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Research Output 1995 2019

47 Citations (Scopus)

26th Hohenheim Concensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition

Biesalski, H. K., Aggett, P. J., Anton, R., Bernstein, P. S., Blumberg, J., Heaney, R. P., Henry, J., Nolan, J. M., Richardson, D. P., van Ommen, B., Witkamp, R. F., Rijkers, G. T. & Zollner, I., 2011, In : Nutrition. 27, 10, p. S1-S20

Research output: Contribution to journalArticleAcademicpeer-review

Glycemic Index
Micronutrients
Health
Probiotics
Macular Degeneration
9 Citations (Scopus)

Absorption, distribution and biliary excretion of cafestol, a potent cholesterol elevating compound in unfiltered coffees in mice

van Cruchten, S. T. J., de Waart, D. R., Kunne, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Katan, M. B., Oude Elferink, R. P. J. & Witkamp, R. F., 2010, In : Drug Metabolism and Disposition. 38, 4, p. 635-640

Research output: Contribution to journalArticleAcademicpeer-review

Coffee
Cholesterol
Bile
Glucuronides
Portal Vein
4 Citations (Scopus)

Adaptation of exercise-induced stress in well-trained healthy young men

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Lenaerts, K., Ridder, L. O., Nierkens, S., Kartaram, S., Verschuren, M. C. M., Pieters, R., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 2017, In : Experimental Physiology. 102, 1, p. 86-99

Research output: Contribution to journalArticleAcademicpeer-review

Exercise
Lactulose
Rhamnose
Energy Metabolism
Urine

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice

Plas, R. L. C., Poland, M., Faber, J., Argilès, J., van Dijk, M., Laviano, A., Meijerink, J., Witkamp, R. F., van Helvoort, A. & van Norren, K., 9 Oct 2019, In : International Journal of Molecular Sciences. 20, 20, 4978.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
diets
leucine
Fish Oils
fishes
Hypercalcemia
17 Citations (Scopus)

Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

Joosten, M. M., Witkamp, R. F. & Hendriks, H. F. J., 2011, In : Metabolism : Clinical and Experimental. 60, 8, p. 1058-1063

Research output: Contribution to journalArticleAcademicpeer-review

Adiponectin
Alcohol Drinking
Molecular Weight
Weights and Measures
Alcohols
2 Citations (Scopus)

Analysis of omega-3 fatty acid derived N-acylethanolamines in biological matrices

Witkamp, R. F. & Balvers, M., 2016, Endocannabinoid signaling: Methods and Protocols. Maccarrone, M. (ed.). Humana Press Inc., Vol. 1412. p. 27-40 (Methods in Molecular Biology; vol. 1412).

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Endocannabinoids
Omega-3 Fatty Acids
N-acylethanolamines
Solid Phase Extraction
Neurites

Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model

Vinke, P., Bowen, T. S., Boekschoten, M. V., Witkamp, R. F., Adams, V. & van Norren, K., 15 Jul 2019, In : Scientific Reports. 9, 1, 10160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Monocrotaline
Pulmonary Hypertension
Myocardium
Skeletal Muscle
Anti-Inflammatory Agents

Arts en diëtist samen verantwoordelijk

Vasse, E., Wijnans-Aerts, G. J. M., Witkamp, R. F. & van Binsbergen, J. J., 2010, In : Nederlands Tijdschrift voor Voeding en Dietetiek. 65, 4, p. 7-10

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Associations between medication use and homocysteine levels in an older population, and potential mediation by vitamin B12 and folate: data from the B-PROOF study

Ham, A. C., Enneman, A. W., van Dijk, S. C., van Wijngaarden, J. P., van der Zwaluw, N. L., Brouwer, E. M., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M. & Witkamp, R. F., 2014, In : Drugs & Aging. 31, 8, p. 611-621

Research output: Contribution to journalArticleAcademicpeer-review

Vitamin B Complex
Osteoporotic Fractures
Homocysteine
Vitamin B 12
Folic Acid
1 Citation (Scopus)

Associations of hyperosmolar medications administered via nasogastric or nasoduodenal tubes and feeding adequacy, food intolerance and gastrointestinal complications amongst critically ill patients: A retrospective study

Wesselink, E., Koekkoek, K. W. A. C., Looijen, M., van Blokland, D. A., Witkamp, R. F. & van Zanten, A. R. H., Jun 2018, In : Clinical Nutrition ESPEN. 25, p. 78-86

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Enteral Nutrition
Critical Illness
Retrospective Studies
Food
Diarrhea
27 Citations (Scopus)

