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Research Output 1983 2019

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internal PhD, WU

Effect-based in vitro bioassays for lipophilic marine biotoxins: a new strategy to replace the mouse bioassay

Bodero, M., 2019, Wageningen: Wageningen University. 176 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Influence of the gut microbiome on plasma metabolite patterns

Behr, C., 2019, Wageningen: Wageningen University. 187 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access

Novel strategies for risk assessment of pyrrolizidine alkaloids

Chen, L., 2019, Wageningen: Wageningen University. 245 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
2018

Alternative developmental toxicity models for assessing the in vivo embryotoxicity of azoles

Dimopoulou, M., 2018, Wageningen: Wageningen University. 198 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Azoles
Tretinoin
Embryonic Structures
Sterols
Toxicology

Phthalates mixtures in bottled water in Iran: human health risk assessment using direct and indirect exposure assessment

Zare Jeddi, M., 2018, Wageningen: Wageningen University. 282 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
2017

Integrated strategy for the assessment of kidney toxicity: the case of aristolochic acids

Abdullah, R., 2017, Wageningen: Wageningen University. 207 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Aristolochic Acids
DNA Adducts
Kidney
Dietary Supplements
aristolochic acid I

Mode of action based risk assessment of the botanical food-borne alkenylbenzenesapiol and myristicin

Alajlouni, A., 2017, Wageningen: Wageningen University. 212 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
risk assessment
food
kinetics
tumor
tea
Open Access
Flavonoids
Biological Availability
Health
Human Body
Biological Assay

Use of physiologically based kinetic modelling facilitated read-across in risk assessment of botanical food-borne alkenylbenzenes

Al-Malahmeh, A., 2017, Wageningen: Wageningen University. 237 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
risk assessment
kinetics
food
modeling
tumor
2016

Alternative testing strategies for predicting developmental toxicity of antifungal compound

Li, H., 2016, Wageningen: Wageningen University. 197 p.

Research output: Thesisinternal PhD, WUAcademic

Computer Simulation
Cell Differentiation
Chickens
Embryonic Structures
In Vitro Techniques

An in vitro – in vivo integrated approach for hazard and risk assessment of silver nanoparticles for soil organisms

Makama, S. I., 2016, Wageningen: Wageningen University. 190 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
nanosilver
nanoparticles
risk assessment
earthworms
uptake mechanisms

Dermal absorption and toxicological risk assessment: pitfalls and promises

Buist, H., 2016, Wageningen: Wageningen University. 200 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Skin Absorption
Toxicology
Skin
Disinfectants
Permeability

In vitro assays for hazard identification of nanoparticles

Kloet, S. K., 2016, Wageningen: Wageningen University. 213 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Nanoparticles
Polystyrenes
Metal Nanoparticles
In Vitro Techniques
Cell Differentiation

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

Sotiriou, A., 2016, Wageningen: Wageningen University. 137 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Resistin
Type 2 Diabetes Mellitus
Pharmaceutical Preparations
Adipocytes
Hypoglycemic Agents

The influence of phase II conjugation on the biological activity of flavonoids

Beekmann, K., 2016, Wageningen: Wageningen University. 171 p.

Research output: Thesisinternal PhD, WUAcademic

Open Access
Flavonoids
Glucuronides
PPAR gamma
Genistein
Protein Kinases
2015

Development of an integrated in vitro model for the prediction of oral bioavailability of nanoparticles

Walczak, A. P., 2015, Wageningen: Wageningen University. 153 p.

Research output: Thesisinternal PhD, WUAcademic

Nanoparticles
Biological Availability
Safety
Digestion
In Vitro Techniques

Improvement of risk assessment by integrating toxicological and epidemiological approaches: the case of isoflavones

Islam, M. A., 2015, Wageningen: Wageningen University. 174 p.

Research output: Thesisinternal PhD, WUAcademic

Isoflavones
Toxicology
Glucuronides
Gene Expression
Estrogens

Innovative mode of action based in vitro assays for detection of marine neurotoxins

Nicolas, J. A. Y., 2015, Wageningen: Wageningen University. 214 p.

Research output: Thesisinternal PhD, WUAcademic

seafood
assay
shellfish
toxin
bioassay
DNA Adducts
Aldehydes
Detoxification
DNA
Animals

Thyroid in a jar: towards an integrated in vitro testing strategy for thyroid-active compounds

Jomaa, B., 2015, Wageningen: Wageningen University. 187 p.

Research output: Thesisinternal PhD, WUAcademic

Thyroid Gland
Thyroid Hormones
Toxicogenetics
Luminol
Iodide Peroxidase
Quercetin
Lipid Metabolism
Flavonoids
Health
High Fat Diet
2014

Contaminants in food supplements and associated health risks

Reeuwijk, N. M., 2014, Wageningen: Wageningen University. 160 p.

Research output: Thesisinternal PhD, WUAcademic

food contamination
dietary supplements
active ingredients
clay
herbal medicines

Factors influencing ER subtype-mediated cell proliferation and apoptosis

Evers, N. M., 2014, Wageningen: Wageningen University. 243 p.

