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Research Output 2000 2019

2013
1 Citation (Scopus)

Caffeoylquinic Acids Biosynthesis and Accumulation in Cynara cardunculus: State of the Art

Moglia, A., Comino, C., Menin, B., Portis, E., Aquadro, A., Beekwilder, M. J., Hehn, A., Bourgaud, F. & Lanteri, S., 2013, In : Acta Horticulturae. 983, p. 401-406

Research output: Contribution to journalArticleAcademicpeer-review

Cynara cardunculus
artichokes
biosynthesis
chlorogenic acid
secondary metabolites
28 Citations (Scopus)

Changes in polyphenol content during production of grape juice concentrate

Capanoglu, E., de Vos, R. C. H., Hall, R. D., Boyacioglu, D. & Beekwilder, M. J., 2013, In : Food Chemistry. 139, 1-4, p. 521-526

Research output: Contribution to journalArticleAcademicpeer-review

juice concentrates
grape juice
Anthocyanins
Vitis
Polyphenols
38 Citations (Scopus)

Changes in sour cherry (Prunus cerasus L.) antioxidants during nectar processing and in vitro gastrointestinal digestion.

Toydemir, G., Capanoglu, E., Kamiloglu, S., Boyacioglu, D., de Vos, C. H., Hall, R. D. & Beekwilder, M. J., 2013, In : Journal of Functional Foods. 5, 3, p. 1402-1413

Research output: Contribution to journalArticleAcademicpeer-review

Plant Nectar
Prunus cerasus
nectar
Digestion
Antioxidants
24 Citations (Scopus)

Construction of a Multifunctional Enzyme Complex via the Strain-Promoted Azide-Alkyne Cycloaddition

Schoffelen, S., Beekwilder, M. J., Debets, M. F., Bosch, H. J. & van Hest, J. C. M., 2013, In : Bioconjugate Chemistry. 24, 6, p. 987-996

Research output: Contribution to journalArticleAcademicpeer-review

Multifunctional Enzymes
Alkynes
Azides
Cycloaddition
Cycloaddition Reaction
30 Citations (Scopus)

Differences in acidity of apples are probably mainly caused by a malic acid transporter gene on LG16

Khan, S. A., Beekwilder, J., Schaart, J. G., Mumm, R., Soriano, J. M., Jacobsen, E. & Schouten, H. J., 2013, In : Tree Genetics and Genomes. 9, 2, p. 475-487

Research output: Contribution to journalArticleAcademicpeer-review

malic acid
Malus
transporters
acidity
apples
28 Citations (Scopus)

Evaluation of Glucosinolate Variation in a Collection of Turnip (Brassica rapa) Germplasm by the Analysis of Intact and Desulfo Glucosinolates

Lee, G. J., Bonnema, G., Zhang, N., Kwak, J. H., de Vos, R. C. H. & Beekwilder, M. J., 2013, In : Journal of Agricultural and Food Chemistry. 61, 16, p. 3984-3993

Research output: Contribution to journalArticleAcademicpeer-review

Glucosinolates
Brassica napus
Brassica rapa
turnips
glucosinolates
35 Citations (Scopus)

Industrial processing effects on phenolic compounds in sour cherry (Prunus cerasus L.) fruit

Toydemir, G., Capanoglu, E., Gomez-Roldan, M. V., de Vos, R. C. H., Boyacioglu, D., Hall, R. D. & Beekwilder, M. J., 2013, In : Food Research International. 53, 1, p. 218-225

Research output: Contribution to journalArticleAcademicpeer-review

Plant Nectar
Prunus cerasus
processing technology
nectar
phenolic compounds
17 Citations (Scopus)
Fruit juices
Prunus cerasus
Anthocyanins
fruit juices
Fruits
5 Citations (Scopus)

In vitro callus-induction in globe artichoke (Cynara cardunculus L. var. scolymus) as a system for the production of caffeoylquinic acids

Menin, B., Moglia, A., Comino, C., Hakkert, J. C., Lanteri, S. & Beekwilder, M. J., 2013, In : Journal of Horticultural Science and Biotechnology. 88, 5, p. 537-542

Research output: Contribution to journalArticleAcademicpeer-review

Cynara cardunculus subsp. cardunculus
Scolymus
Cynara
Cynara scolymus
artichokes
2 Citations (Scopus)

Methane reduction by plant pigments and antioxidants in rumen fluid involves modifications, e.g. hydrogenatioor degradation of the active compoundsn,

Becker, P. M., van Wikselaar, P. G., Ilgenfritz, J., Beekwilder, M. J., de Vos, R. C. H., Franz, C. H. & Zitterl-Eglseer, K., 2013, In : Wiener Tierarztliche Monatsschrift. 100, p. 295-305

