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Research Output 1983 2019

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2019

Analysis of metabolome changes in the bile acid pool in feces and plasma of antibiotic-treated rats

Behr, C., Slopianka, M., Haake, V., Strauss, V., Sperber, S., Kamp, H., Walk, T., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Jan 2019, In : Toxicology and Applied Pharmacology. 363, p. 79-87

Research output: Contribution to journalArticleAcademicpeer-review

Metabolome
Bile Acids and Salts
Feces
Rats
Anti-Bacterial Agents

Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs

Kramer, N. I., Hoffmans, Y., Wu, S., Thiel, A., Thatcher, N., Allen, T. E. H., Levorato, S., Traussnig, H., Schulte, S., Boobis, A., Rietjens, I. M. C. M. & Vinken, M., Aug 2019, In : Archives of Toxicology. 93, 8, p. 2115-2125

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food additives
Food Additives
Safety
Databases
Cardiovascular system
Open Access
Maerua
glucobrassicin
Gene expression
Cytotoxicity
Fruits

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Citrus
Flavors
flavorings
ingredients
flavor
1 Citation (Scopus)

Hazard assessment of Maerua subcordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests

Gebrelibanos Hiben, M., Kamelia, L., de Haan, L., Spenkelink, B., Wesseling, S., Vervoort, J. & Rietjens, I. M. C. M., 15 Sep 2019, In : Journal of Ethnopharmacology. 241, 111978.

Research output: Contribution to journalArticleAcademicpeer-review

Aryl Hydrocarbon Receptors
Fruit
Zebrafish
Isothiocyanates
Traditional Medicine

Induction of EpRE-mediated gene expression by a series of mediterranean botanicals and their constituents

Papadi, G., Wesseling, S., Troganis, A. N., Vervoort, J. & Rietjens, I. M. C. M., 10 Aug 2019, In : Journal of Ethnopharmacology. 240, 13 p., 111940.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Frangula
Rhamnus
Gene Expression
Liquid Chromatography
Mass Spectrometry
Open Access
Aryl Hydrocarbon Receptors
Polycyclic Aromatic Hydrocarbons
Petroleum
Toxicity
Dimethyl Sulfoxide
2 Citations (Scopus)

Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment

Suparmi, S., Ginting, A. J., Mariyam, S., Wesseling, S. & Rietjens, I. M. C. M., 1 Mar 2019, In : Food and Chemical Toxicology. 125, p. 467-478

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
methyleugenol
Eugenol
Beverages
eugenol
Risk assessment
Open Access
Pyrrolizidine Alkaloids
Liver
Dosimetry
Rats
Kinetics
Open Access
exposure scenario
Pyrrolizidine Alkaloids
herbal tea
pyrrolizidine alkaloids
Herbal Medicine
Open Access
Pyrrolizidine Alkaloids
pyrrolizidine alkaloids
Risk assessment
pharmacokinetics
risk assessment
1 Citation (Scopus)
Open Access
Diethylstilbestrol
Toxicity
Rats
Testing
Cell Differentiation
5 Citations (Scopus)
Open Access
Pyrrolizidine Alkaloids
Liver
Computer Simulation
Toxicity
Kinetics
2018
6 Citations (Scopus)

A comparison of the embryonic stem cell test and whole embryo culture assay combined with the BeWo placental passage model for predicting the embryotoxicity of azoles

Dimopoulou, M., Verhoef, A., Gomes, C. A., van Dongen, C. W., Rietjens, I. M. C. M., Piersma, A. H. & van Ravenzwaay, B., 1 Apr 2018, In : Toxicology Letters. 286, p. 10-21

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Azoles
Embryonic Stem Cells
Stem cells
Cell culture
Assays
1 Citation (Scopus)

