1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Frozen evolution of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence

Pascall, D. J., Nomikou, K., Bréard, E., Zientara, S., da Silva Filipe, A., Hoffmann, B., Jacquot, M., Singer, J. B., De Clercq, K., Botner, A., Sailleau, C., Viarouge, C., Batten, C., Puggioni, G., Ligios, C., Savini, G., van Rijn, P. A., Mertens, P. P. C., Biek, R. & Palmarini, M., 28 Apr 2020, In : PloS Biology.

Research output: Contribution to journalArticleProfessional

Open Access
1 Citation (Scopus)
2019

Improved PCR diagnostics using up-to-date in silico validation: An F-gene RT-qPCR assay for the detection of all four lineages of peste des petits ruminants virus

Flannery, J., Rajko-Nenow, P., Arnold, H., van Weezep, E., van Rijn, P. A., Ngeleja, C. & Batten, C., 1 Dec 2019, In : Journal of Virological Methods. 274, 113735.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Novel function of Bleutongue Virus NS3 Protein in Regulation of the MAPK/ERK Signaling Pathway

Kundlacz, C., Pourcelot, M., Fablet, A., Amaral Da Silva Moraes, R., Leger, T., Morlet, B., Viarouge, C., Sailleau, C., Turpaud, M., Gorlier, A., Breard, E., Lecollinet, S., van Rijn, P. A., Zientara, S., Vitour, D. & Caignard, G., Aug 2019, In : Journal of Virology. 93, 16, 17 p., e00336-19.

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

PCR diagnostics: In silico validation by an automated tool using freely available software programs

van Weezep, E., Kooi, B. & van Rijn, P. A., Aug 2019, In : Journal of Virological Methods. 270, p. 106-112

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Prospects of Next-Generation Vaccines for Bluetongue

van Rijn, P. A., 21 Nov 2019, In : Frontiers in Veterinary Science. 6, 407.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Vector competence is strongly affected by a small deletion or point mutations in bluetongue virus

van Gennip, R. G. P., Drolet, B. S., Rozo Lopez, P., Roost, A. J. C., Boonstra, J. & van Rijn, P. A., 11 Oct 2019, In : Parasites & Vectors. 12, 470.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Virus-induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade

Avia, M., Rojas, J. M., Miorin, L., Pascual, E., van Rijn, P. A., Martin, V., Garcia-Sastre, A. & Sevilla, N., 5 Nov 2019, In : Embo Reports. 20, 11, 15 p., e48766.

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2018

African horse sickness virus (AHSV) with a deletion of 77 amino acids in NS3/NS3a protein is not virulent and a safe promising AHS Disabled Infectious Single Animal (DISA) vaccine platform

van Rijn, P. A., Maris-Veldhuis, M. A., Potgieter, C. A. & van Gennip, R. G. P., 5 Apr 2018, In : Vaccine. 36, 15, p. 1925-1933

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Diagnostic DIVA tests accompanying the Disabled Infectious Single Animal (DISA) vaccine platform for African horse sickness

van Rijn, P., Maris-Veldhuis, M. A., Boonstra, J. & van Gennip, H. G. P., 11 May 2018, In : Vaccine. 36, 25, p. 3584-3592

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

One after the other: A novel Bluetongue virus strain related to Toggenburg virus detected in the Piedmont region (North-western Italy), extends the panel of novel atypical BTV strains

Marcacci, M., Sant, S., Mangone, I., Goria, M., Dondo, A., Zoppi, S., van Gennip, R. G. P., Radaelli, M. C., Cammà, C., van Rijn, P. A., Savini, G. & Lorusso, A., Apr 2018, In : Transboundary and Emerging Diseases. 65, 2, p. 370-374

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Recombinant Newcastle disease viruses with targets for PCR diagnostics for rinderpest and peste des petits ruminants

van Rijn, P. A., Boonstra, J. & van Gennip, H. G. P., 12 Jun 2018, In : Journal of Virological Methods. 259, p. 50-53

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
2017

Bluetongue Disabled Infectious Single Animal (DISA) vaccine: Studies on the optimal route and dose in sheep

van Rijn, P. A., Daus, F. J., Maris-Veldhuis, M. A., Feenstra, F. & van Gennip, H. G. P., 5 Jan 2017, In : Vaccine. 35, 2, p. 231-237

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Current and next-generation bleutongue vaccines: Requirements, strategies, and prospects for different field situations