Research output: Contribution to journalArticleAcademicpeer-review

plant pigments
Rumen
Methane
rumen fluids
methane
40 Citations (Scopus)

NON-SMOKY GLYCOSYLTRANSFERASE1 Prevents the Release of Smoky Aroma from Tomato Fruit

Tikunov, Y. M., Molthoff, J. W., de Vos, R. C. H., Beekwilder, M. J., van Houwelingen, A. M. M. L., van der Hooft, J. J. J., Nijenhuis-de Vries, M. A., Labrie, C. W., Verkerke, W., van de Geest, H. C., Víquez Zamora, A. M., Presa, S., Rambla Nebot, J. L., Granell, A., Hall, R. D. & Bovy, A. G., 2013, In : The Plant Cell. 25, 8, p. 3067-3078

Research output: Contribution to journalArticleAcademicpeer-review

Lycopersicon esculentum
Fruit
odors
tomatoes
phenylpropanoids

Oriented antibodies as versatile detection element in biosensors

Trilling, A. K., 2013, S.l.: s.n.. 168 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Biosensors
Monolayers
Bacteria
Azides
Antibodies
44 Citations (Scopus)

The effect of uniform capture molecule orientation on biosensor sensitivity : dependence on analyte properties

Trilling, A. K., Harmsen, M. M., Ruigrok, V. J., Zuilhof, H. & Beekwilder, J., 2013, In : Biosensors and Bioelectronics. 40, 1, p. 219-226

Research output: Contribution to journalArticleAcademicpeer-review

Foot-and-Mouth Disease Virus
Biosensing Techniques
Epitopes
Biosensors
Surface Plasmon Resonance
5 Citations (Scopus)

The Flavonoid Pathway in Tomato Seedlings: Transcript Abundance and the Modeling of Metabolite Dynamics

Groenenboom, M., Gomez-Roldan, V., Stigter, J. D., Astola, L., van Daelen, R., Beekwilder, M. J., Bovy, A. G., Hall, R. D. & Molenaar, J., 2013, In : PLoS ONE. 8, 7, 11 p., e68960.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lycopersicon esculentum
Metabolites
Seedlings
Flavonoids
flavonoids
40 Citations (Scopus)

The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage

Ting, H. M., Wang, B., Ryden, A. M., Woittiez, L. S., Verstappen, F. W. A., Ruyter-Spira, C. P., Beekwilder, M. J., Bouwmeester, H. J., van der Krol, A. R. & van Herpen, T. W. J. M., 2013, In : New Phytologist. 199, 2, p. 352-366

Research output: Contribution to journalArticleAcademicpeer-review

gene dosage
artemisinin
Gene Dosage
Nicotiana benthamiana
chemotypes
2012
2 Citations (Scopus)

Correlation of Rutin Accumulation with 3-O-Glucosyl Transferase and Phenylalanine Ammonia-lyase Activities During the Ripening of Tomato Fruit

Capanoglu, E., Beekwilder, J., Matros, A., Boyacioglu, D., Hall, R. D. & Mock, H. P., 2012, In : Plant Foods for Human Nutrition. 67, 4, p. 371-376

Research output: Contribution to journalArticleAcademicpeer-review

Phenylalanine Ammonia-Lyase
Rutin
phenylalanine ammonia-lyase
Lycopersicon esculentum
rutin
154 Citations (Scopus)

De novo production of the flavonoid naringenin in engineered Saccharomyces erevisiae

Koopman, F., Beekwilder, J., Crimi, B., van Houwelingen, A., Hall, R. D., Bosch, H. J., van Maris, A. J. A., Pronk, J. T. & Daran, J. M., 2012, In : Microbial Cell Factories. 11, 155.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Flavonoids
Saccharomyces
Arabidopsis
Yeast
Saccharomyces cerevisiae
42 Citations (Scopus)

Genetic analysis of metabolites in apple fruits indicates an mQTL hotspot for phenolic compounds on linkage group 16

Khan, S. A., Chibon, P. Y. F. R. P., de Vos, R. C. H., Schipper, B. A., Walraven, A. E. J., Beekwilder, M. J., van Dijk, T., Finkers, H. J., Visser, R. G. F., van de Weg, W. E., Bovy, A. G., Cestaro, A., Velasco, R., Jacobsen, E. & Schouten, H. J., 2012, In : Journal of Experimental Botany. 63, 8, p. 2895-2908

Research output: Contribution to journalArticleAcademicpeer-review

Quantitative Trait Loci
Malus
linkage groups
genetic techniques and protocols
phenolic compounds
25 Citations (Scopus)

