19962020

Research output per year

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Research Output

2020

Adaptation and application of a two-plasmid inducible CRISPR-Cas9 system in Clostridium beijerinckii

Diallo, M., Hocq, R., Collas, F., Chartier, G., Wasels, F., Wijaya, H. S., Werten, M. W. T., Wolbert, E. J. H., Kengen, S. W. M., van der Oost, J., Ferreira, N. L. & López-Contreras, A. M., 1 Feb 2020, In : Methods. 172, p. 51-60 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

CRISPR with a Happy Ending: Non‐Templated DNA Repair for Prokaryotic Genome Engineering

Finger‐bou, M., Orsi, E., Der Oost, J. & Staals, R. H. J., Jul 2020, In : Biotechnology Journal. 15, 1900404.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

Makarova, K. S., Wolf, Y. I., Iranzo, J., Shmakov, S. A., Alkhnbashi, O. S., Brouns, S. J. J., Charpentier, E., Cheng, D., Haft, D. H., Horvath, P., Moineau, S., Mojica, F. J. M., Scott, D., Shah, S. A., Siksnys, V., Terns, M. P., Venclovas, Č., White, M. F., Yakunin, A. F., Yan, W. & 6 others, Zhang, F., Garrett, R. A., Backofen, R., van der Oost, J., Barrangou, R. & Koonin, E. V., Feb 2020, In : Nature Reviews Microbiology. 18, p. 67-83 16 p.

Research output: Contribution to journalArticleAcademicpeer-review

23 Citations (Scopus)

First structural insights into CRISPR-Cas-guided DNA transposition

van der Oost, J. & Mougiakos, I., 3 Mar 2020, In : Cell Research. 30, p. 193-194

Research output: Contribution to journalComment/Letter to the editorAcademic

Open Access

From Eat to trEat: Engineering the mitochondrial Eat1 enzyme for enhanced ethyl acetate production in Escherichia coli

Kruis, A. J., Bohnenkamp, A. C., Nap, B., Nielsen, J., Mars, A. E., Wijffels, R. H., Van Der Oost, J., Kengen, S. W. M. & Weusthuis, R. A., 19 Apr 2020, In : Biotechnology for Biofuels. 13, 1, 76.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a

Creutzburg, S. C. A., Wu, W., Mohanraju, P., Swartjes, T., Alkan, F., Gorodkin, J., Staals, R. H. J. & van der Oost, J., 6 Apr 2020, In : Nucleic acids research. 48, 6, p. 3228–3243 gkz1240.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

Saha, C., Mohanraju, P., Stubbs, A., Dugar, G., Hoogstrate, Y., Kremers, G. J., Van Cappellen, W. A., Horst-Kreft, D., Laffeber, C., Lebbink, J. H. G., Bruens, S., Gaskin, D., Beerens, D., Klunder, M., Joosten, R., Demmers, J. A. A., Van Gent, D., Mouton, J. W., Van Der Spek, P. J., Van Der Oost, J. & 2 others, Van Baarlen, P. & Louwen, R., Jun 2020, In : Science Advances. 6, 25, eaaz4849.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Highly specific enrichment of rare nucleic acid fractions using Thermus thermophilus argonaute with applications in cancer diagnostics

Song, J., Hegge, J. W., Mauk, M. G., Chen, J., Till, J. E., Bhagwat, N., Azink, L. T., Peng, J., Sen, M., Mays, J., Carpenter, E. L., van der Oost, J. & Bau, H. H., 28 Feb 2020, In : Nucleic acids research. 48, 4, p. e19

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

High-Speed Super-Resolution Imaging Using Protein-Assisted DNA-PAINT

Filius, M., Cui, T. J., Ananth, A. N., Docter, M. W., Hegge, J. W., van der Oost, J. & Joo, C., 8 Apr 2020, In : Nano Letters. 20, 4, p. 2264-2270 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Medium-throughput in vitro detection of DNA cleavage by CRISPR-Cas12a

Creutzburg, S. C. A., Swartjes, T. & van der Oost, J., 1 Feb 2020, In : Methods. 172, p. 27-31 5 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
Open Access
1 Citation (Scopus)

