Michel Eppink

prof.dr.ing.

    1992 …2019
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    Research Output 1992 2019

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    2019

    Disruption of microalgae with a novel continuous explosive decompression device

    Günerken, E., D'Hondt, E., Eppink, M. H. M., Wijffels, R. H. & Elst, K., May 2019, In : Algal Research. 39, 101376.

    Research output: Contribution to journalArticleAcademicpeer-review

    microalgae
    algae
    gases
    cells
    shear stress
    1 Citation (Scopus)

    Integrated Product Recovery Will Boost Industrial Cyanobacterial Processes

    van den Berg, C., Eppink, M. H. M. & Wijffels, R. H., May 2019, In : Trends in Biotechnology. 37, 5, p. 454-463

    Research output: Contribution to journalArticleAcademicpeer-review

    Photobioreactors
    Synthetic Biology
    Biological Phenomena
    Terpenes
    Cyanobacteria

    Understanding mild cell disintegration of microalgae in bead mills for the release of biomolecules

    Suarez Garcia, E., Lo, C., Eppink, M. H. M., Wijffels, R. H. & van den Berg, C., 10 Aug 2019, In : Chemical Engineering Science. 203, p. 380-390

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Disintegration
    Biomolecules
    Kinetics
    Algae
    Metabolites
    2018
    12 Citations (Scopus)

    Biorefinery of the macroalgae Ulva lactuca: extraction of proteins and carbohydrates by mild disintegration

    Postma, P. R., Cerezo-Chinarro, O., Akkerman, R. J., Olivieri, G., Wijffels, R. H., Brandenburg, W. A. & Eppink, M. H. M., Apr 2018, In : Journal of Applied Phycology. 30, 2, p. 1281-1293

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    biorefining
    Ulva lactuca
    macroalgae
    carbohydrate
    incubation
    7 Citations (Scopus)

    Fractionation of proteins and carbohydrates from crude microalgae extracts using an ionic liquid based-aqueous two phase system

    Suarez Garcia, E., Suarez Ruiz, C. A., Tilaye, T., Eppink, M. H. M., Wijffels, R. H. & van den Berg, C., 2 Oct 2018, In : Separation and Purification Technology. 204, p. 56-65 10 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Ionic Liquids
    Carbohydrates
    Fractionation
    Complex Mixtures
    Ionic liquids
    39 Citations (Scopus)

    Multi-Product Microalgae Biorefineries: From Concept Towards Reality

    't Lam, G. P., Vermuë, M. H., Eppink, M. H. M., Wijffels, R. H. & van den Berg, C., Feb 2018, In : Trends in Biotechnology. 36, 2, p. 216-227

    Research output: Contribution to journalArticleAcademicpeer-review

    Microalgae
    Costs and Cost Analysis
    Economics
    Costs
    Photobioreactors
    4 Citations (Scopus)

    One-step mild biorefinery of functional biomolecules from microalgae extracts

    Desai, R. K., Monteillet, H. J. M., Li, X., Schuur, B., Wijffels, R. H. & Eppink, M. H. M., Apr 2018, In : Reaction Chemistry & Engineering. 3, 2, p. 182-187

    Research output: Contribution to journalArticleAcademicpeer-review

    Biomolecules
    Proteins
    Pigments
    Ionic Liquids
    Ionic liquids
    10 Citations (Scopus)

    Rubisco separation using biocompatible aqueous two-phase systems

    Suarez Ruiz, C. A., van den Berg, C., Wijffels, R. H. & Eppink, M. H. M., 8 May 2018, In : Separation and Purification Technology. 196, p. 254-261

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Ribulose-Bisphosphate Carboxylase
    Potassium Citrate
    Polyethylene glycols
    Potassium
    Proteins
    7 Citations (Scopus)

    Selective and energy efficient extraction of functional proteins from microalgae for food applications

    Suarez Garcia, E., van Leeuwen, J., Safi, C., Sijtsma, L., Eppink, M. H. M., Wijffels, R. H. & van den Berg, C., 1 Nov 2018, In : Bioresource Technology. 268, p. 197-203

