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Research Output 2002 2020

2020
1 Citation (Scopus)

Bacterial folate biosynthesis and colorectal cancer risk: more than just a gut feeling

Kok, D. E. G., Steegenga, W. T., Smid, E. J., Zoetendal, E. G., Ulrich, C. M. & Kampman, E., Jan 2020, In : Critical Reviews in Food Science and Nutrition. 60, 2, p. 244-256 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biosynthesis
colorectal neoplasms
Folic Acid
folic acid
Colorectal Neoplasms
2019
3 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mucus
B-Lymphocytes
B-Lymphoid Precursor Cells
Transcriptome
Anti-Inflammatory Agents
2018
6 Citations (Scopus)

Folate and epigenetics: Why we should not forget bacterial biosynthesis

Kok, D. E., Steegenga, W. T. & McKay, J. A., Sep 2018, In : Epigenomics. 10, 9, p. 1147-1150

Research output: Contribution to journalEditorialAcademic

14 Citations (Scopus)

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

van der Lugt, B., Rusli, F., Lute, C., Lamprakis, A., Salazar, E., Boekschoten, M. V., Hooiveld, G. J., Müller, M., Vervoort, J., Kersten, S., Belzer, C., Kok, D. E. G. & Steegenga, W. T., 16 May 2018, In : Aging. 10, 5, p. 930-950

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Gene Expression
Health
Desulfovibrio
Bifidobacterium
5 Citations (Scopus)

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice

Kok, D. E. G., Rusli, F., van der Lugt, B., Lute, C., Laghi, L., Salvioli, S., Picone, G., Franceschi, C., Smidt, H., Vervoort, J., Kampman, E., Müller, M. & Steegenga, W. T., 1 Jun 2018, In : Journal of Nutritional Biochemistry. 56, p. 152-164

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nutrition
Aging of materials
Health
Diet
Metabolites
3 Citations (Scopus)

Plasticity of lifelong calorie-restricted C57BL/6J mice in adapting to a medium-fat diet intervention at old age

Rusli, F., Boekschoten, M. V., Borelli, V., Sun, C., Lute, C., Menke, A. L., van den Heuvel, J., Salvioli, S., Franceschi, C., Müller, M. & Steegenga, W. T., Apr 2018, In : Aging Cell. 17, 2, e12696.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Fats
Diet
Liver
Hyperphagia
2017
Open Access
DNA Methylation
Leukocytes
Eels
Serum
Health
6 Citations (Scopus)

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice

Rusli, F., Lute, C., Boekschoten, M. V., van Dijk, M., van Norren, K., Menke, A. L., Müller, M. & Steegenga, W. T., 2017, In : Molecular Nutrition & Food Research. 61, 5, 1600677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Fats
adverse effects
Diet
mice
11 Citations (Scopus)

Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups

Steegenga, W. T., Mischke, M., Lute, C., Boekschoten, M. V., Lendvai, A., Pruis, M. G. M., Verkade, H. J., van de Heijning, B. J. M., Boekhorst, J., Timmerman, H. M., Plösch, T., Müller, M. & Hooiveld, G. J. E. J., 2017, In : Molecular Nutrition & Food Research. 61, 1, 1600141.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Maternal Exposure
Microbiota
suckling
intestinal microorganisms
pups
10 Citations (Scopus)

Persistent organic pollutants alter DNA methylation during human adipocyte differentiation

van den Dungen, M. W., Murk, A. J., van Gils-Kok, D. & Steegenga, W. T., 2017, In : Toxicology in Vitro. 40, p. 79-87

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Organic pollutants
DNA Methylation
Adipocytes
Gene expression
Genes
2016
6 Citations (Scopus)
Eels
Dioxins
Organic pollutants
Polychlorinated Biphenyls
Polychlorinated biphenyls
10 Citations (Scopus)

Comprehensive DNA Methylation and Gene Expression Profiling in Differentiating Human Adipocytes

van den Dungen, M. W., Murk, A. J., Kok, D. E. G. & Steegenga, W. T., 2016, In : Journal of Cellular Biochemistry. 117, 12, p. 2707-2718

Research output: Contribution to journalArticleAcademicpeer-review

Gene Expression Profiling
DNA Methylation
Adipocytes
Gene expression
Genes

Cover Image, Volume 117, Number 12, December 2016

van den Dungen, M. W., Murk, A. J., Kok, D. E. & Steegenga, W. T., 1 Dec 2016, In : Journal of Cellular Biochemistry. 117, 12, 1 p.

