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Research Output 2005 2019

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Article
2019
Open Access
immunoglobulin E
Lactoglobulins
beta-lactoglobulin
Lactose
glycation
1 Citation (Scopus)

Fraud vulnerability in the Dutch milk supply chain: Assessments of farmers, processors and retailers

Yang, Y., Huisman, W., Hettinga, K. A., Liu, N., Heck, J., Schrijver, G. H., Gaiardoni, L. & van Ruth, S. M., 1 Jan 2019, In : Food Control. 95, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
fraud
Fraud
supply chain
Milk
farmers

Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants

Prentice, P. M., Schoemaker, M. H., Vervoort, J., Hettinga, K., Lambers, T. T., van Tol, E. A. F., Acerini, C. L., Olga, L., Petry, C. J., Hughes, I. A., Koulman, A., Ong, K. K. & Dunger, D. B., May 2019, In : The Journal of Nutrition. 149, 5, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review

Volatile Fatty Acids
Adiposity
Human Milk
formic acid
Skinfold Thickness
1 Citation (Scopus)
Open Access
Lactoglobulins
glycation
beta-lactoglobulin
hydrophobicity
Hydrophobic and Hydrophilic Interactions

Persistent challenges in safety and hygiene control practices in emerging dairy chains: The case of Tanzania

Ledo, J., Hettinga, K. A., Bijman, J. & Luning, P. A., 1 Nov 2019, In : Food Control. 105, p. 164-173 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Tanzania
Hygiene
hygiene
control methods
dairies

Short communication: Changes under low ambient temperatures in the milk lipodome and metabolome of mid-lactation cows after dehorning as a calf

Baars, T., Jahreis, G., Lorkowski, S., Rohrer, C., Vervoort, J. & Hettinga, K., Mar 2019, In : Journal of Dairy Science. 102, 3, p. 2698-2702

Research output: Contribution to journalArticleAcademicpeer-review

dehorning
metabolome
Metabolome
Lactation
ambient temperature

Variability of Serum Proteins in Chinese and Dutch Human Milk during Lactation

Elwakiel, M., Boeren, S., Hageman, J. A., Szeto, I. M., Schols, H. A. & Hettinga, K. A., 27 Feb 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
breast milk
Lactation
blood proteins
Blood Proteins
2018
4 Citations (Scopus)

Destabilization of UHT milk by protease AprX from Pseudomonas fluorescens and plasmin

Zhang, C., Bijl, E. & Hettinga, K., 15 Oct 2018, In : Food Chemistry. 263, p. 127-134 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

UHT milk
Pseudomonas fluorescens
plasmin
Fibrinolysin
Milk
7 Citations (Scopus)

Evaluation of portable near-infrared spectroscopy for organic milk authentication

Liu, N., Parra, H. A., Pustjens, A., Hettinga, K., Mongondry, P. & van Ruth, S. M., 1 Jul 2018, In : Talanta. 184, p. 128-135

Research output: Contribution to journalArticleAcademicpeer-review

Near infrared spectroscopy
Near-Infrared Spectroscopy
Authentication
Milk
Fraud
3 Citations (Scopus)

Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups

Elwakiel, M., Hageman, J. A., Wang, W., Szeto, I. M., van Goudoever, J. B., Hettinga, K. A. & Schols, H. A., 11 Jul 2018, In : Journal of Agricultural and Food Chemistry. 66, 27, p. 7036-7043

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Colostrum
Human Milk
breast milk
colostrum
Oligosaccharides
7 Citations (Scopus)
Volatile Organic Compounds
Proton transfer
volatile organic compounds
milk composition
protons
4 Citations (Scopus)

Predicting enteric methane emission of dairy cows with milk Fourier-transform infrared spectra and gas chromatography–based milk fatty acid profiles

van Gastelen, S., Mollenhorst, H., Antunes-Fernandes, E. C., Hettinga, K. A., van Burgsteden, G. G., Dijkstra, J. & Rademaker, J. L. W., Jun 2018, In : Journal of Dairy Science. 101, 6, p. 5582-5598

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Methane
Fourier Analysis
Gas Chromatography
Fourier Transform Infrared Spectroscopy
methane

Short communication: The effect of linseed oil and DGAT1 K232A polymorphism on the methane emission prediction potential of milk fatty acids

van Gastelen, S., Antunes-Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., Jun 2018, In : Journal of Dairy Science. 101, 6, p. 5599-5604