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Proteins
    protein
    food
    energy
    Carbohydrates
    1 Citation (Scopus)

    Selective and mild fractionation of microalgal proteins and pigments using aqueous two-phase systems

    Suarez Ruiz, C. A., Emmery, D. P., Wijffels, R. H., Eppink, M. H. M. & van den Berg, C., 1 Sep 2018, In : Journal of Chemical Technology and Biotechnology. 93, 9, p. 2774-2783

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Fractionation
    Pigments
    pigment
    fractionation
    Proteins
    1 Citation (Scopus)
    Open Access
    Tetraselmis suecica
    Gelation
    gelation
    Complex Mixtures
    algae
    2017
    12 Citations (Scopus)

    Characterization of highly concentrated antibody solution - A toolbox for the description of protein long-term solution stability

    Schermeyer, M-T., Woll, A. K., Kokke, B., Eppink, M. H. M. & Hubbuch, J., 15 Jun 2017, In : mAbs. 9, 7, p. 1169-1185

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Antibodies
    Proteins
    Viscosity
    Viscoelastic Substances
    Osmolar Concentration
    30 Citations (Scopus)
    Open Access
    Disintegration
    Carbohydrates
    carbohydrate
    Proteins
    protein
    6 Citations (Scopus)

    Flow cytometry to estimate the cell disruption yield and biomass release of Chlorella sp. during bead milling

    Günerken, E., D'Hondt, E., Eppink, M., Elst, K. & Wijffels, R., 2017, In : Algal Research. 25, p. 25-31

    Research output: Contribution to journalArticleAcademicpeer-review

    Chlorella
    flow cytometry
    microalgae
    biomass
    cells
    9 Citations (Scopus)

    Mild and Selective Protein Release of Cell Wall Deficient Microalgae with Pulsed Electric Field

    't Lam, G., van der Kolk, J. A., Chordia, A., Vermuë, M. H., Olivieri, G., Eppink, M. H. M. & Wijffels, R. H., 2017, In : ACS sustainable chemistry & engineering. 5, 7, p. 6046-6053 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    electric field
    Cells
    Electric fields
    Proteins
    protein
    20 Citations (Scopus)

    Pulsed Electric Field for protein release of the microalgae Chlorella vulgaris and Neochloris oleoabundans

    't Lam, G., Postma, P. R., Fernandes, D. A., Timmermans, R. A. H., Vermuë, M. H., Barbosa, M. J., Eppink, M. H., Wijffels, R. H. & Olivieri, G., 2017, In : Algal Research. 24, Part A, p. 181-187

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Ettlia oleoabundans
    Chlorella vulgaris
    pulsed electric fields
    microalgae
    electroporation
    3 Citations (Scopus)

    Rapid Buffer and Ligand Screening for Affinity Chromatography by Multiplexed Surface Plasmon Resonance Imaging

    Geuijen, K. P. M., van Wijk-Basten, D. E. J. W., Egging, D. F., Schasfoort, R. B. M. & Eppink, M. H. M., 2017, In : Biotechnology Journal. 12, 9 p., 1700154.

    Research output: Contribution to journalArticleAcademicpeer-review

    Surface Plasmon Resonance
    Affinity Chromatography
    Buffers
    Ligands
    Miniaturization
    4 Citations (Scopus)

    Rapid screening of IgG quality attributes - effects on Fc receptor binding

    Geuijen, K. P. M., Oppers-Tiemissen, C., Egging, D. F., Simons, P. J., Boon, L., Schasfoort, R. B. M. & Eppink, M. H. M., 1 Oct 2017, In : FEBS Open Bio. 7, 10, p. 1557-1574

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Screening
    Immunoglobulin G
    Assays
    Antibodies
    Immunoglobulin Fragments
    2016
    4 Citations (Scopus)

    3D-liquid chromatography as a complex mixture characterization tool for knowledge-based downstream process development.