Feenstra, F. & van Rijn, P. A., 2017, In : Critical Reviews in Microbiology. 43, 2, p. 142-155

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Lumpy skin disease: de volgende nieuwkomer? Nodulaire dermatose of "Knopvelsiekte"

van Wuijckhuise, L., Rozendaal, H., Schouten, M. G. C. & van Rijn, P. A., May 2017, In : Tijdschrift voor Diergeneeskunde. 142, 5, p. 25-30

Research output: Contribution to journalArticleAcademic

Replication-Deficient Particles: New Insights into the Next Generation of Bleutongue Virus Vaccines

Celma, C. C., Stewart, M., Wernike, K., Eschbaumer, M., Gonzalez-Molleda, L., Breard, E., Schulz, C., Hoffmann, B., Haegeman, A., De Clercq, K., Zientara, S., van Rijn, P. A., Beer, M. & Roy, P., 2017, In : Journal of Virology. 91, 2, e01892-16.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Structural protein VP2 of African horse sickness virus is not essential for virus replication in vitro

van Gennip, R. G. P., van de Water, S. G. P., Potgieter, C. A. & van Rijn, P. A., 2017, In : Journal of Virology. 91, 4, e01328-16.

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
2016

Balance of RNA sequence requirement and NS3/NS3a expression of segment 10 of orbiviruses

Feenstra, F., Van Gennip, R. G. P., Schreuder, M. & van Rijn, P. A., 2016, In : Journal of General Virology. 97, 2, p. 411-421

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

European bluetongue serotype 8: Disease threat assessment for U.S. sheep

Drolet, B. S., Reister-Hendricks, L. M., Podell, B. K., Breitenbach, J. E., Mcvey, D. S., van Rijn, P. A. & Bowen, R. A., 2016, In : Vector-Borne and Zoonotic Diseases. 16, 6, p. 400-407

Research output: Contribution to journalArticleAcademicpeer-review

Experimental infection of small ruminants with bluetongue virus expressing Toggenburg Orbivirus proteins

van Rijn, P. A., van de Water, S. G. P., Maris-Veldhuis, M. A. & van Gennip, R. G. P., 2016, In : Veterinary Microbiology. 192, p. 145-151

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Requirements and comparative analysis of reverse genetics for bluetongue virus (BTV) and African horse sickness virus (AHSV)

van Rijn, P. A., van de Water, S. G. P., Feenstra, F. & van Gennip, R. G. P., 2016, In : Virology journal. 13, 1, 119.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)
2015

Application of Bluetongue Disabled Infectious Single Animal (DISA) vaccine for different serotypes by VP2 exchange or incorporation of chimeric VP2

Feenstra, F., Pap, J. & van Rijn, P. A., 2015, In : Vaccine. 33, 6, p. 812-818

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
27 Citations (Scopus)

A Review of Knowledge Gaps and Tools for Orbivirus Research

Drolet, B. S., van Rijn, P. A., Howerth, E. W., Beer, M. & Mertens, P., 2015, In : Vector-Borne and Zoonotic Diseases. 15, 6, p. 339-347

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Development of a competitive ELISA for NS3 antibodies as DIVA test accompanying the novel Disabled Infectious Single Animal (DISA) vaccine for bluetongue

Tacken, M. G. J., Daus, F. J., Feenstra, F., van Gennip, H. G. P. & van Rijn, P. A., 2015, In : Vaccine. 33, 42, p. 5539-5545

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Effect of Culicoides sonorensis salivary proteins on clinical disease outcome in experimental Bleutongue virus serotype 8 infection of Dorset sheep

Drolet, B. S., Reister, L. M., Lehiy, C. J., van Rijn, P. A. & Bowen, R. A., 2015, In : Veterinaria Italiana. 51, 4, p. 379-384

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Non-structural protein NS3/NS3a is required for propagation of bluetongue virus in Culicoides sonorensis

Feenstra, F., Drolet, B. S., Boonstra, J. & Van Rijn, P. A., 2015, In : Parasites & Vectors. 8, 1, 9 p., 476.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Turnover rate of NS3 proteins modulates bluetongue virus replication kinetics in a host-specific manner

Ftaich, N., Ciancia, C., Viarouge, C., Barry, G., Ratinier, M., van Rijn, P. A., Breard, E., Vitour, D., Zientara, S., Palmarini, M., Terzian, C. & Arnaud, F., 2015, In : Journal of Virology. 89, 20, p. 10467-10481 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

