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Research Output 1994 2020

2011

LC-MS metabolite profiling on tomato seedlings in a systems biology approach

Gomez Roldan, M. V., Bovy, A. G., de Vos, R. C. H., Groenenboom, M. A. C., Astola, L. J., Molenaar, J., van Eeuwijk, F. A. & Hall, R. D., 2011.

Research output: Contribution to conferencePosterProfessional

17 Citations (Scopus)

Metabolomics of a model fruit: tomato

de Vos, R. C. H., Hall, R. D. & Moing, A., 2011, The Biology of Plant Metabolomics . Annual Plant Reviews. Oxford: Blackwell/Wiley, p. 109-156 405 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

metabolomics
tomatoes
fruits
phenotype
plant physiology
49 Citations (Scopus)

Plant Metabolomics and Its Potential for Systems Biology Research: Background Concepts, Technology, and Methodology

Allwood, J. W., de Vos, C. H., Moing, A., Deborde, C., Erban, A., Kopka, J., Goodacre, R. & Hall, R. D., 2011, Methods in Systems Biology. Jameson, D., Verma, M. & Westerhoff, H. V. (eds.). p. 299-336 (Methods in Enzymology; no. 500).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Mass spectrometry
Throughput
Liquid chromatography
Metabolites
Gene expression
77 Citations (Scopus)
Polyphenols
Metabolites
Spectroscopy
Ions
Glycosylation
20 Citations (Scopus)
Cornus
Cornus mas
Prunus laurocerasus
Proanthocyanidins
procyanidins
54 Citations (Scopus)

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana.

Liu, Q., Majdi, M., Cankar, K., Goedbloed, M. A., Charnikhova, T., Verstappen, F. W. A., de Vos, R. C. H., Beekwilder, M. J., van der Krol, S. & Bouwmeester, H. J., 2011, In : PLoS ONE. 6, 8, 12 p., e23255.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chicory
chicory
Nicotiana benthamiana
Biosynthetic Pathways
Yeast
42 Citations (Scopus)

The patterns of population differentiation in a Brassica rapa core collection

Pino del Carpio, D., Basnet, R. K., de Vos, R. C. H., Maliepaard, C. A., Visser, R. G. F. & Bonnema, A. B., 2011, In : Theoretical and Applied Genetics. 122, 6, p. 1105-1118

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Brassica rapa
metabolites
taxonomy
Population
Genetic Techniques

The role of metabolomics in plant studies – views on sampling and data acquisition

Allwood, J. W., Moing, A., de Vos, C. H., Deborde, C., Kokpa, J. & Hall, R. D., 2011, Methods in Systems Biology. Westerhoff, H., Verma, M. & Jameson, D. (eds.). (Methods in Systems Biology; no. 500).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Tomatinase from Cladosporium fulvum is required for full virulence by degrading a-tomatine during tomato infection

Ökmen, B., Etalo, D. W., Collemare, J., Stergiopoulos, I., de Vos, R. C. H., Joosten, M. H. A. J. & de Wit, P. J. G. M., 2011, Book of Abstracts of the EPS PhD Autumn School 'Host-Microbe Interactomics', Wageningen, The Netherlands, 1-3 November 2011. Wageningen, The Netherlands, p. 37-38

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

Passalora fulva
virulence
tomatoes
infection
Fusarium oxysporum
48 Citations (Scopus)

Transcriptomic profiling of citrus fruit peel tissues reveals fundamental effects of phenylpropanoids and ethylene on induced resistance

Ballester Frutos, A. R., Lafuente, M. T., Forment, J., Gadea, J., de Vos, C. H. R., Bovy, A. G. & Gonzalez-Candelas, L., 2011, In : Molecular Plant Pathology. 12, 9, p. 879-897

Research output: Contribution to journalArticleAcademicpeer-review

fruit peels
Citrus
induced resistance
citrus fruits
phenylpropanoids
2010
65 Citations (Scopus)
Open Access
phenylpropanoids
Lycopersicon esculentum
Fruit
tomatoes
fruits
165 Citations (Scopus)

Biochemical and molecular analysis of pink tomatoes: deregulated expression of the gene encoding transcription factor SlMYB12 leads to pink tomato fruit colour

Ballester, A. R., Molthoff, J. W., de Vos, C. H., Lintel Hekkert, B., Orzaez, D., Fernandez-Moreno, J. P., Tripodi, S., Grandillo, S., Martin, C., Heldens, J., Ykema, M., Granell, A. & Bovy, A. G., 2010, In : Plant Physiology. 152, p. 71-84