    Hanke, A. T., Tsintavi, E., Del Pilar Ramirez Vazquez, M., van der Wielen, L. A. M., Verhaert, P. D. E. M., van de Sandt, E. J. A. X., Eppink, M. H. M. & Ottens, M., 2016, In : Biotechnology Progress. 32, 5, p. 1283-1291 32 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Complex Mixtures
    Hydrophobic and Hydrophilic Interactions
    Liquid Chromatography
    Adsorption
    Enzymes
    1 Citation (Scopus)

    Characterization of low affinity Fcγ receptor biotinylation under controlled reaction conditions by mass spectrometry and ligand binding analysis

    Geuijen, K. P. M., Egging, D. F., Bartels, S., Schouten, J., Schasfoort, R. B. & Eppink, M. H. M., 2016, In : Protein Science. 25, 10, p. 1841-1852

    Research output: Contribution to journalArticleAcademicpeer-review

    Biotinylation
    Fc Receptors
    Mass spectrometry
    Mass Spectrometry
    Ligands
    11 Citations (Scopus)

    Influence of nitrogen depletion in the growth of N. oleoabundans on the release of cellular components after beadmilling

    Günerken, E., D'Hondt, E., Eppink, M., Elst, K. & Wijffels, R., 2016, In : Bioresource Technology. 214, p. 89-95

    Research output: Contribution to journalArticleAcademicpeer-review

    Nitrogen
    Biomass
    nitrogen
    Lipids
    biomass
    35 Citations (Scopus)

    Novel astaxanthin extraction from Haematococcus pluvialis using cell permeabilising ionic liquids

    Desai, R. K., Streefland, M., Wijffels, R. H. & Eppink, M. H. M., 2016, In : Green Chemistry. 18, 5, p. 1261-1267

    Research output: Contribution to journalArticleAcademicpeer-review

    Ionic Liquids
    Ionic liquids
    Biopolymers
    cyst
    Pigments
    6 Citations (Scopus)

    Prediction of protein retention times in hydrophobic interaction chromatography by robust statistical characterization of their atomic-level surface properties.

    Hanke, A. T., Klijn, M. E., Verhaert, P. D., van der Wielen, L., Ottens, M., Eppink, M. H. M. & van de Sandt, E. J. A. X., 2016, In : Biotechnology Progress. 32, 2, p. 372-381

    Research output: Contribution to journalArticleAcademicpeer-review

    Surface Properties
    Hydrophobic and Hydrophilic Interactions
    Chromatography
    Membrane Proteins
    Proteins
    46 Citations (Scopus)

    Selective extraction of intracellular components from the microalga Chlorella vulgaris by combined pulsed electric field-temperature treatment

    Postma, P. R., Pataro, G., Capitoli, M., Barbosa, M. J., Wijffels, R. H., Eppink, M. H. M., Olivieri, G. & Ferrari, G., 1 Mar 2016, In : Bioresource Technology. 203, p. 80-88

    Research output: Contribution to journalArticleAcademicpeer-review

    microalga
    Carbohydrates
    electric field
    carbohydrate
    Electric fields
    140 Citations (Scopus)

    Towards industrial products from microalgae

    Ruiz Gonzalez, J., Olivieri, G., de Vree, J. H., Bosma, R., Willems, P., Reith, J. H., Eppink, M. H. M., Kleinegris, D. M. M., Wijffels, R. H. & Barbosa, M. J., 2016, In : Energy and Environmental Science. 9, 10, p. 3036-3043

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Biomass
    biomass
    commodity
    food
    Feedstocks
    2015
    16 Citations (Scopus)

    Dosage effect of cationic polymers on the flocculation efficiency of the marine microalga Neochloris oleoabundans

    't Lam, G. P., Zegeye, E. K., Vermuë, M. H., Kleinegris, D. M. M., Eppink, M. H. M., Wijffels, R. H. & Olivieri, G., 2015, In : Bioresource Technology. 198, p. 797-802