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents

Zare Jeddi, M., Eshaghi Gorji, M., Rietjens, I. M. C. M., Louisse, J., Bruinen de Bruin, Y. & Liska, R., 23 Oct 2018, In : International Journal of Environmental Research and Public Health. 15, 11, 2336.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Environmental Monitoring
Dibutyl Phthalate
phthalic acid
Health
Safety
7 Citations (Scopus)

Effects of systematic variation in size and surface coating of silver nanoparticles on their in vitro toxicity to macrophage RAW 264.7 cells

Makama, S. I., Kloet, S. K., Piella, J., van den Berg, J. H. J., de Ruijter, N. C. A., Puntes, V. F., Rietjens, I. M. C. M. & van den Brink, N. W., 1 Mar 2018, In : Toxicological sciences. 162, 1, p. 79-88

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Silver
Nanoparticles
Toxicity
Reactive Oxygen Species
8 Citations (Scopus)

Exposure assessment of process-related contaminants in food by biomarker monitoring

Rietjens, I. M. C. M., Dussort, P., Günther, H., Hanlon, P., Honda, H., Mally, A., O’Hagan, S., Scholz, G., Seidel, A., Swenberg, J., Teeguarden, J. & Eisenbrand, G., Jan 2018, In : Archives of Toxicology. 92, 1, p. 15-40

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Process Assessment (Health Care)
Biomarkers
Impurities
Food
Monitoring
2 Citations (Scopus)

Impact of lincosamides antibiotics on the composition of the rat gut microbiota and the metabolite profile of plasma and feces

Behr, C., Ramírez-Hincapié, S., Cameron, H. J., Strauss, V., Walk, T., Herold, M., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Oct 2018, In : Toxicology Letters. 296, p. 139-151

Research output: Contribution to journalArticleAcademicpeer-review

Lincosamides
Microbiota
Metabolites
Feces
Rats
2 Citations (Scopus)
Open Access
Physical Chemistry
Physical chemistry
Nanoparticles
Polystyrenes
Adhesion

Introduction and summary of the 2018 dietary glutamate workshop

Cynober, L., Fernstrom, J. D., Koletzko, B., Rietjens, I. M. C. M., Roberts, A., Tennant, D. R., Tomé, D. & Vorhees, C. V., Dec 2018, In : Annals of Nutrition and Metabolism. 73, Suppl 5, 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glutamates
No-Observed-Adverse-Effect Level
Glutamic Acid
Education
Safety
2 Citations (Scopus)

Microbiome-related metabolite changes in gut tissue, cecum content and feces of rats treated with antibiotics

Behr, C., Sperber, S., Jiang, X., Strauss, V., Kamp, H., Walk, T., Herold, M., Beekmann, K., Rietjens, I. M. C. M. & van Ravenzwaay, B., 15 Sep 2018, In : Toxicology and Applied Pharmacology. 355, p. 198-210

Research output: Contribution to journalArticleAcademicpeer-review

Cecum
Microbiota
Metabolites
Feces
Rats
6 Citations (Scopus)

Natural occurrence of genotoxic and carcinogenic alkenylbenzenes in Indonesian jamu and evaluation of consumer risks

Suparmi, S., Widiastuti, D., Wesseling, S. & Rietjens, I. M. C. M., Aug 2018, In : Food and Chemical Toxicology. 118, p. 53-67

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
methyleugenol
average daily intake
Herbal Medicine
herbal medicines
Traditional Medicine
4 Citations (Scopus)

Perceived versus real toxicological safety of pangasius catfish: a review modifying market perspectives

Murk, A. J., Rietjens, I. M. C. M. & Bush, S. R., Mar 2018, In : Reviews in Aquaculture. 10, 1, p. 123-134

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Pangasianodon hypophthalmus
catfish
safety
markets
market
2 Citations (Scopus)

Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test

Kamelia, L., Brugman, S., de Haan, L. H. J., Ketelslegers, H. B., Rietjens, I. M. C. M. & Boogaard, P., 7 Dec 2018, In : Altex. 36, 2, p. 245-260

