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Research Output 1983 2019

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Review article
2019

Biotransformation and bioactivation reactions – 2018 literature highlights

Khojasteh, S. C., Bumpus, N. N., Driscoll, J. P., Miller, G. P., Mitra, K., Rietjens, I. M. C. M. & Zhang, D., 6 Aug 2019, In : Drug Metabolism Reviews. 51, 2, p. 121-161

Research output: Contribution to journalReview articleAcademicpeer-review

Biotransformation
Pharmaceutical Preparations
Drug Discovery
Computer Simulation
Toxicology
1 Citation (Scopus)

Novel approaches to derive points of departure for food chemical risk assessment

Levorato, S., Rietjens, I. M. C. M., Carmichael, P. L. & Hepburn, P. A., 16 Mar 2019, In : Current Opinion in Food Science.

Research output: Contribution to journalReview articleAcademicpeer-review

chemical risk assessment
toxicogenomics
Food
in vivo studies
toxicity testing
2018
3 Citations (Scopus)

Biotransformation and bioactivation reactions – 2017 literature highlights

Khojasteh, S. C., Miller, G. P., Mitra, K. & Rietjens, I. M. C. M., 3 Jul 2018, In : Drug Metabolism Reviews. 50, 3, p. 221-255

Research output: Contribution to journalReview articleAcademicpeer-review

Biotransformation
Toxicology
Industry
Students
1 Citation (Scopus)

Risk assessment paradigm for glutamate

Roberts, A., Lynch, B. & Rietjens, I. M. C. M., Dec 2018, In : Annals of Nutrition and Metabolism. 73, Suppl 5, p. 53-64

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
No-Observed-Adverse-Effect Level
Glutamic Acid
Food Safety
Body Weight
Uncertainty
2 Citations (Scopus)

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., 28 Mar 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Food Safety
Flavors
Metabolism
Safety
Glucuronic Acid

Use of proteomics to detect sex-related differences in effects of toxicants: implications for using proteomics in toxicology

Rietjens, I. M. C. M., Vervoort, J., Maslowska-Górnicz, A., Van den Brink, N. & Beekmann, K., 14 Sep 2018, In : Critical Reviews in Toxicology. 48, 8, p. 666-681

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Sex Characteristics
Proteomics
Toxicology
Toxic Actions
Biomarkers
2017
3 Citations (Scopus)

Biotransformation and bioactivation reactions–2016 literature highlights

Khojasteh, S. C., Rietjens, I. M. C. M., Dalvie, D. & Miller, G., 2017, In : Drug Metabolism Reviews. 49, 3, p. 285-317

Research output: Contribution to journalReview articleAcademicpeer-review

Biotransformation
Manuscripts
Metabolic Networks and Pathways
Research
Pharmaceutical Preparations
2015
8 Citations (Scopus)

Matrix-derived combination effects influencing absorption, distribution, metabolism and excretion (ADME) of food-borne toxic compounds: implications for risk assessment

Rietjens, I., Tyrakowska, B., van den Berg, S. J. P. L., Soffers, A. E. M. F. & Punt, A., 2015, In : Toxicology Research. 4, p. 23-35

Research output: Contribution to journalReview articleAcademicpeer-review

Poisons
Metabolism
Risk assessment
Food
Bioassay
73 Citations (Scopus)

Nitrate and nitrite in the diet: How to assess their benefit and risk for human health

Habermeyer, M., Roth, A., Guth, S. & Rietjens, I. M. C. M., 2015, In : Molecular Nutrition & Food Research. 59, 1, p. 106-128

Research output: Contribution to journalReview articleAcademicpeer-review

Nitrites
Nitrates
nitrites
human health
nitrates
59 Citations (Scopus)

Progress and future of in vitro models to study translocation of nanoparticles

Braakhuis, H. M., Kloet, S. K., Kezic, S., Kuper, F., Park, M., Bellmann, S., van der Zande, M., Le Gac, S., Krystek, P., Peters, R. J. B., Rietjens, I. M. C. M. & Bouwmeester, H., 2015, In : Archives of Toxicology. 89, 9, p. 1469-1495

