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Research Output 1981 2020

2017
4 Citations (Scopus)

Measurement of allergen-specific IgG in serum is of limited value for the management of dogs diagnosed with cutaneous adverse food reactions

Hagen-Plantinga, E. A., Leistra, M. H. G., Sinke, J. D., Vroom, M. W., Savelkoul, H. F. J. & Hendriks, W. H., 2017, In : The Veterinary Journal. 220, p. 111-116

Research output: Contribution to journalArticleAcademicpeer-review

allergens
blood serum
Allergens
Immunoglobulin G
Dogs
3 Citations (Scopus)

Nutrition and allergic diseases

van Neerven, R. J. J. & Savelkoul, H., 2017, In : Nutrients. 9, 7, 762.

Research output: Contribution to journalEditorialAcademicpeer-review

Open Access
Breast Feeding
breast feeding
nutrition
Pregnant Women
Synbiotics
19 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
4 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Immunoglobulin E
Nut Hypersensitivity
Food
39 Citations (Scopus)

The impact of gut microbiota on gender-specific differences in immunity

Fransen, F., van Beek, A. A., Borghuis, T., Meijer, B., Hugenholtz, F., van der Gaast-de Jongh, C., Savelkoul, H. F., de Jonge, M. I., Faas, M. M., Boekschoten, M. V., Smidt, H., Aidy, S. E. & de Vos, P., 2017, In : Frontiers in Immunology. 8, 14 p., 754.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Immune System
Immunity
Interferon Type I
DNA Damage

Treating autism spectrum disorder with gluten-free and casein-free diet: the underlying microbiota-gut-brain axis mechanisms

Ciéslińska, A., Kostyra, E. & Savelkoul, H. F. J., 2017, In : HSOA Journal of Clinical Immunology and Immunotherapy. 3, 11 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Glutens
Caseins
Diet
Brain
Autism Spectrum Disorder
9 Citations (Scopus)

Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice

van Beek, A. A., Hugenholtz, F., Meijer, B., Sovran, B., Perdijk, O. I. J., Vermeij, W., Brandt, R. M., Barnhoorn, R., Hoeijmakers, J. H. J., de Vos, P., Leenen, P. J., Hendriks, R. W. & Savelkoul, H. F. J., 2017, In : Journal of Leukocyte Biology. 101, 4, p. 811-821

Research output: Contribution to journalArticleAcademicpeer-review

Tryptophan
B-Lymphocytes
Bone Marrow
DNA Repair-Deficiency Disorders
Immune Tolerance

Using IgE levels as an alternative phenotype to identify genomic regions associated with insect bite hypersensivity

Lamberigts, C., Francois, L., Velie, B. D., Stinckens, A., Hoskens, H., Blott, S., Tinel, S., Peeters, L., Savelkoul, H. F. J., Tijhaar, E. J., Lindgren, G., Janssens, S., Ducro, B. J., Buys, N. & Schurink, A., 2017.

Research output: Contribution to conferenceAbstractAcademic

12 Citations (Scopus)

Vitamin D receptor gene polymorphisms associated with childhood autism

Ciéslińska, A., Kostyra, E., Chwała, B., Moszyńska-Dumara, M., Fiedorowicz, E., Teodorowicz, G. & Savelkoul, H. F. J., 2017, In : Brain Sciences. 7, 9, 115.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Calcitriol Receptors
Autistic Disorder
Vitamins
Genes
Alleles

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Language

Voedselallergie - hoe kom je er vanaf? WURcademy

Savelkoul, H. F. J., 2017

Research output: Non-textual formDigital or Visual ProductsOther research output

Open Access
2016
12 Citations (Scopus)

A proteomics-based identification of putative biomarkers for disease in bovine milk

van Altena, S. E. C., de Klerk, B., Hettinga, K. A., van Neerven, R. J. J., Boeren, S., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 174, p. 11-18

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Cattle Diseases
Lactoferrin
Proteomics
proteomics
biomarkers
6 Citations (Scopus)

