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Research Output 1981 2020

731 Citations (Scopus)

1alpha,25-dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells

Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. J. & O'Garra, A., 2001, In : The Journal of Immunology. 167, p. 4974-4980

Research output: Contribution to journalArticleAcademicpeer-review

Th2 Cells
Calcitriol
T-Lymphocytes
Interleukin-4
MafF Transcription Factor
27 Citations (Scopus)

a+- Thalassemia Protects against Anemia Associated with Asymptomatic Malaria: Evidence from Community-Based Surveys in Tanzania and Kenya

Veenemans, J., Andang'o, P. E. A., Mbugi, E. V., Kraaijenhagen, R., Mwaniki, D., Mockenhaupt, F. P., Roewer, S., Olomi, R. M., Shao, J. F., van der Meer, J. W. M., Savelkoul, H. F. J. & Verhoef, J. C. M., 2008, In : The Journal of Infectious Diseases. 198, p. 401-408

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Thalassemia
Tanzania
Kenya
Malaria
Anemia
4 Citations (Scopus)

A comparative in vitro study of the effects of separate and combined products of citrus e fructibus and cydonia e fructibus on immunological parameters of seasonal allergic rhinitis

Baars, E. W., Jong, M. C., Boers, I., Nierop, A. F. M. & Savelkoul, H. F. J., 2012, In : Mediators of Inflammation. 2012, 8 p., 109829.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Rosaceae
Seasonal Allergic Rhinitis
Citrus
Allergens
In Vitro Techniques

A comparative in vitro study of the effects of the product Citrus e fructibus/Cydonia e fructibus as a whole and its single preparations on immunological parameters of seasonal allergic rhinitis

Baars, E., Boers, I., Jong, M., Nierop, D. & Savelkoul, H. F. J., 2010, Abstracts ECIM 2010, 4th European Congress for Integrative Medicine (ECIM), Berlin, Germany, 3-4 December 2010. Vol. 2. p. 176-177

Research output: Chapter in Book/Report/Conference proceedingAbstract

32 Citations (Scopus)

Activation and re-activation potential of T cells responding to staphylococcal enterotoxin B

Hamel, M. E., Eynon, E. E., Savelkoul, H. F. J., van Oudenaren, A. & Kruisbeek, A. M., 1995, In : International immunology. 7, 7, p. 1065-1077

Research output: Contribution to journalArticleAcademicpeer-review

T-Lymphocytes
Superantigens
staphylococcal enterotoxin B
Interleukin-2
Phenotype

Activation of high endothelial venules in peripheral lymph nodes.The involvement of interferon-gamma

Kraal, G., Schornagel, K., Savelkoul, H. & Maruyama, T., 1994, In : International immunology. 6, p. 1195-1201.

Research output: Contribution to journalArticleAcademicpeer-review

Venules
Interferon-gamma
Lymph Nodes
Monocytes
Freund's Adjuvant

Activity of T-cell subsets in allergic asthma

Boonstra, P. A. & Savelkoul, H. F. J., 1999, New and exploratory therapeutic agents for asthma.. Yeadon, M. & Diamant, Z. (eds.). New York: Marcel Dekker, p. 343-360

Research output: Chapter in Book/Report/Conference proceedingChapter

49 Citations (Scopus)

ADHD as a (non) allergic hypersensitivity disorder : A hypothesis

Pelsser, L., Buitelaar, J. & Savelkoul, H. F. J., 2009, In : Pediatric Allergy and Immunology. 20, 2, p. 107-112

Research output: Contribution to journalArticleAcademicpeer-review

Attention Deficit Disorder with Hyperactivity
Hypersensitivity
Environmental Illness
Food
Genetic Research
38 Citations (Scopus)

Adoptive transfer of natural antibodies to non-immunized chickens affects subsequent antigen-specific humoral and cellular immune responses

Lammers, A., Klomp, M. E. V., Nieuwland, M. G. B., Savelkoul, H. F. J. & Parmentier, H. K., 2004, In : Developmental and Comparative Immunology. 28, 1, p. 51-60

Research output: Contribution to journalArticleAcademicpeer-review

Adoptive Transfer
Humoral Immunity
Cellular Immunity
Chickens
Antigens
7 Citations (Scopus)

Age-associated Impairment of the Mucus Barrier Function is Associated with Profound Changes in Microbiota and Immunity

Sovran, B., Hugenholtz, F., Elderman, M., Van Beek, A. A., Graversen, K., Huijskes, M., Boekschoten, M. V., Savelkoul, H. F. J., De Vos, P., Dekker, J. & Wells, J. M., 5 Feb 2019, In : Scientific Reports. 9, 1, 1437.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Mucus
Immunity
Paneth Cells
T-Lymphocytes
47 Citations (Scopus)

Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice

Fransen, F., van Beek, A. A., Borghuis, T., El Aidy, S., Hugenholtz, F., van der Gaast - de Jongh, C., Savelkoul, H. F. J., de Jonge, M. I., Boekschoten, M. V., Smidt, H., Faas, M. M. & de Vos, P., 2 Nov 2017, In : Frontiers in Immunology. 8, 1385.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Microbiota
Inflammation
Proteobacteria
Peyer's Patches
Gastrointestinal Microbiome

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

Van Beek, A. A., Fransen, F., Meijer, B., de Vos, P., Knol, E. F. & Savelkoul, H. F. J., 29 Nov 2018, In : Immunity and Ageing. 15, 1, 32.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Basophils
Microbiota
Bone Marrow
Phenotype
Spleen

Age-independent responsiveness of porcine neonates and adults after TLR2 and TLR9 stimulation

Vreman, S., Auray, G., Savelkoul, H. F. J., Rebel, J. M. J., Summerfield, A. & Stockhofe, N., 2018, p. 42-42. 1 p.

Research output: Contribution to conferenceAbstractAcademic

A genuine T-lymphocyte associated role for IFN-y-2 in carp (Cyprinus carpio L.)

Verburg-van Kemenade, B. M. L., Stolte, H. H., Arts, J. A. J., Tijhaar, E., Wiegertjes, G. F., Flik, G. & Savelkoul, H. F. J., 2009.

Research output: Contribution to conferenceAbstractAcademic

Age related shifts in intestinal antibody expression and repertoire as determined by spectratyping

den Hartog, C. G., Crooijmans, R. P. J. M., Savelkoul, H. F. J., Parmentier, H. K. & Lammers, A., 2008.

Research output: Contribution to conferencePosterProfessional

Age related shifts in intestinal antibody expression and repertoire as determined by spectratyping.

den Hartog, C. G., Crooijmans, R. P. J. M., Savelkoul, H. F. J., Parmentier, H. K. & Lammers, A., 2008.

Research output: Contribution to conferenceAbstractAcademic

24 Citations (Scopus)

A Gly15Arg mutation in the Interleukin-10 gene reduces secretion of Interleukin-10 in Crohn disease

van der Linde, K., Boor, P. P. C., Sandkuijl, L. A., Meijssen, M. A. C., Savelkoul, H. F. J., Wilson, J. H. P. & Rooij, F. W. M., 2003, In : Scandinavian Journal of Gastroenterology. 38, 6, p. 611-617

Research output: Contribution to journalArticleAcademicpeer-review

Crohn Disease
Interleukin-10
Mutation
Genes
HL-60 Cells
3 Citations (Scopus)

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1 -/Δ7 mice

van der Lugt, B., van Beek, A. A., Aalvink, S., Meijer, B., Sovran, B., Vermeij, W. P., Brandt, R. M. C., de Vos, W. M., Savelkoul, H. F. J., Steegenga, W. T. & Belzer, C., 8 Mar 2019, In : Immunity and Ageing. 16, 1, 6.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Mucus
B-Lymphocytes
B-Lymphoid Precursor Cells
Transcriptome
Anti-Inflammatory Agents

Alginate encapsulation of cytokine gene-transfected cells.Chapter 13.5

Savelkoul, H. F. J., 1997, Manual of immunological methods.. Lefkovits, I. (ed.). London: Academic Press, p. 1030-1035

Research output: Chapter in Book/Report/Conference proceedingChapter

16 Citations (Scopus)

Allelic discrimination, three-dimensional analysis and gene expression of multiple transferrin alleles of common carp (Cyprinus carpio L.)

Jurecka, P. M., Irnazarow, I., Westphal, A., Forlenza, M., Arts, J. A. J., Savelkoul, H. F. J. & Wiegertjes, G. F., 2009, In : Fish and Shellfish Immunology. 26, 4, p. 573-581

Research output: Contribution to journalArticleAcademicpeer-review

transferrin
Transferrin
Cyprinus carpio
Gene expression
gene expression

Allelic variation of MHC class II B in genetically different lines of common carp

Rakus, K. L., Stet, R. J. M., Irnazarow, I., Pilarczyk, A., Savelkoul, H. F. J. & Wiegertjes, G. F., 2003, 9th International Congress of ISDCI, St. Andrews Scotland. Dyrynda, E. A. (ed.). p. 175

Research output: Chapter in Book/Report/Conference proceedingAbstract

Allergenen (hoofdstuk 2)

Savelkoul, H. F. J. & Dubois, A. E. J., 2006, Werkboek Kinderallergologie. Brands, P. L. P., Kneepkens, C. M. F., van der Laag, J. & Rikkers-Mutsaerts, E. R. V. M. (eds.). Amsterdam, p. 23-28 210 p. (Werkboeken Kindergeneeskunde).

