomics. 7, 1, p. 15-24

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

Volatile compound fingerprinting of mixed cultutre fermentations

de Bok, F. A. M., Janssen, P. W. M., Bayjanov, J. R., Sieuwerts, S., Lommen, A., van Hylckama, J. & Molenaar, D., 2011, In : Applied and Environmental Microbiology. 77, 17, p. 6233-6239

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
32 Citations (Scopus)
2009

MetAlign: Interface-Driven, Versatile Metabolomics Tool for Hyphenated Full-Scan Mass Spectrometry Data Preprocessing

Lommen, A., 2009, In : Analytical Chemistry. 81, 8, p. 3079-3086

Research output: Contribution to journalArticleAcademicpeer-review

470 Citations (Scopus)