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Research Output 2005 2020

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Article
2020

A customized assessment tool to differentiate safety and hygiene control practices in emerging dairy chains

Ledo, J., Hettinga, K. A. & Luning, P. A., 1 May 2020, In : Food Control. 111, 107072.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Hygiene
hygiene
control methods
dairies
farmers

Effect of heat treatment on bacteriostatic activity and protein profile of bovine whey proteins

Xiong, L., Li, C., Boeren, S., Vervoort, J. & Hettinga, K., 1 Jan 2020, In : Food Research International. 127, 108688.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
antibacterial proteins
whey protein
Milk
Hot Temperature
heat treatment

Stability of fat globules in UHT milk during proteolysis by the AprX protease from Pseudomonas fluorescens and by plasmin

Zhang, C., Bijl, E., Muis, K. E. & Hettinga, K., Jan 2020, In : Journal of Dairy Science. 103, 1, p. 179-190

Research output: Contribution to journalArticleAcademicpeer-review

UHT milk
Pseudomonas fluorescens
plasmin
fat globules
Fibrinolysin
2019
1 Citation (Scopus)
Open Access
lactoglobulins
immunoglobulin E
Lactoglobulins
Lactose
glycation
1 Citation (Scopus)

Fraud vulnerability in the Dutch milk supply chain: Assessments of farmers, processors and retailers

Yang, Y., Huisman, W., Hettinga, K. A., Liu, N., Heck, J., Schrijver, G. H., Gaiardoni, L. & van Ruth, S. M., 1 Jan 2019, In : Food Control. 95, p. 308-317

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
fraud
Fraud
supply chain
Milk
farmers

Geography and ethnicity related variation in the Chinese human milk serum proteome

Zhang, L., Ma, Y., Yang, Z., Jiang, S., Liu, J., Hettinga, K. A., Lai, J. & Zhou, P., 1 Dec 2019, In : Food and Function. 10, 12, p. 7818-7827 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Geography
Human Milk
Proteome
breast milk
geography

How processing may affect milk protein digestion and overall physiological outcomes: A systematic review

van Lieshout, G. A. A., Lambers, T. T., Bragt, M. C. E. & Hettinga, K. A., 22 Aug 2019, In : Critical Reviews in Food Science and Nutrition.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
systematic review
dairy protein
Proteolysis
digestion
1 Citation (Scopus)

Human Milk Short-Chain Fatty Acid Composition is Associated with Adiposity Outcomes in Infants

Prentice, P. M., Schoemaker, M. H., Vervoort, J., Hettinga, K., Lambers, T. T., van Tol, E. A. F., Acerini, C. L., Olga, L., Petry, C. J., Hughes, I. A., Koulman, A., Ong, K. K. & Dunger, D. B., May 2019, In : The Journal of Nutrition. 149, 5, p. 716-722

Research output: Contribution to journalArticleAcademicpeer-review

Volatile Fatty Acids
Adiposity
Human Milk
formic acid
Skinfold Thickness
1 Citation (Scopus)
Open Access
lactoglobulins
Lactoglobulins
glycation
hydrophobicity
Hydrophobic and Hydrophilic Interactions
1 Citation (Scopus)

Persistent challenges in safety and hygiene control practices in emerging dairy chains: The case of Tanzania

Ledo, J., Hettinga, K. A., Bijman, J. & Luning, P. A., 1 Nov 2019, In : Food Control. 105, p. 164-173 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Tanzania
Hygiene
hygiene
control methods
dairies

Short communication: Changes under low ambient temperatures in the milk lipodome and metabolome of mid-lactation cows after dehorning as a calf

Baars, T., Jahreis, G., Lorkowski, S., Rohrer, C., Vervoort, J. & Hettinga, K., Mar 2019, In : Journal of Dairy Science. 102, 3, p. 2698-2702

Research output: Contribution to journalArticleAcademicpeer-review

dehorning
metabolome
Metabolome
Lactation
ambient temperature

The Beneficial Effect of Farm Milk Consumption on Asthma, Allergies, and Infections: From Meta-Analysis of Evidence to Clinical Trial

Brick, T., Hettinga, K., Kirchner, B., Pfaffl, M. W. & Ege, M. J., 23 Nov 2019, In : The Journal of Allergy and Clinical Immunology: In Practice.