Off-target activity inhibitors for guided endonucleases

Notebaart, R. A., Künne, T. A., Brouns, S. J. J. & Van Der Oost, J., 2 Apr 2020, Patent No. WO2020065062, Priority date 28 Sep 2018, Priority No. GB20180015820

Research output: PatentOther research output

Open Access
2019

Addiction systems antagonize bacterial adaptive immunity

van Sluijs, L., van Houte, S., van der Oost, J., Brouns, S. J. J., Buckling, A. & Westra, E. R., 1 Mar 2019, In : FEMS Microbiology Letters. 366, 5, fnz047.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Argonaute bypasses cellular obstacles without hindrance during target search

Cui, T. J., Klein, M., Hegge, J. W., Chandradoss, S. D., van der Oost, J., Depken, M. & Joo, C., 26 Sep 2019, In : Nature Communications. 10, 4390.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Bicistronic Design-Based Continuous and High-Level Membrane Protein Production in Escherichia coli

Claassens, N. J., Finger-Bou, M., Scholten, B., Muis, F., De Groot, J. J., De Gier, J. W., De Vos, W. M. & Van Der Oost, J., 17 Jun 2019, In : ACS synthetic biology. 8, 7, p. 1685-1690 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Bowel Biofilms: Tipping Points between a Healthy and Compromised Gut?

Tytgat, H. L. P., Nobrega, F. L., van der Oost, J. & de Vos, W. M., Jan 2019, In : Trends in Microbiology. 27, 1, p. 17-25

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
Open Access
7 Citations (Scopus)

Distant Non-Obvious Mutations Influence the Activity of a Hyperthermophilic Pyrococcusfuriosus Phosphoglucose Isomerase

Subramanian, K., Mitusińska, K., Raedts, J., Almourfi, F., Joosten, H. J., Hendriks, S., Sedelnikova, S. E., Kengen, S. W. M., Hagen, W. R., Góra, A., Martins Dos Santos, V. A. P., Baker, P. J., van der Oost, J. & Schaap, P. J., 31 May 2019, In : Biomolecules. 9, 6, 212.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute

Hegge, J. W., Swarts, D. C., Chandradoss, S. D., Cui, T. J., Kneppers, J., Jinek, M., Joo, C. & van der Oost, J., 20 Jun 2019, In : Nucleic acids research. 47, 11, p. 5809-5821 13 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Editor's cut: DNA cleavage by CRISPR RNA-guided nucleases Cas9 and Cas12a

Swartjes, T., Staals, R. H. J. & van der Oost, J., 24 Dec 2019, In : Biochemical Society Transactions. 48, 1, BST20190563.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Efficient Cas9-based genome editing of Rhodobacter sphaeroides for metabolic engineering

Mougiakos, I., Orsi, E., Ghiffary, M. R., Post, W., de Maria, A., Adiego-Perez, B., Kengen, S. W. M., Weusthuis, R. A. & van der Oost, J., 25 Nov 2019, In : Microbial Cell Factories. 18, 1, 1 p., 204.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Enrichment of nucleic acids

Bau, H., Song, J., Liu, C., Mauk, M., van der Oost, J. & Hegge, J. W., 19 Sep 2019, Patent No. WO2019178346, Priority date 14 Mar 2018

Research output: PatentOther research output

Open Access

Haarfijn gewassen verbeteren

van der Oost, J., 31 May 2019

Research output: Non-textual formWeb publication/siteProfessional

Open Access

Harnessing type I CRISPR–Cas systems for genome engineering in human cells

Cameron, P., Coons, M. M., Klompe, S. E., Lied, A. M., Smith, S. C., Vidal, B., Donohoue, P. D., Rotstein, T., Kohrs, B. W., Nyer, D. B., Kennedy, R., Banh, L. M., Williams, C., Toh, M. S., Irby, M. J., Edwards, L. S., Lin, C. H., Owen, A. L. G., Künne, T., van der Oost, J. & 7 others, Brouns, S. J. J., Slorach, E. M., Fuller, C. K., Gradia, S., Kanner, S. B., May, A. P. & Sternberg, S. H., 18 Dec 2019, In : Nature Biotechnology. 37, p. 1471-1477

