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Research Output 1995 2019

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1 Citation (Scopus)

Intraileal casein infusion increases plasma concentrations of amino acids in humans: A randomized cross over trial

Ripken, D., van Avesaat, M., Troost, F. J., Masclee, A. A., Witkamp, R. F. & Hendriks, H. F., 2017, In : Clinical Nutrition. 36, 1, p. 143-149

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Caseins
Cross-Over Studies
Amino Acids
Oxylipins
C-Reactive Protein
3 Citations (Scopus)

In vitro anti-inflammatory and radical scavenging properties of chinotto (Citrus myrtifolia Raf.) essential oils

Plastina, P., Apriantini, A., Meijerink, J., Witkamp, R., Gabriele, B. & Fazio, A., 18 Jun 2018, In : Nutrients. 10, 6, 783.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Citrus
Volatile Oils
essential oils
Anti-Inflammatory Agents
Fruit

Ionized and Total Magnesium Levels Change during Repeated Exercise in Older Adults

Terink, R., Balvers, M. G., Bongers, C. C. W. G., Eijsvogels, T. M. H., Witkamp, R. F., Mensink, M., Hopman, M. T. & Klein Gunnewiek, J. M. T., Jun 2019, In : Journal of Nutrition, Health and Aging. 23, 6, p. 595-601 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Magnesium
Walking
Exercise
Health
Population
5 Citations (Scopus)

Let thy food be thy medicine….when possible

Witkamp, R. F. & van Norren, K., 5 Oct 2018, In : European Journal of Pharmacology. 836, p. 102-114

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Medicine
Food
Life Style
Health Transition
Food-Drug Interactions
11 Citations (Scopus)

Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice

Wei, H., Hu, C., Wang, M., van den Hoek, A. M., Reijmers, T. H., Wopereis, S., Bouwman, J., Ramaker, R., Korthout, H. A. A. J., Vennik, M., Hankemeier, T., Havekes, L. M., Witkamp, R. F., Verheij, E. R., Xu, G. & de Greef, J., 2012, In : PLoS ONE. 7, 1, e30332.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biochemistry
rimonabant
metabolic syndrome
biochemistry
mice
23 Citations (Scopus)

Liquid chromatography–tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells

Balvers, M. G. J., Wortelboer, H. M., Witkamp, R. F. & Verhoeckx, K. C. M., 2013, In : Analytical Biochemistry. 434, 2, p. 275-283

Research output: Contribution to journalArticleAcademicpeer-review

Ethanolamines
Plasma Cells
Nonesterified Fatty Acids
Mass spectrometry
Blood Cells
3 Citations (Scopus)

Macronutrient Intakes in 553 Dutch Elite and Sub-Elite Endurance, Team, and Strength Athletes: Does Intake Differ between Sport Disciplines?

Wardenaar, F., Brinkmans, N., Ceelen, I., Van Rooij, B., Mensink, M., Witkamp, R. & De Vries, J., 2017, In : Nutrients. 9, 2, 119.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
athletes
sports
Athletes
Sports
Energy Intake
24 Citations (Scopus)

Measurement of palmitoylethanolamide and other N-acylethanolamines during physiological and pathological conditions

Balvers, M. G. J., Verhoeckx, K. C. M., Meijerink, J., Wortelboer, H. M. & Witkamp, R. F., 2013, In : CNS & Neurological Disorders. 12, 1, p. 26-33

Research output: Contribution to journalArticleAcademicpeer-review

Ethanolamines
amidase
palmidrol
N-acylethanolamines
Physiological Phenomena
42 Citations (Scopus)

Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study

Ham, A. C., Swart, K. M. A., Enneman, A. W., van Dijk, S. C., Araghi, S. O., van Wijngaarden, J. P., van der Zwaluw, N. L., Brouwer, E. M., Dhonukshe-Rutten, R. A. M., van Schoor, N. M., van der Cammen, T. J. M., Lips, P., Uitterlinden, A. G., Witkamp, R. F., Stricker, B. H., van der Velde, N. & de Groot, C. P. G. M., 2014, In : Drugs & Aging. 31, 12, p. 917-927

