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Research Output 1981 2020

1981
11 Citations (Scopus)

Two separate genes regulate self-Ia and carrier recognition in H-2-restricted helper factors secreted by hybridoma cells

Lonai, P., Savelkoul, H. F. J., Puri, J. & Hammerling, G., 1981, In : Journal of Experimental Medicine. 154, 6, p. 1910-1921

Research output: Contribution to journalArticleAcademicpeer-review

TCF Transcription Factors
Hybridomas
Sepharose
Lymphoma
T-Lymphocytes
1982

Factors, receptors, and their ligands: studies with H-2 restricted helper hybridoma clones

Lonai, P., Arman, E., Savelkoul, H. F. J., Friedman, V., Puri, J. & Hammerling, G., 1982, Isolation, characterization, and utilization of T lymphocyte clones.. Fathman, C. G. & Fitch, F. W. (eds.). New York: Academic Press, p. 109-117

Research output: Chapter in Book/Report/Conference proceedingChapter

1983

Short term immunosuppressive effects of Cis-diaminedichloroplatinum (II) (DDP) in mice

Nikkels, P. G. J., Bril, H., Savelkoul, H. F. J., van Oudenaren, A. & Ploemacher, R. E., 1983, Modern Trends in Clinical Immunosuppression.. Weimar, W., Marquet, R. L., Bijnen, A. B. & Ploeg, R. J. (eds.). Rotterdam.: Dept.Renal Transplantation, p. 167-174

Research output: Chapter in Book/Report/Conference proceedingChapter

1985

Isolation, characterization and quantitation of murine IgE

Savelkoul, H. F. J., Greeve, A. A. M., Soeting, P. W. C., Benner, R. & Radl, J., 1985, Unknown. p. 611-614. (Protides of the biological fluids; no. 33).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Quantitation of murine IgE in an automatic ELISA system

Savelkoul, H. F. J., Soeting, P. W. C., Benner, R. & Radl, J., 1985, In : Advances in Experimental Medicine and Biology. 186, p. 757-765

Research output: Contribution to journalArticleAcademicpeer-review

1987

Isolation of monoclonal antibodies from in vitro cultures of human B cell lines employing an automated three-column FPLC system

Savelkoul, H. F. J. & van der Linde-Preesman, A. A., 1987, Proceedings second FPLC symposium. Woerden: Pharmacia Nederland, p. 73-82

Research output: Chapter in Book/Report/Conference proceedingConference paper

Occurrence of damaged heavy chains during purification of murine IgE antibodies by fast protein liquid chromatography (FPLC) and their effect on the determination of concentration and affinity in ELISA

Savelkoul, H. F. J., Pathak, S. S. & van der Linde-Preesman, A. A., 1987, Unknown. p. 375-382 (Protides of the biological fluids; no. 35).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rapid purification of mouse IgE antibodies by multi column liquid chromatography

Savelkoul, H. F. J., Pathak, S. S. & van der Linde Preesman, A. A., 1987, In: Proceedings second FPLC symposium. Woerden: Pharmacia Nederland, p. 83-93

Research output: Chapter in Book/Report/Conference proceedingConference paper

1988

An alternative method for immunoblotting on Phast System

van der Linde-Preesman, A. A. & Savelkoul, H. F. J., 1988, Pharmacia Separations. [S.l.]: S.n., p. 1-3

Research output: Chapter in Book/Report/Conference proceedingChapter

Frequency analysis of functional Ig Ce gene expression in the presence and absence of interleukin 4 in lipopolysaccharide-reactive murine B cells from high and low IgE responder strains

Savelkoul, H. F. J., Termeulen, J., Coffman, R. L. & van der Linde-Preesman, A. A., 1988, In : European journal of immunology. 18, p. 1209-1215.

Research output: Contribution to journalArticleAcademicpeer-review

Frequency analysis of functional immunoglobulin CE gene expression in LPS reactive murine B cells

Savelkoul, H. F. J., Linssen, P. C. L. M., Termeulen, J., van der Linde-Preesman, A. A. & Benner, R., 1988, Lymphocyte activation and differentiation.. Mani, J. C. & Dornand, J. (eds.). p. 585-589

Research output: Chapter in Book/Report/Conference proceedingChapter

Generation and measurement of antibodies

Savelkoul, H. F. J., Pathak, S. S., Sabbele, N. R. & Benner, R., 1988, Handbook of Experimental Pharmacology. Vol 85. Bray, M. A. & Morley, J. (eds.). p. 141-185

