Hilde Smith

dr.

    1991 …2020

    Research output per year

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    2020

    Identification of conditionally essential genes for Streptococcus suis infection in pigs

    Arenas, J., Zomer, A., Harders-Westerveen, J., Bootsma, H. J., De Jonge, M. I., Stockhofe-Zurwieden, N., Smith, H. E. & De Greeff, A., 18 May 2020, In : Virulence. 11, 1, p. 446-464 19 p.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    2019

    Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations

    Willemse, N., van der Ark, K. C. H., Stockhofe-Zurwieden, N., Smith, H., Picavet, D. I., van Solt-Smits, C., Wisselink, H. J., Schultsz, C. & de Greeff, A., 28 Oct 2019, In : Scientific Reports. 9, 1, 15429.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    3 Citations (Scopus)

    In vivo transcriptomes of Streptococcus suis reveal genes required for niche-specific adaptation and pathogenesis

    Arenas, J., Bossers-de Vries, R., Harders-Westerveen, J., Buys, H., Ruuls-van Stalle, L. M. F., Stockhofe-Zurwieden, N., Zaccaria, E., Tommassen, J., Wells, J. M., Smith, H. E. & de Greeff, A., 7 Apr 2019, In : Virulence. 10, 1, p. 334-351

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    4 Citations (Scopus)
    2018

    Genomic and functional characterisation of IncX3 plasmids encoding bla SHV-12 in Escherichia coli from human and animal origin

    Liakopoulos, A., Van Der Goot, J., Bossers, A., Betts, J., Brouwer, M. S. M., Kant, A., Smith, H., Ceccarelli, D. & Mevius, D., 1 Dec 2018, In : Scientific Reports. 8, 1, 7674.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    8 Citations (Scopus)
    2017

    Genome plasticity and polymorphisms in critical genes correlate with increased virulence of Dutch outbreak-related Coxiella burnetii strains

    Kuley, R., Kuijt, E., Smits, M. A., Roest, H. I. J., Smith, H. E. & Bossers, A., 10 Aug 2017, In : Frontiers in Microbiology. 8, 1526.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    7 Citations (Scopus)
    2016

    An emerging zoonotic clone in the Netherlands provides clues to virulence and zoonotic potential of Streptococcus suis

    Willemse, N., Howell, K. J., Weinert, L. A., Heuvelink, A., Pannekoek, Y., Wagenaar, J. A., Smith, H. E., Van Der Ende, A. & Schultsz, C., 2016, In : Scientific Reports. 6, 28984.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    20 Citations (Scopus)

    First Complete Genome Sequence of the Dutch Veterinary Coxiella burnetii Strain NL3262, Originating from the Largest Global Q Fever Outbreak, and Draft Genome Sequence of Its Epidemiologically Linked Chronic Human Isolate NLhu3345937

    Kuley, R., Smith, H. E., Janse, I., Harders, F. L., Baas, F., Schijlen, E., Nabuurs-Fransen, M. H., Smits, M. A., Roest, H. I. J. & Bossers, A., 2016, In : Genome Announcements. 4, 2, 2 p., e00245-16.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    9 Citations (Scopus)

    Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

    Tunjungputri, R. N., de Jonge, M. I., de Greeff, A., van Selm, S., Buys-Bergen, H., Harders-Westerveen, J. F., Stockhofe-Zurwieden, N., Urbanus, R. T., De Groot, P. G., Smith, H. E., van der Ven, A. J. & de Mast, Q., 2016, In : Thrombosis Research. 144, p. 123-126

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)

    Pneumococcal colonization and invasive disease studied in a porcine model

    de Greeff, A., van Selm, S., Buys, H., Harders-Westerveen, J. F., Tunjungputri, R. N., de Mast, Q., van der Ven, A. J., Stockhofe-Zurwieden, N., de Jonge, M. I. & Smith, H. E., 2016, In : BMC Microbiology. 16, 1, 102.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    10 Citations (Scopus)