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin B Complex
Osteoporotic Fractures
Confidence Intervals
Independent Living
Population
12 Citations (Scopus)

Micronutrient Intakes in 553 Dutch Elite and Sub-Elite Athletes: Prevalence of Low and High Intakes in Users and Non-Users of Nutritional Supplements

Wardenaar, F., Brinkmans, N., Ceelen, I., Van Rooij, B., Mensink, M., Witkamp, R. & De Vries, J., 2017, In : Nutrients. 9, 2, 142.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Micronutrients
athletes
dietary minerals
Athletes
dietary supplements
3 Citations (Scopus)

Moderate alcohol consumption after a mental stressor attenuates the endocrine stress response

Schrieks, I. C., Joosten, M. M., Klöpping-Ketelaars, W. A. A., Witkamp, R. F. & Hendriks, H. F. J., 2016, In : Alcohol. 57, p. 29-34

Research output: Contribution to journalArticleAcademicpeer-review

alcohol consumption
Alcohol Drinking
alcohol
Alcohols
Beer
18 Citations (Scopus)

Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men

Joosten, M. M., van Erk, M. J., Pellis, E. P. M., Witkamp, R. F. & Hendriks, H. F. J., 2012, In : British Journal of Nutrition. 108, 4, p. 620-627

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Transcriptome
Alcohol Drinking
Leukocytes
Proteins
10 Citations (Scopus)

Moderate alcohol consumption stimulates food intake and food reward of savoury foods

Schrieks, I. C., Stafleu, A., Griffioen-Roose, S., de Graaf, K., Witkamp, R. F., Boerrigter-Rijneveld, R. & Hendriks, H. F. J., 1 Jun 2015, In : Appetite. 89, p. 77-83

Research output: Contribution to journalArticleAcademicpeer-review

Satureja
Reward
Alcohol Drinking
Eating
Alcohols
31 Citations (Scopus)

Multi-laboratory study of the analysis and kinetics of stanozolol and its metabolites in treated calves

de Brabander, H. F., de Wasch, K., van Ginkel, L. A., Sterk, S. S., Blokland, M. H., Delahaut, P., Taillieu, X., Dubois, M., Arts, C. J. M., van Baak, M. J., Gramberg, L. G., Schilt, R., van Bennekom, E. O., Courtheyn, D., Vercammen, J. & Witkamp, R. F., 1998, In : The Analyst. 123, p. 2599-2604

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)
Endocannabinoids
Macrophage Activation
Docosahexaenoic Acids
Macrophages
Omega-3 Fatty Acids

N-Eicosapentaenoyl Dopamine, A Conjugate of Dopamine and Eicosapentaenoic Acid (EPA), Exerts Anti-inflammatory Properties in Mouse and Human Macrophages

Augimeri, G., Plastina, P., Gionfriddo, G., Rovito, D., Giordano, C., Fazio, A., Barone, I., Catalano, S., Andò, S., Bonofiglio, D., Meijerink, J. & Witkamp, R., 18 Sep 2019, In : Nutrients. 11, 9, 2247.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Eicosapentaenoic Acid
eicosapentaenoic acid
dopamine
anti-inflammatory activity
Dopamine

Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages

de Bus, I., Zuilhof, H., Witkamp, R., Balvers, M. & Albada, B., Nov 2019, In : Journal of Lipid Research. 60, 11, p. 1829-1840

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Ethanolamine
Macrophages
Omega-3 Fatty Acids
Cyclooxygenase 2
Metabolites
8 Citations (Scopus)

Nutrient-induced glucagon like peptide-1 release is modulated by serotonin

Ripken, D., van der Wielen, N., Wortelboer, H. M., Meijerink, J., Witkamp, R. F. & Hendriks, H. F. J., 2016, In : Journal of Nutritional Biochemistry. 32, p. 142-150

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glucagon-Like Peptide 1
Nutrients
Serotonin
Food
Safflower Oil
12 Citations (Scopus)

Nutrient Intake by Ultramarathon Runners: Can They Meet Recommendations?