Genetic mapping and characterization of the globe artichoke (+)-germacrene A synthase gene, encoding the first dedicated enzyme for biosynthesis of the bitter sesquiterpene lactone cynaropicrin

Menin, B., Comino, C., Portis, E., Moglia, A., Cankar, K., Bouwmeester, H. J., Lanteri, S. & Beekwilder, M. J., 2012, In : Plant Science. 190, p. 1-8

Research output: Contribution to journalArticleAcademicpeer-review

Cynara scolymus
artichokes
germacrene
Sesquiterpenes
sesquiterpenoid lactones
3 Citations (Scopus)

Globe Artichoke Callus as an Alternative System for the Production of Dicaffeoylquinic Acids

Moglia, A., Menin, B., Comino, C., Lanteri, S. & Beekwilder, M. J., 2012, VII International Symposium on In Vitro Culture and Horticultural Breeding, Ghent Belgium, 18-22 September 2011. Geelen, D. (ed.). Leuven: ISHS, Vol. 961. p. 261-266

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

artichokes
production technology
callus
acids
chlorogenic acid
3 Citations (Scopus)

In Vitro Callogenesis and Agrobacterium-Mediated Transformation of Globe Artichoke

Menin, B., Moglia, A., Comino, C., Lanteri, S., van Herpen, T. W. J. M. & Beekwilder, M. J., 2012, Proceedings of the VIIth international symposium on in vitro culture and horticultural breeding : Ghent Belgium September 18-22, 2011. Geelen, D. (ed.). Leuven: ISHS, Vol. 961. p. 267-271

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

artichokes
callus formation
Agrobacterium
explants
callus
8 Citations (Scopus)
Open Access
Anthocyanins
Malus
Fruits
Fruit
Oxidoreductases
2011
19 Citations (Scopus)

A Broad Set of Different Llama Antibodies Specific for a 16kDa Heat Shock Protein of Mycobacterium tuberculosis

Trilling, A. K., de Ronde, H., Noteboom, L., van Houwelingen, A. M. M. L., Roelse, M., Srivastava, S. K., Haasnoot, W., Jongsma, M. A., Kolk, A., Zuilhof, H. & Beekwilder, J., 2011, In : PLoS ONE. 6, 10, 10 p., e26754.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
New World Camelids
specific heat
llamas
Mycobacterium tuberculosis
Heat-Shock Proteins
50 Citations (Scopus)

A chicory cytochrome P450 mono-oxygenase CYP71AV8 for the oxidation of (+)-valencene

Cankar, K., van Houwelingen, A. M. M. L., Bosch, H. J., Sonke, T., Bouwmeester, H. J. & Beekwilder, M. J., 2011, In : FEBS Letters. 585, 1, p. 178-182

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chicory
Oxygenases
Cytochrome P-450 Enzyme System
Oxidation
Sesquiterpenes
13 Citations (Scopus)
Cysteine Proteases
cysteine proteinases
disulfide bonds
hypersensitive response
Lycopersicon esculentum
58 Citations (Scopus)

Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.)

Majdi, M., Liu, Q., Karimzadeh, G., Malboobi, M. A., Beekwilder, J., Cankar, K., de Vos, C. H., Todorovic, S., Simonovic, A. & Bouwmeester, H. J., 2011, In : Phytochemistry. 72, 14-15, p. 1739-1750

Research output: Contribution to journalArticleAcademicpeer-review

Tanacetum parthenium
Trichomes
Biosynthesis
trichomes
biosynthesis
29 Citations (Scopus)

Co-Evolution of Insect Proteases and Plant Protease Inhibitors.

Jongsma, M. A. & Beekwilder, M. J., 2011, In : Current Protein and Peptide Science. 12, 5, p. 437-447

Research output: Contribution to journalReview articleAcademicpeer-review

Protease Inhibitors
Insects
Peptide Hydrolases
Herbivory
Mammals
83 Citations (Scopus)

GLYCOALKALOID METABOLISM1 Is Required for Steroidal Alkaloid Glycosylation and Prevention of Phytotoxicity

Itkin, M., Rogachev, I., Alkan, N., Rosenberg, T., Malitsky, S., Masini, L., Meir, S., Lijima, Y., Aoki, K., de Vos, R. C. H., Prusky, D., Beekwilder, M. J. & Aharoni, A., 2011, In : The Plant Cell. 23, 12, p. 4507-4525

Research output: Contribution to journalArticleAcademicpeer-review

glycoalkaloids
Lycopersicon esculentum
phytotoxicity
glycosylation
Glycosylation
77 Citations (Scopus)
Polyphenols
Metabolites
Spectroscopy
Ions
Glycosylation
18 Citations (Scopus)
Cornus
Cornus mas
Prunus laurocerasus
Proanthocyanidins
procyanidins
52 Citations (Scopus)

Reconstitution of the Costunolide Biosynthetic Pathway in Yeast and Nicotiana benthamiana.