A standardised approach towards PROving the efficacy of foods and Food Constituents for Health CLAIMs (PROCLAIM: providing guidance

Gallagher, A. M., Meijer, G. W., Richardson, D. P., Rondeau, V., Skarp, M., Stasse-Wolthuis, M., Tweedie, G. C. & Witkamp, R. F., 2011, In : British Journal of Nutrition. 106, Suppl. 2, p. S16-S28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food
Health
Research
Food Industry
Insurance Benefits
23 Citations (Scopus)

Behavioural changes are a major contributing factor in the reduction of sarcopenia in caloric-restricted ageing mice

van Norren, K., Rusli, F., van Dijk, M., Lute, C., Nagel, J. C., Dijk, F. J., Dwarkasing, J. T., Boekschoten, M. V., Luiking, Y., Witkamp, R. F., Müller, M. R. & Steegenga, W. T., 2015, In : Journal of cachexia, sarcopenia and muscle. 6, 3, p. 253-268

Research output: Contribution to journalArticleAcademicpeer-review

Sarcopenia
Caloric Restriction
Muscles
Diet
Rodentia

Bestaat de ideale afslankpil?

Witkamp, R. F., 2015

Research output: Non-textual formDigital or Visual ProductsOther research output

Open Access
23 Citations (Scopus)

Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages

Verhoeckx, K. C. M., Doornbos, R. P., Witkamp, R. F., de Greef, J. & Rodenburg, R. J. T., 2006, In : International Immunopharmacology. 6, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

Chemokine CXCL6
Oncostatin M
Adrenergic beta-Agonists
Vascular Endothelial Growth Factor A
Macrophages
5 Citations (Scopus)

Beta-blocker use and fall risk in older individuals: Original results from two studies with meta-analysis

Ham, A. C., van Dijk, S. C., Swart, K. M. A., Enneman, A. W., van der Zwaluw, N. L., Brouwer-Brolsma, E. M., van Schoor, N. M., Zillikens, M. C., Lips, P., de Groot, L. C. P. G. M., Hofman, A., Witkamp, R. F., Uitterlinden, A. G., Stricker, B. H. & van der Velde, N., 2017, In : British Journal of Clinical Pharmacology. 83, 10, p. 2292-2302

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Meta-Analysis
Cytochrome P-450 CYP2D6
Solubility
Odds Ratio
Confidence Intervals
1 Citation (Scopus)

Biologically Active Compounds in Food Products and Their Effects on Obesity and Diabetes

Witkamp, R. F., 2010, Comprehensive Natural Products II: Chemistry and Biology. Oxford, p. 509-545 36 p. (Comprehensive Natural Products; no. 3).

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

16 Citations (Scopus)
Colostrum
Athletes
Exercise
Powders
Milk

Cafestol: a multi-faced compound kinetics and metabolic effects of cafestol in mice

van Cruchten, S. T. J., 2010, [S.l.: S.n.. 196 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Biotransformation
Liver
Coffee
cafestol
Enzyme Induction
2 Citations (Scopus)
Open Access
Microfluidics
HEK293 Cells
G-Protein-Coupled Receptors
calcium
Calcium
2 Citations (Scopus)

Capsaicin analogues derived from n-3 polyunsaturated fatty acids (PUFAs) reduce inflammatory activity of macrophages and stimulate insulin secretion by β-cells in vitro

Cione, E., Plastina, P., Pingitore, A., Perri, M., Caroleo, M. C., Fazio, A., Witkamp, R. & Meijerink, J., 1 Apr 2019, In : Nutrients. 11, 4, 915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
capsaicin
long chain polyunsaturated fatty acids
insulin secretion
Capsaicin
Omega-3 Fatty Acids
3 Citations (Scopus)

Changes in iron metabolism during prolonged repeated walking exercise in middle-aged men and women

Terink, R., ten Haaf, D., Bongers, C. W. G., Balvers, M. G. J., Witkamp, R. F., Mensink, M., Eijsvogels, T. M. H., Klein Gunnewiek, J. M. T. & Hopman, M. T. E., Nov 2018, In : European Journal of Applied Physiology. 118, 11, p. 2349–2357

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Walking
Iron
Exercise
Haptoglobins
Ferritins
11 Citations (Scopus)

Cholecystokinin regulates satiation idependently of the abdominal vagal nerve in a pig model of total subdiaphragmatic vagotomy

Ripken, D., van der Wielen, N., van der Meulen, J., Schuurman, T., Witkamp, R. F., Hendriks, H. F. J. & Koopmans, S. J., 2015, In : Physiology and Behavior. 139, 2015, p. 167-176

Research output: Contribution to journalArticleAcademicpeer-review

Satiation
Glucagon-Like Peptide 1
Vagotomy
Cholecystokinin
Swine
40 Citations (Scopus)

Commentary: "A systems view on the future of medicine: Inspiration from Chinese medicine?"

