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Research Output 1996 2019

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Review article
2019
3 Citations (Scopus)

The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut

Elzinga, J., van der Oost, J., de Vos, W. M. & Smidt, H., 13 Mar 2019, In : Microbiology and Molecular Biology Reviews. 83, 2, p. 1-40

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Synbiotics
Organoids
Germ-Free Life
Microbiota
Probiotics
2018
6 Citations (Scopus)

Exploration and exploitation of the environment for novel specialized metabolites

Loureiro, C., Medema, M. H., van der Oost, J. & Sipkema, D., 1 Apr 2018, In : Current Opinion in Biotechnology. 50, p. 206-213

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Multigene Family
Metabolites
Genes
Peptide Synthases
Polyketide Synthases
16 Citations (Scopus)

Genome editing by natural and engineered CRISPR-associated nucleases

Wu, W. Y., Lebbink, J. H. G., Kanaar, R., Geijsen, N. & van der Oost, J., 1 Jul 2018, In : Nature Chemical Biology. 14, 7, p. 642-651

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Peptides
Research
Gene Editing
17 Citations (Scopus)

Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects

Mougiakos, I., Bosma, E. F., Ganguly, J., van der Oost, J. & van Kranenburg, R., 1 Apr 2018, In : Current Opinion in Biotechnology. 50, p. 146-157

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Metabolic engineering
Metabolic Engineering
Throughput
Clostridium
11 Citations (Scopus)

Prokaryotic Argonaute proteins: novel genome-editing tools?

Hegge, J. W., Swarts, D. C. & van der Oost, J., 1 Jan 2018, In : Nature Reviews Microbiology. 16, 1, p. 5-11

Research output: Contribution to journalReview articleAcademicpeer-review

Argonaute Proteins
Nucleic Acids
Archaea
RNA Interference
Eukaryota
2 Citations (Scopus)

Shooting the messenger: RNA-targetting CRISPR-Cas systems

Zhu, Y., Klompe, S. E., Vlot, M., van der Oost, J. & Staals, R. H. J., 21 Jun 2018, In : Bioscience Reports. 38, 3, BSR20170788.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
Messenger RNA
RNA
Deoxyribonucleases
2016
50 Citations (Scopus)

Next Generation Prokaryotic Engineering: The CRISPR-Cas Toolkit

Mougiakos, I., Bosma, E. F., de Vos, W. M., van Kranenburg, R. & van der Oost, J., 2016, In : Trends in Biotechnology. 34, 7, p. 575-587

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Cas Systems
Genes
Bacteria
Chemical Phenomena
2014
15 Citations (Scopus)

DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications

Falcicchio, P., Wolterink-van Loo, S., Franssen, M. C. R. & van der Oost, J., 2014, In : Extremophiles. 18, 1, p. 1-13

Research output: Contribution to journalReview articleAcademicpeer-review

Aldehyde-Lyases
Biochemistry
Carbon
Dihydroxyacetone Phosphate
Synthetic Chemistry Techniques
122 Citations (Scopus)

The evolutionary journey of Argonaute proteins

Swarts, D. C., Makarova, K., Wang, Y., Nakanishi, K., Ketting, R. F., Koonin, E. V., Patel, D. J. & van der Oost, J., 2014, In : Nature Structural and Molecular Biology. 21, 9, p. 743-753

Research output: Contribution to journalReview articleAcademicpeer-review

Argonaute Proteins
RNA Interference
Carrier Proteins
75 Citations (Scopus)

The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria

Louwen, R., Staals, R. H. J., Endtz, H. P., van Baarlen, P. & van der Oost, J., 2014, In : Microbiology and Molecular Biology Reviews. 78, 1, p. 74-88

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Virulence
Bacteria
Archaeal Genome
Interspersed Repetitive Sequences
297 Citations (Scopus)

Unravelling the structural and mechanistic basis of CRISPR-Cas systems

van der Oost, J., Westra, E. R., Jackson, R. N. & Wiedenheft, B., 2014, In : Nature Reviews Microbiology. 12, 7, p. 479-492

Research output: Contribution to journalReview articleAcademicpeer-review

CRISPR-Cas Systems
Clustered Regularly Interspaced Short Palindromic Repeats
CRISPR-Associated Proteins
Archaea
Adaptive Immunity
2013
16 Citations (Scopus)

Potential of proton-pumping rhodopsins: engineering photosystems into microorganisms

Claassens, N. J. H. P., Volpers, M., Martins Dos Santos, V. A. P., van der Oost, J. & de Vos, W. M., 2013, In : Trends in Biotechnology. 31, 11, p. 633-642

Research output: Contribution to journalReview articleAcademicpeer-review

Rhodopsin
Microorganisms
Protons
Light
Microbial Rhodopsins
25 Citations (Scopus)

Reporter-based screening and selection of enzymes

van Rossum, T., Kengen, S. W. M. & van der Oost, J., 2013, In : FEBS Journal. 280, 13, p. 2979-2996

Research output: Contribution to journalReview articleAcademicpeer-review

Screening
Enzymes
Riboswitch
High-Throughput Screening Assays
Catalytic RNA
2012
22 Citations (Scopus)

Characterization of Aptamer-Protein Complexes by X-ray Crystallography and Alternative Approaches

Ruigrok, V. J. B., Levisson, M., Hekelaar, J., Smidt, H., Dijkstra, B. W. & van der Oost, J., 2012, In : International Journal of Molecular Sciences. 13, 8, p. 10537-10552

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
X ray crystallography
X Ray Crystallography
crystallography
proteins
Proteins
180 Citations (Scopus)

The CRISPRs, They Are A-Changin': How Prokaryotes Generate Adaptive Immunity

Westra, E. R., Swarts, D. C., Staals, R. H. J., Jore, M. M., Brouns, S. J. J. & van der Oost, J., 2012, In : Annual Review of Genetics. 46, p. 311-339

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Adaptive Immunity
DNA
Bacteria
Escherichia coli K12
2011
108 Citations (Scopus)

Alternative affinity tools: more attractive than antibodies?

