Kees de Gooijer

Research output

Research output per year 1988 1990 1992 1994 1995 1996 2003

• 48 Article
• 38 Abstract
• 24 Conference paper
• 4 Chapter
• 3 More
  • 1 Book editing
  • 1 Report
  • 1 Inaugural speech

Research output per year

Research output per year

Search results

• 2003

  Monte Carlo simulation of the alpha-amylolysis of amylopectin potato starch. 2. alpha-amylolysis of amylopectin

  Marchal, L. M., Ulijn, R. V., de Gooijer, C. D., Franke, G. T. & Tramper, J., 2003, In: Bioprocess and Biosystems Engineering. 26, p. 123-132

  Research output: Contribution to journal › Article › Academic › peer-review

  • Amylopectins 100%
  • Amylopectin 89%
  • Solanum tuberosum 69%
  • Starch 65%
  • Hydrolysis 63%
  14 Citations (Scopus)

• Optimization of a feed medium for fed-batch culture of insect cells using a genetic algorithm

  Marteijn, R. C. L., Jurrius, O., Dhont, J., de Gooijer, C. D., Tramper, J. & Martens, D. E., 2003, In: Biotechnology and Bioengineering. 81, 3, p. 269-278

  Research output: Contribution to journal › Article › Academic › peer-review

  • Batch Cell Culture Techniques 100%
  • Fermentation 79%
  • Insecta 74%
  • Genetic algorithms 50%
  • Metabolism 30%
  48 Citations (Scopus)

• Ruimte voor kwaliteit en ondernemerschap : Wageningen Universiteits & Researchcentrum, Instellingsplan Wageningen Universiteit, Ondernemingsplan Stichting DLO, 2003-2006

  Bartelink, H. H., van Berlo, J. M., Bouma, J., de Gooijer, C. D., Groen, A. F., Groot, R., Jongebreur, A. A., de Klerk-Engels, B., Oorschot, R. & Schlebaum, W., 2003, Wageningen: Wageningen UR. 69 p.

  Research output: Book/Report › Report › Professional
• 2002

  Opening academisch jaar 2002-2003 Wageningen Universiteit, Theater Junushoff, 2 september 2002

  Dijkhuizen, A. A., Odink, B. J., de Leeuw, J. F. & de Gooijer, C. D., 2002, Wageningen: Wageningen Universiteit. 22 p.

  Research output: Book/Report › Inaugural speech

  Open Access
• 2001

  Lethal effects of bubbles in animal-cell culture

  Martens, D. E., Muller, M. F., de Gooijer, C. D. & Tramper, J., 2001, Multiphase Bioreactor Design. Cabral, J. M. S., Mota, M. & Tramper, J. (eds.). London: Taylor & Francis, p. 427-462

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
• 2000

  De novo generation of defective interfering baculovirus in insect cells

  Pijlman, G. P., van der Born, E. B., Martens, D. E., de Gooijer, C. D. & Vlak, J. M., 2000, 33rd Annual Meeting of the Society for Invertebrate Pathology. Guanajuato, p. 80

  Research output: Chapter in Book/Report/Conference proceeding › Abstract

• Effect of low inoculation density in the scale-up of insect cell cultures

  Marteijn, R. C. L., Oude Elferink, M. M. A., Martens, D. E., de Gooijer, C. D. & Tramper, J., 2000, In: Biotechnology Progress. 16, p. 795-799

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hemiptera 100%
  • Cell Culture Techniques 46%
  • Suspensions 31%
  • Growth 30%
  • Cell Line 21%
  10 Citations (Scopus)

• Origin of defective interfering baculoviruses

  Pijlman, G. P., van den Born, E. B., de Gooijer, C. D. & Vlak, J. M., 2000, 19th Annual Meeting of the American Society for Virology. Fort Collins, p. 132

  Research output: Chapter in Book/Report/Conference proceeding › Abstract
• 1999

  Detection of defective interfering baculoviruses after a first passage in cell culture

