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Research Output 1995 2019

1995
27 Citations (Scopus)

Infection (Actinobacillus pleuropneumoniae)-medicated suppression of oxidative hepatic drug metabolism and cytochrome P 4503A mRNA levels in pigs

Monshouwer, M., Witkamp, R. F., Nijmeijer, S. M., van Leengoed, L. A. M. G. & van Miert, A. S. J. P. A. M., 1995, In : Drug Metabolism and Disposition. 23, p. 44-47

Research output: Contribution to journalArticleAcademicpeer-review

1998
31 Citations (Scopus)

Multi-laboratory study of the analysis and kinetics of stanozolol and its metabolites in treated calves

de Brabander, H. F., de Wasch, K., van Ginkel, L. A., Sterk, S. S., Blokland, M. H., Delahaut, P., Taillieu, X., Dubois, M., Arts, C. J. M., van Baak, M. J., Gramberg, L. G., Schilt, R., van Bennekom, E. O., Courtheyn, D., Vercammen, J. & Witkamp, R. F., 1998, In : The Analyst. 123, p. 2599-2604

Research output: Contribution to journalArticleAcademicpeer-review

2001
61 Citations (Scopus)

Development of an androgen reporter gene assay (AR-LUX) utilizing a human cell line with an endogenously regulated androgen receptor

Blankvoort, B. M. G., de Groene, E. M., van Meeteren-Kreikamp, A. P., Witkamp, R. F., Rodenburg, R. J. T. & Aarts, J. M. M. J. G., 2001, In : Analytical Biochemistry. 298, p. 93-102

Research output: Contribution to journalArticleAcademicpeer-review

Androgen Receptors
Reporter Genes
Androgens
Assays
Genes
2006
23 Citations (Scopus)

Beta-adrenergic receptor agonists induce the release of granulocyte chemotactic protein-2, oncostatin M, and vascular endothelial growth factor from macrophages

Verhoeckx, K. C. M., Doornbos, R. P., Witkamp, R. F., de Greef, J. & Rodenburg, R. J. T., 2006, In : International Immunopharmacology. 6, 1, p. 1-7

Research output: Contribution to journalArticleAcademicpeer-review

Chemokine CXCL6
Oncostatin M
Adrenergic beta-Agonists
Vascular Endothelial Growth Factor A
Macrophages
34 Citations (Scopus)

Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated bu CB1 en CB2 receptor coupled pathways

Verhoeckx, K. C. M., Korthout, H. A. A. J., van Meeteren-Kreikamp, A. P., Ehlert, K. A., Wang, M., de Greef, J., Rodenburg, R. J. T. & Witkamp, R. F., 2006, In : International Immunopharmacology. 6, 4, p. 656-665

Research output: Contribution to journalArticleAcademicpeer-review

Cannabinoid Receptor CB2
Dronabinol
Cannabis
Acids
Tumor Necrosis Factor-alpha
2008

De verrassende X-factor van klinische voeding

de Vries, J. H. M., Witkamp, R. F. & Schols, A. M., 2008, In : Voeding Nu. 10, 12, p. 26-27

Research output: Contribution to journalArticleProfessional

Food-drug interactions in older people

Witkamp, R. F., 2008, Food for the Ageing Population. Raats, M., de Groot, C. P. G. M. & van Staveren, W. A. (eds.). London: Woodhead Publishing, p. 458-477 652 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Food-Drug Interactions
Food
Pharmaceutical Preparations
Drug Interactions
Micronutrients

Interplay between macrophages and adipocytes: stimulation of secretion of adipokines and the role of endocannabinoids

Wortelboer, H. M., Lancee, C. A. A., Meijerink, J. & Witkamp, R. F., 2008, In : International Journal of Obesity. 32, S1, p. S64

Research output: Contribution to journalAbstractAcademic

Endocannabinoids
Adipokines
Adipocytes
Lipopolysaccharides
Macrophages
6 Citations (Scopus)

Use of Animal Models of Disease in the Preclinical Safety Evaluation of Biopharmaceuticals

te Koppele, J. & Witkamp, R. F., 2008, Preclinical safety evaluation of biopharmaceuticals: A science-based approach to facilitating clinical trials. Cavagnaro, J. A. (ed.). Hoboken, New Jersey: John Wiley and Sons, p. 293-308 1034 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

2009
40 Citations (Scopus)

Commentary: "A systems view on the future of medicine: Inspiration from Chinese medicine?"