VP2 exchange and NS3/NS3a deletion in African horsesickness virus (AHSV) towards AHS Disabled Infectious Single Animal (DISA) vaccine candidates

van de Water, S. G. P., van Gennip, H. G. P., Potgieter, C. A., Wright, I. M. & van Rijn, P. A., 2015, In : Journal of Virology. 89, 17, p. 8764-8772

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)
2014

Bluetongue, Schmallenberg - what is next? Culicoides-borne viral diseases in the 21st Century

Koenraadt, C. J. M., Balenghien, T., Carpenter, S., Ducheyne, E., Elbers, A. R. W., Fife, M., Garros, C., Ibanez-Justicia, A., Kampen, H., Kormelink, R. J. M., Losson, B., van der Poel, W. H. M., de Regge, N., van Rijn, P. A., Sanders, C., Schaffner, F., Sloet van Oldruitenborgh-Oosterbaan, M. M., Takken, W., Werner, D. & Seelig, F., 2014, In : BMC Veterinary Research. 10, 6 p., 77.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
20 Citations (Scopus)

Bluetongue virus nonstructural protein NS3/NS3a is not essential for virus replication

van Gennip, H. G. P., van de Water, S. G. P. & van Rijn, P. A., 2014, In : PLoS ONE. 9, 1, 8 p., e85788.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Bluetongue virus without NS3/NS3a expression is not virulent and protects against virulent bluetongue virus challenge.

Feenstra, F., van Gennip, H. G. P., Maris-Veldhuis, M. A., Verheij, E. & van Rijn, P. A., 2014, In : Journal of General Virology. 95, Pt. 9, p. 2019-2029

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)

Immunogenicity of recombinant VP2 proteins of all nive serotypes of African horse sickness virus

Kanai, Y., van Rijn, P. A., Maris-Veldhuis, M. A., Kaname, Y., Athmaram, T. N. & Roy, P., 2014, In : Vaccine. 32, 39, p. 4932-4937 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

RNA Elements in Open Reading Frames of the Bluetongue Virus Genome Are Essential for Virus Replication

Feenstra, F., van Gennip, H. G. P., van de Water, S. G. P. & van Rijn, P. A., 2014, In : PLoS ONE. 9, 3, e92377.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
19 Citations (Scopus)

Viral replication kinetics and in vitro cytopathogenicity of parental and reassortant strains of bluetongue virus serotype 1, 6 and 8

Coetzee, M. P. A., van Vuuren, M., Stokstad, M., Myrmel, M., van Gennip, H. G. P., van Rijn, P. A. & Venter, E. H., 2014, In : Veterinary Microbiology. 171, 1-2, p. 53-65

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

Virus and host factors affecting the clinical outcome of Bluetongue Virus infection

Caporale, M., Gialleonorado, L., Janowicz, A., Wilkie, G., Shaw, A., Savini, G., van Rijn, P. A., Mertens, P., Ventura, M. & Palmarini, M., 2014, In : Journal of Virology. 88, 18, p. 10399-10411

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)

VP2-serotyped live-attenuated bluetongue virus without NS3/NS3a expression provided serotype-specific protection and enables DIVA.

Feenstra, F., Maris-Veldhuis, M. A., Daus, F. J., Tacken, M. G. J., Moormann, R. J. M., van Gennip, H. G. P. & van Rijn, P. A., 2014, In : Vaccine. 32, 52, p. 7108-7114

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)
2013

Bluetongue virus with mutated genome segment 10 to differentiate infected from vaccinated animals: A genetic DIVA approach

van Rijn, P. A., van de Water, S. G. P. & van Gennip, H. G. P., 2013, In : Vaccine. 31, 44, p. 5005-5008

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Experimental infection of white-tailed deer with bluetongue virus serotype 8

Drolet, B. S., Reister, L. M., Mecham, J. O., Wilson, W. C., Nol, P., Vercauteren, K. C., van Rijn, P. A. & Bowen, R. A., 2013, In : Veterinary Microbiology. 166, 3-4, p. 347-355

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Preliminary mapping of non-conserved epitopes on envelope glycoprotein E2 of bovine viral diarrhea virus type 1 and 2