Verpoorte, R., Crommelin, D., Danhof, M., Gilissen, L. J. W. J., Schuitmaker, H., de Greef, J. & Witkamp, R. F., 2009, In : Journal of Ethnopharmacology. 121, 3, p. 479-481

Research output: Contribution to journalLetterAcademic

Metabolomics
Systems Biology
Evidence-Based Medicine
Prodrugs
Quality Control
48 Citations (Scopus)
Sambucus
Rubus
Fruits
anti-inflammatory activity
Italy
23 Citations (Scopus)

Cross-Species Comparison of Genes Related to Nutrient Sensing Mechanisms Expressed along the Intestine

van der Wielen, N., van Avesaat, M., de Wit, N. J. W., Vogels, J., Troost, F., Masclee, A., Koopmans, S. J., van der Meulen, J., Boekschoten, M. V., Müller, M. R., Hendriks, H. F. J., Witkamp, R. F. & Meijerink, J., 2014, In : PLoS ONE. 9, 9, 9 p., e107531.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nutrients
Intestines
intestines
Swine
Genes
55 Citations (Scopus)

Current and future drug targets in weight management

Witkamp, R. F., 2011, In : Pharmaceutical Research. 28, 8, p. 1792-1818 27 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Adipose Tissue
Phentermine
Body Weight
Serotonin 5-HT2 Receptor Agonists
Anti-Obesity Agents
6 Citations (Scopus)

CYP2C9 genotypes modify benzodiazepine-related fall risk: Original results from three studies with meta-analysis

Ham, A. C., Ziere, G., Broer, L., van Wijngaarden, J. P., van der Zwaluw, N. L., Brouwer, E. M., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M. & Witkamp, R. F., 2017, In : Journal of the American Medical Directors Association. 18, 1, p. 88.e1-88.e15

Research output: Contribution to journalArticleAcademicpeer-review

Benzodiazepines
Meta-Analysis
Genotype
Alleles
Confidence Intervals

De associatie tussen medicijngebruik en het homocysteïnegehalte in een Nederlandse populatie ouderen.

van Wijngaarden, J. P., Schoufour, J. D., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M., Janse, A. & Witkamp, R. F., 2011, Geriatriedagen Den Bosch, 3-4 februari 2011. Den Bosch, p. 151

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

Open Access
2 Citations (Scopus)
Athletes
Magnesium
Exercise
Athletic Performance
Research
7 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

Allergens
Immunoglobulins
Immunoglobulin G
Serum
Eating
62 Citations (Scopus)
Plasma (human)
Endocannabinoids
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
61 Citations (Scopus)

Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor

Blankvoort, B. M. G., de Groene, E. M., van Meeteren-Kreikamp, A. P., Witkamp, R. F., Rodenburg, R. J. T. & Aarts, J. M. M. J. G., 2001, In : Analytical Biochemistry. 298, p. 93-102

Research output: Contribution to journalArticleAcademicpeer-review

Androgen Receptors
Reporter Genes
Androgens
Assays
Genes

De verrassende X-factor van klinische voeding

de Vries, J. H. M., Witkamp, R. F. & Schols, A. M., 2008, In : Voeding Nu. 10, 12, p. 26-27

Research output: Contribution to journalArticleProfessional

19 Citations (Scopus)
Serotonin
Eating
Neuropeptide Y
Neoplasms
Lewis Lung Carcinoma
70 Citations (Scopus)

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties

Balvers, M. G. J., Verhoeckx, K. C. M., Plastina, P., Wortelboer, H. M., Meijerink, J. & Witkamp, R. F., 2010, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1801, 10, p. 1107-1114

Research output: Contribution to journalArticleAcademicpeer-review

Ethanolamines
Ethanolamine
Eicosapentaenoic Acid
Docosahexaenoic Acids
Adipocytes
7 Citations (Scopus)
Interleukin-17
Omega-3 Fatty Acids
Serotonin
Anti-Inflammatory Agents
Macrophages
8 Citations (Scopus)
Interleukin-17
Blood Cells
Serotonin
Fatty Acids
Interleukin-23
1 Citation (Scopus)

Drug-Nutrition Interactions in Older People

van Orten-Luiten, A. C., Janse, A. & Witkamp, R., 2016, Food for the Aging Population: Second Edition. Elsevier Inc. Academic Press, p. 203-222