Research output: Contribution to journalArticleAcademicpeer-review

Petroleum
Zebrafish
Embryonic Stem Cells
Polycyclic Aromatic Hydrocarbons
Gases
9 Citations (Scopus)

Risk assessment of aflatoxin B1 exposure from maize and peanut consumption in Indonesia using the margin of exposure and liver cancer risk estimation approaches

Nugraha, A., Khotimah, K. & Rietjens, I. M. C. M., 1 Mar 2018, In : Food and Chemical Toxicology. 113, p. 134-144

Research output: Contribution to journalArticleAcademicpeer-review

Aflatoxin B1
risk estimate
Indonesia
liver neoplasms
aflatoxin B1
2 Citations (Scopus)

Risk assessment of genotoxic and carcinogenic alkenylbenzenes in botanical containing products present on the Chinese market

Ning, J., Cui, X. Y., Kong, X. N., Tang, Y. F., Wulandari, R., Chen, L., Wesseling, S. & Rietjens, I. M. C. M., May 2018, In : Food and Chemical Toxicology. 115, p. 344-357

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chinese Traditional Medicine
herbal tea
Risk assessment
risk assessment
Medicine

Soy supplementation: Impact on gene expression in different tissues of ovariectomized rats and evaluation of the rat model to predict (post)menopausal health effect

Islam, M. A., Hooiveld, G. J. E. J., van den Berg, J. H. J., van der Velpen, V., Murk, A. J., Rietjens, I. M. C. M. & van Leeuwen, F. X. R., 24 Oct 2018, In : Toxicology Reports. 5, p. 1087-1097

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Gene expression
Rats
Health
Tissue
Gene Expression
Open Access
Tretinoin
Estrogen Receptors
Estrogens
Retinoic Acid Receptors
Gene expression
8 Citations (Scopus)

The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays

Kamelia, L., Louisse, J., de Haan, L., Maslowska-Gornicz, A., Ketelslegers, H. B., Brouwer, A., Rietjens, I. M. C. M. & Boogaard, P. J., 1 Aug 2018, In : Toxicological sciences. 164, 2, p. 576-591

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dioxins
Polycyclic Aromatic Hydrocarbons
Petroleum
Luciferases
Reporter Genes
3 Citations (Scopus)
Open Access
Dosimetry
Rats
Assays
Estrogens
Yeasts
4 Citations (Scopus)

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., 1 Mar 2018, In : Food and Chemical Toxicology. 113, p. 171-178

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Flavors
ingredients
flavor
Safety
Food
9 Citations (Scopus)
Open Access
riddelliine
hepatotoxicity
Cytotoxicity
Liver
Dosimetry
2017
3 Citations (Scopus)

A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture

Dimopoulou, M., Verhoef, A., Pennings, J. L. A., van Ravenzwaay, B., Rietjens, I. M. C. M. & Piersma, A. H., 1 Dec 2017, In : Toxicology. 392, p. 96-105

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Azoles
Rats
Embryonic Structures
Sterols
Tretinoin
4 Citations (Scopus)
Retinoic Acid Receptors
Ants
Ligands
Assays
Retinoids
9 Citations (Scopus)

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in basil-containing sauce of pesto

Al-Malahmeh, A. J., Al-Ajlouni, A. M., Wesseling, S., Vervoort, J. & Rietjens, I. M. C. M., 2017, In : Toxicology Reports. 4, p. 1-8

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
methyleugenol
Ocimum basilicum
Risk assessment
Risk Management
Risk management
6 Citations (Scopus)

Determination and risk assessment of naturally occurring genotoxic and carcinogenic alkenylbenzenes in nutmeg-based plant food supplements

Al-Malahmeh, A. J., Alajlouni, A., Ning, J., Wesseling, S., Vervoort, J. & Rietjens, I. M. C. M., 2017, In : Journal of Applied Toxicology. 37, 10, p. 1254-1264

Research output: Contribution to journalArticleAcademicpeer-review

Myristica fragrans
Dietary Supplements
Risk assessment
Body Weight
Risk Management
3 Citations (Scopus)
Phenol
Toxicity
Kinetics
Dosimetry
Population
4 Citations (Scopus)

Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis

Dimopoulou, M., Verhoef, A., Pennings, J. L. A., van Ravenzwaay, B., Rietjens, I. M. C. M. & Piersma, A. H., 2017, In : Toxicology and Applied Pharmacology. 322, p. 15-26

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Azoles
Ketoconazole
Rats
Sterols
Embryonic Structures
10 Citations (Scopus)

Gut microbiome-related metabolic changes in plasma of antibiotic-treated rats

Behr, C., Kamp, H., Fabian, E., Krennrich, G., Mellert, W., Peter, E., Strauss, V., Walk, T., Rietjens, I. M. C. M. & van Ravenzwaay, B., 2017, In : Archives of Toxicology. 91, 10, p. 3439-3454

Research output: Contribution to journalArticleAcademicpeer-review

Microbiota
Rats
Metabolites
Anti-Bacterial Agents
Plasmas
11 Citations (Scopus)
Open Access
Phenols
Toxicity
Kinetics
Dosimetry
Stem cells
5 Citations (Scopus)
Biological Assay
Health
In Vitro Techniques
4 Citations (Scopus)

In vitro-in silico-based analysis of the dose-dependent in vivo oestrogenicity of the soy phytoestrogen genistein in humans

Boonpawa, R., Spenkelink, A., Punt, A. & Rietjens, I. M. C. M., 2017, In : British Journal of Pharmacology. 174, 16, p. 2739-2757

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Phytoestrogens
Genistein
Computer Simulation
In Vitro Techniques
Benchmarking
12 Citations (Scopus)
Seafood
seafood
twenty first century
seafoods
Disease Outbreaks
4 Citations (Scopus)

Nitrite in processed meat products in Khartoum, Sudan and dietary intake

Adam, A. H. B., Mustafa, N. E. M. & Rietjens, I. M. C. M., 2017, In : Food Additives & Contaminants Part B-Surveillance. 10, 2, p. 79-84

Research output: Contribution to journalArticleAcademicpeer-review

Sudan
Meat Products
Meats
Nitrites
meat products
1 Citation (Scopus)

Pflanzliche Kontaminanten in Lebensmitteln: Vorkommen, Wirkung und Risikobewertung

Dusemund, B., Rietjens, I. M. C. M., Cartus, A., Schaefer, B. & Lampen, A., 2017, In : Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz. 60, 7, p. 728-736

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Food Chain
Food
Carcinogens
DNA
4 Citations (Scopus)

Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans

Boonpawa, R., Spenkelink, B., Punt, A. & Rietjens, I., 2017, In : Molecular Nutrition & Food Research. 61, 8, 1600894.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Hesperidin
hesperidin
kinetics
metabolism
dosage
13 Citations (Scopus)

Physiologically based kinetic modeling of the bioactivation of myristicin

Al-Malahmeh, A. J., Al-Ajlouni, A., Wesseling, S., Soffers, A. E. M. F., Al-Subeihi, A., Kiwamoto, R., Vervoort, J. & Rietjens, I. M. C. M., 2017, In : Archives of Toxicology. 91, 22 p., 713.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Safrole
Kinetics
Metabolites
Rats
Liver
6 Citations (Scopus)
Open Access
Polycyclic Aromatic Hydrocarbons
Petroleum
Stem cells
Toxicity
Testing
15 Citations (Scopus)
Open Access
Pyrrolizidine Alkaloids
Dietary Supplements
Risk assessment
Risk Management
Risk management
6 Citations (Scopus)
Anethum graveolens
Petroselinum
dill
parsley
Dietary Supplements