Wardenaar, F. C., de Vries, J. H. M., Witkamp, R. F. & Mensink, M. R., 2015, In : International Journal of Sport Nutrition & Exercise Metabolism. 25, 4, p. 375-386

Research output: Contribution to journalArticleAcademicpeer-review

Food
Recommended Dietary Allowances
Nonparametric Statistics
Sports
Carbohydrates
12 Citations (Scopus)

Nutritional Supplement Use by Dutch Elite and Sub-Elite Athletes: Does Receiving Dietary Counselling Make a Difference?

Wardenaar, F. C., Ceelen, I. J. M., van Dijk, J. W., Hangelbroek, R. W. J., van Roy, L., van der Pouw, B., de Vries, J. H. M., Mensink, M. R. & Witkamp, R. F., 2017, In : International Journal of Sport Nutrition & Exercise Metabolism. 27, 1, p. 32-42

Research output: Contribution to journalArticleAcademicpeer-review

Athletes
Counseling
Sports
Energy Drinks
beta-Alanine
12 Citations (Scopus)

Optimal nutrition and the ever-changing dietary landscape: a conference report

Shao, A., Drewnowski, A., Willcox, D. C., Krämer, L., Lausted, C., Eggersdorfer, M., Mathers, J., Bell, J. D., Randolph, R. K., Witkamp, R. & Griffiths, J. C., 2017, In : European Journal of Nutrition. 56, suppl.1, 21 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food
Nutritional Sciences
Sedentary Lifestyle
Deficiency Diseases
Nutrition Policy
23 Citations (Scopus)

Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common Cold

Keppel Hesselink, J. M., de Boer, T. & Witkamp, R. F., 2013, In : International Journal of Inflammation. 2013, 8 p., 151028.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Common Cold
Human Influenza
Anti-Inflammatory Agents
Neuralgia
palmidrol
6 Citations (Scopus)

Palmitoylethanolamide (PEA)—‘Promiscuous’ anti-inflammatory and analgesic molecule at the interface between nutrition and pharma

Keppel Hesselink, J. M., Kopsky, D. J. & Witkamp, R. F., 2014, In : PharmaNutrition. 2, 1, p. 19-25

Research output: Contribution to journalArticleAcademicpeer-review

peanut meal
central nervous system diseases
Non-Steroidal Anti-Inflammatory Agents
analgesics
pharmacology
36 Citations (Scopus)

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

Joosten, M. M., Balvers, M. G. J., Verhoeckx, K. C. M., Hendriks, H. F. J. & Witkamp, R. F., 2010, In : Nutrition & Metabolism. 7, 6 p., 49.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nonesterified Fatty Acids
Fasting
Fatty Acids
Appetite Regulation
Lunch

Plasma citrulline concentration, a marker for intestinal functionality, reflects exercise intensity in healthy young men

Kartaram, S., Mensink, M., Teunis, M., Schoen, E., Witte, G., Janssen Duijghuijsen, L., Verschuren, M., Mohrmann, K., M'Rabet, L., Knipping, K., Wittink, H., van Helvoort, A., Garssen, J., Witkamp, R., Pieters, R. & van Norren, K., Oct 2019, In : Clinical Nutrition. 38, 5, p. 2251-2258 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Citrulline
Glutamine
Exercise
Workload
Amino Acids
43 Citations (Scopus)

Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators in the intestinal tract

Verhoeckx, K. C. M., Voortman, T., Balvers, M. G. J., Hendriks, H. F. J., Wortelboer, H. M. & Witkamp, R. F., 2011, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1811, 10, p. 578-586