Verpoorte, R., Crommelin, D., Danhof, M., Gilissen, L. J. W. J., Schuitmaker, H., de Greef, J. & Witkamp, R. F., 2009, In : Journal of Ethnopharmacology. 121, 3, p. 479-481

Research output: Contribution to journalLetterAcademic

Metabolomics
Systems Biology
Evidence-Based Medicine
Prodrugs
Quality Control
62 Citations (Scopus)
Plasma (human)
Endocannabinoids
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography
4 Citations (Scopus)

Herbal products: Marketing strategies and legislation

Hooyenga, P. A., Witkamp, R. F. & Groen, K. P., 2009, In : International Journal of Green Pharmacy. 3, 4, p. 270-276

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
European Union
Marketing
Legislation
Jurisprudence
Dietary Supplements

Mogelijkheden voor reductie van medicijngebruik door gezonde voeding(sproducten) in zorginstellingen

van der Sluis, A. A., Peppelenbos, H. W., Witkamp, R. F., Rompelberg, C. J. M., de Jong, N. & Verhagen, H., 2009, Wageningen: AFSG. 29 p.

Research output: Book/ReportReportProfessional

Open Access

Review of the potential health impact of ß-casomorphins and related peptides: Report of the DATEX Working Group on ß-casomorphins

De Noni, I., FitzGerald, R. J., Korhonen, H. J. T., Le Roux, Y., Livesey, C. T., Thorsdottir, I., Tomé, D. & Witkamp, R. F., 2009, Brussel: European Food Safety Authority. 107 p. (EFSA Scientific report / European Food Safety Authority; no. 231)

Research output: Book/ReportReportAcademic

Open Access
22 Citations (Scopus)

Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase-Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

Plastina, P., Vincken, J. P., Gruppen, H., Witkamp, R. F. & Gabriele, B., 2009, In : Letters in Organic Chemistry. 6, 6, p. 444-447

Research output: Contribution to journalArticleAcademicpeer-review

Acylation
Ethanolamine
Hexanes
Lipase
Unsaturated Fatty Acids
40 Citations (Scopus)
Humulus lupulus
Humulus
Chemokine CCL2
Macrophages
hops
2010
9 Citations (Scopus)

Absorption, distribution and biliary excretion of cafestol, a potent cholesterol elevating compound in unfiltered coffees in mice

van Cruchten, S. T. J., de Waart, D. R., Kunne, C., Hooiveld, G. J. E. J., Boekschoten, M. V., Katan, M. B., Oude Elferink, R. P. J. & Witkamp, R. F., 2010, In : Drug Metabolism and Disposition. 38, 4, p. 635-640

Research output: Contribution to journalArticleAcademicpeer-review

Coffee
Cholesterol
Bile
Glucuronides
Portal Vein

Arts en diëtist samen verantwoordelijk

Vasse, E., Wijnans-Aerts, G. J. M., Witkamp, R. F. & van Binsbergen, J. J., 2010, In : Nederlands Tijdschrift voor Voeding en Dietetiek. 65, 4, p. 7-10

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Biologically Active Compounds in Food Products and Their Effects on Obesity and Diabetes

Witkamp, R. F., 2010, Comprehensive Natural Products II: Chemistry and Biology. Oxford, p. 509-545 36 p. (Comprehensive Natural Products; no. 3).

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Cafestol: a multi-faced compound kinetics and metabolic effects of cafestol in mice

van Cruchten, S. T. J., 2010, [S.l.: S.n.. 196 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Biotransformation
Liver
Coffee
cafestol
Enzyme Induction
70 Citations (Scopus)

Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties

Balvers, M. G. J., Verhoeckx, K. C. M., Plastina, P., Wortelboer, H. M., Meijerink, J. & Witkamp, R. F., 2010, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1801, 10, p. 1107-1114

Research output: Contribution to journalArticleAcademicpeer-review

Ethanolamines
Ethanolamine
Eicosapentaenoic Acid
Docosahexaenoic Acids
Adipocytes

Interacties tussen geneesmiddelen en voeding: geneesmiddelen en de voedingsstatus

Witkamp, R. F., 2010, In : Patient Care. 33, 4, p. 28-32

Research output: Contribution to journalArticleProfessional

Interacties tussen geneesmiddelen en voeding: updat over de invloed van voeding op geneesmiddelen

Witkamp, R. F., 2010, In : Patient Care. 33, 4, p. 24-27

Research output: Contribution to journalArticleProfessional

Interacties voeding en geneesmiddelen bij chronische hart- en vaatziekten: De diëtist is aan zet:

Vasse, E., Wijnans-Aerts, G. J. M., Witkamp, R. F. & van Binsbergen, J. J., 2010, In : Nederlands Tijdschrift voor Voeding en Dietetiek. 65, p. 7-10

