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Research Output 2001 2019

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2019

A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice

Kuipers, E. N., Held, N. M., In Het Panhuis, W., Modder, M., Ruppert, P. M. M., Kersten, S., Kooijman, S., Guigas, B., Houtkooper, R. H., Rensen, P. C. N. & Boon, M. R., Nov 2019, In : American Journal of Physiology. Endocrinology and Metabolism. 317, 5, p. E820-E830

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Brown Adipose Tissue
High Fat Diet
Insulin Resistance
Lipids
Mitochondrial Dynamics
3 Citations (Scopus)

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice

Oteng, A-B., Ruppert, P. M. M., Boutens, L., Dijk, W., van Dierendonck, X. A. M. H., Olivecrona, G., Stienstra, R. & Kersten, S., Oct 2019, In : Journal of Lipid Research. 60, p. 1741-1754

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Adipocytes
Lipids
Chylous Ascites
Acute-Phase Reaction

Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease

Oteng, A. B., Loregger, A., van Weeghel, M., Zelcer, N. & Kersten, S., Oct 2019, In : Molecular Nutrition and Food Research. 63, 19, 1900385.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Sterol Regulatory Element Binding Protein 2
Trans Fatty Acids
trans fatty acids
fatty liver
sterols

Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet

Nyrén, R., Makoveichuk, E., Malla, S., Kersten, S., Nilsson, S. K., Ericsson, M. & Olivecrona, G., 1 Mar 2019, In : American journal of physiology. Renal physiology. 316, 3, p. F558-F571

Research output: Contribution to journalArticleAcademicpeer-review

Lipoprotein Lipase
High Fat Diet
Nutritional Status
Kidney
Angiopoietins
2 Citations (Scopus)

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Dahlmans, D., Houzelle, A., Andreux, P., Wang, X., Jörgensen, J. A., Moullan, N., Daemen, S., Kersten, S., Auwerx, J. & Hoeks, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6601-6610

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Unfolded Protein Response
Mitochondrial Proteins
MicroRNAs
Muscle Cells
Muscle
2 Citations (Scopus)

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S., Jun 2019, In : Current Opinion in Lipidology. 30, 3, p. 205-211

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Lipoprotein Lipase
Lipid Metabolism
Cardiovascular Diseases
Coronary Artery Disease
1 Citation (Scopus)

No effect of 25-hydroxyvitamin D supplementation on the skeletal muscle transcriptome in vitamin D deficient frail older adults

Hangelbroek, R. W. J., Vaes, A. M. M., Boekschoten, M. V., Verdijk, L. B., Hooiveld, G. J. E. J., van Loon, L. J. C., De Groot, L. C. P. G. M. & Kersten, S., 28 May 2019, In : BMC Geriatrics. 19, 151.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Calcifediol
Frail Elderly
Transcriptome
Vitamin D
Skeletal Muscle
3 Citations (Scopus)

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

Ji, Y., Sun, S., Shrestha, N., Darragh, L. B., Shirakawa, J., Xing, Y., He, Y., Carboneau, B. A., Kim, H., An, D., Ma, M., Oberholzer, J., Soleimanpour, S. A., Gannon, M., Liu, C., Naji, A., Kulkarni, R. N., Wang, Y., Kersten, S. & Qi, L., 20 May 2019, In : Nature Immunology. 20, 6, p. 677-686

Research output: Contribution to journalArticleAcademicpeer-review

Toll-Like Receptors
Obesity
Diet
Cell Proliferation
Cyclin D2
1 Citation (Scopus)

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

Ruppert, P. M. M., Park, J-G., Xu, X., Hur, K. Y., Lee, A-H. & Kersten, S., 11 Mar 2019, In : BMC Genomics. 20, 199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Peroxisome Proliferator-Activated Receptors
Carrier Proteins
Liver
Ketogenic Diet
Lipid Metabolism
2018
14 Citations (Scopus)