Research output: Contribution to journalArticleAcademicpeer-review

Lycopersicon esculentum
Fruit
Transcription Factors
transcription factors
Color
129 Citations (Scopus)

Carotenoid and Fatty Acid Metabolism in Light-Stressed Dunaliella salina

Lamers, P. P., Laak, C. W., Kaasenbrood, P. S., Lorier, J., Janssen, M. G. J., de Vos, C. H., Bino, R. J. & Wijffels, R. H., 2010, In : Biotechnology and Bioengineering. 106, 4, p. 638-648

Research output: Contribution to journalArticleAcademicpeer-review

Carotenoids
Fatty acids
Metabolism
Fatty Acids
Light

Coffee chemometrics as a new concept: Untargeted metabolic profining of coffee

Lindinger, C., de Vos, C. H., Lambot, C., Pollien, P., Rytz, A., Voirol-Baliguet, E., Fumeaux, R., Robert, F., Yeretzian, C. & Blank, I., 2010, Proceeding of the 12th Weurman symposium, Interlaken, Switzerland, 1 - 4 July, 2008. C. Yeretzian I. Blank, M. W. (ed.). Winterthur: Zürcher Hochschule für Angewandte Wissenschaften, p. 581-584

Research output: Chapter in Book/Report/Conference proceedingConference paper

Open Access

Flavour metabolomics – Holistic metabolic in flavour research

de Vos, C. H., Tikunov, Y. M., Bovy, A. G. & Hall, R. D., 2010, Proceeding of the 12th Weurman symposium, Interlaken, Switzerland, 1 - 4 July, 2008. C. Yeretzian I. Blank, M. W. (ed.). Winterthur: Zürcher Hochschule für Angewandte Wissenschaften, p. 573-580

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

48 Citations (Scopus)

From QTL to candidate gene: Genetical genomics of simple and complex traits in potato using a pooling strategy

Kloosterman, B. A., Oortwijn, M. E. P., uit de Willigen, J., America, A. H. P., de Vos, C. H., Visser, R. G. F. & Bachem, C. W. B., 2010, In : BMC Genomics. 11, 158.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Solanum tuberosum
Genomics
Cooking
Genetic Association Studies
Genes
13 Citations (Scopus)

Physiological responses to folate overproduction in Lactobacillus plantarum WCFS1

Wegkamp, A., Mars, A. E., Faijes, M., Molenaar, D., de Vos, R. C. H., Klaus, M. J., Hanson, A. D., de Vos, W. M. & Smid, E. J., 2010, In : Microbial Cell Factories. 9, 14 p., 100.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactobacillus plantarum
Folic Acid
Metabolites
Gene expression
Proteins
8 Citations (Scopus)

Plant Metabolomics Applications in the Brassicaceae: Added Value for Science and Industry

Hall, R. D., de Vos, C. H. & Ward, J., 2010, In : Acta Horticulturae. 867, p. 191-205

Research output: Contribution to journalArticleAcademicpeer-review

metabolomics
value added
Brassicaceae
industry
proteomics
451 Citations (Scopus)

Plant molecular stress responses face climate change. Trends in Plants

Ahuja, I., de Vos, R. C. H., Bones, A. M. & Hall, R. D., 2010, In : Trends in Plant Science. 15, 12, p. 664-674

Research output: Contribution to journalArticleAcademicpeer-review

stress response
climate change
plant adaptation
sustainable agriculture
food security
26 Citations (Scopus)

Production of novel antioxidative phenolic amides through heterologous expression of the plant’s chlorogenic acid biosynthesis genes in yeast

Moglia, A., Comino, C., Lanteri, S., de Vos, C. H., de Waard, P., van Beek, T. A., Goitre, L., Retta, S. F. & Beekwilder, M. J., 2010, In : Metabolic Engineering. 12, 3, p. 223-232

Research output: Contribution to journalArticleAcademicpeer-review

3-Hydroxyanthranilic Acid
Chlorogenic Acid
Biosynthesis
Amides
Yeast
67 Citations (Scopus)

The Effect of Industrial Food Processing on Potentially Health-beneficial Tomato Antioxidants

Capanoglu, E., Beekwilder, M. J., Boyacioglu, D., de Vos, R. C. H. & Hall, R. D., 2010, In : Critical Reviews in Food Science and Nutrition. 50, 10, p. 919-930

Research output: Contribution to journalArticleAcademicpeer-review

Food processing
Food Handling
Lycopersicon esculentum
Antioxidants
food processing
2009
24 Citations (Scopus)

Automated procedure for candidate compound selection in GCMS metabolomics based on prediction of Kovats retention index

Mihaleva, V. V., Verhoeven, H. A., de Vos, C. H., Hall, R. D. & van Ham, R. C. H. J., 2009, In : Bioinformatics. 25, 6, p. 787-794

Research output: Contribution to journalArticleAcademicpeer-review

Metabolomics
Gas Chromatography-Mass Spectrometry
Libraries
Hits
Prediction
47 Citations (Scopus)

Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus.