Research output: Contribution to journalArticleProfessional

36 Citations (Scopus)

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

Joosten, M. M., Balvers, M. G. J., Verhoeckx, K. C. M., Hendriks, H. F. J. & Witkamp, R. F., 2010, In : Nutrition & Metabolism. 7, 6 p., 49.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nonesterified Fatty Acids
Fasting
Fatty Acids
Appetite Regulation
Lunch

Samenwerkingsproject van RIVM, TNO en Wageningen Universiteit / Gezondheidseffecten van groenten en fruit

Hendriks, H., Verhagen, H., Büchner, F., van Duijnhoven, F. J. B., Witkamp, R. F., Peppelenbos, H. & Woltering, E. J., 2010, In : Voeding Nu. 12, 3, p. 26-28

Research output: Contribution to journalArticleProfessional

8 Citations (Scopus)

Short-term oral exposure to white wine transiently lowers serum free fatty acids

Joosten, M. M., de Graaf, C., Rietman, A., Witkamp, R. F. & Hendriks, H. F. J., 2010, In : Appetite. 55, 1, p. 124-129

Research output: Contribution to journalArticleAcademicpeer-review

Wine
Nonesterified Fatty Acids
Alcohols
Serum
Head
17 Citations (Scopus)
Coffee
Epoxidation
Transcription
Genes
Aflatoxin B1
2011
47 Citations (Scopus)

26th Hohenheim Concensus Conference, September 11, 2010 Scientific substantiation of health claims: Evidence-based nutrition

Biesalski, H. K., Aggett, P. J., Anton, R., Bernstein, P. S., Blumberg, J., Heaney, R. P., Henry, J., Nolan, J. M., Richardson, D. P., van Ommen, B., Witkamp, R. F., Rijkers, G. T. & Zollner, I., 2011, In : Nutrition. 27, 10, p. S1-S20

Research output: Contribution to journalArticleAcademicpeer-review

Glycemic Index
Micronutrients
Health
Probiotics
Macular Degeneration
17 Citations (Scopus)

Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women

Joosten, M. M., Witkamp, R. F. & Hendriks, H. F. J., 2011, In : Metabolism : Clinical and Experimental. 60, 8, p. 1058-1063

Research output: Contribution to journalArticleAcademicpeer-review

Adiponectin
Alcohol Drinking
Molecular Weight
Weights and Measures
Alcohols
27 Citations (Scopus)

A standardised approach towards PROving the efficacy of foods and Food Constituents for Health CLAIMs (PROCLAIM: providing guidance

Gallagher, A. M., Meijer, G. W., Richardson, D. P., Rondeau, V., Skarp, M., Stasse-Wolthuis, M., Tweedie, G. C. & Witkamp, R. F., 2011, In : British Journal of Nutrition. 106, Suppl. 2, p. S16-S28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food
Health
Research
Food Industry
Insurance Benefits
16 Citations (Scopus)
Colostrum
Athletes
Exercise
Powders
Milk
55 Citations (Scopus)

Current and future drug targets in weight management

Witkamp, R. F., 2011, In : Pharmaceutical Research. 28, 8, p. 1792-1818 27 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Adipose Tissue
Phentermine
Body Weight
Serotonin 5-HT2 Receptor Agonists
Anti-Obesity Agents

De associatie tussen medicijngebruik en het homocysteïnegehalte in een Nederlandse populatie ouderen.

van Wijngaarden, J. P., Schoufour, J. D., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M., Janse, A. & Witkamp, R. F., 2011, Geriatriedagen Den Bosch, 3-4 februari 2011. Den Bosch, p. 151

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

Open Access

Een cross-sectionele studie naar de associatie tussen medicijngebruik en nutriëntenstatus bij een poliklinische geriatrie-populatie.

Schoufour, J. D., van Wijngaarden, J. P., Dhonukshe-Rutten, R. A. M., de Groot, C. P. G. M., Witkamp, R. F. & Janse, A., 2011, Geriatriedagen Den Bosch, 3-4 februari. Den Bosch, p. 142

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

Open Access
Open Access
Adiponectin
Alcohol Drinking
Cross-Over Studies
Type 2 Diabetes Mellitus
Cohort Studies
41 Citations (Scopus)

Pharma-nutrition interface: The gap is narrowing

Georgiou, N. A., Garssen, J. & Witkamp, R. F., 2011, In : European Journal of Pharmacology. 651, 1-3, p. 1-8 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Nutritional Sciences
Food
Gene-Environment Interaction
Nutritionists
Central Nervous System Diseases
43 Citations (Scopus)

Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators in the intestinal tract