    Rapid detection of Streptococcus uberis in raw milk by loop-mediated isothermal amplification

    Cornelissen, J. B. W. J., De Greeff, A., Heuvelink, A. E., Swarts, M., Smith, H. E. & Van der Wal, F. J., 2016, In : Journal of Dairy Science. 99, 6, p. 4270-4281

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    17 Citations (Scopus)

    Simultaneous Quantification and Differentiation of Streptococcus suis Serotypes 2 and 9 by Quantitative Real-time PCR, Evaluated in Tonsillar and Nasal Samples of Pigs

    Dekker, N., Daemen, I., Verstappen, K. M., de Greeff, A., Smith, H. E. & Duim, B., 2016, In : Pathogens. 5, 3, 46.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    5 Citations (Scopus)
    2015

    Cell-Free Propagation of Coxiella burnetii Does Not Affect Its Relative Virulence

    Kuley, R., Smith, H. E., Frangoulidis, D., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : PLoS ONE. 10, 3, 16 p., e0121661.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    15 Citations (Scopus)

    Characterization of epidemic IncI1-Iγ plasmids harboring ambler class A and C genes in Escherichia coli and Salmonella enterica from animals and humans

    Smith, H., Bossers, A., Harders, F., Wu, G., Woodford, N., Schwarz, S., Guerra, B., Rodríguez, I., Van Essen-Zandbergen, A., Brouwer, M. & Mevius, D., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 9, p. 5357-5365

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    32 Citations (Scopus)

    Host-pathogen interaction at the intestinal mucosa correlates with zoonotic potential of Streptococcus suis

    Ferrando, M. L., De Greeff, A., Van Rooijen, W. J. M., Stockhofe-Zurwieden, N., Nielsen, J., Wichgers Schreur, P. J., Pannekoek, Y., Heuvelink, A., Van Der Ende, A., Smith, H. & Schultsz, C., 2015, In : The Journal of Infectious Diseases. 212, 1, p. 95-105

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    26 Citations (Scopus)

    Incl shufflons: Assembly issues in the next-generation sequencing era

    Brouwer, M. S., Tagg, K. A., Mevius, D. J., Iredell, J. R., Bossers, A., Smith, H. E. & Partridge, S. R., 2015, In : Plasmid. 80, p. 111-117

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    17 Citations (Scopus)

    Major differential gene regulation in Coxiella burnetii between in vivo and in vitro cultivation models

    Kuley, R., de Vries, R., Smith, H. E., Smits, M. A., Roest, H. I. J. & Bossers, A., 2015, In : BMC Genomics. 16, 953.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    14 Citations (Scopus)
    2014

    A naturally occurring nucleotide polymorphism in the orf2/folc promoter is associated with Streptococcus suis virulence

    de Greeff, A., Buys, H., Wells, J. M. & Smith, H. E., 2014, In : BMC Microbiology. 14, 1, 264.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    3 Citations (Scopus)

    Complete genome sequences of Incl1 Plasmids carrying extended-spectrum B-Lactamase genes

    Brouwer, M. S. M., Bossers, A., Harders, F., van Essen-Zandbergen, A., Mevius, D. J. & Smith, H. E., 2014, In : Genome Announcements. 2, 4, e00859-14.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    11 Citations (Scopus)
    2013

    Comparative genomic analysis of twelve Streptococcus suis (pro)phages

    Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genomics. 101, 6, p. 336-344

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    25 Citations (Scopus)

    Complete Genome Sequence of the Streptococcus suis Temperate Bacteriophage varphiNJ2

    Tang, F., Bossers, A., Harders, F. L., Lu, C. & Smith, H. E., 2013, In : Genome Announcements. 1, 1, e00008-12.