Bovine natural antibodies in antibody-dependent bactericidal activity against Escherichia coli and Salmonella Typhimurium and risk of mastitis

van Altena, S. E. C., Peen, M. A., van der Linden, F. H., Parmentier, H. K., Savelkoul, H. F. J. & Tijhaar, E. J., 2016, In : Veterinary Immunology and Immunopathology. 171, p. 21-27

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mastitis
Salmonella typhimurium
Salmonella Typhimurium
mastitis
Escherichia coli
13 Citations (Scopus)

Calcium homeostasis and low-frequency magnetic and electric field exposure: A systematic review and meta-analysis of in vitro studies

Golbach, L. A., Portelli, L. A., Savelkoul, H. F. J., Terwel, S. R., Kuster, N., de Vries, R. B. M. & Verburg-van Kemenade, B. M. L., 2016, In : Environment International. 92-93, p. 695-706

Research output: Contribution to journalArticleAcademicpeer-review

meta-analysis
homeostasis
electric field
calcium
magnetic field
4 Citations (Scopus)

House dust mite-specific IgA2 is associated with protection against eczema in allergic patients

Den Hartog, G., Van Neerven, R. J. J., Boot, J. D., Jansen, A. P. H. & Savelkoul, H. F. J., 2016, In : Allergy. 71, 4, p. 563-566

Research output: Contribution to journalArticleAcademicpeer-review

Pyroglyphidae
Eczema
Immunoglobulin A
Saliva
Rhinitis
11 Citations (Scopus)

Immunological Characterization of Dutch Sesame Seed-Allergic Patients

Teodorowicz, M., Terlouw, R. J., Jansen, A., Savelkoul, H. F. J. & Ruinemans-Koerts, J., 2016, In : International Archives of Allergy and Immunology. 169, 1, p. 13-22

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Sesamum
Seeds
Allergens
Nuts
Hypersensitivity
5 Citations (Scopus)

Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response

van Beek, A. A., Hoogerland, J., Belzer, C., de Vos, P., de Vos, W. M., Savelkoul, H. F. J. & Leenen, P. J., 2016, In : Beneficial Microbes. 7, 2, p. 275-287

Research output: Contribution to journalArticleAcademicpeer-review

Macrophages
Lactobacillus casei
Lactobacillus plantarum
Lactococcus lactis
Cytokines
4 Citations (Scopus)

Intestinal immune maturation is accompanied by temporal changes in the composition of the microbiota

den Hartog, C. G., de Vries Reilingh, G., Wehrmaker, A. M., Savelkoul, H. F. J., Parmentier, H. K. & Lammers, A., 2016, In : Beneficial Microbes. 7, 5, p. 677-685

Research output: Contribution to journalArticleAcademicpeer-review

Microbiota
Immunoglobulin A
Bacteria
Homeostasis
Ecosystem
43 Citations (Scopus)

Microbes and asthma: Opportunities for intervention

Smits, H. H., Hiemstra, P. S., Prazeres Da Costa, C., Ege, M., Edwards, M., Garn, H., Howarth, P. H., Jartti, T., De Jong, E. C., Maizels, R. M., Marsland, B. J., McSorley, H. J., Müller, A., Pfefferle, P. I., Savelkoul, H., Schwarze, J., Unger, W. W. J., Von Mutius, E., Yazdanbakhsh, M. & Taube, C., 2016, In : Journal of Allergy and Clinical Immunology. 137, 3, p. 690-697

Research output: Contribution to journalArticleAcademicpeer-review

Asthma
Immune System
Hygiene Hypothesis
Phenotype
Parasitic Diseases
17 Citations (Scopus)

Molecular and functional characterization of Toll-like receptor (Tlr)1 and Tlr2 in common carp (Cyprinus carpio)