  Pijlman, G. P., Martens, D., de Gooijer, C. D. & Vlak, J. M., 1999, XIth International Congress of Virology : 9 - 13 August 1999, Sydney, Australië : book of abstracts / [by the] International Union of Microbiological Societies (IUMS) [1999]. - [S.l.] : [s.n.], 1999. p. 128

  Research output: Chapter in Book/Report/Conference proceeding › Abstract

• Error analysis of metabolic-rate measurements in mammalian-cell culture by carbon and nitrogen balances

  Bonarius, H. P. J., Houtman, J. H. M., Schmid, G., de Gooijer, C. D. & Tramper, J., 1999, In: Cytotechnology. 29, p. 167-175

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• Flux analysis of mammalian cell cultures : methods and applications

  Bonarius, H. P. J., de Gooijer, C. D. & Tramper, J., 1999, The encyclopedia of cell technology. Spier, R. E. (ed.).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

• Rational medium design for bordetella pertussis : basic metabolism

  Thalen, M., van den Ijssel, J., Jiskoot, W., Zomer, W., Roholl, P., de Gooijer, C. D. & Tramper, J., 1999, In: Journal of Biotechnology. 75, p. 147-159

  Research output: Contribution to journal › Article › Academic › peer-review
  77 Citations (Scopus)
• 1998

  Activity of glutamate dehydrogenase is increased in ammonia-stressed hybridoma cells.

  Bonarius, H. P. J., Houtman, J. H. M., de Gooijer, C. D., Tramper, J. & Schmid, G., 1998, In: Biotechnology and Bioengineering. 57, p. 447-453

  Research output: Contribution to journal › Article › Academic › peer-review
  29 Citations (Scopus)

• Constraints in animal-cell bioreactor design: external factors and gradients.

  de Gooijer, C. D., 1998, Process Integration in Biochemical Engineering: Workshop on Integrated Bioprocess Design, Espoo. p. 26-30

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

• Extractive bioconversions in aqueous two-phase systems.

  Zijlstra, G. M., de Gooijer, C. D. & Tramper, J., 1998, In: Current Opinion in Biotechnology. 9, p. 171-176

  Research output: Contribution to journal › Article › Academic › peer-review

  64 Citations (Scopus)

• Metabolite-balancing techniques vs. 13C tracer experiments to determine metabolic fluxes in hybridoma cells

  Bonarius, H. P. J., Timmerarends, B., de Gooijer, C. D. & Tramper, J., 1998, In: Biotechnology and Bioengineering. 58, p. 258-262

  Research output: Contribution to journal › Article › Academic › peer-review
  39 Citations (Scopus)

• Monte Carlo simulation of the alpha-amylolysis of amylopectin potato starch.

  Marcal, L. M., Ulijn, R. V., Zondervan, J., Bergsma, J., de Gooijer, C. D. & Tramper, J., 1998, Proceedings of the 2nd European Symposium on Biochemical Engineering Science. S. Feyo de Azevedo (ed.). p. 351

  Research output: Chapter in Book/Report/Conference proceeding › Abstract

• The effect of temperature on the saccharide composition obtained after alpha-amylolysis of starch.

  Marchal, L. M., Bergsma, J., Franke, G. T., de Gooijer, C. D., Beeftink, H. H. & Tramper, J., 1998, 19th International Carbohydrate Symposium, San Diego, USA (1998) DP 072.

  Research output: Chapter in Book/Report/Conference proceeding › Abstract
• 1997

  Biologische gewasbescherming. In-het-groot gewasbeschermende virussen produceren.

  de Gooijer, C. D. & Martens, D. E., 1997, In: Chemisch Magazine. 12, p. 440-443

  Research output: Contribution to journal › Article › Professional

• Comparison of optimization methods for fed-batch cultures of hybridoma cells.