Research output: Contribution to journalReview articleAcademicpeer-review

Open Access
Nanoparticles
Skin
Lung
Microfluidics
Testing
2014
24 Citations (Scopus)
Seafood
neurotoxins
Neurotoxins
seafoods
mechanism of action
2013
54 Citations (Scopus)

Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks

Rietjens, I. M. C. M., Sotoca, A. M., Vervoort, J. & Louisse, J., 2013, In : Molecular Nutrition & Food Research. 57, 1, p. 100-113

Research output: Contribution to journalReview articleAcademicpeer-review

Isoflavones
isoflavones
Estrogen Receptors
mechanism of action
cell proliferation
2012
62 Citations (Scopus)

Alkaloids in the human food chain - Natural occurrence and possible adverse effects

Koleva, I., van Beek, T. A., Soffers, A. E. M. F., Dusemund, B. & Rietjens, I., 2012, In : Molecular Nutrition & Food Research. 56, 1, p. 30-52

Research output: Contribution to journalReview articleAcademicpeer-review

human food chain
Food Chain
Alkaloids
alkaloids
adverse effects
40 Citations (Scopus)

A state-of-the-art overview of the effect of metabolic conjugation on the biological activity of flavonoids

Beekmann, K., Actis-Goretta, L., van Bladeren, P. J., Dionisi, F., Destaillats, F. & Rietjens, I., 2012, In : Food & Function. 3, 10, p. 1008-1018

Research output: Contribution to journalReview articleAcademicpeer-review

Flavonoids
bioactive properties
flavonoids
endpoints
Endpoint Determination
9 Citations (Scopus)

Safety assessment of smoke flavouring primary products by the European Food Safety Authority

Theobald, A., Arcella, D., Carere, A., Croera, C., Engel, K. H., Gott, D., Gurtler, R., Meier, D., Pratt, I., Rietjens, I. M. C. M., Simon, R. & Walker, R., 2012, In : Trends in Food Science and Technology. 27, 2, p. 97-108

Research output: Contribution to journalReview articleAcademicpeer-review

safety assessment
Food Safety
flavorings
smoke
Smoke
19 Citations (Scopus)

Toward relevant biomarkers in in vitro developmental toxicity and their extrapolation to the in vivo situation : Reviews

Louisse, J., Woutersen, R. A., Blaauboer, B. J., Verwei, M. & Rietjens, I., 2012, In : Expert Opinion on Drug Metabolism and Toxicology. 8, 1, p. 11-27

Research output: Contribution to journalReview articleAcademicpeer-review

Biomarkers
Extrapolation
Toxicity
Assays
Dosimetry
2011
21 Citations (Scopus)

Safety assessment of plant food supplements (PFS)

van den Berg, S. J. P. L., Serra-Majem, L., Coppens, P. & Rietjens, I., 2011, In : Food & Function. 2, 12, p. 760-768

Research output: Contribution to journalReview articleAcademicpeer-review

safety assessment
Dietary Supplements
dietary supplements
Safety
markets
26 Citations (Scopus)

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients

Adams, T. B., Lucas Gavin, C., McGowen, M. M., Waddell, W. J., Cohen, S. M., Feron, V. J., Marnett, L. J., Munro, I. C., Porthogese, P. S., Rietjens, I. & Smith, R. L., 2011, In : Food and Chemical Toxicology. 49, 10, p. 2471-2494

Research output: Contribution to journalReview articleAcademicpeer-review

Aromatic Hydrocarbons
Flavors
Terpenes
flavorings
Hydrocarbons
46 Citations (Scopus)

Update of risk assessments of main marine biotoxins in the European Union

Paredes, I., Rietjens, I., Vieites, J. M. & Cabado, A. G., 2011, In : Toxicon. 58, 4, p. 336-354