Fink, I. R., Pietretti, D., Voogdt, C. G. P., Westphal, A. H., Savelkoul, H. F. J., Forlenza, M. & Wiegertjes, G. F., 2016, In : Fish and Shellfish Immunology. 56, p. 70-83

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Toll-Like Receptor 1
Cyprinus carpio
ligand
carp
Ligands
21 Citations (Scopus)

Multicentre double-blind placebo-controlled food challenge study in children sensitised to cashew nut

van der Valk, J. P. M., Gerth van Wijk, R., Dubois, A. E. J., de Groot, H., Reitsma, M., Vlieg-Boerstra, B. J., Savelkoul, H. F. J., Wichers, H. J. & de Jong, N. W., 2016, In : PLoS ONE. 11, 3, 12 p., e0151055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
cashew nuts
Nuts
placebos
Allergies
13 Citations (Scopus)

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3

Reitsma, M., Bastiaan-Net, S., Sforza, S., Van Der Valk, J. P. M., Van Gerth Van Wijk, R., Savelkoul, H. F. J., De Jong, N. W. & Wichers, H. J., 2016, In : Journal of Agricultural and Food Chemistry. 64, 5, p. 1191-1201

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Anas
Globulins
6 Citations (Scopus)

Sex impacts Th1 cells, Tregs, and DCs in both intestinal and systemic immunity in a mouse strain and location-dependent manner

Elderman, M., van Beek, A. A., Brandsma, E., de Haan, B., Savelkoul, H. F. J., de Vos, P. & Faas, M. M., 5 Apr 2016, In : Biology of Sex Differences. 7, 21.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Th1 Cells
Peyer's Patches
immunity
Dendritic Cells
Immunity
15 Citations (Scopus)

Supplementation with lactobacillus plantarum wcfs1 prevents decline of mucus barrier in colon of accelerated aging Ercc1-/Δ7 mice

van Beek, A. A., Sovran, B., Hugenholtz, F., Meijer, B., Hoogerland, J. A., Mihailova, V., van der Ploeg, C., Belzer, C., Boekschoten, M. V., Hoeijmakers, J. H. J. & Savelkoul, H. F. J., 2016, In : Frontiers in Immunology. 7, OCT, 408.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactobacillus plantarum
Mucus
Colon
Lactobacillus casei
Probiotics

Tackling the itch: GWAS on insect bite hypersensitivity using IgE levels in two horse populations

Francois, L., Hoskens, H., Savelkoul, H. F. J., Tijhaar, E. J., Velie, B. D., Stinckens, A., Lindgren, G., Blott, S., Buys, N., Ducro, B. J. & Schurink, A., 2016. 1 p.

Research output: Contribution to conferencePosterAcademic

The Mutual influences of man-made pollutants and allergic manifestations

Jeurink, P. V., Damialis, A., Wichers, H. J. & Savelkoul, H. F. J., 2016, In : APSTRACT: Applied Studies in Agribusiness and Commerce. 10, 2-3, p. 97-106

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
pollution
pollutant
atmospheric pollution
soil pollution
cardiovascular disease

Tissue-specific homing potential and kinetics of B and T cell responses to oral cholera vaccination

van Splunter, M. E., Timmerman, H. M., Ulfman, L. H., Witteman, B. J. M., Wells, J. M., Brugman, S., Savelkoul, H. F. J., van Hoffen, E. & van Neerven, R. J. J., 2016, p. C1032-6 . 2 p.

Research output: Contribution to conferenceAbstractAcademic

2015

Antenatal iron supplementation and serum non-transferrin bound iron in Kenyan women: a randomized placebo-controlled trial

Mwangi, M. N., Roth, J. M., Mwangi, A. M., Savelkoul, H. F. J., Hider, R. C., Mens, P. F. & Verhoef, J. C. M., 2015, In : Annals of Nutrition & Metabolism. 67, Suppl.1, p. 341 1 p.