    Research output: Contribution to journalArticleAcademicpeer-review

    microalga
    Flocculation
    flocculation
    Polymers
    Biomass
    5 Citations (Scopus)

    Fourier transform assisted deconvolution of skewed peaks in complex multi-dimensional chromatograms

    Hanke, A. T., Verhaert, P. D. E. M., van der Wielen, L. A. M., Eppink, M. H. M., Sandt, E. J. A. X. & Ottens, M., 2015, In : Journal of Chromatography. A, Including electrophoresis and other separation methods. 1394, p. 54-61

    Research output: Contribution to journalArticleAcademicpeer-review

    Deconvolution
    Fourier Analysis
    Fourier transforms
    Theoretical Models
    Fast Fourier transforms
    10 Citations (Scopus)

    Label-Free Glycoprofiling with Multiplex Surface Plasmon Resonance: A Tool To Quantify Sialylation of Erythropoietin

    Geuijen, K. P. M., Halims, L. A., Schellekens, H., Schasfoort, R. B., Wijffels, R. H. & Eppink, M. H. M., 2015, In : Analytical Chemistry. 87, 16, p. 8115-8122

    Research output: Contribution to journalArticleAcademicpeer-review

    Surface plasmon resonance
    Glycosylation
    Erythropoietin
    Lectins
    Labels
    68 Citations (Scopus)

    Mild disintegration of the green microalgae Chlorella vulgaris using bead milling

    Postma, P. R., Miron, T. L., Olivieri, G., Barbosa, M. J., Wijffels, R. H. & Eppink, M. H. M., 2015, In : Bioresource Technology. 184, p. 297-304

    Research output: Contribution to journalArticleAcademicpeer-review

    Disintegration
    Proteins
    protein
    Biomass
    Water

    Petrochemie op biobasis (interview met Puck Moll en Michel Eppink)

    Eppink, M. H. M., 2015, In : C2W Life Sciences. 18, 4 p.

    Research output: Contribution to journalArticleProfessional

    2014
    31 Citations (Scopus)

    Cationic polymers for successful flocculation of marine microalgae

    't Lam, G. P., Vermuë, M. H., Olivieri, G., van den Broek, L. A. M., Barbosa, M. J., Eppink, M. H. M., Wijffels, R. H. & Kleinegris, D. M. M., 2014, In : Bioresource Technology. 169, p. 804-807

    Research output: Contribution to journalArticleAcademicpeer-review

    Flocculation
    flocculation
    Polymers
    polymer
    Recovery
    17 Citations (Scopus)

    Effect of charged polysaccharides on the techno-functional properties of fractions obtained from algae soluble protein isolate

    Schwenzfeier, A., Wierenga, P. A., Eppink, M. H. M. & Gruppen, H., 2014, In : Food Hydrocolloids. 35, p. 9-18

    Research output: Contribution to journalArticleAcademicpeer-review

    algae
    protein isolates
    Polysaccharides
    Algae
    functional properties
    73 Citations (Scopus)

    Extraction and stability of selected proteins in ionic liquid based aqueous two phase systems

    Desai, R. K., Streefland, M., Wijffels, R. H. & Eppink, M. H. M., 2014, In : Green Chemistry. 16, 5, p. 2670-2679

    Research output: Contribution to journalArticleAcademicpeer-review

    Ionic Liquids
    Ionic liquids
    Proteins
    Ribulose-Bisphosphate Carboxylase
    protein
    3 Citations (Scopus)

    High-throughput and multiplexed regeneration buffer scouting for affinity-based interactions

    Geuijen, K. P. M., Schasfoort, R. B., Wijffels, R. H. & Eppink, M. H. M., 2014, In : Analytical Biochemistry. 454, p. 38-40

    Research output: Contribution to journalArticleAcademicpeer-review

    Regeneration
    Buffers
    Throughput
    Ligands
    Biosensors
    3 Citations (Scopus)

    Kinetic and structural analysis of two transferase domains inPasteurella multocida hyaluronan synthase