Research output: Contribution to journalComment/Letter to the editorAcademic

Gene Expression Profiling
DNA Methylation
Adipocytes
Gene expression
26 Citations (Scopus)

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice

Rusli, F., Deelen, J., Andriyani, E., Boekschoten, M. V., Lute, C., van den Akker, E. B., Müller, M., Beekman, M. & Steegenga, W. T., 2016, In : Scientific Reports. 6, 30484.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Fats
Liver
Peroxisome Proliferator-Activated Receptors
fibroblast growth factor 21
9 Citations (Scopus)

Fish oil supplements, longevity and aging

de Magalhães, J. P., Müller, M., Rainger, G. E. & Steegenga, W., 2016, In : Aging-US. 8, 8, p. 1578-1582

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Fish Oils
Insurance Benefits
Omega-3 Fatty Acids
Heart Diseases
Anti-Inflammatory Agents
82 Citations (Scopus)

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., de Magalhães, J. P., Martinez, P. A., McCord, J. M., Miller, B. F., Müller, M., Nelson, J. F., Ndukum, J., Rainger, G. E., Richardson, A. & 6 others, Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L. & Harrison, D. E., 2016, In : Aging Cell. 15, 5, p. 872-884

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glucosidases
Masoprocol
Antioxidants
Metformin
Sirolimus
7 Citations (Scopus)

Long-term vitamin D deficiency in older adult C57BL/6 mice does not affect bone structure, remodeling and mineralization

Meijden, K., Buskermolen, J., van Essen, H., Schuurman, T., Steegenga, W. T., Brouwer, E. M., Langenbach, G. E. J., van Ruijven, L. J., den Heijer, M., Lips, P. & Bravenboer, N., 2016, In : Journal of Steroid Biochemistry and Molecular Biology. 164, p. 344-352

Research output: Contribution to journalArticleAcademicpeer-review

Physiologic Calcification
Vitamin D Deficiency
Bone Remodeling
Inbred C57BL Mouse
Vitamin D
2015
12 Citations (Scopus)

A weekly alternating diet between caloric restriction and medium-fat protects the liver from fatty liver development in middle-aged C57BL/6J mice

Rusli, F., Boekschoten, M. V., Zubia, A. A., Lute, C., Müller, M. R. & Steegenga, W. T., 2015, In : Molecular Nutrition & Food Research. 59, 3, p. 533-543

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
middle-aged adults
Caloric Restriction
fatty liver
Fatty Liver
Inbred C57BL Mouse
26 Citations (Scopus)

Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice

van Norren, K., Rusli, F., van Dijk, M., Lute, C., Nagel, J. C., Dijk, F. J., Dwarkasing, J. T., Boekschoten, M. V., Luiking, Y., Witkamp, R. F., Müller, M. R. & Steegenga, W. T., 2015, In : Journal of cachexia, sarcopenia and muscle. 6, 3, p. 253-268

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Sarcopenia
Caloric Restriction
Muscles
Diet
Rodentia
13 Citations (Scopus)

Cognitive performance: a cross-sectional study on serum vitamin D and its interplay with glucose homeostasis in Dutch older adults

Brouwer-Brolsma, E. M., Dhonukshe-Rutten, R. A. M., van Wijngaarden, J. P., van der Zwaluw, N. L., in 't Veld, P. H., Wins, S., Swart, K. M. A., Enneman, A. W., Ham, A. C., van Dijk, S. C., van Schoor, N. M., van der Velde, N., Uitterlinden, A. G., Lips, P., Kessels, R. P. C., Steegenga, W. T., Feskens, E. J. M. & de Groot, C. P. G. M., 2015, In : Journal of the American Medical Directors Association. 16, 7, p. 621-627

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Vitamin D
Homeostasis
Cross-Sectional Studies
Glucose
Insulin
8 Citations (Scopus)

Liver DNA methylation analysis in adult female C57BL/6JxFVB mice following perinatal exposure to bisphenol A

van Esterik, J. C., Vitins, A. P., Hodemaekers, H. M., Kamstra, J. H., Legler, J., Pennings, J. L. A., Steegenga, W. T., Lute, C., Jelinek, J., Issa, J. P., Dollé, M. E. T. & van der Ven, L. T. M., 2015, In : Toxicology Letters. 232, 1, p. 293-300

Research output: Contribution to journalArticleAcademicpeer-review

DNA Methylation
Inbred C57BL Mouse
Liver
Body Weight
Phenotype
16 Citations (Scopus)

Steroid hormone related effects of marine persistent organic pollutants in human H295R adrenocortical carcinoma cells

van den Dungen, M. W., Rijk, J. C. W., Kampman, E., Steegenga, W. T. & Murk, A. J., 2015, In : Toxicology in Vitro. 29, 4, p. 769-778

Research output: Contribution to journalArticleAcademicpeer-review

Steroid hormones
Adrenocortical Carcinoma
Organic pollutants
Steroids
Cells

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., Stolk, L., van Schoor, N. M., de Groot, C. P. G. M., Kampman, E. & Steegenga, W. T., 2015.

