20012020

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2020

A lipase fusion feasts on fat

Ruppert, P. M. M. & Kersten, S., 6 Mar 2020, In : Journal of Biological Chemistry. 295, 10, p. 2913-2914 2 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes

Zhou, Z., Torres, M., Sha, H., Halbrook, C. J., van den Bergh, F., Reinert, R. B., Yamada, T., Wang, S., Luo, Y., Hunter, A. H., Wang, C., Sanderson, T. H., Liu, M., Taylor, A., Sesaki, H., Lyssiotis, C. A., Wu, J., Kersten, S., Beard, D. A. & Qi, L., 3 Apr 2020, In : Science. 368, 6486, p. 54-60

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

Ruppert, P. M. M., Michielsen, C. C. J. R., Hazebroek, E. J., Pirayesh, A., Olivecrona, G., Afman, L. A. & Kersten, S., Oct 2020, In : Molecular Metabolism. 40, 101033.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

HILPDA Uncouples Lipid Droplet Accumulation in Adipose Tissue Macrophages from Inflammation and Metabolic Dysregulation

van Dierendonck, X. A. M. H., de la Rosa Rodriguez, M. A., Georgiadi, A., Mattijssen, F., Dijk, W., van Weeghel, M., Singh, R., Borst, J. W., Stienstra, R. & Kersten, S., 11 Feb 2020, In : Cell Reports. 30, 6, p. 1811-1822.e6

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Mechanisms of Action of trans Fatty Acids

Oteng, A. B. & Kersten, S., 1 May 2020, In : Advances in nutrition (Bethesda, Md.). 11, 3, p. 697-708 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

MicroRNA-204-5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans

Houzelle, A., Dahlmans, D., Nascimento, E. B. M., Schaart, G., Jörgensen, J. A., Moonen-Kornips, E., Kersten, S., Wang, X. & Hoeks, J., 26 May 2020, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access
Open Access

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling

Shrestha, N., Liu, T., Ji, Y., Reinert, R. B., Torres, M., Li, X., Zhang, M., Tang, C-H. A., Hu, C-C. A., Liu, C., Naji, A., Liu, M., Lin, J. D., Kersten, S., Arvan, P. & Qi, L., 1 Jul 2020, In : The Journal of Clinical Investigation. 130, 7, p. 3499-3510

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)
2019

A single day of high-fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice

Kuipers, E. N., Held, N. M., In Het Panhuis, W., Modder, M., Ruppert, P. M. M., Kersten, S., Kooijman, S., Guigas, B., Houtkooper, R. H., Rensen, P. C. N. & Boon, M. R., Nov 2019, In : American Journal of Physiology. Endocrinology and Metabolism. 317, 5, p. E820-E830

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice

Oteng, A-B., Ruppert, P. M. M., Boutens, L., Dijk, W., van Dierendonck, X. A. M. H., Olivecrona, G., Stienstra, R. & Kersten, S., Oct 2019, In : Journal of Lipid Research. 60, p. 1741-1754

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease

Oteng, A. B., Loregger, A., van Weeghel, M., Zelcer, N. & Kersten, S., Oct 2019, In : Molecular Nutrition and Food Research. 63, 19, 1900385.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet

Nyrén, R., Makoveichuk, E., Malla, S., Kersten, S., Nilsson, S. K., Ericsson, M. & Olivecrona, G., 1 Mar 2019, In : American journal of physiology. Renal physiology. 316, 3, p. F558-F571

Research output: Contribution to journalArticleAcademicpeer-review

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

Dahlmans, D., Houzelle, A., Andreux, P., Wang, X., Jörgensen, J. A., Moullan, N., Daemen, S., Kersten, S., Auwerx, J. & Hoeks, J., May 2019, In : Journal of Cellular Physiology. 234, 5, p. 6601-6610

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S., Jun 2019, In : Current Opinion in Lipidology. 30, 3, p. 205-211

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

No effect of 25-hydroxyvitamin D supplementation on the skeletal muscle transcriptome in vitamin D deficient frail older adults

Hangelbroek, R. W. J., Vaes, A. M. M., Boekschoten, M. V., Verdijk, L. B., Hooiveld, G. J. E. J., van Loon, L. J. C., De Groot, L. C. P. G. M. & Kersten, S., 28 May 2019, In : BMC Geriatrics. 19, 151.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

Ji, Y., Sun, S., Shrestha, N., Darragh, L. B., Shirakawa, J., Xing, Y., He, Y., Carboneau, B. A., Kim, H., An, D., Ma, M., Oberholzer, J., Soleimanpour, S. A., Gannon, M., Liu, C., Naji, A., Kulkarni, R. N., Wang, Y., Kersten, S. & Qi, L., 20 May 2019, In : Nature Immunology. 20, 6, p. 677-686

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Transcriptional profiling of PPARα−/− and CREB3L3−/− livers reveals disparate regulation of hepatoproliferative and metabolic functions of PPARα