    Kooy, F. K., Beeftink, H. H., Eppink, M. H. M., Tramper, J., Eggink, G. & Boeriu, C. G., 2014, In : Journal of Molecular Catalysis. B, Enzymatic. 102, p. 138-145 8 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Uridine Diphosphate Sugars
    Transferases
    Oligosaccharides
    Structural analysis
    Sugars
    62 Citations (Scopus)

    Preclinical Profile of the HER2-Targeting ADC SYD983/SYD985: Introduction of a New Duocarmycin-Based Linker-Drug Platform

    Dokter, W., Ubink, R., van der Lee, M., van der Vleuten, M., van Achterberg, T., Jacobs, D., Loosveld, E., van den Dobbelsteen, D., Egging, D., Mattaar, E., Groothuis, P., Beusker, P., Coumans, R., Elgersma, R., Menge, W., Joosten, J., Spijker, H., Huijbregts, T., de Groot, V., Eppink, M. H. M. & 3 othersde Roo, G., Verheijden, G. & Timmers, M., 2014, In : Molecular Cancer Therapeutics. 13, p. 2618-2629

    Research output: Contribution to journalArticleAcademicpeer-review

    Macaca fascicularis
    Heterografts
    Tubulin Modulators
    Pharmaceutical Preparations
    Antibody-Dependent Cell Cytotoxicity
    2013
    204 Citations (Scopus)

    Biorefinery of microalgae for food and fuel

    Vanthoor-Koopmans, M., Wijffels, R. H., Barbosa, M. J. & Eppink, M. H. M., 2013, In : Bioresource Technology. 135, p. 142-149

    Research output: Contribution to journalArticleAcademicpeer-review

    Ionic Liquids
    Soybean Oil
    Palm oil
    Biofuels
    food
    29 Citations (Scopus)

    Cysteine Depletion Causes Oxidative Stress and Triggers Outer Membrane Vesicle Release by Neisseria meningitidis Implications for Vaccine Development

    van de Waterbeemd, B., Zomer, G., van den IJssel, J., van Keulen, L., Eppink, M. H. M., de Ley, P. & van der Pol, L. A., 2013, In : PLoS ONE. 8, 1, 9 p., e54314.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    Neisseria meningitidis
    Oxidative stress
    vaccine development
    Cysteine
    cysteine
    21 Citations (Scopus)

    Foam properties of algae soluble protein isolate: Effect of pH and ionic strength

    Schwenzfeier, A., Lech, F. J., Wierenga, P. A., Eppink, M. H. M. & Gruppen, H., 2013, In : Food Hydrocolloids. 33, 1, p. 111-117

    Research output: Contribution to journalArticleAcademicpeer-review

    algae
    protein isolates
    Algae
    ionic strength
    foams
    23 Citations (Scopus)

    Model-based rational methodology for protein purification process synthesis

    Nfor, B., Ahamed, T., Dedem, G., Verhaert, P., Wielen, L., Eppink, M. H. M., van de Sandt, E. & Ottens, M., 2013, In : Chemical Engineering Science. 89, p. 185-195

    Research output: Contribution to journalArticleAcademicpeer-review

    Purification
    Proteins
    31 Citations (Scopus)

    Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines

    van de Waterbeemd, B., Mommen, G. P. M., Pennings, J. L. A., Eppink, M. H. M., Wijffels, R. H., van der Pol, L. A. & de Jong, A. P. J. M., 2013, In : Journal of Proteome Research. 12, p. 1898-1908 11 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Proteomics
    Detergents
    Vaccines
    Membranes
    Proteins

    Structural and functional evidence for two separate oligosaccharide binding sites of Pasteurellamultocida hyaluronan synthase

    Kooy, F. K., Beeftink, H. H., Eppink, M. H. M., Tramper, J., Eggink, G. & Boeriu, C. G., 2013, In : Advances in Enzyme Research. 1, 4, p. 97-111

    Research output: Contribution to journalArticleAcademicpeer-review

    Hyaluronic Acid
    Oligosaccharides
    Binding Sites
    Glycosyltransferases
    Elongation
    2012
    19 Citations (Scopus)