Research output: Contribution to journalAbstractAcademic

Iron
Randomized Controlled Trials
Placebos
Serum
Malaria

BRAVO voor de kracht van het immuunsysteem

Savelkoul, H. F. J., 2015, In : Allergie & Voeding. 1, p. 4-7 4 p.

Research output: Contribution to journalArticleProfessional

3 Citations (Scopus)

Calcium signalling in human neutrophil cell lines is not affected by low-frequency electromagnetic fields

Golbach, L. A., Philippi, J. G. M., Cuppen, J. J. M., Savelkoul, H. F. J. & Verburg-van Kemenade, B. M. L., 2015, In : Bioelectromagnetics. 36, 6, p. 430-443

Research output: Contribution to journalArticleAcademicpeer-review

Electromagnetic Fields
Calcium Signaling
Neutrophils
Cell Line
Calcium
39 Citations (Scopus)

Carp Il10 has anti-inflammatory activities on phagocytes, promotes proliferation of memory T-cells and regulates B-cell differentiation and antibody secretion

Piazzon de Haro, M. C., Savelkoul, H. F. J., Pietretti, D., Wiegertjes, G. & Forlenza, M., 2015, In : The Journal of Immunology. 194, 1, p. 187-199

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carps
Phagocytes
Interleukin-10
Cell Differentiation
B-Lymphocytes
39 Citations (Scopus)

Choice and design of adjuvants for parenteral and mucosal vaccines

Savelkoul, H. F. J., Ferro, V. A., Strioga, M. M. & Schijns, V. E. J. C., 2015, In : Vaccines. 3, 1, p. 148-171

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Vaccines
Antigen-Presenting Cells
Antigen Presentation
Cytokines
T-Lymphocytes
33 Citations (Scopus)

Effect of daily antenatal iron supplementation on plasmodium infection in Kenyan women. A randomized clinical trial

Mwangi, M. N., Roth, J. M., Smit, M. R., Trijsburg, L., Mwangi, A. M., Demir, A. Y., Wielders, J. P. M., Mens, P. F., Verweij, J. J., Cox, S. E., Prentice, A. M., Brouwer, I. D., Savelkoul, H. F. J., Andang'o, P. E. A. & Verhoef, J. C. M., 2015, In : JAMA: The Journal of the American Medical Association. 314, 10, p. 1009-1020

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Malaria
Iron
Randomized Controlled Trials
Mothers
Placebos

Identification and production of recombinant Culicoides obsoletus complex allergens for diagnosis and immunotherapy for insect bite hypersensitive horses

van der Meide, N. M. A., Schurink, A., Savelkoul, H. F. J. & Tijhaar, E. J., 2015, p. 60-60.

Research output: Contribution to conferenceAbstractAcademic

Identification of putative B1 B-cells in cows

van Altena, S. E. C., Meijer, B., Savelkoul, H. F. J. & Tijhaar, E. J., 2015, p. 82. 1 p.

Research output: Contribution to conferenceAbstractAcademic

7 Citations (Scopus)

Immune-relevant thrombocytes of common carp undergo parasite-induced nitric oxide-mediated apoptosis

Fink, I. R., Ribeiro, C. M. S., Forlenza, M., Taverne-Thiele, J. J., Rombout, J. H. W. M., Savelkoul, H. F. J. & Wiegertjes, G., 2015, In : Developmental and Comparative Immunology. 50, 2, p. 146-154

Research output: Contribution to journalArticleAcademicpeer-review

Carps
Nitric Oxide
Parasites
Blood Platelets
Apoptosis
9 Citations (Scopus)

Low-frequency electromagnetic field exposure enhances extracellular trap formation by human neutrophils through the NADPH pathway

Golbach, L. A., Scheer, M. H., Cuppen, J. J. M., Savelkoul, H. F. J. & Verburg-van Kemenade, B. M. L., 2015, In : Journal of Innate Immunity. 7, 5, p. 459-465

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Electromagnetic Fields
NADP
Neutrophils
NADPH Oxidase
Autophagy
22 Citations (Scopus)