Beekwilder, M. J., Marcozzi, D., Vecchi, S., de Vos, C. H., Janssen, P., Francke, C., van Hylckama Vlieg, J. E. T. & Hall, R. D., 2009, In : Applied and Environmental Microbiology. 75, 11, p. 3447-3454

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
alpha-L-rhamnosidase
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus
Lycopersicon esculentum

Coffee Metabolomics – a real kick!

de Vos, R. C. H., Borem, F. M., Bouwmeester, H. J., Hageman, J., Lindinger, C., Blanc, I., Bino, R. J. & Hall, R. D., 2009, Metabomeeting 2009, 5-8 July 2009, Norwich, UK. Norwich, UK.: Norwich BioScience Institutes, Institute of Food Research/John Innes Centre, p. 69

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

metabolomics
coffee beans
metabolites
postharvest treatment
Coffea arabica
111 Citations (Scopus)

Developmental, genetic and environmental factors affect the expression of flavonoid genes, enzymes and metabolites in strawberry fruits

Carbone, F., Preuss, A., de Vos, C. H., d'Amico, E., Perrotta, G., Bovy, A. G., Martens, S. & Rosati, C., 2009, In : Plant, Cell & Environment. 32, 8, p. 1117-1131

Research output: Contribution to journalArticleAcademicpeer-review

Fragaria
Flavonoids
strawberries
Fruit
flavonoids
131 Citations (Scopus)

Fruit-Surface Flavonoid Accumulation in Tomato Is Controlled by a SlMYB12-Regulated Transcriptional Network

Adato, A., Mandel, T., Mintz-Orion, S., Venger, I., Levy, D., Yativ, M., Dominguez, E., Wang, Z., de Vos, C. H., Jetter, R., Schreiber, L., Heredia, A., Rogachev, I. & Aharoni, A., 2009, In : Plos Genetics. 5, 12, 23 p., e1000777.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Gene Regulatory Networks
Lycopersicon esculentum
Flavonoids
Fruit
flavonoids
15 Citations (Scopus)

Identification of Ethyl Formate as a Quality Marker of the Fermented Off-note in Coffee by a Nontargeted Chemometric Approach

Lindinger, C., Pollien, P., de Vos, C. H., Tikunov, Y. M., Hageman, J. A., Lambot, C., Fumeaux, R., Voirol-Baliguet, E. & Blank, I., 2009, In : Journal of Agricultural and Food Chemistry. 57, 21, p. 9972-9978

Research output: Contribution to journalArticleAcademicpeer-review

Coffee
formates
chemometrics
roasting
brewing
33 Citations (Scopus)

Isolation and mapping of a C3'H gene (CYP98A49) from globe artichoke, and its expression upon UV-C stress

Moglia, A., Comino, C., Portis, E., Acquadro, A., de Vos, C. H., Beekwilder, M. J. & Lanteri, S., 2009, In : Plant Cell Reports. 28, 6, p. 963-974

Research output: Contribution to journalArticleAcademicpeer-review

artichokes
chlorogenic acid
genes
acids
linkage groups
69 Citations (Scopus)

Metabolomic and genetic analyses of flavonol synthesis in Arabidopsis thaliana support the in vivo involvement of leucoanthocyanidin dioxygenase

Stracke, R., de Vos, R. C. H., Bartelniewoehner, L., Ishihara, H., Sagasser, M., Martens, S. & Weisshaar, B., 2009, In : Planta. 229, 2, p. 427-445

Research output: Contribution to journalArticleAcademicpeer-review

Metabolomics
metabolomics
flavonols
Arabidopsis
Arabidopsis thaliana
166 Citations (Scopus)

System-wide molecular evidence for phenotypic buffering in Arabidopsis

Fu, J., Keurentjes, J. J. B., Bouwmeester, H. J., America, T., Verstappen, F., Ward, J. L., Beale, M. H., de Vos, C. H., Dijkstra, M., Scheltema, R. A., Johannes, F., Koornneef, M., Vreugdenhil, D., Breitling, R. & Jansen, R. C., 2009, In : Nature Genetics. 41, 2, p. 166-167

