Research output per year
Research output per year
Project: LVVN project
Summary
ESBLs are increasingly found in people and in animals. In humans, this occurs both in the open population as in the different layers of the health care since 2004. A rapid increase In farm animals is also observed synchronized in time. Genetic relationships have been demonstrated between isolates that cause human infections and are found in animals and animal products. The contribution from livestock and animals in general to this public health problem is still unknown, nor is known what the main transmission routes are to humans.
The objective of the project is: how to determine the contribution of various animal production chains (pig, poultry, cattle, calves) and links within these chains, to the exposure of humans to ESBLs. Determine the contribution of human exposure from these chains in order of priority: directly (through food of animal and plant origin) indirectly (contact with animals, products, environment) is to assess how the relationship with the human exposure from other sources (human-human contacts, pets, hospital, etc) the effects of reductions (prevalences or numbers) of ESBLs in these links on contamination rates of the product and, therefore, on exposure of humans.
The work is organized in 5 workpackages. WP1 concerns project management, and controls the consortium agreement and the agreements on data storage and management. In WP2 and 3 the quantitative data on the occurrence of ESBLs in animal production chains, in the different transmission routes to human beings and in people are quantified. In WP4 the ESBLs are uniformly characterized. In WP5 a mathematical model is built, in which based on the data the attribution analysis of ESBLs and the effects of interventions on animal production and in the transmission chains can be quantified.
Products are quantitative data on the occurrence and characteristics of ESBLs in animal production chains, the environment, animal products and humans. Mathematical models about the attribution of ESBLs in people to different reservoirs (animal and human) and the contribution of different chains to human exposure. Quantitative assessment of effect of reductions of ESBLs in animal reservoirs and in the chains on occurrence of ESBLs in humans.
Status | Finished |
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Effective start/end date | 1/01/13 → 29/12/17 |
Research output: Book/Report › Report › Professional
Research output: Book/Report › Report › Professional