    Research output: Contribution to journalArticleAcademicpeer-review

    Early host response in the mammary gland after experimental Streptococcus uberis challenge in heifers

    de Greeff, A., Zadoks, R. N., Ruuls, L., Toussaint, M., Nguyen, T. K., Downing, A., Rebel, J. M. J., Stockhofe-Zurwieden, N. & Smith, H. E., 2013, In : Journal of Dairy Science. 96, 6, p. 3723-3736

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    11 Citations (Scopus)

    Extended-spectrum-ß-lactamase- and AmpC-ß-lactamase-producing Escherichia coli in Dutch broilers and broiler farms

    Dierikx, C. M., van der Goot, J. A., Fabri, T., van Essen-Zandbergen, A., Smith, H. E. & Mevius, D. J., 2013, In : Journal of Antimicrobial Chemotherapy. 68, 1, p. 60-67

    Research output: Contribution to journalArticleAcademicpeer-review

    149 Citations (Scopus)

    Presence of ESBL/AmpC-producing Escherichia coli in the broiler production pyramid: a descriptive study.

    Dierikx, C. M., van der Goot, J. A., Smith, H. E., Kant, A. & Mevius, D. J., 2013, In : PLoS ONE. 8, 11 p., e79005.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    111 Citations (Scopus)
    2012

    Immunomodulatory effects of streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival.

    Meijerink, M., Ferrando, M. L., Lammers, G., Taverne, N., Smith, H. E. & Wells, J., 2012, In : PLoS ONE. 7, 4, e35849.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    26 Citations (Scopus)

    Lysozyme Resistance in Streptococcus suis Is Highly Variable and Multifactorial

    Wichgers, P. J., van Weeghel, C., Rebel, J. M. J., Smits, M. A., van Putten, J. P. M. & Smith, H. E., 2012, In : PLoS ONE. 7, 4, e36281.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    12 Citations (Scopus)
    2011

    ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment

    Fulde, M., Willenborg, J., de Greeff, A., Benga, L., Smith, H. E., Valentin-Weigand, P. & Goethe, R., 2011, In : Microbiology. 157, 2, p. 572-582

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    45 Citations (Scopus)

    Genetic diversity of Streptococcus suis isolates as determined by comparative genome hybridization

    de Greeff, A., Wisselink, H. J., de Bree, F. M., Schultsz, C., Baums, C. G., Ngo Thi, H., Stockhofe-Zurwieden, N. & Smith, H. E., 2011, In : BMC Microbiology. 11, 15 p., 161.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    41 Citations (Scopus)

    Lgt processing is an essential step in Streptococcus suis lipoprotein mediated innate immune activation

    Wichgers, P. J., Rebel, J. M. J., Smits, M. A., van Putten, J. P. & Smith, H. E., 2011, In : PLoS ONE. 6, 7, e22299.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    26 Citations (Scopus)

    Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis

    Willenborg, J., Fulde, M., De Greeff, A., Rohde, M., Smith, H. E., Valentin-Weigand, P. & Goethe, R., 2011, In : Microbiology. 157, 6, p. 1823-1833

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    67 Citations (Scopus)

    Strengthening insights into host responses to mastitis infection in ruminants by combining heterogeneous microarray data sources

    Genini, S., Badaoui, B., Sclep, G., Bishop, S. C., Waddington, D., Pinard van der Laan, M. H., Klopp, C., Cabau, C., Seyfert, H. M., Petzl, W., Jensen, K., Glass, E. J., de Greeff, A., Smith, H. E., Smits, M. A., Olsaker, I., Boman, G. M., Pisoni, G., Moroni, P., Castiglioni, B. & 6 others, Cremonesi, P., del Corvo, M., Foulon, E., Foucras, G., Rupp, R. & Giuffra, E., 2011, In : BMC Genomics. 12, 17 p., 225.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    33 Citations (Scopus)

    TroA of Streptococcus suis is required for manganese acquisition and full virulence