Ruigrok, V. J. B., Levisson, M., Eppink, M. H. M., Smidt, H. & van der Oost, J., 2011, In : Biochemical Journal. 436, 1, p. 1-13

Research output: Contribution to journalReview articleAcademicpeer-review

Antibodies
Nucleic Acids
Carrier Proteins
Drug delivery
Purification
96 Citations (Scopus)

Clustered regularly interspaced short palindromic repeats (CRISPRs): the hallmark of an ingenious antiviral defense mechanism in prokaryotes

Al-Attar, S., Westra, E. R., van der Oost, J. & Brouns, S. J. J., 2011, In : Biological Chemistry. 392, 4, p. 277-289

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Antiviral Agents
DNA
Prokaryotic Cells
Immunologic Memory
1118 Citations (Scopus)

Evolution and classification of the CRISPR-Cas systems

Makarova, K. S., Brouns, S. J. J. & van der Oost, J., 2011, In : Nature Reviews Microbiology. 9, 6, p. 467-477

Research output: Contribution to journalReview articleAcademicpeer-review

CRISPR-Associated Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Archaea
Adaptive Immunity
Phylogeny
58 Citations (Scopus)

Microbial production of bulk chemicals: development of anaerobic processes

Weusthuis, R. A., Lamot, I., van der Oost, J. & Sanders, J. P. M., 2011, In : Trends in Biotechnology. 29, 4, p. 153-158

Research output: Contribution to journalReview articleAcademicpeer-review

Oxygen
Productivity
Metabolism
Fermentation
Oxidation-Reduction
2010
4 Citations (Scopus)

Fidelity in Archaeal Information Processing

de Koning, B., Blombach, F., Brouns, S. J. J. & van der Oost, J., 2010, In : Archaea : an international microbiological journal. 2010, 960298.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Genome Size
information processing
Archaea
Eukaryota
DNA Replication
3 Citations (Scopus)

Hot Transcriptomics

Walther, J., Sierocinski, P. & van der Oost, J., 2010, In : Archaea : an international microbiological journal. 2010, 14 p., 897585.

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
microarray technology
transcriptomics
Technology
Archaea
transcriptome
2009
62 Citations (Scopus)

Carboxylic ester hydrolases from hyperthermophiles

Levisson, M., van der Oost, J. & Kengen, S. W. M., 2009, In : Extremophiles. 13, 4, p. 567-581

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Carboxylic Ester Hydrolases
Esters
Enzymes
Archaea
Esterases
293 Citations (Scopus)

CRISPR-based adaptive and heritable immunity in prokaryotes

van der Oost, J., Jore, M. M., Westra, E. R., Lundgren, N. M. J. & Brouns, S. J. J., 2009, In : Trends in Biochemical Sciences. 34, 8, p. 401-407

Research output: Contribution to journalReview articleAcademicpeer-review

Clustered Regularly Interspaced Short Palindromic Repeats
Adaptive Immunity
DNA
Guide RNA
Interspersed Repetitive Sequences
2007
132 Citations (Scopus)

Hyperthermophilic enzymes - stability, activity and implementation strategies for high temperature applications

Unsworth, L. D., van der Oost, J. & Koutsopoulos, S., 2007, In : FEBS Journal. 274, 16, p. 4044-4056

Research output: Contribution to journalReview articleAcademicpeer-review

Enzyme Stability
High temperature applications
Temperature
Enzymes
Enzyme immobilization
2005
17 Citations (Scopus)

Discovering novel biology by in silico archaeology

Ettema, T. J. G., de Vos, W. M. & van der Oost, J., 2005, In : Nature Reviews Microbiology. 3, 11, p. 859-869

Research output: Contribution to journalReview articleAcademicpeer-review

Archaeology
Archaea
Computer Simulation
Archaeal Genome
Genomics
2003
134 Citations (Scopus)

An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi

Cohen, G., Barbe, V., Flament, D., Galperin, M., Heilig, R., Lecompte, O., Prieur, D., Poch, O., Querellou, J., Thierry, J. C., van der Oost, J., Weissenbach, J., Zivanovic, Y. & Forterre, P., 2003, In : Molecular Microbiology. 47, p. 1495-1512

Research output: Contribution to journalReview articleAcademicpeer-review

Pyrococcus abyssi
Archaea
Genome
Archaeal DNA
Archaeal Genes
185 Citations (Scopus)

The Lrp family of transcriptional regulators

Brinkman, A. B., Ettema, T. J. G., de Vos, W. M. & van der Oost, J., 2003, In : Molecular Microbiology. 48, 2, p. 287-294

Research output: Contribution to journalReview articleAcademicpeer-review

Binding Sites
Leucine-Responsive Regulatory Protein
DNA
Pyrococcus furiosus
Genome
166 Citations (Scopus)

Unique features of glycolysis in Archaea

Verhees, C. H., Kengen, S. W. M., Tuininga, J. E., Schut, G. J., Adams, M. W. W., de Vos, W. M. & van der Oost, J., 2003, In : Biochemical Journal. 375, p. 231-246

Research output: Contribution to journalReview articleAcademicpeer-review

Archaea
Glycolysis
Enzymes
Bacteria
Genomics