Research output: Contribution to journalLetterAcademicpeer-review

9 Citations (Scopus)

Improved protein production and codon optimization analyses in Escherichia coli by bicistronic design

Nieuwkoop, T., Claassens, N. J. & van der Oost, J., 2019, In : Microbial Biotechnology. 12, 1, p. 173-179

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Incorporation of a Synthetic Amino Acid into dCas9 Improves Control of Gene Silencing

Koopal, B., Kruis, A. J., Claassens, N. J., Nobrega, F. L. & Van Der Oost, J., 1 Jan 2019, In : ACS synthetic biology. 8, 2, p. 216-222

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Inducible Fibril Formation of Silk-Elastin Diblocks

Willems, L., Roberts, S., Weitzhandler, I., Chilkoti, A., Mastrobattista, E., Van Der Oost, J. & De Vries, R., 23 May 2019, In : ACS Omega. 4, 5, p. 9135-9143 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Microbial Diversity and Organic Acid Production of Guinea Pig Faecal Samples

Palakawong Na Ayudthaya, S., van der Oost, H., van der Oost, J., van Vliet, D. M. & Plugge, C. M., Apr 2019, In : Current Microbiology. 76, 4, p. 425-434

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Multiplex genome editing of microorganisms using CRISPR-Cas

Adiego-Pérez, B., Randazzo, P., Daran, J. M., Verwaal, R., Roubos, J. A., Daran-Lapujade, P. & van der Oost, J., 14 May 2019, In : FEMS Microbiology Letters. 366, 8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide

Willems, L., Van Westerveld, L., Roberts, S., Weitzhandler, I., Calcines Cruz, C., Hernandez-Garcia, A., Chilkoti, A., Mastrobattista, E., Van Der Oost, J. & De Vries, R., Oct 2019, In : Biomacromolecules. 20, 10, p. 3641-3647

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

Carrión, V. J., Perez-Jaramillo, J., Cordovez, V., Tracanna, V., De Hollander, M., Ruiz-Buck, D., Mendes, L. W., van Ijcken, W. F. J., Gomez-Exposito, R., Elsayed, S. S., Mohanraju, P., Arifah, A., van der Oost, J., Paulson, J. N., Mendes, R., van Wezel, G. P., Medema, M. H. & Raaijmakers, J. M., 1 Nov 2019, In : Science. 366, 6465, p. 606-612 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Thermostable Cas9 nucleases with reduced off-target activity

van der Oost, J., van Kranenburg, R., Bosma, E. F., Mougiakos, I. & Mohanraju, P., 18 Apr 2019, Patent No. WO2019072596, Priority date 10 Oct 2017

Research output: PatentOther research output

Open Access

The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut

Elzinga, J., van der Oost, J., de Vos, W. M. & Smidt, H., 13 Mar 2019, In : Microbiology and Molecular Biology Reviews. 83, 2, p. 1-40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)
2018

Alcohol acetyl transferases for alkyl alkanoate production

Kruis, A. J., Levisson, M., Mars, A. E., Kengen, S. W. M., van der Oost, J., Sanders, J. P. M. & Weusthuis, R. A., 7 Jun 2018, Patent No. WO2018099719, Priority date 1 Dec 2016

Research output: PatentOther research output

Open Access

Alcohol acetyl transferases for ethyl acetate production

Kruis, A. J., Levisson, M., Mars, A. E., Kengen, S. W. M., van der Oost, J., Sanders, J. P. M. & Weusthuis, R. A., 7 Jun 2018, Patent No. WO2018100097, Priority date 1 Dec 2016

Research output: PatentOther research output

Open Access

Bacteriophage DNA glucosylation impairs target DNA binding by type I and II but not by type V CRISPR–Cas effector complexes

Vlot, M., Houkes, J., Lochs, S. J. A., Swarts, D. C., Zheng, P., Kunne, T., Mohanraju, P., Anders, C., Jinek, M., Van Der Oost, J., Dickman, M. J. & Brouns, S. J. J., 25 Jan 2018, In : Nucleic acids research. 46, 2, p. 873-885