    Wichgers Schreur, P. J., Rebel, J. M. J., Smits, M. A., van Putten, J. P. M. & Smith, H. E., 2011, In : Journal of Bacteriology. 193, 19, p. 5073-5080

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    34 Citations (Scopus)
    2010

    ApuA, a multifunctional x-glucan-degrading enzyme of Streptococcus suis, mediates adhesion to porcine epithelium and mucus

    Ferrando, M. L., Fuentes, S., de Greeff, A., Smith, H. E. & Wells, J., 2010, In : Microbiology. 156, p. 2818-2828

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    29 Citations (Scopus)

    ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage

    Estorninho, M., Smith, H. E., Thole, J. E. R., Harders-Westerveen, S. F., Kierzek, A., Butler, R. E., Neyrolles, O. & Stewart, G. R., 2010, In : Microbiology. 156, p. 3445-3455

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    41 Citations (Scopus)

    Differential activation of the Toll-like receptor 2/6 complex by lipoproteins of Streptococcus suis serotypes 2 and 9

    Wichgers, P. J., Rebel, J. M. J., Smits, M. A., van Putten, J. P. & Smith, H. E., 2010, In : Veterinary Microbiology. 143, 2-4, p. 363-370

    Research output: Contribution to journalArticleAcademicpeer-review

    24 Citations (Scopus)

    Increased detection of extended spectrum beta-lactamase producing Salmonella enterica and Escherichia coli isolates from poultry

    Dierikx, C. M., van Essen-Zandbergen, A., Veldman, K. T., Smith, H. E. & Mevius, D. J., 2010, In : Veterinary Microbiology. 145, 3-4, p. 273-278

    Research output: Contribution to journalArticleAcademicpeer-review

    138 Citations (Scopus)

    Involvement of NF-κB and MAP-kinases in the transcriptional response of alveolar macrophages to Streptococcus suis

    de Greeff, A., Benga, A., Wichgers, P. J., Valentin-Weigand, P., Rebel, J. M. J. & Smith, H. E., 2010, In : Veterinary Microbiology. 141, 1-2, p. 59-67

    Research output: Contribution to journalArticleAcademicpeer-review

    23 Citations (Scopus)
    2009

    Mastitis diagnostics and performance monitoring: a practical approach

    Lam, T. J. G. M., Olde Riekerink, R., Sampimon, O. C. & Smith, H. E., 2009, In : Irish Veterinary Journal. 62, Supl.4, p. 34-39

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    30 Citations (Scopus)

    Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

    Holden, M. T. G., Hauser, H., Sanders, M., Hoa Ngo, T., Cherevach, I., Cronin, A., Goodhead, I., Mungall, K., Quail, M. A., Price, C., Rabbinowitsch, E., Sharp, S., Croucher, N., Chieu, T. B., Nguyen, T. H. M., To, S. D., Nguyen, T. C., Kehoe, M., Leigh, J. A., Ward, P. N. & 15 others, Dowson, C. G., Whatmore, A. M., Chanter, N., Iversen, P., Gottschalk, M., Slater, J. D., Smith, H. E., Spratt, B. G., Jianguo, X., Changyun, Y., Bentley, S., Barrell, B. G., Schultsz, C., Maskell, D. J. & Parkhill, J., 2009, In : PLoS ONE. 7 p., e6072.

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    157 Citations (Scopus)
    2007

    Occurance and characteristics of class 1, 2 and 3 integrons in Escherichia coli, Salmonella and Campylobacter spp. in the Netherlands

    van Essen-Zandbergen, A., Smith, H. E., Veldman, K. T. & Mevius, D. J., 2007, In : Journal of Antimicrobial Chemotherapy. 59, 4, p. 746-750

    Research output: Contribution to journalArticleAcademicpeer-review

    92 Citations (Scopus)

    Udder health: Bacteriological diagnostic examination

    Smith, H. E., Sampimon, O. C. & Lam, T. J. G. M., 2007, In : Tijdschrift voor Diergeneeskunde. 132, 19, p. 740-743