Research output: Contribution to journalArticleAcademicpeer-review

Meta-Analysis
Hypersensitivity
Milk
Asthma
Clinical Trials
3 Citations (Scopus)

The Extracellular Protease AprX from Pseudomonas and its Spoilage Potential for UHT Milk: A Review

Zhang, C., Bijl, E., Svensson, B. & Hettinga, K., Jul 2019, In : Comprehensive Reviews in Food Science and Food Safety. 18, 4, p. 834-852

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
UHT milk
Pseudomonas
psychrotrophic bacteria
spoilage
Milk
2 Citations (Scopus)

Variability of Serum Proteins in Chinese and Dutch Human Milk during Lactation

Elwakiel, M., Boeren, S., Hageman, J. A., Szeto, I. M., Schols, H. A. & Hettinga, K. A., 27 Feb 2019, In : Nutrients. 11, 3

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
breast milk
Lactation
blood proteins
Blood Proteins
2018
5 Citations (Scopus)

Destabilization of UHT milk by protease AprX from Pseudomonas fluorescens and plasmin

Zhang, C., Bijl, E. & Hettinga, K., 15 Oct 2018, In : Food Chemistry. 263, p. 127-134 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
UHT milk
Pseudomonas fluorescens
plasmin
Fibrinolysin
Milk
10 Citations (Scopus)

Evaluation of portable near-infrared spectroscopy for organic milk authentication

Liu, N., Parra, H. A., Pustjens, A., Hettinga, K., Mongondry, P. & van Ruth, S. M., 1 Jul 2018, In : Talanta. 184, p. 128-135

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Near infrared spectroscopy
Authentication
Fatty Acids
Milk
Discriminant analysis
6 Citations (Scopus)

Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups

Elwakiel, M., Hageman, J. A., Wang, W., Szeto, I. M., van Goudoever, J. B., Hettinga, K. A. & Schols, H. A., 11 Jul 2018, In : Journal of Agricultural and Food Chemistry. 66, 27, p. 7036-7043

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Colostrum
Human Milk
breast milk
colostrum
Oligosaccharides
7 Citations (Scopus)
Volatile Organic Compounds
Proton transfer
volatile organic compounds
milk composition
protons
6 Citations (Scopus)

Predicting enteric methane emission of dairy cows with milk Fourier-transform infrared spectra and gas chromatography–based milk fatty acid profiles

van Gastelen, S., Mollenhorst, H., Antunes-Fernandes, E. C., Hettinga, K. A., van Burgsteden, G. G., Dijkstra, J. & Rademaker, J. L. W., Jun 2018, In : Journal of Dairy Science. 101, 6, p. 5582-5598

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Methane
Fourier Analysis
Fourier Transform Infrared Spectroscopy
Gas Chromatography
methane

Short communication: The effect of linseed oil and DGAT1 K232A polymorphism on the methane emission prediction potential of milk fatty acids

van Gastelen, S., Antunes-Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., Jun 2018, In : Journal of Dairy Science. 101, 6, p. 5599-5604

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diacylglycerol O-Acyltransferase
Linseed Oil
acyltransferases
linseed oil
Methane
1 Citation (Scopus)

The relationship between milk metabolome and methane emission of Holstein Friesian dairy cows: Metabolic interpretation and prediction potential

van Gastelen, S., Antunes Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., Mar 2018, In : Journal of Dairy Science. 101, 3, p. 2110-2126

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
metabolome
Metabolome
Methane
methane
Milk

Use of UV treated milk powder to increase vaccine efficacy in the elderly

Schaefer, S., Hettinga, K. A., Cullor, J., German, J. B. & Henrick, B. M., 17 Oct 2018, In : Frontiers in Immunology. 9, OCT, 2254.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Powders
Milk
Vaccines
Immune System
Soybean Proteins
2017
13 Citations (Scopus)

An interactomics overview of the human and bovine milk proteome over lactation

Zhang, L., van Dijk, A-J. & Hettinga, K., 2017, In : Proteome Science. 15, 1.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
Proteome
Lactation
Milk
Milk Proteins
15 Citations (Scopus)

Effect of processing intensity on immunologically active bovine milk serum proteins

Brick, T., Ege, M., Boeren, S., Böck, A., Von Mutius, E., Vervoort, J. & Hettinga, K., 2017, In : Nutrients. 9, 9, p. 1-14 963.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
whey
blood proteins
Blood Proteins
Milk

