Beyond low-hanging fruit: using CRISPR-Cas9 to produce the next generation of antibiotics

    Project: NWO project

    Project Details

    Description

    The emergence of antibiotic-resistant pathogens demands continuous research in the discovery of novel antibiotic compounds. Most of the known antibiotics are or derive from natural products found in soil bacteria, fungi and plants. However, the discovery and production of these compounds is complicated and limited due to the difficulties in cultivating and modifying most of the producing organisms. Here, we propose a standardized, engineering workflow for the production and derivation of these compounds using the bacterium Pseudomonas putida, a novel laboratory workhorse whose characteristics are optimal for product discovery and derivation, as well as for industrial production.
    StatusFinished
    Effective start/end date1/01/2130/10/21

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