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Research Output 1996 2019

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internal PhD, WU
2019

Artificial viral capsid proteins: mimicking nature to deliver medicines

Willems, L., 2019, Wageningen: Wageningen University. 139 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Double kill : the DNase and RNase activity of CRISPR-Cas type III systems

Zhu, Y., 2019, Wageningen: Wageningen University. 184 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Feel the burn: a collection of stories on hot’n’sharp DNA engineering

Mougiakos, I., 2019, Wageningen: Wageningen University. 301 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

The journey of prokaryotic argonaute proteins: From fundamentals to application

Hegge, J. W., 2019, Wageningen: Wageningen University. 209 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Zooming in: from multi-omics to single function in hyperthermophilic archaeon Sulfolobus solfataricus

Sierocinski, P., 2019, Wageningen: Wageningen University. 209 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
2018

Access denied: A closer look at anti-phage defense mechanisms

Vlot, M., 2018, Wageningen: Wageningen University. 178 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Development of a transcriptional regulator-based bioreporter: towards a generic selection method for novel enzymes

van Rossum, T., 2018, Wageningen: Wageningen University. 240 p.

Research output: Thesisinternal PhD, WUAcademic

Towards biobased ethyl acetate and beyond: Identification and application of the elusive Eat1 enzyme

Kruis, A. J., 2018, Wageningen: Wageningen University. 251 p.

Research output: Thesisinternal PhD, WUAcademic

2017

Adapting to change : on the mechanism of type I-E CRISPR-Cas defence

Künne, T. A., 2017, Wageningen: Wageningen University. 239 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
RNA
Nucleotides
Nucleic Acids
Electrophoretic Mobility Shift Assay

Bacteriophage: from exploration to exploitation

Nobrega, F. L., 2017, Wageningen: Wageningen University. 338 p.

Research output: Thesisinternal PhD, WUAcademic

Bacteriophages
Host Specificity
Genome
Breast Neoplasms
Research

Lignocellulolytic capacities of Geobacillus thermodenitrificans: towards consolidated bioprocessing

Daas, M. J. A., 2017, Wageningen: Wageningen University. 180 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Bacillus thermodenitrificans
bioprocessing
Geobacillus
endo-1,4-beta-glucanase
xylan

Tuning for light and more: engineering phototrophy and membrane proteins in Escherichia coli

Claassens, N. J. H. P., 2017, Wageningen: Wageningen University. 328 p.

Research output: Thesisinternal PhD, WUAcademic

codons
membrane proteins
engineering
Escherichia coli
translation (genetics)
2016

Breaking down barriers: construction of a hybrid heterochiral membrane

Siliakus, M., 2016, Wageningen: Wageningen University. 237 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Lipids
Membranes
Extreme Cold
Bacteria
Butanols

Thermococcus kodakarensis: the key to affordable biohydrogen production

Spaans, S. K., 2016, Wageningen: Wageningen University. 245 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
2015

Bridging domains : a comparison between information processing in Archaea and Eukarya

de Koning, B., 2015, Wageningen: Wageningen University. 154 p.

Research output: Thesisinternal PhD, WUAcademic

queuine tRNA-ribosyltransferase
Archaea
Eukaryota
Archaeal Proteins
Automatic Data Processing

Evolution, role and mechanism of prokaryotic Argonaute proteins

Swarts, D. C., 2015, Wageningen: Wageningen University. 228 p.

Research output: Thesisinternal PhD, WUAcademic

Argonaute Proteins
Bacillus smithii
thermophilic microorganisms
engineering
organisms
saccharification
2014

Biological hydrogen formation by thermophilic bacteria

Bielen, A. A. M., 2014, Wageningen: Wageningen University. 230 p.

Research output: Thesisinternal PhD, WUAcademic

2013

Adaptive & heritable immunity in bacteria : on the regulation and mechanism of CRISPR defense

Westra, E. R., 2013, S.l.: s.n.. 254 p.

Research output: Thesisinternal PhD, WUAcademic

Clustered Regularly Interspaced Short Palindromic Repeats
Immunity
Bacteria

Archaeal virus-host interactions

Quax, T. E. F., 2013, Wageningen: Wageningen UR. 186 p.

Research output: Thesisinternal PhD, WUAcademic

Archaeal Viruses
Rudiviridae
Viruses
Proteins
Operon

Selection and characterization of DNA aptamers

Ruigrok, V. J. B., 2013, S.l.: s.n.. 152 p.

Research output: Thesisinternal PhD, WUAcademic

Nucleotide Aptamers
Surface plasmon resonance
Streptavidin
Oligonucleotides
DNA
2012

Post-genomic characterization of metabolic pathways in Sulfolobus solfataricus

Walther, J., 2012, S.l.: s.n.. 162 p.

Research output: Thesisinternal PhD, WUAcademic

zeaxanthin
biochemical pathways
genomics
arabinose
oxygen
2011

Molecular characterization and optimization of enzymes involved in glycosaminoglycan biosynthesis

Raedts, J. G. J., 2011, [S.l.]: S.n.. 154 p.

Research output: Thesisinternal PhD, WUAcademic

Racemases and Epimerases
Biosynthesis
Glycosaminoglycans
Heparin
Animals
2010

CRISPR-mediated antiviral defence in prokaryotes

Jore, M. M., 2010, S.l.: s.n.. 154 p.

Research output: Thesisinternal PhD, WUAcademic

Clustered Regularly Interspaced Short Palindromic Repeats
Antiviral Agents

Functional genomics analysis of the secretory pathway in Aspergillus niger

Oliveira, J. M., 2010, [S.l.: S.n.. 191 p.