  Roubos, J. A., de Gooijer, C. D., van Straten, G. & van Boxtel, A. J. B., 1997, In: Bioprocess Engineering. 17, 2, p. 99-102

  Research output: Contribution to journal › Article › Academic › peer-review

  27 Citations (Scopus)

• Metabolic flux analysis of hybridoma cells using mass balances, CO2 mass spectrometry and NMR spectrometry.

  Bonarius, H. P. J., Ozemre, A., Timmerarends, B., Skrabal, P., Heinzle, E., de Gooijer, C. D., Tramper, J. & Schmid, G., 1997, Proceedings 14th ESACT-meeting 1996 Vilamoura Portugal. M.J.T. Carrondo et al. (eds) Animal Cell Technology. p. 633-638

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

• On-line immunoanalysis of monoclonal antibodies during a continuous culture of hybridoma cells.

  van der Pol, J. J., Machnik, M., Biselli, M., Portela-Klein, T., de Gooijer, C. D., Tramper, J. & Wandrey, C., 1997, In: Cytotechnology. 24, p. 19-30

  Research output: Contribution to journal › Article › Academic › peer-review
  9 Citations (Scopus)

• Serial air-lift bioreactors for the approximation of aerated plug flow.

  Bakker, W. A. M., Overdevest, P. E. M., Beeftink, H. H., Tramper, J. & de Gooijer, C. D., 1997, In: Trends in Biotechnology. 15, p. 264-269

  Research output: Contribution to journal › Article › Academic › peer-review
  4 Citations (Scopus)

• When and how to use the Baculovirus expression vector.

  de Gooijer, C. D., van Lier, F. L. J. & Tramper, J., 1997, Transient gene expression conference Jersey (1997).

  Research output: Chapter in Book/Report/Conference proceeding › Abstract
• 1996

  Automation of selective assays for on-line bioprocess monitoring by flowinjection analysis.

  van der Pol, J. J., de Gooijer, C. D., Biselli, M., Wandrey, C. & Tramper, J., 1996, In: Trends in Biotechnology. 14, p. 471-477

  Research output: Contribution to journal › Article › Academic › peer-review

  • Flow Injection Analysis 100%
  • Automation 65%
  • Assays 62%
  • Robustness (control systems) 31%
  • Enzymes 30%
  23 Citations (Scopus)

• Bioreactors in series: an overview of design procedures and practical applications.

  de Gooijer, C. D., Bakker, W. A. M., Beeftink, H. H. & Tramper, J., 1996, In: Enzyme and Microbial Technology. 18, p. 202-219

  Research output: Contribution to journal › Article › Academic › peer-review
  47 Citations (Scopus)

• Current applications of cell culture engineering - Vol.2. Insect cell cultures: Fundamental and applied aspects.

  Vlak, J. M. (ed.), de Gooijer, C. D. (ed.), Tramper, J. (ed.) & Miltenburger, H. G. (ed.), 1996, Dordrecht: Kluwer Academic Publishers. 309 p.

  Research output: Book/Report › Book editing › Academic

• Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers.

  Martens, D. E., Nollen, E. A. A., Hardeveld, M., van der Velden-de Groot, C. A. M., de Gooijer, C. D., Beuvery, E. C. & Tramper, J., 1996, In: Cytotechnology. 21, p. 45-59

  Research output: Contribution to journal › Article › Academic › peer-review
  12 Citations (Scopus)

• Design of aqueous two-phase systems supporting animal cell growth: a first step toward extractive bioconversions.

  Zijlstra, G. M., de Gooijer, C. D., van der Pol, L. A. & Tramper, J., 1996, In: Enzyme and Microbial Technology. 19, p. 2-8

  Research output: Contribution to journal › Article › Academic › peer-review

  • Bioconversion 100%
  • Cell growth 89%
  • Polyethylene glycols 82%
  • Culture Media 68%
  • Animals 61%
  28 Citations (Scopus)

• Determination of amino acids using 0-phthalaldehyde-2-mercaptoethanol derivation. Effect of reaction conditions.