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative Trait Loci
Arabidopsis
Mass Spectrometry
Electrophoresis, Gel, Two-Dimensional
Liquid Chromatography
2008
21 Citations (Scopus)

Accurate mass error correction in liquid chromatography time-of-flight mass spectrometry based metabolomics

Mihaleva, V. V., Vorst, O. F. J., Maliepaard, C. A., Verhoeven, H. A., de Vos, C. H., Hall, R. D. & van Ham, R. C. H. J., 2008, In : Metabolomics. 4, 2, p. 171-182

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Boidae
Metabolomics
Automation
Liquid chromatography
Error correction
308 Citations (Scopus)

Antioxidants, phenolic compounds, and nutritional quality of different strawberry genotypes

Tulipani, S., Mezzetti, B., Capocasa, F., Bompadre, S., Beekwilder, M. J., de Vos, C. H., Capanoglu, E., Bovy, A. G. & Battino, M., 2008, In : Journal of Agricultural and Food Chemistry. 56, 3, p. 696-704

Research output: Contribution to journalArticleAcademicpeer-review

Fragaria
Nutritive Value
strawberries
phenolic compounds
Antioxidants

A two-component system for seedless fruit development

Bovy, A. G., de Vos, C. H., Schijlen, E. G. W. M. & Angenent, G. C., 31 Jan 2008, Patent No. WO2008013450, Priority date 24 Jul 2006

Research output: PatentOther research output

Open Access
fruiting
eggplants
melons
seed set
pepper
186 Citations (Scopus)

Changes in antioxidant and metabolite profiles during production of tomato paste

Capanoglu, E., Beekwilder, M. J., Boyacioglu, D., Hall, R. D. & de Vos, C. H., 2008, In : Journal of Agricultural and Food Chemistry. 56, 3, p. 964-973

Research output: Contribution to journalArticleAcademicpeer-review

tomato paste
Lycopersicon esculentum
Ointments
Metabolites
Fruits
107 Citations (Scopus)

Exploring and exploiting carotenoid accumulation in Dunaliella salina for cell-factory applications

Lamers, P. P., Janssen, M. G. J., de Vos, C. H., Bino, R. J. & Wijffels, R. H., 2008, In : Trends in Biotechnology. 26, 11, p. 631-638

Research output: Contribution to journalArticleAcademicpeer-review

Carotenoids
Industrial plants
Plastoquinone
Algae
Oxidation-Reduction
55 Citations (Scopus)
Open Access
Metabolomics
Liquid chromatography
Lycopersicon esculentum
Metabolites
Liquid Chromatography
20 Citations (Scopus)

Metabolism of carotenoids and apocarotenoids during ripening of raspberry fruit

Beekwilder, M. J., van der Meer, I. M., Simic, A., Uitdewilligen, J., van Arkel, J., de Vos, C. H., Jonker, H. H., Verstappen, F. W. A., Bouwmeester, H. J., Sibbesen, O., Qvist, I., Mikkelsen, J. D. & Hall, R. D., 2008, In : BioFactors. 34, 1, p. 57-66

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carotenoids
Fruits
Metabolism
Fruit
Norisoprenoids
86 Citations (Scopus)

Stress -induced biosynthesis of dicaffeoylquinic acids in globe artichoke

Moglia, A., Lanteri, S., Comino, C., Acquadro, A., de Vos, C. H. & Beekwilder, M. J., 2008, In : Journal of Agricultural and Food Chemistry. 56, 18, p. 8641-8649

Research output: Contribution to journalArticleAcademicpeer-review

Cynara scolymus
artichokes
Biosynthesis
biosynthesis
acids
152 Citations (Scopus)

The Impact of the Absence of Aliphatic Glucosinolates on Insect Herbivory in Arabidopsis

Beekwilder, J., van Leeuwen, W., van Dam, N. M., Bertossi, M., Grandi, V., Mizzi, L., Soloview, M., Szabados, L., Molthoff, J. W., Schipper, B., Verbocht, H., de Vos, C. H., Morandini, P., Aarts, M. G. M. & Bovy, A. G., 2008, In : PLoS ONE. 3, 4, 12 p., e2068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glucosinolates
Herbivory
glucosinolates
Arabidopsis
Insects
257 Citations (Scopus)

Tomato strigolactones are derived from carotenoids and their biosynthesis is promoted by phosphate starvation

Lopez Raez, J. A., Charnikhova, T., Gomez-Roldan, M. V., Matusova, R., Kohlen, W., de Vos, C. H., Verstappen, F. W. A., Puech-Pages, V., Becard, G., Mulder, P. P. J. & Bouwmeester, H. J., 2008, In : New Phytologist. 178, 4, p. 863-874

Research output: Contribution to journalArticleAcademicpeer-review

parasitic plants
Carotenoids
Lycopersicon esculentum
Germination
Starvation
2007
136 Citations (Scopus)

Characterization of major enzymes and genes involved in flavonoid and proanthocyanidin biosynthesis during fruit development in strawberry (Fragaria x ananassa).