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Citations (Scopus)

Increase of precursor frequency and clonal size of murine IgE-secreting cells by IL-4

Savelkoul, H. F. J., Lebman, D. A., Benner, R. & Coffman, R. L., 1988, In : The Journal of Immunology. 141, 3, p. 749-755

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-4
Immunoglobulin E
Clone Cells
Immunoglobulin M
Feeder Cells
4 Citations (Scopus)

Rapid procedure for coupling of protein antigens to red cells to be used in plaque assays by prewashing in chromium chloride

Savelkoul, H. F. J., Greeve, A. A. M., Rijkers, G. T., Marwitz, P. A. & Benner, R., 1988, In : Journal of Immunological Methods. 111, 1, p. 31-37

Research output: Contribution to journalArticleAcademicpeer-review

Staphylococcal Protein A
Antigens
Proteins
gamma-Globulins
Hybridomas
625 Citations (Scopus)

The role of helper T cell products in mouse B cell differentiation and isotype regulation

Coffman, R. L., Seymour, B. W. P., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelkoul, H. F. J., Finkelman, F. D., Bond, M. W. & Mosmann, T. R., 1988, In : Immunological reviews. 102, 1, p. 5-28

Research output: Contribution to journalArticleAcademicpeer-review

1989
34 Citations (Scopus)

Cytokine regulation of immunoglobulin isotype switching and expression

Coffman, R. L., Savelkoul, H. F. J. & Lebman, D. A., 1989, In : Seminars in Immunology. 1, 1, p. 55-63.

Research output: Contribution to journalArticleAcademic

Modulation of total IgE levels in serum of normal and athymic nude BALB/c mice by cells and exogenous antigenic stimulation

Savelkoul, H. F. J., van den Akker, T. W., Soeting, P. W. C., van Oudenaren, A. & Benner, R., 1989, In : International Archives of Allergy and Immunology. 89, p. 113-119.

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin E
Serum
T-Lymphocytes
Thymectomy
Nude Mice
2 Citations (Scopus)

Terasaki-ELISA for murine IgE-anibodies III. determination of concentration and functional affinity by sequential equilibrium binding analysis

Pathak, S. S., Vos, Q. & Savelkoul, H. F. J., 1989, In : Journal of Immunological Methods. 123, 1, p. 71-81

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin E
Enzyme-Linked Immunosorbent Assay
Antibody Affinity
Antibodies
Dialysis
4 Citations (Scopus)

Terasaki-ELISA for murine IgE-antibodies.I.Quality of the detecting antibody: production and specificity testing of antisera specific for IgE

Savelkoul, H. F. J., Soeting, P. W. C., Radl, J. & van der Linde-Preesman, A. A., 1989, In : Journal of Immunological Methods. 116, 2, p. 265-275

Research output: Contribution to journalArticleAcademicpeer-review

Antibody Specificity
Immunoglobulin E
Antibody Formation
Immune Sera
Enzyme-Linked Immunosorbent Assay
7 Citations (Scopus)

Terasaki-ELISA for murine IgE antibodies.II.Quantitation of absolute concentration of antigen-specific and total IgE

Savelkoul, H. F. J., Soeting, P. W. C., de Josselin de Jong, J. E. & Pathak, S. S., 1989, In : Journal of Immunological Methods. 116, 2, p. 277-285

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin E
Enzyme-Linked Immunosorbent Assay
Antigens
Antibodies
Galactosidases
1990

Immunologie

Savelkoul, H. F. J., 1990, In : O'dokter. 9, Issue, p. 12-14

Research output: Contribution to journalArticleProfessional

Regulation of the production of IgE

Benner, R. & Savelkoul, H. F. J., 1990, Post Graduate Course Pollinosis 1990 Erasmus University, Rotterdam. Rotterdam: Erasmus University, p. 15-18

Research output: Chapter in Book/Report/Conference proceedingChapter

1991

Cytokines from transfected cells

Savelkoul, H. F. J., 1991, Course Book International Biotechnology: Cell culture for clinic and pharmaceutical industry. Utrecht: S.n., p. 1-3

Research output: Chapter in Book/Report/Conference proceedingChapter

Evaluation of the purity of synthetic oligonucleotides for PCR amplification by ion exchange FPLC

Savelkoul, H. F. J. & van der Plas, D., 1991, In : Science Tools: the L K B instrument journal. 35:, p. 1-3.