Research output: Contribution to journalArticleAcademicpeer-review

Diacylglycerol O-Acyltransferase
Linseed Oil
acyltransferases
linseed oil
Methane
1 Citation (Scopus)

The relationship between milk metabolome and methane emission of Holstein Friesian dairy cows: Metabolic interpretation and prediction potential

van Gastelen, S., Antunes Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., Mar 2018, In : Journal of Dairy Science. 101, 3, p. 2110-2126

Research output: Contribution to journalArticleAcademicpeer-review

metabolome
Metabolome
Methane
methane
Milk

Use of UV treated milk powder to increase vaccine efficacy in the elderly

Schaefer, S., Hettinga, K. A., Cullor, J., German, J. B. & Henrick, B. M., 17 Oct 2018, In : Frontiers in Immunology. 9, OCT, 2254.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Powders
Milk
Vaccines
Immune System
Soybean Proteins
2017
10 Citations (Scopus)

An interactomics overview of the human and bovine milk proteome over lactation

Zhang, L., van Dijk, A-J. & Hettinga, K., 2017, In : Proteome Science. 15, 1.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
Proteome
Lactation
Milk
Milk Proteins
12 Citations (Scopus)

Effect of processing intensity on immunologically active bovine milk serum proteins

Brick, T., Ege, M., Boeren, S., Böck, A., Von Mutius, E., Vervoort, J. & Hettinga, K., 2017, In : Nutrients. 9, 9, p. 1-14 963.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
whey
blood proteins
Blood Proteins
Milk

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access
9 Citations (Scopus)

Human milk peptides differentiate between the preterm and term infant and across varying lactational stages

Dingess, K. A., de Waard, M., Boeren, S., Vervoort, J., Lambers, T. T., van Goudoever, J. B. & Hettinga, K., 1 Oct 2017, In : Food & Function. 8, 10, p. 3769-3782

Research output: Contribution to journalArticleAcademicpeer-review

Human Milk
breast milk
Premature Infants
peptides
Peptides

Invloed van natuurkorst op ontwikkeling van geur tijdens kaasrijping

Hettinga, K. A., 2017, In : De zelfkazer. 69, 2, p. 10-12

Research output: Contribution to journalArticleProfessional

6 Citations (Scopus)
Open Access
Linseed Oil
linseed oil
Rumen
Methane
nitrogen metabolism
15 Citations (Scopus)

Recent advances in phospholipids from colostrum, milk and dairy by-products

Verardo, V., Gómez-Caravaca, A. M., Arráez-Román, D. & Hettinga, K., 2017, In : International Journal of Molecular Sciences. 18, 1, 173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Colostrum
milk
Dairy Products
Dairies
Phospholipids
6 Citations (Scopus)

Relationships between methane emission of Holstein Friesian dairy cows and fatty acids, volatile metabolites and non-volatile metabolites in milk

van Gastelen, S., Antunes-Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., 2017, In : Animal. 11, 9, p. 1539-1548

Research output: Contribution to journalArticleAcademicpeer-review

volatile fatty acids
methane
Holstein
dairy cows
metabolites
2016
12 Citations (Scopus)

A proteomics-based identification of putative biomarkers for disease in bovine milk

van Altena, S. E. C., de Klerk, B., Hettinga, K. A., van Neerven, R. J. J., Boeren, S., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 174, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cattle Diseases
Lactoferrin
Proteomics
proteomics
biomarkers
13 Citations (Scopus)

Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Zhang, L., de Waard, M., Verheijen, H., Boeren, S., Hageman, J. A., van Hooijdonk, T., Vervoort, J., van Goudoever, J. B. & Hettinga, K., 2016, In : Journal of Proteomics. 147, p. 40-47

Research output: Contribution to journalArticleAcademicpeer-review

Digestive system
Digestive System
Milk Proteins
Immune system
Human Milk
8 Citations (Scopus)
glycation
Lactose
whey protein
lactose
Digestion
8 Citations (Scopus)

Milk metabolome relates enteric methane emission to milk synthesis and energy metabolism pathways

Antunes-Fernandes, E. C., van Gastelen, S., Dijkstra, J., Hettinga, K. A. & Vervoort, J., 2016, In : Journal of Dairy Science. 99, 8, p. 6251-6262

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
milk synthesis
metabolome
Metabolome
Methane
energy metabolism
6 Citations (Scopus)

Proteomics data in support of the quantification of the changes of bovine milk proteins during mammary gland involution