Jelsma, H., Loeffen, W. L. A., van Beuningen, A. R. & van Rijn, P. A., 2013, In : Veterinary Microbiology. 166, 1-2, p. 195-199

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Rapid generation of replication-deficient monovalent and multivalent vaccines for bluetongue virus: protection against virulent virus challenge in cattle and sheep

Celma, C. C. P., Boyce, M., van Rijn, P. A., Eschbaumer, M., Wernike, K., Hoffmann, B., Beer, M., De Clercq, K. & Roy, P., 2013, In : Journal of Virology. 87, 17, p. 9856-9864

Research output: Contribution to journalArticleAcademicpeer-review

36 Citations (Scopus)
2012

Bluetongue Viruses Based on Modified-Live Vaccine Serotype 6 with Exchanged Outer Shell Proteins Confer Full Protection in Sheep against Virulent BTV8

van Gennip, H. G. P., van de Water, S. G. P., Maris-Veldhuis, M. A. & van Rijn, P. A., 2012, In : PLoS ONE. 7, 9, e44619.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Bluetongue virus serotype 6 in Europe in 2008 - Emergence and disappearance of an unexpected non-virulent BTV

van Rijn, P. A., Geurts, Y., van der Spek, A. N., Veldman, D. & van Gennip, H. G. P., 2012, In : Veterinary Microbiology. 158, 1-2, p. 23-32

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Rescue of recent virulent and avirulent field strains of Bluetongue virus by reverse genetics

van Gennip, H. G. P., van de Water, S. G. P., Potgieter, C. A., Wright, I. M., Veldman, D. & van Rijn, P. A., 2012, In : PLoS ONE. 7, 2, e30540.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
33 Citations (Scopus)

Sustaines high throughput polymerase chain reaction diagnostics during the European epidemic of Bluetongue serotype 8

van Rijn, P. A., Heutink, C. G., Boonstra, J., Kramps, J. A. & van Gennip, H. G. P., 2012, In : Journal of Veterinary Diagnostic Investigation. 24, 3, p. 469-478

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
2010

Bluetongue virus serotype 8 (BTV-8) infection reduces fertility of Dutch dairy cattle and is vertically transmitted to offspring

Santman-Berends, I. M. G. A., Hage, J. J., van Rijn, P. A., Stegeman, J. A. & van Schaik, G., 2010, In : Theriogenology. 74, 8, p. 1377-1384

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Scopus)

Evaluation of an indirect ELISA for detection of antibodies in bulk mlik against bluetongue virus infections in the Netherlands

Mars, M. H., van Maanen, C., Vellema, P., Kramps, J. A. & van Rijn, P. A., 2010, In : Veterinary Microbiology. 146, 3-4, p. 209-214

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Full Genome Characterisation of Bluetonge Virus Seroptype 6 from the Netherlands 2008 and Comparison to Other Field and Vaccine Strains

Maan, S., Maan, N. S., van Rijn, P. A., van Gennip, H. G. P., Sanders, A. A., Wright, I. M., Batten, C., Hoffmann, B., Eschbaumer, M., Oura, C. A. L., Potgieter, C., Nomikou, K. & Mertens, P. P. C., 2010, In : PLoS ONE. 5, 4, 17 p., e10323.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
103 Citations (Scopus)

Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments

van Gennip, H. G. P., Veldman, D., van de Water, S. G. P. & van Rijn, P. A., 2010, In : Virology journal. 7, 261.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Potential role of ticks as vectors of bluetongue virus

Bouwknegt, C., van Rijn, P. A., Schipper, J. M. J., Holzel, D. R., Boonstra, J., Nijhof, A., van Rooij, E. M. A. & Jongejan, F., 2010, In : Experimental and Applied Acarology. 52, 2, p. 183-192

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
35 Citations (Scopus)

Questionnaire survey about the motives of commercial livestock farmers and hobby holders to vaccinate their animals against Bluetongue virus serotype 8 in 2008–2009 in the Netherlands

Elbers, A. R. W., de Koeijer, A. A., Scolamacchia, F. & van Rijn, P. A., 2010, In : Vaccine. 28, 13, p. 2473-2481

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Vertical transmission of bluetongue virus serotype 8 virus in Dutch dairy herds in 2007

Santman-Berends, I. M. G. A., van Wuijckhuise, L., Vellema, P. & van Rijn, P. A., 2010, In : Veterinary Microbiology. 141, 1-2, p. 31-35

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)