Research output: Contribution to conferenceAbstract

45 Citations (Scopus)

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., van Schoor, N. M., Hooiveld, G. J. E. J., de Groot, C. P. G. M., Kampman, E. & Steegenga, W. T., 2015, In : Clinical Epigenetics. 7, 14 p., 121.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
DNA Methylation
Vitamin B 12
Folic Acid
Genome
Placebos
2014

Effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., Stolk, L., van Schoor, N. M., de Groot, C. P. G. M., Kampman, E. & Steegenga, W. T., 2014.

Research output: Contribution to conferenceAbstract

81 Citations (Scopus)

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs

Steegenga, W. T., Boekschoten, M. V., Lute, C., Hooiveld, G. J. E. J., de Groot, P. J., Morris, T. J., Teschendorff, A. E., Butcher, L. M., Beck, S. & Müller, M. R., 2014, In : Age / the official journal of the American Aging Association. 36, 3, p. 1523-1540 18 p., 9648.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
DNA Methylation
Blood Cells
Genome
Gene Expression
Methylation
11 Citations (Scopus)

No role for vitamin D or a moderate fat diet in aging induced cognitive decline and emotional reactivity in C57BL/6 mice

Brouwer, E. M., Schuurman, T., de Groot, C. P. G. M., Feskens, E. J. M., Lute, C., Naninck, E. F. G., Arndt, S. S., van der Staay, F. J., Bravenboer, N., Korosi, A. & Steegenga, W. T., 2014, In : Behavioural Brain Research. 267, p. 133-143

Research output: Contribution to journalArticleAcademicpeer-review

Inbred C57BL Mouse
Vitamin D
Fats
Diet
Type 2 Diabetes Mellitus
25 Citations (Scopus)

Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice

Steegenga, W. T., Mischke, M., Lute, C., Boekschoten, M. V., Pruis, M. G. M., Lendvai, A., Verkade, H. J., Boekhorst, J., Timmerman, H. M., Plösch, T. & Müller, M. R., 2014, In : Biology of Sex Differences. 5, 17 p., 11.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Small Intestine
Colon
Intestines
Genes

The effects of folic acid and vitamin B12 on global and genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., Stolk, L., van Schoor, N. M., de Groot, C. P. G. M., Kampman, E. & Steegenga, W. T., 2014.

Research output: Contribution to conferencePoster

The effects of folic acid and vitamin B12 on global and genome-wide DNA methylation in elderly subjects

Kok, D. E. G., Dhonukshe-Rutten, R. A. M., Lute, C., Heil, S. G., Uitterlinden, A. G., van der Velde, N., van Meurs, J. B. J., Stolk, L., de Groot, C. P. G. M., Kampman, E. & Steegenga, W. T., 2014.

Research output: Contribution to conferencePoster

2013
35 Citations (Scopus)
Open Access
Dementia
Fasting
Insulin
Depression
Glucose
26 Citations (Scopus)

Maternal western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring

Mischke, M., Pruis, M. G. M., Boekschoten, M. V., Groen, A. K., Fitri, A. R., van de Heijning, B. J. M., Verkade, H. J., Müller, M., Plösch, T. & Steegenga, W. T., 2013, In : PLoS ONE. 8, 11 p., e78623.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
High Fat Diet
high fat diet
Nutrition
Liver
Fats
3 Citations (Scopus)

Plasma B vitamins and LINE-1 DNA methylation in leukocytes of patients with a history of colorectal adenomas

Jung, A. Y., Botma, A., Lute, C., Blom, H. J., Ueland, P. M., Kvalheim, G., Midttun, O., Nagengast, F., Steegenga, W. T. & Kampman, E., 2013, In : Molecular Nutrition & Food Research. 57, 4, p. 698-708

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin B Complex
vitamin B complex
adenoma
DNA methylation
DNA Methylation

Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly

Brouwer, E. M., Nieuwerth-van de Rest, O., Tieland, C. A. B., van der Zwaluw, N. L., Steegenga, W. T., Adam, J. J., van Loon, L. J. C., Feskens, E. J. M. & de Groot, C. P. G. M., 2013, Alzheimer’s Association International Conference. Vol. 9. p. P883-P883