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Complete Genome Sequence of Geobacillus thermodenitrificans T12, A Potential Host for Biotechnological Applications

Daas, T., Vriesendorp, B., van de Weijer, T., van der Oost, J. & van Kranenburg, R., Jan 2018, In : Current Microbiology. 75, 1, p. 49-56

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Contribution of Eat1 and other alcohol acyltransferases to ester production in Saccharomyces cerevisiae

Kruis, A. J., Gallone, B., Jonker, T., Mars, A. E., van Rijswijck, I. M. H., Wolkers-Rooijackers, J. C. M., Smid, E. J., Steensels, J., Verstrepen, K. J., Kengen, S. W. M., van der Oost, J. & Weusthuis, R. A., 21 Dec 2018, In : Frontiers in Microbiology. 9, 11 p., 3202.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Converting Escherichia coli into an archaebacterium with a hybrid heterochiral membrane

Caforio, A., Siliakus, M. F., Exterkate, M., Jain, S., Jumde, V. R., Andringa, R. L. H., Kengen, S. W. M., Minnaard, A. J., Driessen, A. J. M. & van der Oost, J., 3 Apr 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 14, p. 3704-3709

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
22 Citations (Scopus)

Engineering Geobacillus thermodenitrificans to introduce cellulolytic activity; expression of native and heterologous cellulase genes

Daas, M. J. A., Nijsse, B., van de Weijer, A. H. P., Groenendaal, B. W. A. J., Janssen, F., van der Oost, J. & van Kranenburg, R., 27 Jun 2018, In : BMC Biotechnology. 18, 1, 42.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
3 Citations (Scopus)

Exploration and exploitation of the environment for novel specialized metabolites

Loureiro, C., Medema, M. H., van der Oost, J. & Sipkema, D., 1 Apr 2018, In : Current Opinion in Biotechnology. 50, p. 206-213

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Genome editing by natural and engineered CRISPR-associated nucleases

Wu, W. Y., Lebbink, J. H. G., Kanaar, R., Geijsen, N. & van der Oost, J., 1 Jul 2018, In : Nature Chemical Biology. 14, 7, p. 642-651

Research output: Contribution to journalArticleAcademicpeer-review

32 Citations (Scopus)

Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects

Mougiakos, I., Bosma, E. F., Ganguly, J., van der Oost, J. & van Kranenburg, R., 1 Apr 2018, In : Current Opinion in Biotechnology. 50, p. 146-157

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
28 Citations (Scopus)

Microbial genome editing

van der Oost, J., van Kranenburg, R., Bosma, E. F. & Mougiakos, I., 11 May 2018, Patent No. WO2018083128, Priority date 11 Feb 2016

Research output: PatentOther research output

Open Access

Mining for novel bacterial defence systems

Barrangou, R. & van der Oost, J., 30 Apr 2018, In : Nature Microbiology. 3, p. 535-536

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Progress of CRISPR-Cas based genome editing in Photosynthetic microbes

Naduthodi, M. I. S., Barbosa, M. J. & van der Oost, J., Sep 2018, In : Biotechnology Journal. 13, 9

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

Prokaryotic Argonaute proteins: novel genome-editing tools?

Hegge, J. W., Swarts, D. C. & van der Oost, J., 1 Jan 2018, In : Nature Reviews Microbiology. 16, 1, p. 5-11

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Scopus)

Prokaryotic argonaute proteins and uses thereof

van der Oost, J. & Hegge, J. W., 18 Jan 2018, Patent No. WO2018011236, Priority date 7 Dec 2016

Research output: PatentOther research output

Open Access

Shooting the messenger: RNA-targetting CRISPR-Cas systems

Zhu, Y., Klompe, S. E., Vlot, M., van der Oost, J. & Staals, R. H. J., 21 Jun 2018, In : Bioscience Reports. 38, 3, BSR20170788.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

The alcohol acetyltransferase Eat1 is located in yeast mitochondria

Kruis, A. J., Mars, A. E., Kengen, S. W. M., Borst, J. W., van der Oost, J. & Weusthuis, R. A., Oct 2018, In : Applied and Environmental Microbiology. 84, 19, p. 1-11 e01640-18.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)