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access
10 Citations (Scopus)

Human milk peptides differentiate between the preterm and term infant and across varying lactational stages

Dingess, K. A., de Waard, M., Boeren, S., Vervoort, J., Lambers, T. T., van Goudoever, J. B. & Hettinga, K., 1 Oct 2017, In : Food & Function. 8, 10, p. 3769-3782

Research output: Contribution to journalArticleAcademicpeer-review

Human Milk
breast milk
Premature Infants
peptides
Peptides

Invloed van natuurkorst op ontwikkeling van geur tijdens kaasrijping

Hettinga, K. A., 2017, In : De zelfkazer. 69, 2, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access
6 Citations (Scopus)
Open Access
Linseed Oil
linseed oil
Rumen
Methane
nitrogen metabolism
17 Citations (Scopus)

Recent advances in phospholipids from colostrum, milk and dairy by-products

Verardo, V., Gómez-Caravaca, A. M., Arráez-Román, D. & Hettinga, K., 2017, In : International Journal of Molecular Sciences. 18, 1, 173.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Colostrum
milk
Dairy Products
Dairies
Phospholipids
8 Citations (Scopus)

Relationships between methane emission of Holstein Friesian dairy cows and fatty acids, volatile metabolites and non-volatile metabolites in milk

van Gastelen, S., Antunes-Fernandes, E. C., Hettinga, K. A. & Dijkstra, J., 2017, In : Animal. 11, 9, p. 1539-1548

Research output: Contribution to journalArticleAcademicpeer-review

volatile fatty acids
methane
Holstein
dairy cows
metabolites
2016
12 Citations (Scopus)

A proteomics-based identification of putative biomarkers for disease in bovine milk

van Altena, S. E. C., de Klerk, B., Hettinga, K. A., van Neerven, R. J. J., Boeren, S., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 174, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cattle Diseases
Lactoferrin
Proteomics
proteomics
biomarkers
15 Citations (Scopus)

Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Zhang, L., de Waard, M., Verheijen, H., Boeren, S., Hageman, J. A., van Hooijdonk, T., Vervoort, J., van Goudoever, J. B. & Hettinga, K., 2016, In : Journal of Proteomics. 147, p. 40-47

Research output: Contribution to journalArticleAcademicpeer-review

Digestive system
Digestive System
Milk Proteins
Immune system
Human Milk
3 Citations (Scopus)

Data article: Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant

Zhang, L., de Waard, M., Verheijen, H., Boeren, S., Hageman, J. A., van Hooijdonk, T., Vervoort, J., van Goudoever, J. B. & Hettinga, K., Jun 2016, In : Data in Brief. 7, p. 362-365

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Digestive System
Milk Proteins
Human Milk
Lactation
Proteomics
8 Citations (Scopus)
glycation
Lactose
whey protein
lactose
Digestion
10 Citations (Scopus)

Milk metabolome relates enteric methane emission to milk synthesis and energy metabolism pathways

Antunes-Fernandes, E. C., van Gastelen, S., Dijkstra, J., Hettinga, K. A. & Vervoort, J., 2016, In : Journal of Dairy Science. 99, 8, p. 6251-6262

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
milk synthesis
metabolome
Metabolome
Methane
energy metabolism
7 Citations (Scopus)

Proteomics data in support of the quantification of the changes of bovine milk proteins during mammary gland involution

Boggs, I., Hine, B., Smolenksi, G., Hettinga, K., Zhang, L. & Wheeler, T. T., 2016, In : Data in Brief. 8, p. 52-55

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
quantification
18 Citations (Scopus)

Proteomic study on the stability of proteins in bovine, camel, and caprine milk sera after processing

Zhang, L., Boeren, S., Smits, M., van Hooijdonk, T., Vervoort, J. & Hettinga, K., 2016, In : Food Research International. 82, p. 104-111

Research output: Contribution to journalArticleAcademicpeer-review

camel milk
Pasteurization
Camelus
Protein Stability
Milk Proteins
9 Citations (Scopus)

Relationships between milk fatty acid profiles and enteric methane production in dairy cattle fed grass- or grass silage-based diets

Dijkstra, J., van Gastelen, S., Antunes Fernandes, E. C., Warner, D., Hatew, B., Klop, G., Podesta, S. C., van Lingen, H. J., Hettinga, K. A. & Bannink, A., 2016, In : Animal Production Science. 56, 3, p. 541-548