Research output: Chapter in Book/Report/Conference proceedingChapter

Allergenic responses of total protein extract and purified fractions from L. angustifolius and L. albus: what's new?

Sirtori, E., O'Kane, F., Wichers, H. J., Savelkoul, H. F. J. & Arnoldi, A., 2008.

Research output: Contribution to conferenceAbstractAcademic

46 Citations (Scopus)

Allergen immunotherapy inhibits airway eosinophilia and hyperresponsiveness associated with decreased IL-4 production by lymphocytes in a murine model of allergic asthma

van Oosterhout, A. J. M., van Esch, B., Hofman, G., Hofstra, C. L., van Ark, I., Nijkamp, F. P., Kapsenberg, M. L., Savelkoul, H. F. J. & Weller, F. R., 1998, In : American Journal of Respiratory Cell and Molecular Biology. 19, 4, p. 622-628

Research output: Contribution to journalArticleAcademicpeer-review

Immunologic Desensitization
Lymphocytes
Ovalbumin
Eosinophilia
Interleukin-4

Allergie : een probleem voor mens en dier

Savelkoul, H. F. J., 2005, In : Animal Sciences Krant. p. 2

Research output: Contribution to journalArticlePopular

Allergie : ook voor allergie geldt: voorkomen is beter dan genezen

Savelkoul, H. F. J., 2005, In : Patient Care. 32, 10, p. 56-58 3 p.

Research output: Contribution to journalArticleProfessional

Allergie: overgevoeligheid voor voedsel genetisch aangepakt

Savelkoul, H. F. J. & Gilissen, L. J. W. J., 2004, In : Resource: weekblad voor Wageningen UR. 13, p. 12-14

Research output: Contribution to journalArticlePopular

Allergie en de hygienehypothese: de rol van een verstoord regulatoir netwerk

Eek, A. & Savelkoul, H. F. J., 2003, In : Foliolum. 3, p. 7-13

Research output: Contribution to journalArticlePopular

Allergie op retour; toename stokt dankzij gezonde manier

Savelkoul, H. F. J., 2009, In : Spits. p. 1 1 p.

Research output: Contribution to journalArticlePopular

Allergie voor dieren : inventarisatie over het voorkomen van allergische reacties bij de mens als gevolg blootstelling aan dierlijke allergenen

Terreehorst, I., Willemse, T., Heederik, D. J. J., van der Zee, J. S., de Groot, H., Savelkoul, H. F. J., Kerkhoffs, M. & de Wolf, I. D., 2007, Den Haag: Raad voor Dierenaangelegenheden. 76 p.

Research output: Book/ReportReportProfessional

Open Access
Food Chain
Netherlands
Hypersensitivity
Food

Allergy to molluscans is mainly caused by crustacean species

den Hartog, C. G., Smaal, A. C. & Savelkoul, H. F. J., 2011.

Research output: Contribution to conferenceAbstractAcademic

Alterations in early cytokine-mediated immune regulation to Plasmodium falciparum infection in micronutrient deficient Tanzanian children: A cross-sectional survey

Mbugi, E. V., Meijerink, M., Veenemans, J., McCall, M., Olomi, R. M., Shao, J. F., Wielders, J. P. M., Verhoef, H. & Savelkoul, H. F. J., 2009, The 5th MIM Pan African Malaria Conference, Nairobi, Kenya, 2 - 6 November. p. 138

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access
10 Citations (Scopus)

Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey

Mbugi, E. V., Meijerink, M., Veenemans, J., Jeurink, P. V., McCall, M., Olomi, R. M., Shao, J. F., Verhoef, H. & Savelkoul, H. F. J., 2010, In : Malaria Journal. 9, 13 p., 130.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Plasmodium falciparum
Malaria
Minerals
Cross-Sectional Studies
Micronutrients
35 Citations (Scopus)

A mouse model to study immunity against pseudorabies virus infection: Significance of CD4+ and CD8+ cells in protective immunity

Bianchi, A. T. J., Moonen-Leusen, H. W. M., van Milligen, F. J., Savelkoul, H. F. J., Zwart, R. J. & Kimman, T. G., 1998, In : Vaccine. 16, p. 1550-1558

Research output: Contribution to journalArticleAcademicpeer-review

Suid Herpesvirus 1
Suid herpesvirus 1
Virus Diseases
Immunity
immunity

An alternative inhibition method for determining cross-reactive allergens

Schmidt-Hieltjes, Y., Teodorowicz, G., Jansen, A., Den Hartog, G., Elfvering-Berendsen, L., De Jong, N. W., Savelkoul, H. F. J. & Ruinemans-Koerts, J., 2017, In : Clinical Chemistry and Laboratory Medicine. 55, 2, p. 248-253