Boggs, I., Hine, B., Smolenksi, G., Hettinga, K., Zhang, L. & Wheeler, T. T., 2016, In : Data in Brief. 8, p. 52-55

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
quantification
16 Citations (Scopus)

Proteomic study on the stability of proteins in bovine, camel, and caprine milk sera after processing

Zhang, L., Boeren, S., Smits, M., van Hooijdonk, T., Vervoort, J. & Hettinga, K., 2016, In : Food Research International. 82, p. 104-111

Research output: Contribution to journalArticleAcademicpeer-review

camel milk
Pasteurization
Camelus
Protein Stability
Milk Proteins
9 Citations (Scopus)

Relationships between milk fatty acid profiles and enteric methane production in dairy cattle fed grass- or grass silage-based diets

Dijkstra, J., van Gastelen, S., Antunes Fernandes, E. C., Warner, D., Hatew, B., Klop, G., Podesta, S. C., van Lingen, H. J., Hettinga, K. A. & Bannink, A., 2016, In : Animal Production Science. 56, 3, p. 541-548

Research output: Contribution to journalArticleAcademicpeer-review

Silage
cattle feeds
Methane
grass silage
Poaceae
4 Citations (Scopus)

Short communication: Influence of shortening the dry period of Swedish dairy cows on plasmin activity in milk

de Vries, R., Brandt, M., Lundh, Å., Holtenius, K., Hettinga, K. & Johansson, M., 2016, In : Journal of Dairy Science. 99, 11, p. 9300-9306

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
dry period (lactation)
plasmin
Fibrinolysin
shortenings
animal communication
16 Citations (Scopus)
Open Access
Maillard Reaction
binding capacity
Maillard reaction
whey protein
Heating
13 Citations (Scopus)

The protein and lipid composition of the membrane of milk fat globules depends on their size

Lu, J., Argov-Argaman, N., Anggrek, J., Boeren, S., van Hooijdonk, T., Vervoort, J. & Hettinga, K. A., 2016, In : Journal of Dairy Science. 99, 6, p. 4726-4738 74498.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
fat globules
protein composition
Membrane Lipids
lipid composition
milk fat
2015
13 Citations (Scopus)

A proteomic perspective on the changes in milk proteins due to high somatic cell count

Zhang, L., Boeren, J. A., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 8, p. 5339-5351

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
milk proteins
somatic cell count
Proteomics
proteomics
32 Citations (Scopus)

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

Zhang, L., Boeren, J. A., Hageman, J. A., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : PLoS ONE. 10, 2, 19 p., e0116710.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Digestive system
Digestive System
Immune system
Proteome
proteome
4 Citations (Scopus)

Changes in the repertoire of bovine milk proteins during mammary involution.

Boggs, I., Hine, B., Smolenski, G., Hettinga, K. A., Zhang, L. & Wheeler, T., 2015, In : EuPA Open Proteomics. 9, p. 65-75

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
Milk
Breast
Proteolysis
Dairies
6 Citations (Scopus)

Dairy in a sustainable diet: a question of balance

van Hooijdonk, A. C. M. & Hettinga, K. A., 2015, In : Nutrition Reviews. 73, S1, p. 48-54

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diet
Food
Dairy Products
Milk
Gases
16 Citations (Scopus)

Difference in the Breast Milk Proteome between Allergic and Non-Allergic Mothers

Hettinga, K. A., Reina, F. M., Boeren, J. A., Zhang, L., Koppelman, G. H., Postma, D. S., Vervoort, J. J. M. & Wijga, A. H., 2015, In : PLoS ONE. 10, 3, 11 p., e0122234.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
Proteome
breast milk
proteome
Allergies
13 Citations (Scopus)

Effect of the DGAT1 K232A genotype of dairy cows on the milk metabolome and proteome

Lu, J., Boeren, S., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 5, p. 3460-3469

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diacylglycerol O-Acyltransferase
diacylglycerol acyltransferase
metabolome
Metabolome
Proteome
33 Citations (Scopus)

Endogenous human milk Peptide release is greater after preterm birth than term birth

Dallas, D. C., Smink, C. J., Robinson, R. C., Tian, T., Guerrero, A., Parker, E. A., Smilowitz, J. T., Hettinga, K. A., Underwood, M. A., Lebrilla, C. B., German, J. B. & Barile, D., 2015, In : The Journal of Nutrition. 145, 3, p. 425-433