A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

van den Berg, R., Kooijman, S., Noordam, R., Ramkisoensing, A., Abreu-Vieira, G., Tambyrajah, L. L., Dijk, W., Ruppert, P., Mol, I. M., Kramar, B., Caputo, R., Puig, L. S., de Ruiter, E. M., Kroon, J., Hoekstra, M., van der Sluis, R. J., Meijer, O. C., Willems van Dijk, K., van Kerkhof, L. W. M., Christodoulides, C. & 8 others, Karpe, F., Gerhart-Hines, Z., Kersten, S., Meijer, J. H., Coomans, C. P., van Heemst, D., Biermasz, N. R. & Rensen, P. C. N., 27 Mar 2018, In : Cell Reports. 22, 13, p. 3521-3533

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Brown Adipose Tissue
Circadian Rhythm
Tissue
Lipids
Plasmas
12 Citations (Scopus)

Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes

Dijk, W., Ruppert, P. M. M., Oost, L. J. & Kersten, S., 7 Sep 2018, In : Journal of Biological Chemistry. 293, 36, p. 14134-14145 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Furin
Lipoprotein Lipase
Adipocytes
Proprotein Convertases
26 Citations (Scopus)

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., van Marken Lichtenbelt, W. D., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Insulin Resistance
Circadian Clocks
Skeletal Muscle
Fatty Acids
Muscles

Global testing of shifts in metabolic phenotype

Fazelzadeh, P., Hoefsloot, H. C. J., Hankemeier, T., Most, J., Kersten, S., Blaak, E. E., Boekschoten, M. & van Duynhoven, J., 4 Oct 2018, In : Metabolomics. 14, 10, 139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Polyphenols
Weight Loss
Phenotype
Fasting
Testing
4 Citations (Scopus)

Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Bhattacharya, A., Sun, S., Wang, H., Liu, M., Long, Q., Yin, L., Kersten, S., Zhang, K. & Qi, L., 15 Nov 2018, In : EMBO Journal. 37, 22, e99277.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Endoplasmic Reticulum-Associated Degradation
Metabolism
Degradation
Liver
Fasting
8 Citations (Scopus)

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase

Padmanabha Das, K. M., Wechselberger, L., Liziczai, M., De La Rosa Rodriguez, M., Grabner, G. F., Heier, C., Viertlmayr, R., Radler, C., Lichtenegger, J., Zimmermann, R., Borst, J. W., Zechner, R., Kersten, S. & Oberer, M., 2018, In : Journal of Lipid Research. 59, 3, p. 531-541

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipase
Lipids
Triglycerides
Proteins
Genes
14 Citations (Scopus)

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

van der Lugt, B., Rusli, F., Lute, C., Lamprakis, A., Salazar, E., Boekschoten, M. V., Hooiveld, G. J., Müller, M., Vervoort, J., Kersten, S., Belzer, C., Kok, D. E. G. & Steegenga, W. T., 16 May 2018, In : Aging. 10, 5, p. 930-950

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Inbred C57BL Mouse
Gene Expression
Health
Desulfovibrio
Bifidobacterium
11 Citations (Scopus)

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K. & Kersten, S., Jun 2018, In : Diabetologia. 61, 6, p. 1447-1458

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glucose Intolerance
Abdominal Obesity
Obesity
Diet
Intra-Abdominal Fat

Multiple effects of cold exposure on livers of male mice

Grefhorst, A., van den Beukel, J. C., Dijk, W., Steenbergen, J., Voortman, G. J., Leeuwenburgh, S., Visser, T. J., Kersten, S., Friesema, E. C. H., Themmen, A. P. N. & Visser, J. A., 1 Aug 2018, In : Journal of Endocrinology. 238, 2, p. 91-106

Research output: Contribution to journalArticleAcademicpeer-review

Liver
Lipid Metabolism
Bile Acids and Salts
Triglycerides
White Adipose Tissue
3 Citations (Scopus)

Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: Role of enhanced low grade inflammation

Gruppen, E. G., Kersten, S. & Dullaart, R. P. F., 27 Mar 2018, In : Lipids in Health and Disease. 17, 60.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Angiopoietins
Phospholipid Transfer Proteins
Inflammation
Plasmas
C-Reactive Protein
6 Citations (Scopus)

Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue

Dijk, W., Schutte, S., Aarts, E. O., Janssen, I. M. C., Afman, L. & Kersten, S., May 2018, In : Journal of Clinical Lipidology. 12, 3, p. 773-783

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Adipose Tissue
Lipoprotein Lipase
Subcutaneous Fat
Messenger RNA
Triglycerides
3 Citations (Scopus)

Short-term cooling increases serum angiopoietin-like 4 levels in healthy lean men

Nahon, K. J., Hoeke, G., Bakker, L. E. H., Jazet, I. M., Berbée, J. F. P., Kersten, S., Rensen, P. C. N. & Boon, M. R., Feb 2018, In : Journal of Clinical Lipidology. 12, 1, p. 56-61

Research output: Contribution to journalArticleAcademicpeer-review

Serum
Nonesterified Fatty Acids
Adipose Tissue
White Adipose Tissue
Lipoprotein Lipase
9 Citations (Scopus)

The Peroxisome Proliferator-Activated Receptor α is dispensable for cold-induced adipose tissue browning in mice

Defour, M., Dijk, W., Ruppert, P., Nascimento, E. B. M., Schrauwen, P. & Kersten, S., Apr 2018, In : Molecular Metabolism. 10, p. 39-54

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
PPAR alpha
Peroxisome Proliferator-Activated Receptors
Adipose Tissue
White Adipose Tissue
Groin

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A., Sugahara, G., Hooiveld, G. J. E. J., Ishida, Y., Tateno, C. & Kersten, S., 7 Jun 2018, In : BMC Genomics. 19, 443.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Fenofibrate
Peroxisome Proliferator-Activated Receptors
Transcriptome
Hepatocytes
Liver
7 Citations (Scopus)

Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects

Fazelzadeh, P., Hangelbroek, R. W. J., Joris, P. J., Schalkwijk, C. G., Esser, D., Afman, L., Hankemeier, T., Jacobs, D. M., Mihaleva, V. V., Kersten, S., van Duynhoven, J. & Boekschoten, M. V., 1 Apr 2018, In : Metabolomics. 14, 4, 46.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Metabolome
Transcriptome
Meals
Weight Loss
Blood Cells
2017
19 Citations (Scopus)

Angiopoietin-like 3 in lipoprotein metabolism

Kersten, S., 1 Dec 2017, In : Nature Reviews Endocrinology. 13, 12, p. 731-739

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Lipoproteins
Atherosclerosis
Lipoprotein Lipase
Triglycerides
7 Citations (Scopus)

ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota

Janssen, A. W. F., Dijk, W., Boekhorst, J., Kuipers, F., Groen, A. K., Lukovac, S., Hooiveld, G. J. E. J. & Kersten, S., 2017, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 10, p. 1056-1067

Research output: Contribution to journalArticleAcademicpeer-review

Taurocholic Acid
Bile Acids and Salts
Triglycerides
Gastrointestinal Microbiome
angiopoietin 4
5 Citations (Scopus)

Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites

Oteng, A. B., Bhattacharya, A., Brodesser, S., Qi, L., Tan, N. S. & Kersten, S., 2017, In : Journal of Lipid Research. 58, 6, p. 1100-1113

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Foam Cells
Ascites
Foams
Nutrition
7 Citations (Scopus)

Hypoxia-inducible lipid droplet-associated is not a direct physiological regulator of lipolysis in adipose tissue

Dijk, W., Mattijssen, F., De La Rosa Rodriguez, M., Valdes, A. L., Loft, A., Mandrup, S., Kalkhoven, E., Qi, L., Borst, J. & Kersten, S., 2017, In : Endocrinology. 158, 5, p. 1231-1251

Research output: Contribution to journalArticleAcademicpeer-review

Lipolysis
Adipose Tissue
Adipocytes
Adrenergic Agents
Nonesterified Fatty Acids
27 Citations (Scopus)

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

Janssen, A. W. F., Houben, T., Katiraei, S., Dijk, W., Boutens, L., van der Bolt, N., Wang, Z., Brown, J. M., Hazen, S. L., Mandard, S., Shiri-Sverdlov, R., Kuipers, F., Willems van Dijk, K., Vervoort, J., Stienstra, R., Hooiveld, G. J. E. J. & Kersten, S., 2017, In : Journal of Lipid Research. 58, 7, p. 1399-1416

Research output: Contribution to journalArticleAcademicpeer-review

guar gum
Bile Acids and Salts
Liver
Modulation
Inflammation
26 Citations (Scopus)

Potential mediators linking gut bacteria to metabolic health: A critical view

Janssen, A. W. F. & Kersten, S., 2017, In : Journal of Physiology. 595, 2, p. 477-487

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Bacteria
Insulin Resistance
Adipose Tissue
Health
Obesity
18 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Lipids
Adipose Tissue
Skeletal Muscle
Triglycerides
20 Citations (Scopus)

System-wide Benefits of Intermeal Fasting by Autophagy

Martinez-Lopez, N., Tarabra, E., Toledo, M., Garcia-Macia, M., Sahu, S., Coletto, L., Batista-Gonzalez, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., Kersten, S. & Singh, R., 5 Dec 2017, In : Cell Metabolism. 26, 6, p. 856-871.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Autophagy
Fasting
Caloric Restriction
Meals
Obesity
49 Citations (Scopus)

The role and regulation of the peroxisome proliferator activated receptor alpha in human liver

Kersten, S. & Stienstra, R., 2017, In : Biochimie. 136, p. 75-84

Research output: Contribution to journalArticleAcademicpeer-review

PPAR alpha
Peroxisome Proliferator-Activated Receptors
Liver
Fatty Acids
Peroxisome Proliferators
2016
50 Citations (Scopus)

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G. & Kersten, A. H., 2016, In : Journal of Lipid Research. 57, 9, p. 1670-1683

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Lipoprotein Lipase
Adipocytes
Degradation
Endoplasmic Reticulum
10 Citations (Scopus)

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

van der Kolk, B. W., Goossens, G. H., Jocken, J. W., Kersten, S. & Blaak, E. E., 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 6, p. 2332-2339

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Lipid Metabolism
Muscle
Skeletal Muscle
Meals
21 Citations (Scopus)

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

Park, J-G., Xu, X., Cho, S., Hur, K. Y., Lee, M-S., Kersten, S. & Lee, A-H., 2016, In : Scientific Reports. 6, 27938.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipolysis
Adipose Tissue
Liver
Nonesterified Fatty Acids
Ketogenic Diet
27 Citations (Scopus)

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

IJssennagger, N., Janssen, A. W. F., Milona, A., Ramos Pittol, J. M., Hollman, D. A. A., Mokry, M., Betzel, B., Berends, F. J., Janssen, I. M., van Mil, S. W. C. & Kersten, S., 2016, In : Journal of Hepatology. p. 1158-1166 64.

Research output: Contribution to journalArticleAcademicpeer-review

Gene Expression Profiling
Liver
Fatty Liver
Bile Acids and Salts
Transcriptome
8 Citations (Scopus)

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice

Evers-van Gogh, I. J. A., Oteng, A. B., Alex, S., Hamers, N., Catoire, M., Stienstra, R., Kalkhoven, E. & Kersten, S., 2016, In : Diabetologia. 59, 3, p. 624-633

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chemokine CCL2
Insulin Resistance
Insulin
Skeletal Muscle
Inflammation
60 Citations (Scopus)

Regulation of lipid metabolism by angiopoietin-like proteins

Dijk, W. & Kersten, S., 2016, In : Current Opinion in Lipidology. p. 249-256 3.

Research output: Contribution to journalArticleAcademicpeer-review

Angiopoietins
Lipid Metabolism
Lipoprotein Lipase
Triglycerides
Proteins
2015
54 Citations (Scopus)

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M. K. C., Reue, K., van Marken Lichtenbelt, W. D., Olivecrona, G., Rensen, P. C. N., Heeren, J. & Kersten, S., 2015, In : eLife. 4, 23 p., e08428.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Angiopoietins
Brown Adipose Tissue
Tissue
Lipids
Lipoprotein Lipase
67 Citations (Scopus)

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

Khedoe, P. P. S. J., Hoeke, G., Kooijman, S., Dijk, W., Buijs, J. T., Kersten, S., Havekes, L. M., Hiemstra, P. S., Berbée, J. F. P., Boon, M. R. & Rensen, P. C. N., 2015, In : Journal of Lipid Research. 56, 1, p. 51-59

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Brown Adipose Tissue
Lipolysis
Triglycerides
Tissue
Plasmas
18 Citations (Scopus)

Deletion of the gene encoding G0/G1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

El-Assaad, W., El-Kouhen, K., Mohammad, A. H. & Kersten, S., 2015, In : Diabetologia. 58, 1, p. 149-157

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
White Adipose Tissue
Gene Deletion
High Fat Diet
Weight Gain
Insulin Resistance
1 Citation (Scopus)

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring

Van Ewijk, P. A., Paglialunga, S., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., Kornips, E., Jörgensen, J. A., Hoeks, J., Wildberger, J. E., Hesselink, M. K. C., Glatz, J. F. C., Heerschap, A., Kersten, S., Schrauwen, P. & Schrauwen-Hinderling, V. B., 2015, In : Obesity. 23, 11, p. 2242-2250

Research output: Contribution to journalArticleAcademicpeer-review

Lipid Metabolism
Fats
Lipids
High Fat Diet
Liver
19 Citations (Scopus)

Electric pulse stimulation of myotubes as an in vitro exercise model: Cell-mediated and non-cell-mediated effects

Evers-Van Gogh, I. J. A., Alex, S., Stienstra, R., Brenkman, A. B., Kersten, S. & Kalkhoven, E., 19 Jun 2015, In : Scientific Reports. 5, 11 p., 10944.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Skeletal Muscle Fibers
Electric Stimulation
Gene Expression
In Vitro Techniques
Hepatocytes
7 Citations (Scopus)

Exercise training improves liver steatosis in mice

Alex, S., Boss, A., Heerschap, A. & Kersten, S., 2015, In : Nutrition & Metabolism. 12, 11 p., 29.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Fatty Liver
Exercise
Liver
Triglycerides
Lipogenesis
10 Citations (Scopus)

Global profiling of the muscle metabolome: method optimization, validation and application to determine exercise-induced metabolic effects

Alves, R. D. A. M., Dane, A. D., Harms, A., Strassburg, K., Seifar, R. M., Verdijk, L. B., Kersten, S., Berger, R., Hankemeier, T. & Vreeken, R. J., 2015, In : Metabolomics. 11, 2, p. 271-285

Research output: Contribution to journalArticleAcademicpeer-review

Metabolome
Muscle
Muscles
Skeletal Muscle
Oxylipins
5 Citations (Scopus)

Hepatic genome-wide expression of lipid metabolism in diet-induced obesity rats treated with cocoa polyphenols

Ali, F., Ismail, A., Esa, N. M., Pei, C. P. & Kersten, S., 2015, In : Journal of Functional Foods. 17, p. 969-978

Research output: Contribution to journalArticleAcademicpeer-review

Polyphenols
Lipid Metabolism
lipid metabolism
polyphenols
obesity
59 Citations (Scopus)

IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

Sun, S., Shi, G., Sha, H. & Kersten, S., 2015, In : Nature Cell Biology. 17, 12, p. 1546-1555

Research output: Contribution to journalArticleAcademicpeer-review

Endoplasmic Reticulum-Associated Degradation
Proteins
Dysbiosis
Unfolded Protein Response
Endoplasmic Reticulum Stress
14 Citations (Scopus)

Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging

Billecke, N., Bosma, M., Rock, W., Fleissner, F., Best, G., Schrauwen, P., Kersten, S., Bonn, M., Hesselink, M. K. C. & Parekh, S. H., 2015, In : Integrative Biology (United Kingdom). 7, 4, p. 467-476

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipids
Imaging techniques
Muscles
Muscle
Type 2 Diabetes Mellitus
187 Citations (Scopus)

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus

Hanssen, M. J. W., Hoeks, J., Brans, B., Boekschoten, M. V. & Kersten, A. H., 2015, In : Nature Medicine. 21, 8, p. 863-865

Research output: Contribution to journalArticleAcademicpeer-review

Brown Adipose Tissue
Acclimatization
Medical problems
Type 2 Diabetes Mellitus
Insulin Resistance