Research output: Contribution to journalArticleAcademicpeer-review

Serotonin
Fatty Acids
Neurotransmitter Agents
Ethanolamines
Diet
6 Citations (Scopus)

Public health relevance of drug–nutrition interactions

Péter, S., Navis, G., de Borst, M. H., von Schacky, C., van Orten-Luiten, A. C. B., Zhernakova, A., Witkamp, R. F., Janse, A., Weber, P., Bakker, S. L. J. & Eggersdorfer, M., 2017, In : European Journal of Nutrition. 56, suppl. 2, p. 23-36

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Public Health
Pharmaceutical Preparations
Polypharmacy
Food
Drug Evaluation

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
allergens
saliva
Saliva
Allergens
peanuts

Samenwerkingsproject van RIVM, TNO en Wageningen Universiteit / Gezondheidseffecten van groenten en fruit

Hendriks, H., Verhagen, H., Büchner, F., van Duijnhoven, F. J. B., Witkamp, R. F., Peppelenbos, H. & Woltering, E. J., 2010, In : Voeding Nu. 12, 3, p. 26-28

Research output: Contribution to journalArticleProfessional

22 Citations (Scopus)

Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

Plastina, P., Vincken, J. P., Gruppen, H., Witkamp, R. F. & Gabriele, B., 2009, In : Letters in Organic Chemistry. 6, 6, p. 444-447

Research output: Contribution to journalArticleAcademicpeer-review

Acylation
Ethanolamine
Hexanes
Lipase
Unsaturated Fatty Acids
8 Citations (Scopus)

Short-term oral exposure to white wine transiently lowers serum free fatty acids

Joosten, M. M., de Graaf, C., Rietman, A., Witkamp, R. F. & Hendriks, H. F. J., 2010, In : Appetite. 55, 1, p. 124-129

Research output: Contribution to journalArticleAcademicpeer-review

Wine
Nonesterified Fatty Acids
Alcohols
Serum
Head
Open Access
oxaliplatin
Observational Studies
Colorectal Neoplasms
Skeletal Muscle
Retrospective Studies
11 Citations (Scopus)

Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model

Ripken, D., van der Wielen, N., Wortelboer, H. M., Meijerink, J., Witkamp, R. F. & Hendriks, H. F., 2014, In : Journal of Agricultural and Food Chemistry. 62, 33, p. 8365-8370 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

peptide YY
steviol
Peptide YY
glucagon-like peptide 1
Glucagon-Like Peptide 1
8 Citations (Scopus)

The Biphasic Effects of Moderate Alcohol Consumption with a Meal on Ambiance-Induced Mood and Autonomic Nervous System Balance: A Randomized Crossover Trial

Schrieks, I. C., Stafleu, A., Kallen, V. L., Grootjen, M., Witkamp, R. F. & Hendriks, H. F. J., 2014, In : PLoS ONE. 9, 1, e86199.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
autonomic nervous system
Autonomic Nervous System
Neurology
emotions
meals (menu)
Open Access
Calcium
DNA
Calcium-Sensing Receptors
Proteins
Oligonucleotide Array Sequence Analysis
10 Citations (Scopus)

The effect of endurance exercise on intestinal integrity in well-trained healthy men

Janssen Duijghuijsen, L., Mensink, M., Lenaerts, K., Fiedorowicz, E., van Dartel, D. A. M., Mes, J. J., Luiking, Y. C., Keijer, J., Wichers, H. J., Witkamp, R. F. & van Norren, K., 1 Oct 2016, In : Physiological Reports. 4, 20, e12994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Exercise
Lactulose
Rhamnose
Permeability
Glucagon-Like Peptide 2
51 Citations (Scopus)
Open Access
Fish Oils
Chemokine CCL2
Peritoneal Macrophages
Inflammation
Omega-3 Fatty Acids
10 Citations (Scopus)