Verhoeckx, K. C. M., Voortman, T., Balvers, M. G. J., Hendriks, H. F. J., Wortelboer, H. M. & Witkamp, R. F., 2011, In : Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids. 1811, 10, p. 578-586

Research output: Contribution to journalArticleAcademicpeer-review

Serotonin
Fatty Acids
Neurotransmitter Agents
Ethanolamines
Diet
51 Citations (Scopus)
Open Access
Fish Oils
Chemokine CCL2
Peritoneal Macrophages
Inflammation
Omega-3 Fatty Acids
2012
19 Citations (Scopus)

Effects of Long- and Short-Chain Fatty Acids on the Release of Gastrointestinal Hormones using an ex Vivo Porcine Intestinal Tissue Model

Voortman, T., Hendriks, H. F. J., Witkamp, R. F. & Wortelboer, H. M., 2012, In : Journal of Agricultural and Food Chemistry. 60, 36, p. 9035-9042 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

gastrointestinal hormones
Gastrointestinal Hormones
Volatile Fatty Acids
long chain fatty acids
short chain fatty acids
67 Citations (Scopus)

Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues

Balvers, M. G. J., Verhoeckx, K. C. M., Bijlsma, S., Rubingh, C. M., Meijerink, J., Wortelboer, H. M. & Witkamp, R. F., 2012, In : Metabolomics. 8, 6, p. 1130-1147

Research output: Contribution to journalArticleAcademicpeer-review

Oxylipins
Endocannabinoids
Metabolome
Fish Oils
Tissue
11 Citations (Scopus)

Lipidomics reveals multiple pathway effects of a multi components preparation on lipd biochemistry in ApoeE*3Leiden.CETP mice

Wei, H., Hu, C., Wang, M., van den Hoek, A. M., Reijmers, T. H., Wopereis, S., Bouwman, J., Ramaker, R., Korthout, H. A. A. J., Vennik, M., Hankemeier, T., Havekes, L. M., Witkamp, R. F., Verheij, E. R., Xu, G. & de Greef, J., 2012, In : PLoS ONE. 7, 1, e30332.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Biochemistry
rimonabant
metabolic syndrome
biochemistry
mice
18 Citations (Scopus)

Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men

Joosten, M. M., van Erk, M. J., Pellis, E. P. M., Witkamp, R. F. & Hendriks, H. F. J., 2012, In : British Journal of Nutrition. 108, 4, p. 620-627

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lipid Metabolism
Transcriptome
Alcohol Drinking
Leukocytes
Proteins

n-3 Fatty acid derived endocannabinoids: a new link between fish oil and inflammation

Balvers, M. G. J., 2012, S.l.: s.n.. 206 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
eicosanoids
fish oils
omega-3 fatty acids
inflammation
anti-inflammatory activity
36 Citations (Scopus)

Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet

Balvers, M. G. J., Verhoeckx, K. C. M., Meijerink, J., Bijlsma, S., Rubingh, C. M., Wortelboer, H. M. & Witkamp, R. F., 2012, In : International Immunopharmacology. 13, 2, p. 204-214

Research output: Contribution to journalArticleAcademicpeer-review

Endocannabinoids
Eicosanoids
Fish Oils
Inbred C57BL Mouse
Ileum
2013
48 Citations (Scopus)
Sambucus
Rubus
Fruits
anti-inflammatory activity
Italy

Is neural regulation of satiation more important than hormonal regulation of satiation?

Ripken, D., Wielen, N., van der Meulen, J., Schuurman, T., Witkamp, R. F., Hendriks, H. & Koopmans, S. J., 2013, In : Obesity Facts. 6, Suppl. 1, p. 5-5 T1:RS1.3.

Research output: Contribution to journalAbstractAcademic

Open Access

Is use of medication associated with blood levels of micronutrients? A cross-sectional study of a geriatric hospital population

van Orten-Luiten, A. C. B., Janse, A., Dhonukshe-Rutten, R. A. M. & Witkamp, R. F., 2013, Proceedings of the 1st National Congress on Nutritional Medicine of the Dutch Nutraceutical Association. Bast, A., Brouns, F., Dekker, W., Feskens, E. J. M. & Kardinaal, A. (eds.). Karger, Vol. 62. p. 154-154

Research output: Chapter in Book/Report/Conference proceedingAbstractAcademic

24 Citations (Scopus)

Liquid chromatography–tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells

Balvers, M. G. J., Wortelboer, H. M., Witkamp, R. F. & Verhoeckx, K. C. M., 2013, In : Analytical Biochemistry. 434, 2, p. 275-283

Research output: Contribution to journalArticleAcademicpeer-review

Ethanolamines
Plasma Cells
Nonesterified Fatty Acids
Mass spectrometry
Blood Cells