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Nutrition
Nutritional Status
Drug Interactions
nutrition
Polypharmacy
1 Citation (Scopus)

Drug use is associated with lower plasma magnesium levels in geriatric outpatients; possible clinical relevance

van Orten-Luiten, A. C. B., Janse, A., Verspoor, E., Brouwer-Brolsma, E. M. & Witkamp, R. F., Dec 2019, In : Clinical Nutrition. 38, 6, p. 2668-2676

Research output: Contribution to journalArticleAcademicpeer-review

Geriatrics
Magnesium
Outpatients
Pharmaceutical Preparations
Polypharmacy

Een cross-sectionele studie naar de associatie tussen medicijngebruik en nutriëntenstatus bij een poliklinische geriatrie-populatie.

Schoufour, J. D., van Wijngaarden, J. P., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M., Witkamp, R. F. & Janse, A., 2011, Geriatriedagen Den Bosch, 3-4 februari. Den Bosch, p. 142

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

Open Access
19 Citations (Scopus)

Effects of Long- and Short-Chain Fatty Acids on the Release of Gastrointestinal Hormones using an ex Vivo Porcine Intestinal Tissue Model

Voortman, T., Hendriks, H. F. J., Witkamp, R. F. & Wortelboer, H. M., 2012, In : Journal of Agricultural and Food Chemistry. 60, 36, p. 9035-9042 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

gastrointestinal hormones
Gastrointestinal Hormones
Volatile Fatty Acids
long chain fatty acids
short chain fatty acids
7 Citations (Scopus)

Effects of mood inductions by meal ambiance and moderate alcohol consumption on endocannabinoids and N-acylethanolamines in humans: A randomized crossover trial

Schrieks, I. C., Ripken, D., Stafleu, A., Witkamp, R. F. & Hendriks, H. F. J., 2015, In : PLoS ONE. 10, 5, 15 p., e0126421.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Endocannabinoids
emotions
sparkling wines
Alcohol Drinking
Cross-Over Studies

Endocannabinoids derived from n-3 PUFAs - Formation, release and possible roles in inflammation and obesity

Wang, Y., 2017, Wageningen: Wageningen University. 195 p.

Research output: Thesisinternal PhD, WUAcademic

Endocannabinoids
Omega-3 Fatty Acids
Serotonin
Obesity
Fatty Acids
6 Citations (Scopus)

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactulose
allergens
peanuts
lactulose
exercise
Open Access
Athletes
Sports
Carbohydrates
Population
Micronutrients
27 Citations (Scopus)

Fatty acids, endocannabinoids and inflammation

Witkamp, R., 2016, In : European Journal of Pharmacology. 785, p. 96-107

Research output: Contribution to journalArticleAcademicpeer-review

Endocannabinoids
Fatty Acids
Inflammation
Physiological Phenomena
Ligands
4 Citations (Scopus)

Feeding mitochondria: Potential role of nutritional components to improve critical illness convalescence

Wesselink, E., Koekkoek, W. A. C., Grefte, S., Witkamp, R. F. & van Zanten, A. R. H., Jun 2019, In : Clinical Nutrition. 38, 3, p. 982-995

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
coenzyme Q10
Micronutrients
Critical Illness
Mitochondria
Selenium
67 Citations (Scopus)

Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues

Balvers, M. G. J., Verhoeckx, K. C. M., Bijlsma, S., Rubingh, C. M., Meijerink, J., Wortelboer, H. M. & Witkamp, R. F., 2012, In : Metabolomics. 8, 6, p. 1130-1147

Research output: Contribution to journalArticleAcademicpeer-review

Oxylipins
Endocannabinoids
Metabolome
Fish Oils
Tissue
11 Citations (Scopus)

Fish oil LC-PUFAs do not affect blood coagulation parameters and bleeding manifestations: Analysis of 8 clinical studies with selected patient groups on omega-3-enriched medical nutrition

Jeansen, S., Witkamp, R. F., Garthoff, J. A., van Helvoort, A. & Calder, P. C., Jun 2018, In : Clinical Nutrition. 37, 3, p. 948-957

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Fish Oils
Omega-3 Fatty Acids
Blood Coagulation
Hemorrhage
Vulnerable Populations

Food-drug interactions in older people

Witkamp, R. F., 2008, Food for the Ageing Population. Raats, M., de Groot, C. P. G. M. & van Staveren, W. A. (eds.). London: Woodhead Publishing, p. 458-477 652 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Food-Drug Interactions
Food
Pharmaceutical Preparations
Drug Interactions
Micronutrients