Mucosal immune development in early life: setting the stage

Brugman, S., Perdijk, O. I. J., van Neerven, R. J. J. & Savelkoul, H. F. J., 2015, In : Archivum Immunologiae et Therapiae Experimentalis. 63, 4, p. 251-268

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Immune System
Infant, Newborn, Diseases
Immunity
Epithelial Cells
Food

Seasonal allergic rhinitis and systems biology-oriented biomarker discovery

Baars, E. W., Nierop, A. F. M. & Savelkoul, H. F. J., 2015, General Methods in Biomarker Research and their Applications. Springer Netherlands, p. 1251-1275

Research output: Chapter in Book/Report/Conference proceedingChapter

Systems Biology
Seasonal Allergic Rhinitis
Biomarkers
Homeostasis
Cytokines

Wat gebeurt er bij een allergie

van Vuuren, A., Gerth van Wijk, R., Savelkoul, H. F. J. & den Hartog, C. G., 2015, In : Voedingswaarde : vaktijdschrift over gezondheid, voeding en suppletie. augustus, p. 12-15

Research output: Contribution to journalArticleProfessional

2014

Analyse van de interactie tussen voeding en het immuunsysteem

Meijer, B. & Savelkoul, H. F. J., 2014, In : Analyse. 2014, 5, p. 148-155

Research output: Contribution to journalArticleProfessional

De rol van microbiota voor een evenwichtig afweersysteem

Translated title of the contribution: The role of microbiota for a balanced immune systemSmits, M. A., Jansman, A. J. M., Savelkoul, H. F. J. & Rebel, J. M. J., 2014, In : Tijdschrift voor Diergeneeskunde. 139, 6, p. 22-26

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)

Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women

Mwangi, M. N., Maskey, S., Andang'o, P. E. A., Shinali, N. K., Roth, J. M., Trijsburg, L., Mwangi, A. M., Zuilhof, H., van Lagen, B., Savelkoul, H. F. J., Demir, A. Y. & Verhoef, J. C. M., 2014, In : BMC Medicine. 12, 229.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Pregnant Women
Iron
Hemoglobins
Erythropoiesis
Ferritins

Ercc1-/¿7 mice are a suitable model for ageing of mucosal immunity and microbiota

van Beek, A. A., Meijer, B., Sovran, B., de Vos, P., Hoeijmakers, J. J. H., Leenen, P. J., Hugenholtz, F., Boekschoten, M. V. & Savelkoul, H. F. J., 2014.

Research output: Contribution to conferenceAbstractAcademic

Mucosal Immunity
Microbiota
Ileum
Colon
Immune System
13 Citations (Scopus)

Evaluation of a diagnostic ELISA for insect bite hypersensitivity in horses using recombinant Obsoletus complex allergens

van der Meide, N. M. A., Savelkoul, H. F. J., Meulenbroeks, C., Ducro, B. J. & Tijhaar, E. J., 2014, In : The Veterinary Journal. 200, 1, p. 31-37

Research output: Contribution to journalArticleAcademicpeer-review

Insect Bites and Stings
allergens
hypersensitivity
Allergens
Horses
4 Citations (Scopus)

Factors associated with Culicoides Obsoletus complex spp.-specific IgE reactivity in Icelandic horses and Shetland ponies

Schurink, A., van der Meide, N. M. A., Savelkoul, H. F. J., Ducro, B. J. & Tijhaar, E. J., 2014, In : The Veterinary Journal. 201, p. 395-400

Research output: Contribution to journalArticleAcademicpeer-review

Culicoides obsoletus
Ceratopogonidae
immunoglobulin E
Immunoglobulin E
Horses

Het brein en het metaboolsyndroom

de Vos, R., Kruyswijk-van der Heijden, A. M. & Savelkoul, H. F. J., 2014, In : Voedingswaarde : vaktijdschrift over gezondheid, voeding en suppletie. 5, p. 16-17

Research output: Contribution to journalArticlePopular