  Dorresteijn, R. C., Berwald, L. G., Zomer, G., de Gooijer, C. D., Wieten, G. & Beuvery, E. C., 1996, In: Journal of Chromatography. A, Including electrophoresis and other separation methods. 724, p. 159-167

  Research output: Contribution to journal › Article › Academic › peer-review

  68 Citations (Scopus)

• Gel immobilised living cell systems: Part 2.

  Wijffels, R. H., de Gooijer, C. D. & Tramper, J., 1996, Immobilised living cell systems: modelling and experimental methods. Willaert, R. G. (ed.). p. 215-236

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

• Hybridoma and CHO cell partitioning in aqueous two-phase systems.

  Zijlstra, G. M., Michielsen, M. J. F., de Gooijer, C. D., van der Pol, L. A. & Tramper, J., 1996, In: Biotechnology Progress. 12, p. 363-370

  Research output: Contribution to journal › Article › Academic › peer-review
  21 Citations (Scopus)

• Hybridomas in a bioreactor cascade: modeling and determination of growth and death kinetics.

  Bakker, W. A. M., Schäfer, T., Beeftink, H. H., Tramper, J. & de Gooijer, C. D., 1996, In: Cytotechnology. 21, p. 263-277

  Research output: Contribution to journal › Article › Academic › peer-review
  10 Citations (Scopus)

• Immobilized-cell growth: diffusion limitation in expanding micro-colonies.

  Wijffels, R. H., de Gooijer, C. D., Schepers, A. W. & Tramper, J., 1996, Immobilized cells: basics and applications, R.H. Wijffels et al. (eds.). Elsevier Sciences BV. p. 249-256

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

  5 Citations (Scopus)

• Large-scale in vitro production of baculoviruses - from bug to bioreactor to bioinsecticide.

  de Gooijer, C. D., Moeckel, B., Waller, M., D'Alwis, B., Colbers, E. M. M., van Oorschot, A., Miltenburger, H. G., Santiago-Alvarez, C., Rhodes, D. J., Vlak, J. M. & Tramper, J., 1996, Abstract 29th Annual Meeting Society for Invertebrate Pathology, Cordoba, Spain. p. 19

  Research output: Chapter in Book/Report/Conference proceeding › Abstract

• Long-term semi-continuous production of recombinant baculovirus protein in a repeated (fed-)batch two-stage reactor system.

  van Lier, F. L. J., van den Hombergh, J. P. T. W., de Gooijer, C. D., den Boer, M. M., Vlak, J. M. & Tramper, J., 1996, In: Enzyme and Microbial Technology. 18, p. 460-466

  Research output: Contribution to journal › Article › Academic › peer-review

  • Recombinant proteins 100%
  • Inoculum 78%
  • Baculoviridae 69%
  • Viruses 67%
  • Recombinant Proteins 57%
  19 Citations (Scopus)

• Metabolic flux analysis of hybridoma cells in different culture media using mass balances.

  Bonarius, H. P. J., Hatzimanikatis, V., Meesters, K. P. H., de Gooijer, C. D., Schmid, G. & Tramper, J., 1996, In: Biotechnology and Bioengineering. 50, p. 299-318

  Research output: Contribution to journal › Article › Academic › peer-review
  210 Citations (Scopus)

• Modelling of the baculovirus infection process in insect-cell reactor configurations.

  de Gooijer, C. D., Koken, R. H. M., van Lier, F. L. J., Kool, M., Vlak, J. M. & Tramper, J., 1996, Computer and information science applications in bioprocess engineering, A.R. Moreira, K.K. Wallace (eds.). Kluwer Acad. Publ., Dordrecht NL. p. 301-316

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

• Nitrite conversion by immobilized Nitrobacter agilis cells in an air-lift loop bioreactor cascade: effects of combined substrate and product inhibition.