Research output: Thesisinternal PhD, WUAcademic

Estrogen Receptors
Estrogens
Cell Proliferation
Apoptosis
Ligands

New concepts for risk and safety assessment of botanicals and botanical preparations including plant food supplements (PFS)

van den Berg, S. J. P. L., 2014, Wageningen: Wageningen University. 253 p.

Research output: Thesisinternal PhD, WUAcademic

2013

In vitro reporter gene assays for assessment of PPAR- and Nrf2-mediated health effects of tomato and its bioactive constituents

Gijsbers, L., 2013, S.l.: s.n.. 159 p.

Research output: Thesisinternal PhD, WUAcademic

reporter genes
tomatoes
gene expression
assays
extracts
Sulfotransferases
DNA Adducts
methyleugenol
Ocimum basilicum
Flavonoids
Safrole
omega-Chloroacetophenone
Spices
DNA Adducts
Food
methyleugenol
Liver
Sulfotransferases
Metabolic Networks and Pathways
Ocimum basilicum

Toxicogenomics-based in vitro alternatives for estrogenicity testing

Wang, S., 2013, S.l.: s.n.. 193 p.

Research output: Thesisinternal PhD, WUAcademic

Toxicogenetics
Estrogens
Estrogen Receptors
Biological Assay
Uterus

Unravelling hazards of nanoparticles to earthworms, from gene to population

van der Ploeg, M., 2013, S.l.: s.n.. 192 p.

Research output: Thesisinternal PhD, WUAcademic

nanoparticles
earthworms
Lumbricus rubellus
genes
endpoints
2012

Development and hazard assessment of nanoparticles

Bhattacharjee, S., 2012, S.l.: s.n.. 240 p.

Research output: Thesisinternal PhD, WUAcademic

Silicon
Hazards
Nanoparticles
Cytotoxicity
Amines

Development and validation of in vitro bioassays for thyroid hormone receptor mediated endocrine disruption

de Freitas, J., 2012, [S.l.]: s.n.. 192 p.

Research output: Thesisinternal PhD, WUAcademic

Thyroid Hormone Receptors
Thyroid Hormones
Biological Assay
Poisons
Energy Metabolism
Carcinogens
DNA
DNA Adducts
Food
Animal Use Alternatives
Computer Simulation
Safety
Chemical Safety
Toxicity Tests
Poisons
2011

A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man

van de Pas, N., 2011, [S.l.]: S.n..

Research output: Thesisinternal PhD, WUAcademic

Cholesterol
Pharmaceutical Preparations
Liver
Pravastatin
Esterification

Development of aquatic biomonitoring models for surface waters used for drinking water supply

Penders, E. J. M., 2011, [S.l.]: S.n.. 176 p.

Research output: Thesisinternal PhD, WUAcademic

biomonitoring
quality control
bioassay
early warning system
genotoxicity
Drug Discovery
Aryl Hydrocarbon Receptors
Hep G2 Cells
Cell Line
Mammalian Chromosomes
2010

Hormonal effects of prohormones : novel approaches towards effect based screening in veterinary growth promoter control

Rijk, J. C. W., 2010, [S.l.: S.n.. 207 p.

Research output: Thesisinternal PhD, WUAcademic

prasterone
screening
steroids
livestock production
androgens

Increasing hesperetin bioavailability by modulating intestinal metabolism and transport

Brand, W., 2010, [S.l.: S.n.. 168 p.

Research output: Thesisinternal PhD, WUAcademic

Safety of herbal preparations on the Dutch market

Martena, M. J., 2010, [S.l.]: S.n.. 224 p.

Research output: Thesisinternal PhD, WUAcademic

mercury
polycyclic aromatic hydrocarbons
markets
ingredients
acids

The analysis of lipophilic marine toxins : development of an alternative method

Gerssen, A., 2010, [S.l.: S.n.. 199 p.

Research output: Thesisinternal PhD, WUAcademic

Marine Toxins
Shellfish
Electrospray ionization
Assays
Screening

Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds

Sotoca Covaleda, A. M., 2010, [S.l.: S.n.. 186 p.

Research output: Thesisinternal PhD, WUAcademic

Estrogens
Food
Cell Proliferation
Estrogen Receptor alpha
Proteomics
2009

Isothiocyanates from cruciferous vegetables: kinetics, biomarkers and effects

Vermeulen, M., 2009, [S.l.: S.n.. 144 p.

Research output: Thesisinternal PhD, WUAcademic

isothiocyanates
biomarkers
vegetables
kinetics
broccoli
2008

Effectiveness and safety of botanical pesticides applied in black pepper (Piper nigrum) plantations

Wiratno, 2008, [S.l.]: S.n.. 126 p.

Research output: Thesisinternal PhD, WUAcademic

botanical pesticides
Piper nigrum
black pepper
pesticides
plantations

In vivo relevance of in vitro detected estrogenic effects of food associated compounds

ter Veld, M. G. R., 2008, [S.l.]: S.n.. 152 p.

Research output: Thesisinternal PhD, WUAcademic

Estrogens
Fetus
Food
Dichlorodiphenyl Dichloroethylene
Diethylhexyl Phthalate