Research output: Contribution to journalArticleProfessional

30 Citations (Scopus)

IL-4 can correct defective IgE production in SJA/9 mice

Savelkoul, H. F. J., Seymour, B. W. P., Sullivan, L. & Coffman, R. L., 1991, In : The Journal of Immunology. 146, 6, p. 1801-1805

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-4
Immunoglobulin E
Helminths
T-Lymphocytes
Parasitic Diseases

Isolation of monoclonal antibodies from in vitro cultures of human B cell lines employing an automated three-column FLPC system

Savelkoul, H. F. J. & van der Linde-Preesman, A. A., 1991, Proceedings of the fourth FPLC symposium. Woerden: Pharmacia, p. 73-82

Research output: Chapter in Book/Report/Conference proceedingConference paper

Purity evaluation of synthetic oligonucleotides for PCR amplification by ion exchange FPLC

Savelkoul, H. F. J., van der Plas, D. & van Helden-Meeuwsen, C. G., 1991, Proceedings of the fourth FPLC symposium. Woerden: Pharmacia, p. 12-22

Research output: Chapter in Book/Report/Conference proceedingConference paper

Rapid purification of mouse IgE antibodies by multi-column liquid chromatography

Savelkoul, H. F. J., Pathak, S. S. & van der Linde-Preesman, A. A., 1991, Proceedings of the fourth FPLC symposium. Woerden: Pharmacia, p. 83-93

Research output: Chapter in Book/Report/Conference proceedingConference paper

14 Citations (Scopus)

Regulation of IgE production in mice

Benner, R. & Savelkoul, H. F. J., 1991, In : European Respiratory Journal. 4, 13, p. 97s-104s.

Research output: Contribution to journalArticleAcademicpeer-review

Immunoglobulin E
Lymphokines
Helper-Inducer T-Lymphocytes
Interleukin-4
Interferon-gamma
2 Citations (Scopus)

Suppression of graft-versus-host reactivity by a single host-specific blood transfusion to prospective donors of hemopoietic cells

Knulst, A. C., Bril-Bazuin, C., Savelkoul, H. F. J. & Benner, R., 1991, In : Transplantation. 52, 3, p. 534-539

Research output: Contribution to journalArticleAcademicpeer-review

Blood Transfusion
Transplants
Spleen
Clone Cells
T-Lymphocytes
1992

Cytokines in lethal graft-versus-host disease

Knulst, A. C., Bril-Bazuin, C., Tibbe, G. J. M., van Oudenaren, A., Savelkoul, H. F. J. & Benner, R., 1992, In : Transplant International. 5, p. 679-680.

Research output: Contribution to journalArticleAcademicpeer-review

Graft vs Host Disease
Cytokines
T-Lymphocytes
Interleukin-2
Cytokine Receptors

Interleukines from transfected cell lines

Savelkoul, H. F. J., 1992, Course manual "Cell culture for clinic and pharmaceutical industry". Utrecht: University Hospital, p. 1-6

Research output: Chapter in Book/Report/Conference proceedingChapter

1993
243 Citations (Scopus)

Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs

Oosterhout, A. J. M., Ladenius, A. R. C., Savelkoul, H. F. J., van Ark, I., Delsman, K. C. & Nijkamp, F. P., 1993, In : American review of respiratory disease. 147, 3, p. 548-552

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-5
Eosinophils
Ovalbumin
Guinea Pigs
Antibodies
16 Citations (Scopus)

Recombinant interleukin-5 induces in vivo airway hyperresponsiveness to histamine in guinea pigs

van Oosterhout, A. J. M., van Ark, I., Hofman, G., Savelkoul, H. F. J. & Nijkamp, F. P., 1993, In : European Journal of Pharmacology. 236, 3, p. 379-383

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-5
Histamine
Guinea Pigs
Therapeutic Irrigation
Antibodies

Rol van cytokines in de regulatie van immuunrespons

Savelkoul, H. F. J., 1993, Het medisch jaar.. van Es, J. C., Mandema, E., Olthuis, G. & Verstraete, M. (eds.). Houten: Bohn Stafleu Van Loghum bv, p. 321-333

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

The influence of dendritic cells on T-cell cytokine production

van Wilsem, E., BrevÃ, J., van Hoogstraten, I., Savelkoul, H. & Kraal, G., 1993, Dendritic cells in fundamental and clinical immunology.. Kamperdijk, E. W. A., Nieuwenhuis, P. & Hoefsmit, E. C. M. (eds.). New York: Plenum Press, p. 111-115

Research output: Chapter in Book/Report/Conference proceedingChapter

1994

Activation of high endothelial venules in peripheral lymph nodes.The involvement of interferon-gamma

Kraal, G., Schornagel, K., Savelkoul, H. & Maruyama, T., 1994, In : International immunology. 6, p. 1195-1201.