Research output: Contribution to journalReview articleAcademicpeer-review

Imines
Tetrodotoxin
European Union
Risk assessment
Hazards
2010
29 Citations (Scopus)

In silico methods for physiologically based biokinetic models describing bioactivation and detoxification of coumarin and estragole: Implications for risk assessment

Rietjens, I., Punt, A., Schilter, B., Scholz, G., Delatour, T. & van Bladeren, P. J., 2010, In : Molecular Nutrition & Food Research. 54, 2, p. 195-207

Research output: Contribution to journalReview articleAcademicpeer-review

methyl chavicol
coumarin
Computer Simulation
risk assessment
Chemical Safety
30 Citations (Scopus)

Safety assessment of botanicals and botanical preparations used as ingredients in food supplements: Testing an EFS tired approach

Speijers, G., Bottex, B., Dusemund, B., Lugasi, A., Toth, J., Amberg-Muller, J., Galli, C., Silano, V. & Rietjens, I., 2010, In : Molecular Nutrition & Food Research. 54, p. 175-185

Research output: Contribution to journalReview articleAcademicpeer-review

safety assessment
Dietary Supplements
dietary supplements
ingredients
Safety
2008
60 Citations (Scopus)

Promises and pitfalls of Quantitative Structure-Activity Relationship approaches for predicting metabolism and toxicity

Zvinavashe, E., Murk, A. J. & Rietjens, I. M. C. M., 2008, In : Chemical Research in Toxicology. 21, 12, p. 2229-2236

Research output: Contribution to journalReview articleAcademicpeer-review

Quantitative Structure-Activity Relationship
Metabolism
Toxicity
Guidelines
Economics
23 Citations (Scopus)

The FEMA GRAS assessment of a,b-unsaturated aldehydes and related substances used as flavor ingredients

Adams, T. B., Lucas-Gavin, C., Taylor, S. V., Waddell, W. J., Cohen, S. M., Feron, V. J., Goodman, J., Rietjens, I. M. C. M., Marnett, L. J., Portoghese, P. S. & Smith, R. L., 2008, In : Food and Chemical Toxicology. 46, 9, p. 2935-2967

Research output: Contribution to journalReview articleAcademicpeer-review

Flavors
flavorings
Aldehydes
aldehydes
ingredients
2006
120 Citations (Scopus)

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients

Brand, W., Schutte, M. E., van Bladeren, P. J. & Rietjens, I. M. C. M., 2006, In : Biomedicine and Pharmacotherapy. 60, 9, p. 508-519 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

ATP-Binding Cassette Transporters
Poisons
Flavonoids
Biological Availability
Food
2005
62 Citations (Scopus)

Molecular mechanisms of toxicity of important food-borne phytotoxins

Rietjens, I. M. C. M., Martena, M. J., Boersma, M. G., Spiegelenberg, W. & Alink, G. M., 2005, In : Molecular Nutrition & Food Research. 49, 2, p. 131-158 27 p.

Research output: Contribution to journalReview articleAcademicpeer-review

food intoxication
methyleugenol
phytotoxins
Phytochemicals
Tea
32 Citations (Scopus)

The definition of hormesis and its implications for in vitro to in vivo extrapolation and risk assessment

van der Woude, H., Alink, G. M. & Rietjens, I. M. C. M., 2005, In : Critical Reviews in Toxicology. 35, 6, p. 603-607 5 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Hormesis
Cell proliferation
Extrapolation
Risk assessment
Pharmacokinetics
2004
113 Citations (Scopus)

Safety evaluation of neem (Azadirachta indica) derived pesticides

Boeke, S. J., Boersma, M. G., Alink, G. M., van Loon, J. J. A., van Huis, A., Dicke, M. & Rietjens, I. M. C. M., 2004, In : Journal of Ethnopharmacology. 94, 1, p. 25-41 17 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Azadirachta
Poisons
Pesticides
Safety
Insecticides