Almeida, J. R., d'Amico, E., Preuss, A., Carbone, F. & de Vos, C. H., 2007, In : Archives of Biochemistry and Biophysics. 465, 1, p. 61-71

Research output: Contribution to journalArticleAcademicpeer-review

Fragaria
Biosynthesis
Fruits
Flavonoids
Fruit
19 Citations (Scopus)

Iridoids from Pentas lanceolata (Forssk.) Deflers

Schripsema, J., Caprini, C. P., van der Heijden, R., Bino, R. J., de Vos, C. H. & Dagnino, D., 2007, In : Journal of Natural Products. 70, 9, p. 1495-1498

Research output: Contribution to journalArticleAcademicpeer-review

Iridoids
Rubiaceae
Iridoid Glucosides
High Pressure Liquid Chromatography
Antennas
232 Citations (Scopus)

Metabolomics technologies and metabolite identification

Moco, S. I. A., Bino, R. J., de Vos, C. H. & Vervoort, J. J. M., 2007, In : TrAC : Trends in Analytical Chemistry. 26, 9, p. 855-866

Research output: Contribution to journalArticleAcademicpeer-review

Metabolites
Biological systems
Mass spectrometry
Nuclear magnetic resonance
Liquid chromatography
154 Citations (Scopus)

RNA interference silencing of chalcone synthase, the first step in the flavonoid biosynthesis pathway, leads to parthenocarpic tomato fruits

Schijlen, E. G. W. M., de Vos, C. H., Martens, S., Jonker, H. H., Rosin, F. M. A., Molthoff, J. W., Tikunov, Y. M., Angenent, G. C., van Tunen, A. J. & Bovy, A. G., 2007, In : Plant Physiology. 144, 3, p. 1520-1530

Research output: Contribution to journalArticleAcademicpeer-review

naringenin-chalcone synthase
Lycopersicon esculentum
RNA Interference
RNA interference
Flavonoids
137 Citations (Scopus)

Tissue specialization at the metabolite level is perceived during the development of tomota fruit.

Moco, S. I. A., Capanoglu, E., Tikunov, Y. M., Bino, R. J., Boyacioglu, D., Hall, R. D., Vervoort, J. J. M. & de Vos, C. H., 2007, In : Journal of Experimental Botany. 58, 15-16, p. 4131-4146

Research output: Contribution to journalArticleAcademicpeer-review

Lycopersicon esculentum
fruiting
Fruit
metabolites
tomatoes
39 Citations (Scopus)

Unravelling enzymatic discoloration in potato through a combined approach of candidate genes, QTL, and expression analysis

Werij, J. S., Kloosterman, B. A., Celis-Gamboa, C., de Vos, C. H., America, A. H. P., Visser, R. G. F. & Bachem, C. W. B., 2007, In : Theoretical and Applied Genetics. 115, 2, p. 245-252

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Quantitative Trait Loci
Solanum tuberosum
discoloration
quantitative trait loci
potatoes
483 Citations (Scopus)

Untargeted large-scale plant metabolomics using liquid chromatography coupled to mass spectrometry

de Vos, C. H., Moco, S. I. A., Lommen, A., Keurentjes, J. J. B., Bino, R. J. & Hall, R. D., 2007, In : Nature protocols. 2, 4, p. 778-791

Research output: Contribution to journalArticleAcademicpeer-review

Metabolomics
Liquid chromatography
Metabolites
Liquid Chromatography
Mass spectrometry

Untargeted metabolomics as a novel tool in coffee research

de Vos, C. H., Borém, F. M., Bouwmeester, H. J. & Bino, R. J., 2007.

Research output: Contribution to conferenceAbstractAcademic

Open Access
2006
363 Citations (Scopus)

A liquid chromatography-mass spectrometry-based metabolome database for tomato

Moco, S. I. A., Bino, R. J., Vorst, O. F. J., Verhoeven, H. A., de Groot, J. C. W., van Beek, T. A., Vervoort, J. J. M. & de Vos, C. H., 2006, In : Plant Physiology. 141, 4, p. 1205-1218

Research output: Contribution to journalArticleAcademicpeer-review

metabolome
Metabolome
Lycopersicon esculentum
Liquid Chromatography
liquid chromatography