Research output: Contribution to journalArticleAcademicpeer-review

Allergens
Ficus
Assays
Enzyme-Linked Immunosorbent Assay
Carica

An alternative method for immunoblotting on Phast System

van der Linde-Preesman, A. A. & Savelkoul, H. F. J., 1988, Pharmacia Separations. [S.l.]: S.n., p. 1-3

Research output: Chapter in Book/Report/Conference proceedingChapter

Analyse van de interactie tussen voeding en het immuunsysteem

Meijer, B. & Savelkoul, H. F. J., 2014, In : Analyse. 2014, 5, p. 148-155

Research output: Contribution to journalArticleProfessional

13 Citations (Scopus)

Analysis of cytokine gene expression in stimulated T cells of small children by semi-quantitative PCR

Koning, H., Baert, M. R. M., de Groot, R., Neijens, H. J. & Savelkoul, H. F. J., 1995, In : Mediators of Inflammation. 4, 3, p. 196-204

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
38 Citations (Scopus)

Analysis of genomic and expressed major histocompatibility class Ia and class II genes in a hexaploid Lake Tana African 'large' barb individual (Barbus intermedius)

Kruiswijk, C. P., Hermsen, G. J., Fujiki, K., Dixon, B., Savelkoul, H. F. J. & Stet, R. J. M., 2004, In : Immunogenetics. 55, 11, p. 770-781 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

Cyprinidae
MHC Class II Genes
Histocompatibility
Lakes
Major Histocompatibility Complex

Animal nutrition and immunity in pigs and poultry

Bouwens, M. & Savelkoul, H., 2019, Poultry and pig nutrition: Challenges of the 21st century. Hendriks, W. H., Verstegen, M. W. A. & Babinszky, L. (eds.). Wageningen Academic Publishers, p. 105-127

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
animal nutrition
immune system
poultry
immunity
swine

An investigation into parasite PAMPs activating carp macrophages via TLR2-ROS signaling

Ribeiro, C. M. S., Savelkoul, H. F. J. & Wiegertjes, G. F., 2008, Book of Abstracts. Vol. 33. p. 169

Research output: Chapter in Book/Report/Conference proceedingAbstract

A novel functional class I lineage in three cyprinid species: Barbus, carp and zebrafish

Kruiswijk, C. P., Hermsen, G. T., Savelkoul, H. F. J. & Stet, R. J. M., 2001, Abstracts Nederlandse Vereniging voor Immunologie : NVVI Conference, Noordwijkerhout, december 2001. - [S.l.] : [s.n.], 2001.

Research output: Chapter in Book/Report/Conference proceedingAbstract

52 Citations (Scopus)

A novel functional class I lineage in zebrafish (Danio rerio), carp (Cyprinus carpio), and large barbus (Barbus intermedius)showing an unusual conservation of the peptide binding domains.

Kruiswijk, C. P., Hermsen, G. J., Westphal, A. H., Savelkoul, H. F. J. & Stet, R. J. M., 2002, In : The Journal of Immunology. 169, p. 1936-1947

Research output: Contribution to journalArticleAcademicpeer-review

Cyprinidae
Carps
MHC Class I Genes
Zebrafish
MHC Class II Genes
11 Citations (Scopus)

A novel soluble immune-type receptor (SITR) in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite

Ribeiro, C. M. S., Raes, G., Ghassabeh, G. H., Schijns, V. E. J. C., Pontes, M. J. S. L., Savelkoul, H. F. J. & Wiegertjes, G. F., 2011, In : PLoS ONE. 6, 1, 20 p., e15986.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Carps
carp
Fish
Macrophages
nitric oxide

Antenatal iron supplementation and serum non-transferrin bound iron in Kenyan women: a randomized placebo-controlled trial

Mwangi, M. N., Roth, J. M., Mwangi, A. M., Savelkoul, H. F. J., Hider, R. C., Mens, P. F. & Verhoef, J. C. M., 2015, In : Annals of Nutrition & Metabolism. 67, Suppl.1, p. 341 1 p.

Research output: Contribution to journalAbstractAcademic

Iron
Randomized Controlled Trials
Placebos
Serum
Malaria

Antibodies, parameters for natural resistance in bovine milk?

Ploegaert, T. C. W., Tijhaar, E., Parmentier, H. K., van der Poel, J. J., van Arendonk, J. A. M. & Savelkoul, H. F. J., 2009.

Research output: Contribution to conferencePosterProfessional