    Research output: Contribution to journalArticleAcademicpeer-review

    2005

    Detection of extracellular factor-positive Streptococcus suis serotype 2 strains in tonsillar swabs of live sows by PCR

    Swildens, B., Wisselink, H. J., Engel, B., Smith, H. E., Nielen, M., Verheijden, J. H. & Stegeman, J. A., 2005, In : Veterinary Microbiology. 109, 3-4, p. 223-228

    Research output: Contribution to journalArticleAcademicpeer-review

    12 Citations (Scopus)
    2004

    Both ApxI and ApxII of Actinobacillus pleuropneumoniae serotype 1 are necessary for full virulence

    Boekema, B. K. H. L., Kamp, E. M., Smits, M. A., Smith, H. E. & Stockhofe-Zurwieden, N., 2004, In : Veterinary Microbiology. 100, 1-2, p. 17-23

    Research output: Contribution to journalArticleAcademicpeer-review

    26 Citations (Scopus)

    Host Cell Contact-Induced Transcription of the Type IV Fimbria Gene Cluster of Actinobacillus pleuropneumoniae

    Boekema, B. K. H. L., Putten, J. P. M., Stockhofe-Zurwieden, N. & Smith, H. E., 2004, In : Infection and Immunity. 72, 2, p. 691-700

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    33 Citations (Scopus)

    Long-term results of peripheral arterial disease rehabilitation

    Menard, J. R., Smith, H. E., Riebe, D., Braun, C. M., Blissmer, B. & Patterson, R. B., 2004, In : Journal of Vascular Surgery. 39, 6, p. 1186-1192

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    62 Citations (Scopus)
    2003

    Adherence of Actinobacillus pleuropneumoniae to primary cultures of porcine lung epithelial cells.

    Boekema, B. K. H. L., Stockhofe, N., Smith, H. E., Kamp, E. M., van Putten, J. P. & Verheijden, J. H., 2003, In : Veterinary Microbiology. 93, 2, p. 133-144

    Research output: Contribution to journalArticleAcademicpeer-review

    13 Citations (Scopus)

    A Woman with a Lobar Infiltrate due to Psittacosis Detected by Polymerase Chain Reaction

    Heddema, E. R., Kraan, M., Buys-Bergen, W. E. C. M., Smith, H. E. & Wertheim-van Dillen, P. M. E., 2003, In : Scandinavian Journal of Infectious Diseases. 35, 6-7, p. 422-423

    Research output: Contribution to journalArticleAcademicpeer-review

    8 Citations (Scopus)

    Lipoprotein signal peptidase of Streptococcus suis serotype 2

    de Greeff, A., Buijs, H., van Alphen, L. & Smith, H. E., 2003, In : Microbiology. 149, 6, p. 1399-1407

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    24 Citations (Scopus)
    2002

    Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2

    de Greeff, A., Buys, H., Verhaar, R., Dijkstra, J., van Alphen, L. & Smit, H. E., 2002, In : Infection and Immunity. 70, 3, p. 1319-1325

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    122 Citations (Scopus)

    Distribution of environmentally regulated genes of Streptococcus suis serotype 2 among S-suis serotypes and other organisms

    de Greeff, A., Buijs, H., Verhaar, R., van Alphen, L. & Smith, H. E., 2002, In : Journal of Clinical Microbiology. 40, 9, p. 3261-3268

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    8 Citations (Scopus)

    Identification and characterization of two temperature-induced surface-associated proteins of Streptococcus suis with high homologies to members of the arginine deiminase system of Streptococcus pyogenes

    Winterhoff, N., Goethe, R., Gruening, P., Rohde, M., Kalisz, H., Smith, H. E. & Valentin-Weigand, P., 2002, In : Journal of Bacteriology. 184, 24, p. 6768-6776

    Research output: Contribution to journalArticleAcademicpeer-review

    Open Access
    68 Citations (Scopus)