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Term Birth
Premature Birth
Human Milk
Milk
Peptides
48 Citations (Scopus)
Open Access
Silage
Volatile Fatty Acids
Rumen
Methane
grass silage
12 Citations (Scopus)

Peptidomic analysis of healthy and subclinically mastitic bovine milk

Guerrero, A., Dallas, D. C., Contreras, S., Bhandari, A., Canovas, A., Islas-Trejo, A., Medrano, J. F., Parker, E. A., Wang, M., Hettinga, K. A., Chee, S., German, J. B., Barile, D. & Lebrilla, C. B., 2015, In : International Dairy Journal. 46, p. 46-52

Research output: Contribution to journalArticleAcademicpeer-review

Milk
peptides
milk
Peptides
Mastitis
13 Citations (Scopus)

Perspective on calf and mammary gland development through changes in the bovine milk proteome over a complete lactation

Zhang, L., Boeren, J. A., Hageman, J. A., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 8, p. 5362-5373

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Proteome
Human Mammary Glands
proteome
Lactation
mammary glands
2014
19 Citations (Scopus)

Comprehensive peptidomic and glycomic evaluation reveals that sweet whey permeate from colostrum is a source of milk protein-derived peptides and oligosaccharides

Dallas, D. C., Weinborn, V., de Moura Bell, J. M. L. N., Wang, M., Parker, E. A., Guerrero, A., Hettinga, K. A., Lebrilla, C. B., German, J. B. & Barile, D., 2014, In : Food Research International. 63, part B, p. 203-209

Research output: Contribution to journalArticleAcademicpeer-review

Glycomics
Colostrum
permeates
Milk Proteins
colostrum
11 Citations (Scopus)

Identification of lipid synthesis and secretion proteins in bovine milk

Lu, J., van Hooijdonk, A. C. M., Boeren, S., Vervoort, J. & Hettinga, K. A., 2014, In : Journal of Dairy Research. 81, 1, p. 65-72

Research output: Contribution to journalArticleAcademicpeer-review

protein secretion
Proteomics
proteomics
Milk
protein synthesis
63 Citations (Scopus)

Influence of different proteolytic strains of Streptococcus thermophilus in co-culture with Lactobacillus delbrueckii subsp. bulgaricus on the metabolite profile of set-yoghurt

Settachaimongkon, S., Nout, M. J. R., Antunes Fernandes, E. C., Hettinga, K. A., Vervoort, J. J. M., van Hooijdonk, A. C. M., Zwietering, M. H., Smid, E. J. & van Valenberg, H. J. F., 2014, In : International Journal of Food Microbiology. 177, p. 29-36

Research output: Contribution to journalArticleAcademicpeer-review

Lactobacillus delbrueckii
Streptococcus thermophilus
Yogurt
Lactobacillus delbrueckii subsp. bulgaricus
coculture

Smediger kaas door juiste voer

Hettinga, K. A. & Dijkstra, J., 2014, In : De zelfkazer. 66, 6, p. 10-11

Research output: Contribution to journalArticleProfessional

2013
42 Citations (Scopus)

Changes in milk proteome and metabolome associated with dry period length, energy balance and lactation stage in post parturient dairy cows

Lu, J., Antunes Fernandes, E. C., Páez Cano, A. E., Vinitwatanakhun, J., Boeren, S., van Hooijdonk, A. C. M., van Knegsel, A. T. M., Vervoort, J. & Hettinga, K. A., 2013, In : Journal of Proteome Research. 12, 7, p. 3288-3296

Research output: Contribution to journalArticleAcademicpeer-review

Metabolome
Dairies
Proteome
Energy balance
Lactation
15 Citations (Scopus)

Concentrations of n-3 and n-6 fatty acids in Dutch bovine milk fat and their contribution to human dietary intake

van Valenberg, H. J. F., Hettinga, K. A., Dijkstra, J., Bovenhuis, H. & Feskens, E. J. M., 2013, In : Journal of Dairy Science. 96, 7, p. 4173-4181

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
docosapentaenoic acid
omega-6 fatty acids
milk fat
linoleic acid
food intake
23 Citations (Scopus)

Milk Fat Content and DGAT1 Genotype Determine Lipid Composition of the Milk Fat Globule Membrane

Argov-Argaman, N., Mida, K., Cohen, B. C., Visker, M. H. P. W. & Hettinga, K. A., 2013, In : PLoS ONE. 8, 7, 8 p., e68707.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diacylglycerol O-Acyltransferase
diacylglycerol acyltransferase
fat globules
lipid composition
milk fat