Ruppert, P. M. M., Park, J-G., Xu, X., Hur, K. Y., Lee, A-H. & Kersten, S., 11 Mar 2019, In : BMC Genomics. 20, 199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)
2018

A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening

van den Berg, R., Kooijman, S., Noordam, R., Ramkisoensing, A., Abreu-Vieira, G., Tambyrajah, L. L., Dijk, W., Ruppert, P., Mol, I. M., Kramar, B., Caputo, R., Puig, L. S., de Ruiter, E. M., Kroon, J., Hoekstra, M., van der Sluis, R. J., Meijer, O. C., Willems van Dijk, K., van Kerkhof, L. W. M., Christodoulides, C. & 8 others, Karpe, F., Gerhart-Hines, Z., Kersten, S., Meijer, J. H., Coomans, C. P., van Heemst, D., Biermasz, N. R. & Rensen, P. C. N., 27 Mar 2018, In : Cell Reports. 22, 13, p. 3521-3533

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes

Dijk, W., Ruppert, P. M. M., Oost, L. J. & Kersten, S., 7 Sep 2018, In : Journal of Biological Chemistry. 293, 36, p. 14134-14145 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle

Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., van Marken Lichtenbelt, W. D., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L. & Schrauwen, P., 24 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. 7789-7794

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
39 Citations (Scopus)

Global testing of shifts in metabolic phenotype

Fazelzadeh, P., Hoefsloot, H. C. J., Hankemeier, T., Most, J., Kersten, S., Blaak, E. E., Boekschoten, M. & van Duynhoven, J., 4 Oct 2018, In : Metabolomics. 14, 10, 139.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

Bhattacharya, A., Sun, S., Wang, H., Liu, M., Long, Q., Yin, L., Kersten, S., Zhang, K. & Qi, L., 15 Nov 2018, In : EMBO Journal. 37, 22, e99277.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase

Padmanabha Das, K. M., Wechselberger, L., Liziczai, M., De La Rosa Rodriguez, M., Grabner, G. F., Heier, C., Viertlmayr, R., Radler, C., Lichtenegger, J., Zimmermann, R., Borst, J. W., Zechner, R., Kersten, S. & Oberer, M., 2018, In : Journal of Lipid Research. 59, 3, p. 531-541

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice

van der Lugt, B., Rusli, F., Lute, C., Lamprakis, A., Salazar, E., Boekschoten, M. V., Hooiveld, G. J., Müller, M., Vervoort, J., Kersten, S., Belzer, C., Kok, D. E. G. & Steegenga, W. T., 16 May 2018, In : Aging. 10, 5, p. 930-950

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
17 Citations (Scopus)

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K. & Kersten, S., Jun 2018, In : Diabetologia. 61, 6, p. 1447-1458

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Multiple effects of cold exposure on livers of male mice

Grefhorst, A., van den Beukel, J. C., Dijk, W., Steenbergen, J., Voortman, G. J., Leeuwenburgh, S., Visser, T. J., Kersten, S., Friesema, E. C. H., Themmen, A. P. N. & Visser, J. A., 1 Aug 2018, In : Journal of Endocrinology. 238, 2, p. 91-106

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Plasma angiopoietin-like 4 is related to phospholipid transfer protein activity in diabetic and non-diabetic subjects: Role of enhanced low grade inflammation

Gruppen, E. G., Kersten, S. & Dullaart, R. P. F., 27 Mar 2018, In : Lipids in Health and Disease. 17, 60.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue

Dijk, W., Schutte, S., Aarts, E. O., Janssen, I. M. C., Afman, L. & Kersten, S., May 2018, In : Journal of Clinical Lipidology. 12, 3, p. 773-783

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Short-term cooling increases serum angiopoietin-like 4 levels in healthy lean men

Nahon, K. J., Hoeke, G., Bakker, L. E. H., Jazet, I. M., Berbée, J. F. P., Kersten, S., Rensen, P. C. N. & Boon, M. R., Feb 2018, In : Journal of Clinical Lipidology. 12, 1, p. 56-61

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

The Peroxisome Proliferator-Activated Receptor α is dispensable for cold-induced adipose tissue browning in mice

Defour, M., Dijk, W., Ruppert, P., Nascimento, E. B. M., Schrauwen, P. & Kersten, S., Apr 2018, In : Molecular Metabolism. 10, p. 39-54

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

de la Rosa Rodriguez, M. A., Sugahara, G., Hooiveld, G. J. E. J., Ishida, Y., Tateno, C. & Kersten, S., 7 Jun 2018, In : BMC Genomics. 19, 443.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Weight loss moderately affects the mixed meal challenge response of the plasma metabolome and transcriptome of peripheral blood mononuclear cells in abdominally obese subjects