  Bakker, W. A. M., Kers, P., Beeftink, H. H., Tramper, J. & de Gooijer, C. D., 1996, In: Journal of fermentation and bioengineering. 81, p. 390-393

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• On-line estimation of the biomass activity during animal-cell cultivations.

  Dorresteijn, R. C., Harbrink Numan, K., de Gooijer, C. D., Tramper, J. & Beuvery, E. C., 1996, In: Biotechnology and Bioengineering. 50, p. 206-214

  Research output: Contribution to journal › Article › Academic › peer-review
  16 Citations (Scopus)

• Optimum design of a series of continuous stirred tank reactors containing immobilised growing cells.

  de Gooijer, C. D., Beeftink, H. H. & Tramper, J., 1996, In: Biotechnology Letters. 18, p. 397-402

  Research output: Contribution to journal › Article › Academic › peer-review
  6 Citations (Scopus)

• Oxygen gradients in small and big sparged insect-cell bioreactors.

  Tramper, J., Vlak, J. M. & de Gooijer, C. D., 1996, In: Cytotechnology. 20, p. 231-238

  Research output: Contribution to journal › Article › Academic › peer-review
  2 Citations (Scopus)

• Scale up aspects of sparged insect-cell bioreactors.

  Tramper, J., Vlak, J. M. & de Gooijer, C. D., 1996, In: Cytotechnology. 20, p. 221-229

  Research output: Contribution to journal › Article › Academic › peer-review
  7 Citations (Scopus)

• Separation of hybridoma cells from their IgG product using aqueous two-phase systems.

  Zijlstra, G. M., Michielsen, M. F. J., de Gooijer, C. D., van der Pol, L. A. & Tramper, J., 1996, In: Bioseparation. 6, p. 201-210

  Research output: Contribution to journal › Article › Academic › peer-review

  23 Citations (Scopus)
• 1995

  A combined cell-cycle and metabolic model for the growth of hybridoma cells.

  Martens, D. E., Sipkema, E. M., de Gooijer, C. D., Beuvery, E. C. & Tramper, J., 1995, In: Biotechnology and Bioengineering. 48, p. 49-65

  Research output: Contribution to journal › Article › Academic › peer-review

  17 Citations (Scopus)

• Carbon dioxide evolution rates in animal cell culture in bicarbonate buffered and bicarbonate free medium.

  Bonarius, H. P., de Gooijer, C. D., Tramper, J. & Schmid, G., 1995, Animal cell technology: developments towards the 21st Century, E.C. Beuvery et al. (eds.). Kluwer Acad. Publ., Dordrecht. p. 677-681

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

• Determination of the respiration quotient in mammalian cell culture in bicarbonate buffered media.

  Bonarius, H. P. J., de Gooijer, C. D., Tramper, J. & Schmid, G., 1995, In: Biotechnology and Bioengineering. 45, p. 524-535

  Research output: Contribution to journal › Article › Academic › peer-review
  65 Citations (Scopus)

• Dynamic modeling of immobilized Nitrosomonas europaea: implementation of diffusion limitation over expanding microcolonies.

  Wijffels, R. H., de Gooijer, C. D., Schepers, A. W., Beuling, E. E., Mallée, L. F. & Tramper, J., 1995, In: Enzyme and Microbial Technology. 17, p. 462-471

  Research output: Contribution to journal › Article › Academic › peer-review
  42 Citations (Scopus)

• Hybridomas in a bioreactor cascade for kinetic parameter determination.

  Bakker, W. A. M., Beeftink, H. H., Tramper, J. & de Gooijer, C. D., 1995, ESACT/JAACT meeting, 1994 Veldhoven, The Netherlands. p. 1-5

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

• Hybridomas in bioreacor cascade for kinetic parameters determination.

  Bakker, W. A. M., Beeftink, H. H., Tramper, J. & de Gooijer, C. D., 1995, Animal cell technology: developments towards the 21st century, E.C. Beuvery et al. (eds.). Kluwer Acad. Publ., Dordrecht. p. 655-659

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic