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Research Output 1981 2019

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Article
2019
7 Citations (Scopus)

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M., Van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., De Vos, P., Dekker, J. & Wells, J. M., 5 Feb 2019, In : Scientific Reports. 9, 1, 1437.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Mucus
Immunity
Paneth Cells
T-Lymphocytes
3 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mucus
B-Lymphocytes
B-Lymphoid Precursor Cells
Transcriptome
Anti-Inflammatory Agents
1 Citation (Scopus)
Open Access
lactoglobulins
immunoglobulin E
Lactoglobulins
Lactose
glycation

Genomic regions associated with IgE levels against culicoides spp. Antigens in three horse breeds

François, L., Hoskens, H., Velie, B. D., Stinckens, A., Tinel, S., Lamberigts, C., Peeters, L., Savelkoul, H. F. J., Tijhaar, E., Lindgren, G., Janssens, S., Ducro, B. J., Buys, N. & Schurink, A., 1 Aug 2019, In : Genes. 10, 8, 597.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Ceratopogonidae
Insect Bites and Stings
Immunoglobulin E
Horses
Hypersensitivity
4 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Allergens
Immunoglobulin E
Anacardiaceae
1 Citation (Scopus)

Oxidative stress and immune aberrancies in attention-deficit/hyperactivity disorder (ADHD): a case–control comparison

Verlaet, A. A. J., Breynaert, A., Ceulemans, B., De Bruyne, T., Fransen, E., Pieters, L., Savelkoul, H. F. J. & Hermans, N., 1 May 2019, In : European Child and Adolescent Psychiatry. 28, 5, p. 719-729 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Oxidative Stress
Malondialdehyde
Immunoglobulin E
coenzyme Q10

Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women

van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E. & Joost van Neerven, R. J., 12 Dec 2019, In : PLoS ONE. 14, 12, e0225825.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Toll-Like Receptors
Myeloid Cells
dendritic cells
young adults
Dendritic Cells
Open Access
Volatile Fatty Acids
Microbiota
Oligosaccharides
Human Milk
Prebiotics
8 Citations (Scopus)

Systematic Comparison of Zwitterionic and Non-Zwitterionic Antifouling Polymer Brushes on a Bead-Based Platform

van Andel, E., Lange, S. C., Pujari, S. P., Tijhaar, E. J., Smulders, M. M. J., Savelkoul, H. F. J. & Zuilhof, H., Feb 2019, In : Langmuir. 35, 5, p. 1181–1191

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
antifouling
brushes
Brushes
beads
Polymers
2 Citations (Scopus)

The Basophil Activation Test reduces the need for a food challenge test in children suspected of IgE-mediated cow's milk allergy

Ruinemans-Koerts, J., Schmidt-Hieltjes, Y., Jansen, A., Savelkoul, H. F. J., Plaisier, A. & van Setten, P., Mar 2019, In : Clinical and Experimental Allergy. 49, 3, p. 350-356

Research output: Contribution to journalArticleAcademicpeer-review

Milk Hypersensitivity
Basophils
Immunoglobulin E
Food
Placebos
1 Citation (Scopus)

The impact of pectin supplementation on intestinal barrier function in healthy young adults and healthy elderly

Wilms, E., Jonkers, D. M. A. E., Savelkoul, H. F. J., Elizalde, M., Tischmann, L., de Vos, P., Masclee, A. A. M. & Troost, F. J., 1 Jul 2019, In : Nutrients. 11, 7, 1554.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
young adults
pectins
Young Adult
placebos
Placebos
1 Citation (Scopus)

Toll-like receptor agonists as adjuvants for inactivated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine

Vreman, S., McCaffrey, J., Popma-de Graaf, D. J., Nauwynck, H., Savelkoul, H. F. J., Moore, A., Rebel, J. M. J. & Stockhofe-Zurwieden, N., 1 Jun 2019, In : Veterinary Immunology and Immunopathology. 212, p. 27-37 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Porcine respiratory and reproductive syndrome virus
Porcine reproductive and respiratory syndrome virus
Toll-Like Receptors
agonists
adjuvants

Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol®

Verlaet, A., van der Bolt, N., Meijer, B., Breynaert, A., Naessens, T., Konstanti, P., Smidt, H., Hermans, N., Savelkoul, H. F. J. & Teodorowicz, M., 22 Jan 2019, In : Nutrients. 11, 2

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Toll-Like Receptors
agonists
interleukin-10
microorganisms
metabolism
2018

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

Van Beek, A. A., Fransen, F., Meijer, B., de Vos, P., Knol, E. F. & Savelkoul, H. F. J., 29 Nov 2018, In : Immunity and Ageing. 15, 1, 32.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Basophils
Microbiota
Bone Marrow
Phenotype
Spleen
3 Citations (Scopus)

BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells

den Hartog, C. G., van Osch, T. L. J., Vos, M., Meijer, B., Savelkoul, H. F. J., van Neerven, R. J. J. & Brugman, S., 9 Feb 2018, In : European journal of immunology. 48, 2, p. 283-292

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Interleukin-10
Immunoglobulin A
Blood Cells
B-Lymphocytes
Virus Diseases
2 Citations (Scopus)

Bovine lactoferrin enhances TLR7-mediated responses in plasmacytoid dendritic cells in elderly women: Results from a nutritional intervention study with bovine lactoferrin, GOS and Vitamin D

van Splunter, M., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Floris-Vollenbroek, E. G., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E. & van Neerven, R. J. J., 20 Nov 2018, In : Frontiers in Immunology. 9, 2677.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactoferrin
Vitamin D
Dendritic Cells
Toll-Like Receptors
Placebos
3 Citations (Scopus)

Bovine lactoferrin modulates dendritic cell differentiation and function

Perdijk, O., van Neerven, R. J. J., van den Brink, E., Savelkoul, H. F. J. & Brugman, S., 29 Jun 2018, In : Nutrients. 10, 7, 848.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactoferrin
lactoferrin
dendritic cells
cell differentiation
Dendritic Cells
9 Citations (Scopus)

Cow's milk and immune function in the respiratory tract: Potential mechanisms

Perdijk, O., van Splunter, M., Savelkoul, H. F. J., Brugman, S. & van Neerven, J., 12 Feb 2018, In : Frontiers in Immunology. 9, FEB, 143.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Respiratory System
Milk
Respiratory Tract Infections
Asthma
Allergens

Effects of bovine immunoglobulin on immune function, allergy and infection

Ulfman, L. H., Leusen, J. H. W., Savelkoul, H. F. J., Warner, J. O. & van Neerven, R. J. J., 22 Jun 2018, In : Frontiers in Nutrition. 5, 20 p., 52.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Immunoglobulins
Hypersensitivity
Immunoglobulin G
Infection
Colostrum
1 Citation (Scopus)
Open Access
Maillard Reaction
Advanced Glycosylation End Products
Immunomodulation
Livestock
Pets
7 Citations (Scopus)

Induction of human tolerogenic dendritic cells by 3′-sialyllactose via TLR4 is explained by LPS contamination

Perdijk, O., Joost Van Neerven, R. J., Meijer, B., Savelkoul, H. F. J. & Brugman, S., 1 Mar 2018, In : Glycobiology. 28, 3, p. 126-130

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dendritic Cells
Contamination
3'-sialyllactose
Toll-Like Receptor 4
Toll-Like Receptors
1 Citation (Scopus)

Induction of trained innate immunity in human monocytes by bovine milk and milk-derived immunoglobulin G

van Splunter, M., van Osch, T. L. J., Brugman, S., Savelkoul, H. F. J., Joosten, L. A. B., Netea, M. G. & van Neerven, R. J. J., 27 Sep 2018, In : Nutrients. 10, 10, 1378.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
immunoglobulin G
Innate Immunity
monocytes
Monocytes
Milk
4 Citations (Scopus)

Neonatal porcine blood derived dendritic cell subsets show activation after TLR2 or TLR9 stimulation

Vreman, S., Auray, G., Savelkoul, H. F. J., Rebel, A., Summerfield, A. & Stockhofe-Zurwieden, N., Jul 2018, In : Developmental and Comparative Immunology. 84, p. 361-370

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Dendritic Cells
Swine
Ligands
Toll-Like Receptor 2
Antigen-Presenting Cells
3 Citations (Scopus)

Oral cholera vaccination promotes homing of IgA+ memory B cells to the large intestine and the respiratory tract

van Splunter, M., van Hoffen, E., Floris-Vollenbroek, E. G., Timmerman, H., van de Bos, E. L., Meijer, B., Ulfman, L. H., Witteman, B., Wells, J. M., Brugman, S., Savelkoul, H. F. J. & van Neerven, R. J. J., 2018, In : Mucosal Immunology. 11, 4, p. 1254-1264

Research output: Contribution to journalArticleAcademicpeer-review

Cholera
Large Intestine
Respiratory System
Immunoglobulin A
Vaccination
1 Citation (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Nuts
Anas
3 Citations (Scopus)

Rationale for dietary antioxidant treatment of ADHD

Verlaet, A. A. J., Maasakkers, C. M., Hermans, N. & Savelkoul, H. F. J., 1 Apr 2018, In : Nutrients. 10, 4, 405.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Attention Deficit Disorder with Hyperactivity
Antioxidants
antioxidants
immune system
oxidative stress
12 Citations (Scopus)

Sex and strain dependent differences in mucosal immunology and microbiota composition in mice

Elderman, M., Hugenholtz, F., Belzer, C., Boekschoten, M., van Beek, A., de Haan, B., Savelkoul, H., de Vos, P. & Faas, M., 18 Jun 2018, In : Biology of Sex Differences. 9, 26.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Allergy and Immunology
Sex Characteristics
Disease
Clostridium
2 Citations (Scopus)

Single nucleotide polymorphisms in the vitamin D receptor gene (VDR) may have an impact on acute pancreatitis (AP) development: A prospective study in populations of AP patients and alcohol-abuse controls

Cieślińska, A., Kostyra, E., Fiedorowicz, E., Snarska, J., Kordulewska, N., Kiper, K. & Savelkoul, H. F. J., 1 Jul 2018, In : International Journal of Molecular Sciences. 19, 7, 1919.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
calciferol
Calcitriol Receptors
Vitamins
polymorphism
nucleotides
4 Citations (Scopus)
Open Access
galactooligosaccharides
dendritic cells
Oligosaccharides
oligosaccharides
cell differentiation
2017
44 Citations (Scopus)

Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice

Fransen, F., van Beek, A. A., Borghuis, T., El Aidy, S., Hugenholtz, F., van der Gaast - de Jongh, C., Savelkoul, H. F. J., de Jonge, M. I., Boekschoten, M. V., Smidt, H., Faas, M. M. & de Vos, P., 2 Nov 2017, In : Frontiers in Immunology. 8, 1385.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Inflammation
Proteobacteria
Peyer's Patches
Gastrointestinal Microbiome

An alternative inhibition method for determining cross-reactive allergens

Schmidt-Hieltjes, Y., Teodorowicz, G., Jansen, A., Den Hartog, G., Elfvering-Berendsen, L., De Jong, N. W., Savelkoul, H. F. J. & Ruinemans-Koerts, J., 2017, In : Clinical Chemistry and Laboratory Medicine. 55, 2, p. 248-253

Research output: Contribution to journalArticleAcademicpeer-review

Allergens
Ficus
Assays
Enzyme-Linked Immunosorbent Assay
Carica

Chronisch ontstoken: (zonder dat je het weet)

Savelkoul, H. F. J., 30 Sep 2017, In : gezondnu. januari, p. 80-83

Research output: Contribution to journalArticlePopular

Een tennisveld vol bacterien: de sleutel tot je immuunsysteem

Savelkoul, H. F. J., 2017, In : Allergie & Voeding. 4, p. 6-8

Research output: Contribution to journalArticlePopular

Open Access
5 Citations (Scopus)

Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD): Study protocol for a randomised controlled trial

Verlaet, A. A. J., Ceulemans, B., Verhelst, H., Van West, D., De Bruyne, T., Pieters, L., Savelkoul, H. F. J. & Hermans, N., 2017, In : Trials. 18, 9 p., 145.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Attention Deficit Disorder with Hyperactivity
Randomized Controlled Trials
Methylphenidate
Antioxidants
Placebos
27 Citations (Scopus)

Food processing: The influence of the maillard reaction on immunogenicity and allergenicity of food proteins

Teodorowicz, M., Van Neerven, J. & Savelkoul, H., 2017, In : Nutrients. 9, 8, 835.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Maillard Reaction
Maillard reaction products
allergenicity
Food Handling
Maillard reaction
1 Citation (Scopus)

Genetic aspects of auto-immune profiles of healthy chickens

Parmentier, H. K., van der Vaart, P. S., Nieuwland, M. G. B. & Savelkoul, H. F. J., 2017, In : Developmental and Comparative Immunology. 74, p. 90-100

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Chickens
Antibodies
Immunoglobulin M
Immunoglobulin G
Mothers
13 Citations (Scopus)

Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry

Van Andel, E., De Bus, I., Tijhaar, E. J., Smulders, M. M. J., Savelkoul, H. F. J. & Zuilhof, H., 8 Nov 2017, In : ACS Applied Materials and Interfaces. 9, 44, p. 38211-38221

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Flow cytometry
Biofouling
Polymers
Proteins
Adsorption
4 Citations (Scopus)

Measurement of allergen-specific IgG in serum is of limited value for the management of dogs diagnosed with cutaneous adverse food reactions

Hagen-Plantinga, E. A., Leistra, M. H. G., Sinke, J. D., Vroom, M. W., Savelkoul, H. F. J. & Hendriks, W. H., 2017, In : The Veterinary Journal. 220, p. 111-116

Research output: Contribution to journalArticleAcademicpeer-review

allergens
blood serum
Allergens
Immunoglobulin G
Dogs
19 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
4 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Immunoglobulin E
Nut Hypersensitivity
Food
35 Citations (Scopus)

The impact of gut microbiota on gender-specific differences in immunity

Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., Savelkoul, H. F., de Jonge, M. I., Faas, M. M., Boekschoten, M. V., Smidt, H., Aidy, S. E. & de Vos, P., 2017, In : Frontiers in Immunology. 8, 14 p., 754.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Immune System
Immunity
Interferon Type I
DNA Damage

Treating autism spectrum disorder with gluten-free and casein-free diet: the underlying microbiota-gut-brain axis mechanisms

Ciéslińska, A., Kostyra, E. & Savelkoul, H. F. J., 2017, In : HSOA Journal of Clinical Immunology and Immunotherapy. 3, 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glutens
Caseins
Diet
Brain
Autism Spectrum Disorder
9 Citations (Scopus)

Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O. I. J., Vermeij, W., Brandt, R. M., Barnhoorn, R., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J., Hendriks, R. W. & Savelkoul, H. F. J., 2017, In : Journal of Leukocyte Biology. 101, 4, p. 811-821

Research output: Contribution to journalArticleAcademicpeer-review

Tryptophan
B-Lymphocytes
Bone Marrow
DNA Repair-Deficiency Disorders
Immune Tolerance
10 Citations (Scopus)

Vitamin D receptor gene polymorphisms associated with childhood autism

Ciéslińska, A., Kostyra, E., Chwała, B., Moszyńska-Dumara, M., Fiedorowicz, E., Teodorowicz, G. & Savelkoul, H. F. J., 2017, In : Brain Sciences. 7, 9, 115.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Calcitriol Receptors
Autistic Disorder
Vitamins
Genes
Alleles

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Language
2016
12 Citations (Scopus)

A proteomics-based identification of putative biomarkers for disease in bovine milk

van Altena, S. E. C., de Klerk, B., Hettinga, K. A., van Neerven, R. J. J., Boeren, S., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 174, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cattle Diseases
Lactoferrin
Proteomics
proteomics
biomarkers
6 Citations (Scopus)

Bovine natural antibodies in antibody-dependent bactericidal activity against Escherichia coli and Salmonella Typhimurium and risk of mastitis

van Altena, S. E. C., Peen, M. A., van der Linden, F. H., Parmentier, H. K., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 171, p. 21-27

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mastitis
Salmonella typhimurium
Salmonella Typhimurium
mastitis
Escherichia coli
13 Citations (Scopus)

Calcium homeostasis and low-frequency magnetic and electric field exposure: A systematic review and meta-analysis of in vitro studies

Golbach, L. A., Portelli, L. A., Savelkoul, H. F. J., Terwel, S. R., Kuster, N., de Vries, R. B. M. & Verburg-van Kemenade, B. M. L., 2016, In : Environment International. 92-93, p. 695-706

Research output: Contribution to journalArticleAcademicpeer-review

meta-analysis
homeostasis
electric field
calcium
magnetic field
4 Citations (Scopus)

House dust mite-specific IgA2 is associated with protection against eczema in allergic patients

Den Hartog, G., Van Neerven, R. J. J., Boot, J. D., Jansen, A. P. H. & Savelkoul, H. F. J., 2016, In : Allergy. 71, 4, p. 563-566

Research output: Contribution to journalArticleAcademicpeer-review

Pyroglyphidae
Eczema
Immunoglobulin A
Saliva
Rhinitis