Fazelzadeh, P., Hangelbroek, R. W. J., Joris, P. J., Schalkwijk, C. G., Esser, D., Afman, L., Hankemeier, T., Jacobs, D. M., Mihaleva, V. V., Kersten, S., van Duynhoven, J. & Boekschoten, M. V., 1 Apr 2018, In : Metabolomics. 14, 4, 46.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)
2017

Angiopoietin-like 3 in lipoprotein metabolism

Kersten, S., 1 Dec 2017, In : Nature Reviews Endocrinology. 13, 12, p. 731-739

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota

Janssen, A. W. F., Dijk, W., Boekhorst, J., Kuipers, F., Groen, A. K., Lukovac, S., Hooiveld, G. J. E. J. & Kersten, S., 2017, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 10, p. 1056-1067

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Feeding Angptl4-/- mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites

Oteng, A. B., Bhattacharya, A., Brodesser, S., Qi, L., Tan, N. S. & Kersten, S., 2017, In : Journal of Lipid Research. 58, 6, p. 1100-1113

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Hypoxia-inducible lipid droplet-associated is not a direct physiological regulator of lipolysis in adipose tissue

Dijk, W., Mattijssen, F., De La Rosa Rodriguez, M., Valdes, A. L., Loft, A., Mandrup, S., Kalkhoven, E., Qi, L., Borst, J. & Kersten, S., 2017, In : Endocrinology. 158, 5, p. 1231-1251

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

Janssen, A. W. F., Houben, T., Katiraei, S., Dijk, W., Boutens, L., van der Bolt, N., Wang, Z., Brown, J. M., Hazen, S. L., Mandard, S., Shiri-Sverdlov, R., Kuipers, F., Willems van Dijk, K., Vervoort, J., Stienstra, R., Hooiveld, G. J. E. J. & Kersten, S., 2017, In : Journal of Lipid Research. 58, 7, p. 1399-1416

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)

Potential mediators linking gut bacteria to metabolic health: A critical view

Janssen, A. W. F. & Kersten, S., 2017, In : Journal of Physiology. 595, 2, p. 477-487

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
27 Citations (Scopus)
25 Citations (Scopus)

System-wide Benefits of Intermeal Fasting by Autophagy

Martinez-Lopez, N., Tarabra, E., Toledo, M., Garcia-Macia, M., Sahu, S., Coletto, L., Batista-Gonzalez, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., Kersten, S. & Singh, R., 5 Dec 2017, In : Cell Metabolism. 26, 6, p. 856-871.e5

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

The role and regulation of the peroxisome proliferator activated receptor alpha in human liver

Kersten, S. & Stienstra, R., 2017, In : Biochimie. 136, p. 75-84

Research output: Contribution to journalArticleAcademicpeer-review

69 Citations (Scopus)
2016

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

Dijk, W., Beigneux, A. P., Larsson, M., Bensadoun, A., Young, S. G. & Kersten, A. H., 2016, In : Journal of Lipid Research. 57, 9, p. 1670-1683

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)

Angiopoietin-Like Protein 4 and Postprandial Skeletal Muscle Lipid Metabolism in Overweight and Obese Prediabetics

van der Kolk, B. W., Goossens, G. H., Jocken, J. W., Kersten, S. & Blaak, E. E., 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 6, p. 2332-2339

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis

Park, J-G., Xu, X., Cho, S., Hur, K. Y., Lee, M-S., Kersten, S. & Lee, A-H., 2016, In : Scientific Reports. 6, 27938.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
27 Citations (Scopus)

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

IJssennagger, N., Janssen, A. W. F., Milona, A., Ramos Pittol, J. M., Hollman, D. A. A., Mokry, M., Betzel, B., Berends, F. J., Janssen, I. M., van Mil, S. W. C. & Kersten, S., 2016, In : Journal of Hepatology. p. 1158-1166 64.

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)

Muscle-specific inflammation induced by MCP-1 overexpression does not affect whole-body insulin sensitivity in mice

Evers-van Gogh, I. J. A., Oteng, A. B., Alex, S., Hamers, N., Catoire, M., Stienstra, R., Kalkhoven, E. & Kersten, S., 2016, In : Diabetologia. 59, 3, p. 624-633

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Regulation of lipid metabolism by angiopoietin-like proteins

Dijk, W. & Kersten, S., 2016, In : Current Opinion in Lipidology. p. 249-256 3.

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)
2015

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure

Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M. K. C., Reue, K., van Marken Lichtenbelt, W. D., Olivecrona, G., Rensen, P. C. N., Heeren, J. & Kersten, S., 2015, In : eLife. 4, 23 p., e08428.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
59 Citations (Scopus)

Brown adipose tissue takes up plasma triglycerides mostly after lipolysis

Khedoe, P. P. S. J., Hoeke, G., Kooijman, S., Dijk, W., Buijs, J. T., Kersten, S., Havekes, L. M., Hiemstra, P. S., Berbée, J. F. P., Boon, M. R. & Rensen, P. C. N., 2015, In : Journal of Lipid Research. 56, 1, p. 51-59

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
72 Citations (Scopus)