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Research Output 1996 2019

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Patent
2019

Thermostable Cas9 nucleases with reduced off-target activity

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 18 Apr 2019, Patent No. WO2019072596, Priority date 10 Oct 2017

Research output: PatentOther research output

Open Access
gene deletion
nucleases
Bacillus smithii
Geobacillus
thermophilic bacteria
2018

Alcohol acetyl transferases for alkyl alkanoate production

Kruis, A. J., Levisson, M., Mars, A. E., Kengen, S. W. M., van der Oost, J., Sanders, J. P. M. & Weusthuis, R. A., 8 Jun 2018, Patent No. WO2018099719, Priority date 1 Dec 2016

Research output: PatentOther research output

Open Access
Transferases
Kluyveromyces
Acetyl Coenzyme A
Alcohols
Peptides

Microbial genome editing

van der Oost, J., van Kranenburg, R., Bosma, E. F. & Mougiakos, I., 11 May 2018, Patent No. WO2018083128, Priority date 11 Feb 2016

Research output: PatentOther research output

Open Access
Microbial Genome
Homologous Recombination
Temperature
Plasmids
Microbial Genes

Prokaryotic argonaute proteins and uses thereof

van der Oost, J. & Hegge, J. W., 18 Jan 2018, Patent No. WO2018011236, Priority date 7 Dec 2016

Research output: PatentOther research output

Open Access
Argonaute Proteins
Nucleic Acids
Biotechnology
Peptides
Synthetic Biology

Thermostable Cas9 nucleases

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 21 Jun 2018, Patent No. WO2018108339, Priority date 14 Dec 2016

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Genetic Engineering
Nucleic Acids
Peptides
Polynucleotides

Thermostable Cas9 nucleases

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 21 Jun 2018, Patent No. WO2018109101, Priority date 14 Dec 2016

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Guide RNA
Polynucleotides
Endonucleases
Plasmids
2017

Improved CRISPR-Cas9 genome editing tool

Louwen, R. & van der Oost, J., 14 Sep 2017, Patent No. WO2017155408, Priority date 11 Mar 2016

Research output: PatentOther research output

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Proteins
Gene Editing

Improved CRISPR-Cpf1 genome editing tool 

van der Oost, J., van Baarlen, P. & Louwen, R., 14 Sep 2017, Patent No. WO2017155407, Priority date 11 Mar 2016

Research output: PatentOther research output

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Guide RNA
Proteins
Gene Editing
2016

Nuclease-mediated genome editing

van der Oost, J., 20 Oct 2016, Patent No. WO2016166340, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Nucleic Acids
Peptides
Synthetic Biology
Synthetic Genes
Genetic Techniques

Riboswitch-controlled screening and selection of desired biocatalysts 

Creutzburg, S. C. A. & van der Oost, J., 20 Oct 2016, Patent No. WO2016166303, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Riboswitch
Enzymes
RNA Splicing
Bacterial Genomes
Reading Frames

Riboswitch inducible gene expression

Creutzburg, S. C. A. & van der Oost, J., 20 Oct 2016, Patent No. WO2016166310, Priority date 16 Apr 2015

Research output: PatentOther research output

Open Access
Riboswitch
Gene Expression
Enzymes
Reading Frames
Reporter Genes

Thermostable Cas9 nucleases

van der Oost, J., Daas, M. J. A., Kengen, S. W. M. & de Vos, W. M., 15 Dec 2016, Patent No. WO2016198361, Priority date 12 Jun 2015

Research output: PatentOther research output

Open Access
Micrococcal Nuclease
Genetic Engineering
Nucleic Acids
DNA Cleavage
Peptides
2015

Systematic optimization of coding sequence for functional protein expression

van der Oost, J., 9 Apr 2015, Patent No. WO2015048989, Priority date 2 Oct 2013

Research output: PatentOther research output

Codon
Proteins
2014

DNA-guided DNA interference by a prokaryotic Argonaute

van der Oost, J. & Swarts, D. C., 27 Nov 2014, Patent No. WO2014189628, Priority date 11 Apr 2013

Research output: PatentOther research output

Open Access
Nucleic Acids
DNA
Amino Acids
Chemical analysis

Genetically engineered micro-organisms for production of fatty acids

Weusthuis, R. A., van der Oost, J. & Eggink, G., 30 Jan 2014, Patent No. WO2014016328, Priority date 25 Jul 2012

Research output: PatentOther research output

Open Access
fatty acid
micro-organism
method
2013

Modified cascade ribonucleoproteins and uses thereof 

Brouns, S. J. J. & van der Oost, J., 4 Jul 2013, Patent No. WO2013098244, Priority date 30 Dec 2011

Research output: PatentOther research output

Clustered Regularly Interspaced Short Palindromic Repeats
Ribonucleoproteins
CRISPR-Associated Proteins
Nucleic Acids
Antiviral Agents
2012

Process for polylactic acid production using Monascus

Weusthuis, R. A., Wolbert, E. J. H., Springer, J., van der Oost, J. & Eggink, G., 3 May 2012, Patent No. WO2012055997, Priority date 28 Oct 2010

Research output: PatentOther research output

Open Access
polylactic acid
Monascus
polymerization
lactic acid
fermentation

Use of Monascus in organic acid production

Weusthuis, R. A., Wolbert, E. J. H., Springer, J., van der Oost, J. & Eggink, G., 3 May 2012, Patent No. WO2012055998, Priority date 28 Oct 2010

Research output: PatentOther research output

Open Access
Monascus
organic acids and salts
methodology