Research output: Contribution to journalArticleAcademicpeer-review

Venules
Interferon-gamma
Lymph Nodes
Monocytes
Freund's Adjuvant

A rat anti-mouse CD3 monoclonal antibody induces long-term skin allograft survival without inducing side-effects

Vossen, A. C. T. M., Tibbe, G. J. M., van Oudenaren, A., Vredendaal, A. E. C. M., Benner, R. & Savelkoul, H. F. J., 1994, In : Transplantation Proceedings. 26, 6, p. 3157-3158

Research output: Contribution to journalArticleAcademicpeer-review

51 Citations (Scopus)

Cytokine antagonists and their potential therapeutic use

Debets, R. & Savelkoul, H. F. J., 1994, In : Immunology Today. 15, 10, p. 455-458

Research output: Contribution to journalArticleAcademicpeer-review

Cytokine Receptors
Therapeutic Uses
Cytokines

Cytokine detection and modulation in acute graft vs.host disease in mice

Knulst, A. C., Tibbe, G. J. M., Bril-Bazuin, C., Breedland, E. G., van Oudenaren, A., Benner, R. & Savelkoul, H. F. J., 1994, In : Mediators of Inflammation. 3, p. 33-40.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
18 Citations (Scopus)

Cytokines in clinical and experimental transplantation

Vossen, A. C. T. M. & Savelkoul, H. F. J., 1994, In : Mediators of Inflammation. 3, 6, p. 403-410

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

De regulatie van de IgE antistofvorming

Savelkoul, H. F. J., 1994, In : De allergie bode. Issue, p. 5-8

Research output: Contribution to journalArticleProfessional

32 Citations (Scopus)

Modulation of systemic cytokine levels by implantation of alginate encapsulated cells

Savelkoul, H. F. J., van Ommen, R., Vossen, A. C. T. M., Breedland, E. G., Coffman, R. L. & van Oudenaren, A., 1994, In : Journal of Immunological Methods. 170, 2, p. 185-196

Research output: Contribution to journalArticleAcademicpeer-review

Cytokines
Interleukin-4
Antibodies
Interleukin-5
Hybridomas

Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed against T cells or their subsets.I.Evidence for the induction of a state of tolerance based on suppression

Knulst, A. C., Tibbe, G. J. M., Noort, W. A., Bril-Bazuin, C., Benner, R. & Savelkoul, H. F. J., 1994, In : Bone Marrow Transplantation. 13, p. 293-301.

Research output: Contribution to journalArticleAcademicpeer-review

Graft vs Host Disease
Monoclonal Antibodies
T-Lymphocytes
T-Lymphocyte Subsets
Therapeutics

Prevention of lethal graft-versus-host disease in mice by monoclonal antibodies directed to T cells or their subsets.II.Differential effectiveness of IgG2a and IgG2b isotypes of anti-CD3 and anti-CD4 moAb

Knulst, A. C., Noort, W. A., Tibbe, G. J. M., Benner, R. & Savelkoul, H. F. J., 1994, In : Bone Marrow Transplantation. 14, p. 535-543.

Research output: Contribution to journalArticleAcademicpeer-review

Graft vs Host Disease
Monoclonal Antibodies
T-Lymphocytes
CD4 Antigens
Surface Antigens

Prolonged IL-4 treatment decreases the TNP-specific memory formation for IgG1

van Ommen, R. & Savelkoul, H. F. J., 1994, In vivo immunology: regulatory processes during lymphopoiesis and immunopoiesis.. Heinen, E. (ed.). New York: Plenum Publ., p. 39-43

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Prolonged in vivo IL-4 treatment inhibits antigen-specific IgG1 and IgE formation

van Ommen, R., Vredendaal, A. E. C. M. & Savelkoul, H. F. J., 1994, In : Scandinavian Journal of Immunology. 40, 1, p. 1-9

Research output: Contribution to journalArticleAcademicpeer-review

Interleukin-4
Immunoglobulin E
Immunoglobulin G
Antigens
Therapeutics