Research output: Contribution to journalArticleAcademicpeer-review

Silage
cattle feeds
Methane
grass silage
Poaceae
4 Citations (Scopus)

Short communication: Influence of shortening the dry period of Swedish dairy cows on plasmin activity in milk

de Vries, R., Brandt, M., Lundh, Å., Holtenius, K., Hettinga, K. & Johansson, M., 2016, In : Journal of Dairy Science. 99, 11, p. 9300-9306

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
dry period (lactation)
plasmin
Fibrinolysin
shortenings
animal communication
16 Citations (Scopus)
Open Access
Maillard Reaction
binding capacity
Maillard reaction
whey protein
Heating
15 Citations (Scopus)

The protein and lipid composition of the membrane of milk fat globules depends on their size

Lu, J., Argov-Argaman, N., Anggrek, J., Boeren, S., van Hooijdonk, T., Vervoort, J. & Hettinga, K. A., 2016, In : Journal of Dairy Science. 99, 6, p. 4726-4738 74498.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
fat globules
protein composition
Membrane Lipids
lipid composition
milk fat
2015
13 Citations (Scopus)

A proteomic perspective on the changes in milk proteins due to high somatic cell count

Zhang, L., Boeren, J. A., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 8, p. 5339-5351

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
milk proteins
somatic cell count
Proteomics
proteomics
35 Citations (Scopus)

Bovine Milk Proteome in the First 9 Days: Protein Interactions in Maturation of the Immune and Digestive System of the Newborn

Zhang, L., Boeren, J. A., Hageman, J. A., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : PLoS ONE. 10, 2, 19 p., e0116710.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Digestive system
Digestive System
Immune system
Proteome
proteome
4 Citations (Scopus)

Changes in the repertoire of bovine milk proteins during mammary involution.

Boggs, I., Hine, B., Smolenski, G., Hettinga, K. A., Zhang, L. & Wheeler, T., 2015, In : EuPA Open Proteomics. 9, p. 65-75

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Milk Proteins
Milk
Breast
Proteolysis
Dairies
6 Citations (Scopus)

Dairy in a sustainable diet: a question of balance

van Hooijdonk, A. C. M. & Hettinga, K. A., 2015, In : Nutrition Reviews. 73, S1, p. 48-54

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diet
Food
Dairy Products
Milk
Gases
17 Citations (Scopus)

Difference in the Breast Milk Proteome between Allergic and Non-Allergic Mothers

Hettinga, K. A., Reina, F. M., Boeren, J. A., Zhang, L., Koppelman, G. H., Postma, D. S., Vervoort, J. J. M. & Wijga, A. H., 2015, In : PLoS ONE. 10, 3, 11 p., e0122234.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Human Milk
Proteome
breast milk
proteome
Allergies
4 Citations (Scopus)

Effect of shortening or omitting the dry period of Holstein-Friesian cows on casein composition of milk

de Vries, R. F. M., van Knegsel, A. T. M., Johansson, M., Lindmark-Mansson, H., van Hooijdonk, A. C. M., Holtenius, K. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 12, p. 8678-8687

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
dry period (lactation)
Caseins
milk composition
shortenings
casein
13 Citations (Scopus)

Effect of the DGAT1 K232A genotype of dairy cows on the milk metabolome and proteome

Lu, J., Boeren, S., van Hooijdonk, A. C. M., Vervoort, J. J. M. & Hettinga, K. A., 2015, In : Journal of Dairy Science. 98, 5, p. 3460-3469

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Diacylglycerol O-Acyltransferase
diacylglycerol acyltransferase
metabolome
Metabolome
Proteome
34 Citations (Scopus)

Endogenous human milk Peptide release is greater after preterm birth than term birth

Dallas, D. C., Smink, C. J., Robinson, R. C., Tian, T., Guerrero, A., Parker, E. A., Smilowitz, J. T., Hettinga, K. A., Underwood, M. A., Lebrilla, C. B., German, J. B. & Barile, D., 2015, In : The Journal of Nutrition. 145, 3, p. 425-433

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Term Birth
Premature Birth
Human Milk
Milk
Peptides
52 Citations (Scopus)
Open Access
Silage
Volatile Fatty Acids
Rumen
Methane
grass silage