Liu, Q., Majdi, M., Cankar, K., Goedbloed, M. A., Charnikhova, T., Verstappen, F. W. A., de Vos, R. C. H., Beekwilder, M. J., van der Krol, S. & Bouwmeester, H. J., 2011, In : PLoS ONE. 6, 8, 12 p., e23255.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chicory
chicory
Nicotiana benthamiana
Biosynthetic Pathways
Yeast
12 Citations (Scopus)

Self-Assembled Functional Organic Monolayers on Oxide-Free Copper

Caipa Campos, M. A., Trilling, A. K., Yang, M., Giesbers, M., Beekwilder, J., Paulusse, J. M. J. & Zuilhof, H., 2011, In : Langmuir. 27, 13, p. 8126-8133

Research output: Contribution to journalArticleAcademicpeer-review

Oxides
Copper
Monolayers
copper
oxides
2010
93 Citations (Scopus)

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

van Herpen, T. W. J. M., Cankar, K., Nogueira, M., Bosch, H. J., Bouwmeester, H. J. & Beekwilder, M. J., 2010, In : PLoS ONE. 5, 12, 11 p., e14222.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Amorpha
Production platforms
artemisinin
Nicotiana benthamiana
Tobacco
26 Citations (Scopus)

Production of novel antioxidative phenolic amides through heterologous expression of the plant’s chlorogenic acid biosynthesis genes in yeast

Moglia, A., Comino, C., Lanteri, S., de Vos, C. H., de Waard, P., van Beek, T. A., Goitre, L., Retta, S. F. & Beekwilder, M. J., 2010, In : Metabolic Engineering. 12, 3, p. 223-232

Research output: Contribution to journalArticleAcademicpeer-review

3-Hydroxyanthranilic Acid
Chlorogenic Acid
Biosynthesis
Amides
Yeast
63 Citations (Scopus)

The Effect of Industrial Food Processing on Potentially Health-beneficial Tomato Antioxidants

Capanoglu, E., Beekwilder, M. J., Boyacioglu, D., de Vos, R. C. H. & Hall, R. D., 2010, In : Critical Reviews in Food Science and Nutrition. 50, 10, p. 919-930

Research output: Contribution to journalReview articleAcademicpeer-review

Food processing
Food Handling
Lycopersicon esculentum
Antioxidants
food processing
2009
132 Citations (Scopus)

Bioactive compounds in berries relevant to human health

Battino, M., Beekwilder, M. J., Denoyes-Rothan, B. & Laimer, M., 2009, In : Nutrition Reviews. 67, 1, p. S145-S150

Research output: Contribution to journalArticleAcademicpeer-review

Fruit
Health
Nutritive Value
Allergens
Breeding
45 Citations (Scopus)

Characterization of Rhamnosidases from Lactobacillus plantarum and Lactobacillus acidophilus.

Beekwilder, M. J., Marcozzi, D., Vecchi, S., de Vos, C. H., Janssen, P., Francke, C., van Hylckama Vlieg, J. E. T. & Hall, R. D., 2009, In : Applied and Environmental Microbiology. 75, 11, p. 3447-3454

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
alpha-L-rhamnosidase
Lactobacillus acidophilus
Lactobacillus plantarum
Lactobacillus
Lycopersicon esculentum
33 Citations (Scopus)

Isolation and mapping of a C3'H gene (CYP98A49) from globe artichoke, and its expression upon UV-C stress

Moglia, A., Comino, C., Portis, E., Acquadro, A., de Vos, C. H., Beekwilder, M. J. & Lanteri, S., 2009, In : Plant Cell Reports. 28, 6, p. 963-974

Research output: Contribution to journalArticleAcademicpeer-review

artichokes
chlorogenic acid
genes
acids
linkage groups
2008
299 Citations (Scopus)

Antioxidants, phenolic compounds, and nutritional quality of different strawberry genotypes

Tulipani, S., Mezzetti, B., Capocasa, F., Bompadre, S., Beekwilder, M. J., de Vos, C. H., Capanoglu, E., Bovy, A. G. & Battino, M., 2008, In : Journal of Agricultural and Food Chemistry. 56, 3, p. 696-704