    Identification and optimization of critical process parameters for the production of NOMV vaccine against Neisseria meningitidis

    van de Waterbeemd, B., Streefland, M., van Keulen, L. J. M., van den IJssel, J., Bakker-de Haan, A. M. C., Eppink, M. H. M. & van der Pol, L. A., 2012, In : Vaccine. 30, 24, p. 3683-3690

    Research output: Contribution to journalArticleAcademicpeer-review

    Neisseria meningitidis
    Edetic Acid
    Vaccines
    EDTA (chelating agent)
    vaccines
    25 Citations (Scopus)

    Multi-dimensional fractionation and characterization of crude protein mixtures: Toward establishment of a database of protein purification process development parameters

    Ahamed, T., Pinkse, M. W. H., van der Wielen, L. A. M., Verhaert, P., Dedem, G., Eppink, M. H. M., van de Sandt, E. & Ottens, M., 2012, In : Biotechnology and Bioengineering. 109, 12, p. 3070-3083

    Research output: Contribution to journalArticleAcademicpeer-review

    Protein Databases
    Ion Exchange Chromatography
    Fractionation
    Chromatography
    Purification
    6 Citations (Scopus)

    Self-packed filter plates: a good alternative for pre-packed filter plates for developing purification processes of therapeutic proteins

    Li, X., de Roo, G., Burgers, K., Ottens, M. & Eppink, M. H. M., 2012, In : Biotechnology Journal. 7, 10, p. 1269-1276

    Research output: Contribution to journalArticleAcademicpeer-review

    Smegmamorpha
    Adsorption
    Proteins
    Therapeutics
    2011
    10 Citations (Scopus)

    Techno-economic evaluation of an inclusion body solubilization and recombinant protein refolding process

    Freydell, E. J., van der Wielen, L. A. M., Eppink, M. H. M. & Ottens, M., 2011, In : Biotechnology Progress. 27, 5, p. 1315-1328

    Research output: Contribution to journalArticleAcademicpeer-review

    Protein Refolding
    Inclusion Bodies
    Recombinant Proteins
    Cost-Benefit Analysis
    Dithiothreitol
    2010
    12 Citations (Scopus)

    Ion-exchange chromatographic protein refolding

    Freydell, E., van der Wielen, L., Eppink, M. H. M. & Ottens, M., 2010, In : Journal of Chromatography. A, Including electrophoresis and other separation methods. 1217, 46, p. 7265-7274

    Research output: Contribution to journalArticleAcademicpeer-review

    Protein Refolding
    Ion Exchange
    Ion exchange
    Proteins
    Urea
    17 Citations (Scopus)

    Size-exclusion chromatographic protein refolding: Fundamentals, modelling and operation

    Freydell, E. J., van der Wielen, L., Eppink, M. H. M. & Ottens, M., 2010, In : Journal of Chromatography. A, Including electrophoresis and other separation methods. 1217, 49, p. 7723-7737

    Research output: Contribution to journalArticleAcademicpeer-review

    Protein Refolding
    Size exclusion chromatography
    Gel Chromatography
    Proteins
    Dilution
    21 Citations (Scopus)

    Size-exclusion simulated moving bed chromatographic protein refolding

    Freydell, E., Bulsink, Y., van Hateren, S., van der Wielen, L., Eppink, M. H. M. & Ottens, M., 2010, In : Chemical Engineering Science. 65, 16, p. 4701-4713

    Research output: Contribution to journalArticleAcademicpeer-review

    Proteins
    Size exclusion chromatography
    Chromatography
    Productivity
    Design of experiments
    2009

    Platform Technology for Developing Purification Processes

    Eppink, M. H. M., Schreurs, R., Gijsen, A. & Verhoeven, K., 2009, In : BioPharm International. 22, 3, p. 32-42

    Research output: Contribution to journalArticleProfessional

    Technology
    Robotics
    Proteins
    Lasers
    Ligands