Research output: Chapter in Book/Report/Conference proceedingAbstract

Frail Elderly
Executive Function
Vitamin D
Cognition
Serum
30 Citations (Scopus)
Frail Elderly
Executive Function
Cognition
Cross-Sectional Studies
Fasting
2012
27 Citations (Scopus)
Open Access
Small Intestine
Colon
Microarray Analysis
High Fat Diet
Energy Intake
2010
33 Citations (Scopus)

Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism

Vaes, B. L. T., Lute, C., van der Woning, S. P., Piek, E., Vermeer, J., Blom, H. J., Mathers, J. C., Müller, M. R., de Groot, C. P. G. M. & Steegenga, W. T., 2010, In : Bone. 46, 2, p. 514-523

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Methylation
S-Adenosylmethionine
decitabine
Methyltransferases
2009
38 Citations (Scopus)

Vitamin B12 Deficiency Stimulates Osteoclastogenesis via Increased Homocysteine and Methylmalonic Acid

Vaes, B. L. T., Lute, C., Blom, H. J., Bravenboer, N., de Vries, T. J., Everts, V., Dhonukshe-Rutten, R. A. M., Müller, M. R., de Groot, C. P. G. M. & Steegenga, W. T., 2009, In : Calcified Tissue International. 84, 5, p. 413-422

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Methylmalonic Acid
Vitamin B 12 Deficiency
Homocysteine
Osteogenesis
Osteoblasts
2006
52 Citations (Scopus)

Least Absolute Regression Network Analysis of the Murine Osteoblast Differentation Network

van Someren, E. P., Vaes, B. L. T., Steegenga, W. T., Sijbers, A. M. & Dechering, K. J., 2006, In : Bioinformatics. 22, 4, p. 477-484

Research output: Contribution to journalArticleAcademicpeer-review

Reverse engineering
Osteoblasts
Network Analysis
Transcription
Electric network analysis
2005
77 Citations (Scopus)

Microarray analysis reveals expression regulation of Wnt antagonists in differentiating osteoblasts

Vaes, B. L. T., Dechering, K. J., van Someren, P., Hendriks, J. M. A., van de Ven, C. J. J. M., Feijen, A., Mummery, C. L., Reinders, M. J. T., Olijve, W., van Zoelen, E. J. J. & Steegenga, W. T., 2005, In : Bone. 36, 5, p. 803-811

Research output: Contribution to journalArticleAcademicpeer-review

Microarray Analysis
Osteoblasts
Wnt Proteins
Bone Morphogenetic Protein 2
Alkaline Phosphatase
2004
75 Citations (Scopus)

Identification of Novel Regulators Associated With Early-Phase Osteoblast Differentiation

de Jong, D. S., Vaes, B. L. T., Dechering, K. J., Feijen, A., Hendriks, J. M. A., Wehrens, H. R. M. J., Mummery, C. L., van Zoelen, E. J. J., Olijve, W. & Steegenga, W. T., 2004, In : Journal of Bone and Mineral Research. 19, 6, p. 947-958

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Transfection
Transcription Factors
67 Citations (Scopus)

Regulation of Notch signaling genes during BMP2-induced differentiation of osteoblast precursor cells

de Jong, D. S., Steegenga, W. T., Hendriks, J. M. A., van Zoelen, E. J. J., Olijve, W. & Dechering, K. J., 2004, In : Biochemical and Biophysical Research Communications. 320, 1, p. 100-107

Research output: Contribution to journalArticleAcademicpeer-review

Osteoblasts
Transforming Growth Factor beta
Genes
Signal transduction
Bone Morphogenetic Proteins
2002
87 Citations (Scopus)

Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation

Vaes, B. L. T., Dechering, K. J., Feijen, A., Hendriks, J. M. A., Lefevre, C., Mummery, C. L., Olijve, W., van Zoelen, E. J. J. & Steegenga, W. T., 2002, In : Journal of Bone and Mineral Research. 17, 12, p. 2106-2118

Research output: Contribution to journalArticleAcademicpeer-review

Bone Morphogenetic Protein 2
Microarray Analysis
Osteoblasts
Genes
Expressed Sequence Tags
55 Citations (Scopus)

Microarray analysis of bone morphogenetic protein, transforming growth factor beta, and activin early response genes during osteoblastic cell differentiation.

de Jong, D. S., van Zoelen, E. J. J., Bauerschmidt, S., Olijve, W. & Steegenga, W. T., 2002, In : Journal of Bone and Mineral Research. 12, p. 2119-2129

Research output: Contribution to journalAbstractAcademic

Inhibin-beta Subunits
Bone Morphogenetic Proteins
Transforming Growth Factors
Microarray Analysis
Transforming Growth Factor beta