Research output: Contribution to journalArticleAcademicpeer-review

Fragaria
Nutritive Value
strawberries
phenolic compounds
Antioxidants
6 Citations (Scopus)
crop plant
Phytochemicals
vegetable crops
Vegetables
phytopharmaceuticals
179 Citations (Scopus)

Changes in antioxidant and metabolite profiles during production of tomato paste

Capanoglu, E., Beekwilder, M. J., Boyacioglu, D., Hall, R. D. & de Vos, C. H., 2008, In : Journal of Agricultural and Food Chemistry. 56, 3, p. 964-973

Research output: Contribution to journalArticleAcademicpeer-review

tomato paste
Lycopersicon esculentum
Ointments
Metabolites
Fruits
59 Citations (Scopus)

Cloning and characterisation of a maize carotenoid cleavage dioxygenase (ZmCCD1) and its involvement in the biosynthesis of apocarotenoids with various roles in mutualistic and parasitic interactions

Sun, Z., Hans, J., Walter, M. H., Matusova, R., Beekwilder, M. J., Verstappen, F. W. A., Ming, Z., van Echteld, E., Strack, D., Bisseling, T. & Bouwmeester, H. J., 2008, In : Planta. 228, 5, p. 789-801

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dioxygenases
Carotenoids
Zea mays
Organism Cloning
molecular cloning

Faag-display als bron voor diagnostische antistoffen

Speksnijder, A. G. C. L., Beekwilder, M. J. & van Doorn, J., 2008.

Research output: Contribution to conferencePosterProfessional

Open Access

Generation of recombinant alpaca VHH antibody fragments for the detection of the mycotoxin ochratoxin A

van Houwelingen, A. M. M. L., de Saeger, T., Rusanova, T., Waalwijk, C. & Beekwilder, M. J., 2008, In : World Mycotoxin Journal. 1, 4, p. 407-417

Research output: Contribution to journalArticleAcademicpeer-review

Single-Domain Antibodies
New World Camelids
Immunoglobulin Fragments
alpacas
Mycotoxins
20 Citations (Scopus)

Metabolism of carotenoids and apocarotenoids during ripening of raspberry fruit

Beekwilder, M. J., van der Meer, I. M., Simic, A., Uitdewilligen, J., van Arkel, J., de Vos, C. H., Jonker, H. H., Verstappen, F. W. A., Bouwmeester, H. J., Sibbesen, O., Qvist, I., Mikkelsen, J. D. & Hall, R. D., 2008, In : BioFactors. 34, 1, p. 57-66

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carotenoids
Fruits
Metabolism
Fruit
Norisoprenoids
9 Citations (Scopus)

Plant protease inhibitors: Functional evolution for defense.

Jongsma, M. A. & Beekwilder, M. J., 2008, Induces plant resistance to herbivory. Springer Science, p. 235-251 464 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

11 Citations (Scopus)

Stable recombinant alpaca antibodies for detection of Tulip virus X

Beekwilder, M. J., van Houwelingen, A. M. M. L., van Beckhoven, J. R. C. M. & Speksnijder, A. G. C. L., 2008, In : European Journal of Plant Pathology. 121, 4, p. 477-485

Research output: Contribution to journalArticleAcademicpeer-review

Tulip virus X
alpacas
antibody detection
recombinant antibodies
Flexiviridae
83 Citations (Scopus)

Stress -induced biosynthesis of dicaffeoylquinic acids in globe artichoke

Moglia, A., Lanteri, S., Comino, C., Acquadro, A., de Vos, C. H. & Beekwilder, M. J., 2008, In : Journal of Agricultural and Food Chemistry. 56, 18, p. 8641-8649

Research output: Contribution to journalArticleAcademicpeer-review

Cynara scolymus
artichokes
Biosynthesis
biosynthesis
acids
146 Citations (Scopus)

The Impact of the Absence of Aliphatic Glucosinolates on Insect Herbivory in Arabidopsis

Beekwilder, J., van Leeuwen, W., van Dam, N. M., Bertossi, M., Grandi, V., Mizzi, L., Soloview, M., Szabados, L., Molthoff, J. W., Schipper, B., Verbocht, H., de Vos, C. H., Morandini, P., Aarts, M. G. M. & Bovy, A. G., 2008, In : PLoS ONE. 3, 4, 12 p., e2068.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glucosinolates
Herbivory
glucosinolates
Arabidopsis
Insects
2007

Enzymes

Beekwilder, M. J., Sibbensen, O., Mikkelsen, J. D., van der Meer, I. M., Hall, R. D. & Qvist, I., 8 Nov 2007, Patent No. WO2006010930, Priority date 28 Jul 2004

Research output: PatentOther research output

Open Access
enzymes
nucleic acids
cells