Research output: Thesisinternal PhD, WUAcademic

Aspergillus niger
xylose
genomics
enzymes
maltose

Metabolic engineering toward 1-butanol derivatives in solvent producing clostridia

Siemerink, M. A. J., 2010, [S.l.: S.n.. 202 p.

Research output: Thesisinternal PhD, WUAcademic

metabolic engineering
Clostridium acetobutylicum
butanol
butanediol
acetoin

Molecular characterization of factors involved in regulation of archaeal translation

Blombach, F., 2010, [S.l.: S.n.. 142 p.

Research output: Thesisinternal PhD, WUAcademic

Ribosomes
Eukaryota
Sulfolobus solfataricus
GTP Phosphohydrolases
Ribosome Subunits
2009

Biochemical and structural analysis of thermostable esterases

Levisson, M., 2009, [S.l.: S.n.. 167 p.

Research output: Thesisinternal PhD, WUAcademic

Esterases
Structural analysis
Enzymes
Esters
Carboxylic Ester Hydrolases

Characterization and engineering of thermophilic aldolases : synthesizing nitrogen-heterocycles in biosynthetic routes

Wolterink-van Loo, S., 2009, [S.l.: S.n.. 134 p.

Research output: Thesisinternal PhD, WUAcademic

Aldehyde-Lyases
Aldehydes
Nitrogen
4-hydroxy-tetrahydrodipicolinate synthase
Substrates

Transcriptional profiling of Aspergillus niger

van der Veen, D., 2009, [S.l.: S.n.. 173 p.

Research output: Thesisinternal PhD, WUAcademic

Aspergillus niger
transcription (genetics)
xylose
lipids
fungi
2008

Computational genomics of hyperthermophiles

van de Werken, H. J. G., 2008, [S.l.]: S.n.. 151 p.

Research output: Thesisinternal PhD, WUAcademic

Caldicellulosiruptor saccharolyticus
genomics
genome
Thermococcales
Pyrococcus furiosus

On the natural and laboratory evolution of an antibiotic resistance gene

Salverda, M. L. M., 2008, [S.l.]: S.n.. 144 p.

Research output: Thesisinternal PhD, WUAcademic

antibiotic resistance
mutation
genes
antibiotics
lactams
2007

Characterization and engineering of thermostable glycoside hydrolases

van Lieshout, J. F. T., 2007, [S.l.]: S.n.. 137 p.

Research output: Thesisinternal PhD, WUAcademic

Functional analysis of thermostable proteins involved in carbohydrate metabolism

Akerboom, A. P., 2007, [S.l.]: S.n.. 174 p.

Research output: Thesisinternal PhD, WUAcademic

carbohydrate metabolism
protein metabolism
Pyrococcus furiosus
Thermococcus kodakarensis
Thermococcales

Integrated molecular analysis of sugar metabolism of Sulfolobus solfataricus

Brouns, S. J. J., 2007, [S.l.]: s.n.. 166 p.

Research output: Thesisinternal PhD, WUAcademic

sugars
metabolism
Sulfolobus solfataricus

Microbial alcohol dehydrogenases: identification, characterization and engineering

Machielsen, M. P., 2007, [S.l.]: S.n.. 136 p.

Research output: Thesisinternal PhD, WUAcademic

alcohol dehydrogenase
engineering
alcohols
protein engineering
Pyrococcus furiosus

Structural and functional analysis of Eukaryal-like proteins from the hyperthermophilic archaeon Sulfolobus solfataricus

Wu Hao, 2007, [S.l.]: S.n.. 150 p.

Research output: Thesisinternal PhD, WUAcademic

Archaea
translation (genetics)
transcription (genetics)
genetic engineering
bioinformatics
2006

Molecular analysis of halorespiration in Desulfitobacterium spp. : catalysis and transcriptional regulation

Gabor, K., 2006, [S.l.]: S.n.. 141 p.

Research output: Thesisinternal PhD, WUAcademic

2005

Functional and comparative genomics of the Archaea

Ettema, T. J. G., 2005, [S.l.]: s.n.. 172 p.

Research output: Thesisinternal PhD, WUAcademic

Archaea
Genomics
2004

Molecular studies on protein- and carbohydrate-converting ezymes from thermophilic bacteria

Kluskens, L. D., 2004, Wageningen: s.n.. 138 p.

Research output: Thesisinternal PhD, WUAcademic

2003

Utilization of Lignocellulosic Substrates by Solvent-Producing Clostridia

Lopez Contreras, A. M., 2003, [S.I.]: S.n.. 142 p.

Research output: Thesisinternal PhD, WUAcademic

2002

Molecular characterization of glycolysis in Pyrococcus furiosus

Verhees, C. H., 2002, S.l.: S.n.. 152 p.

Research output: Thesisinternal PhD, WUAcademic

Pyrococcus furiosus
glycolysis
enzymes
fructose
galactokinase
2001

Engineering of β-glycosidases from hyperthermophilic Archaea

Kaper, T., 2001, S.l.: S.n.. 162 p.

Research output: Thesisinternal PhD, WUAcademic

Glycoside Hydrolases
Enzymes
Substrates
Lactose
Glucosidases

Molecular characterization of anaerobic dehalogenation by Desulfitobacterium dehalogenans

Smidt, H., 2001, S.l.: S.n.. 187 p.

Research output: Thesisinternal PhD, WUAcademic

chlorophenol
gene
enzyme
bacterium
protein
1999

Molecular characterisation of the thermostability and catalytic properties of enzymes from hyperthermophiles

Lebbink, J. H. G., 1999, S.l.: S.n.. 192 p.

Research output: Thesisinternal PhD, WUAcademic

Glutamate Dehydrogenase
Enzymes
Ions
Substrates
Catalysis