John Groten

prof.dr.ir.

Special Professor, Toxicology
VLAG

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12 Similar Researchers

Estrogen Receptors Chemical Compounds

Ligands Medicine & Life Sciences

Ants Medicine & Life Sciences

Assays Chemical Compounds

Modulation Chemical Compounds

Retinoic Acid Receptors Chemical Compounds

Estrogens Medicine & Life Sciences

Tretinoin Chemical Compounds

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Research Output 1987 2018

27 Article
2 Abstract
1 Inaugural speech
1 internal PhD, WU

The effects of all-trans retinoic acid on estrogen receptor signaling in the estrogen-sensitive MCF/BUS subline

Miro Estruch, I., de Haan, L. H. J., Melchers, D., Houtman, R., Louisse, J., Groten, J. P. & Rietjens, I. M. C. M., Apr 2018, In : Journal of Receptors and Signal Transduction. 38, 2, p. 112-121

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Estrogen Receptor alpha

Tretinoin

Estrogen Receptors

Estrogens

Retinoic Acid Receptors

4 Citations (Scopus)

Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action

Miro Estruch, I., Melchers, D., Houtman, R., de Haan, L. H. J., Groten, J. P., Louisse, J. & Rietjens, I. M. C. M., 2017, In : Biochimica et Biophysica Acta. Proteins & Proteomics. 1865, 9, p. 1195-1206

Research output: Contribution to journal › Article › Academic › peer-review

Retinoic Acid Receptors

Ants

Ligands

Assays

Retinoids

11 Citations (Scopus)

Cell proliferation and modulation of interaction of estrogen receptors with coregulators induced by ERa and ERB agonists

Evers, N. M., van den Berg, J. H. J., Wang, S., Melchers, D., Houtman, J., de Haan, L. H. J., Ederveen, A. G. H., Groten, J. P. & Rietjens, I., 2014, In : Journal of Steroid Biochemistry and Molecular Biology. 143, p. 376-385

Research output: Contribution to journal › Article › Academic › peer-review

Cell proliferation

Estrogen Receptors

Cell Proliferation

Modulation

Assays

7 Citations (Scopus)

Identification of coregulators influenced by estrogen receptor subtype specific binding of the ER antagonists 4-hydroxytamoxifen and fulvestrant

Evers, N. M., Wang, S., van den Berg, J. H. J., Houtman, J., Melchers, D., de Haan, L. H. J., Ederveen, A. G. H., Groten, J. P. & Rietjens, I., 2014, In : Chemico-Biological Interactions. 220, p. 222-230

Research output: Contribution to journal › Article › Academic › peer-review

Estrogen Receptors

Modulation

Ants

Ligands

Assays

4 Citations (Scopus)

Human T47D-ERß breast cancer cells with tetracycline-dependent ERß expression reflect ERa/ERß ratios in rat and human breast tissue

Evers, N. M., van de Klundert, T. M. C., van Aesch, Y. M., Wang, S., de Roos, W. K., Romano, A., de Haan, L. H. J., Murk, A. J., Ederveen, A. G. H., Rietjens, I. M. C. M. & Groten, J. P., 2013, In : Toxicology in Vitro. 27, 6, p. 1753-1761 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Tetracycline

Rats

Breast

Cells

Tissue

Projects 2007 2018

1 Active
3 Finished

Assessment of phospho-signaling in retinal tissues in vitro and in vivo by kinase activity profiling.

Roy, A., Groten, J. & Rietjens, I.

1/10/18 → …

Project: PhD

The cross talk of retinoic acid receptors with estrogen receptors and the consequences for cell proliferation and breast cancer risks.

Miro Estruch, I., Groten, J., Louisse, J. & Rietjens, I.

1/10/13 → 19/06/18

Project: PhD

The role of ERa and ERß in the risk benefit analysis of mixtures of estrogens; Effect of differential ER expression on cell proliferation and apoptosis.

Evers, N., Groten, J. & Rietjens, I.

1/09/09 → 13/06/14

Project: PhD

Development of improved and new in vitro assays for detecting genotoxic and non-genotoxic carcinogenic potential of chemicals in the discovery phase of drug development.

Groten, J. & Rietjens, I.

1/02/07 → 1/03/11

Project: PhD