The noncaloric sweetener rebaudioside a stimulates glucagon-like peptide 1 release and increases enteroendocrine cell numbers in 2-dimensional mouse organoids derived from different locations of the intestine

van der Wielen, N., ten Klooster, J. P., Muckenschnabl, S., Pieters, R., Hendriks, H. F. J., Witkamp, R. F. & Meijerink, J., 2016, In : The Journal of Nutrition. 146, 12, p. 2429-2435

Research output: Contribution to journalArticleAcademicpeer-review

Organoids
Enteroendocrine Cells
Sweetening Agents
Glucagon-Like Peptide 1
Intestines
17 Citations (Scopus)
Coffee
Epoxidation
Transcription
Genes
Aflatoxin B1
6 Citations (Scopus)

The role of fatty acids and their endocannabinoid-like derivatives in the molecular regulation of appetite

Witkamp, R. F., Dec 2018, In : Molecular Aspects of Medicine. 64, p. 45-67

Research output: Contribution to journalArticleAcademicpeer-review

Appetite Regulation
Endocannabinoids
Fatty Acids
Derivatives
Feeding Behavior
7 Citations (Scopus)
Serotonin
Cachexia
Inflammation
Anorexia
Neoplasms
36 Citations (Scopus)

Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet

Balvers, M. G. J., Verhoeckx, K. C. M., Meijerink, J., Bijlsma, S., Rubingh, C. M., Wortelboer, H. M. & Witkamp, R. F., 2012, In : International Immunopharmacology. 13, 2, p. 204-214

Research output: Contribution to journalArticleAcademicpeer-review

Endocannabinoids
Eicosanoids
Fish Oils
Inbred C57BL Mouse
Ileum
29 Citations (Scopus)

Tolerability and safety of souvenaid in patients with mild Alzheimer's disease: Results of multi-center, 24-week, open-label extension study

Olde Rikkert, M. G. M., Verhey, F. R., Blesa, R., Von Arnim, C. A. F., Bongers, A., Harrison, J., Sijben, J., Scarpini, E., Vandewoude, M. F. J., Vellas, B., Witkamp, R., Kamphuis, P. J. G. H. & Scheltens, P., 2015, In : Journal of Alzheimers Disease. 44, 2, p. 471-480 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Alzheimer Disease
Randomized Controlled Trials
Safety
Food
Neuropsychological Tests
34 Citations (Scopus)

Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated bu CB1 en CB2 receptor coupled pathways

Verhoeckx, K. C. M., Korthout, H. A. A. J., van Meeteren-Kreikamp, A. P., Ehlert, K. A., Wang, M., de Greef, J., Rodenburg, R. J. T. & Witkamp, R. F., 2006, In : International Immunopharmacology. 6, 4, p. 656-665

Research output: Contribution to journalArticleAcademicpeer-review

Cannabinoid Receptor CB2
Dronabinol
Cannabis
Acids
Tumor Necrosis Factor-alpha
10 Citations (Scopus)
Athletes
Nitrogen
Dietary Proteins
Proteins
Urine
24 Citations (Scopus)
Vitamin D
Epidemiologic Studies
Colorectal Neoplasms
Inflammation
Cytokines
79 Citations (Scopus)

Vitamin D. Do we get enough?

Brouwer, E. M., Bischoff-Ferrari, H. A., Bouillon, R., Feskens, E. J. M., Gallagher, C. J., Hypponen, E., Llewellyn, D., Stoecklin, E., Dierkes, J., Kies, A. K., Kok, F. J., Lamberg-Allardt, C., Moser, U., Pilz, S., Saris, W. H. M., van Schoor, N. M., Weber, P., Witkamp, R. F., Zittermann, A. & de Groot, C. P. G. M., 2013, In : Osteoporis International. 24, 5, p. 1567-1577

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin D
Health
11 Citations (Scopus)
Open Access
Polypharmacy
Vitamin D Deficiency
Drug-Related Side Effects and Adverse Reactions
Geriatrics
Outpatients
40 Citations (Scopus)
Humulus lupulus
Humulus
Chemokine CCL2
Macrophages
hops