1994 …2020
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Research Output 1994 2019

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Article
2019
1 Citation (Scopus)

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J. & Masereeuw, R., Oct 2019, In : Toxicology in Vitro. 60, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Goblet Cells
Translational Medical Research
Caco-2 Cells
Nutrients
Extracellular Matrix
1 Citation (Scopus)
Open Access
lactoglobulins
immunoglobulin E
Lactoglobulins
Lactose
glycation
1 Citation (Scopus)
Open Access
lactoglobulins
Lactoglobulins
glycation
hydrophobicity
Hydrophobic and Hydrophilic Interactions
3 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Nuts
Allergens
Immunoglobulin E
Anacardiaceae
1 Citation (Scopus)

Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity

Lacroix, I. M. E., Dávalos Terán, I., Fogliano, V. & Wichers, H. J., Mar 2019, In : International Journal of Food Science and Technology. 54, 3, p. 696-704 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Alphitobius diaperinus
Tenebrio
Dipeptidyl Peptidase 4
Peptides
peptides
1 Citation (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Organic Anion Transporters
Proximal Kidney Tubule
Anions
Indican
Kidney
2018
5 Citations (Scopus)

Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses

Lépine, A. F. P., de Wit, N., Oosterink, E., Wichers, H., Mes, J. & de Vos, P., 2 Jul 2018, In : Frontiers in Microbiology. 9, 1439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactobacillus acidophilus
Tight Junctions
Salmonella typhimurium
Salmonella
Epithelial Cells
1 Citation (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Nuts
Anas

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
allergens
saliva
Saliva
Allergens
peanuts
4 Citations (Scopus)

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

van der Valk, J. P. M., Berends, I., van Wijk, R. G., Arends, N. J. T., van Maaren, M. S., de Groot, H., Wichers, H. J., Emons, J. A. M., Dubois, A. E. J. & de Jong, N. W., Mar 2018, In : Annals of Allergy, Asthma and Immunology. 120, 3, p. 300-303

Research output: Contribution to journalArticleAcademicpeer-review

Anaphylaxis
Epinephrine
Food
Guidelines
Hypersensitivity
26 Citations (Scopus)

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2 Jan 2018, In : Chemistry - A European Journal. 24, 1, p. 47-55

Research output: Contribution to journalArticleAcademicpeer-review

Monophenol Monooxygenase
Proteins
Enzymes
Melanin
Mutagenesis

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2

Arena, M., Govers, C. C. F. M., Lotti, C., Ricciardi, L., Wichers, H. J. & Mes, J. J., 13 Mar 2018, In : Molecules. 23, 3, 644.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Tomatine
gene expression
Gene expression
integrity
Monolayers
2017
3 Citations (Scopus)

Adaptation of exercise-induced stress in well-trained healthy young men

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Lenaerts, K., Ridder, L. O., Nierkens, S., Kartaram, S., Verschuren, M. C. M., Pieters, R., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 2017, In : Experimental Physiology. 102, 1, p. 86-99

Research output: Contribution to journalArticleAcademicpeer-review

Exercise
Lactulose
Rhamnose
Energy Metabolism
Urine
20 Citations (Scopus)

Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7- proteinases hydrolyzed tilapia muscle proteins

Toopcham, T., Mes, J. J., Wichers, H. J., Roytrakul, S. & Jirawat, Y., 2017, In : Food Chemistry. 220, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

Virgibacillus
Myeloblastin
Tilapia
Muscle Proteins
peptidyl-dipeptidase A
7 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

Allergens
Immunoglobulins
Immunoglobulin G
Serum
Eating

Dietary Protein: Key to Feeding th 10 Billion

Wichers, H. J., Sep 2017, In : World of Food Ingredients. september, p. 70-72

Research output: Contribution to journalArticleProfessional

6 Citations (Scopus)

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Lactulose
allergens
peanuts
lactulose
exercise

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access
6 Citations (Scopus)

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase

Toopcham, T., Mes, J. J., Wichers, H. J. & Yongsawatdigul, J., 2017, In : Food Chemistry. 224, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

Virgibacillus
Myeloblastin
Protein Hydrolysates
pea protein
protein hydrolysates
8 Citations (Scopus)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

van der Valk, J. P. M., el Bouche, R., Gerth van Wijk, R., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Translational Allergy. 7, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
Pistacia
Mangifera
Nuts
Hypersensitivity
2 Citations (Scopus)

Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype

Tang, Y., Govers, C., Wichers, H. J. & Mes, J. J., 2017, In : Journal of Functional Foods. 36, p. 280-289

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Polysaccharides
macrophages
polysaccharides
Macrophages
Phenotype
5 Citations (Scopus)

Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes claudin 7

Janssen Duijghuijsen, L. M., Grefte, S., de Boer, V. C. J., Zeper, L., van Dartel, D. A. M., van der Stelt, I., Bekkenkamp-Grovenstein, M., van Norren, K., Wichers, H. J. & Keijer, J., 11 Oct 2017, In : Frontiers in Physiology. 8, 13 p., 794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Adenosine Triphosphate
Caco-2 Cells
Claudin-2
Carbonyl Cyanide m-Chlorophenyl Hydrazone
Galactose
17 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
lipopolysaccharides
protein sources
Lipopolysaccharides
Food
Proteins
4 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Nuts
Immunoglobulin E
Nut Hypersensitivity
Food
29 Citations (Scopus)

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2017, In : Angewandte Chemie-International Edition. 56, 33, p. 9812-9815

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Monophenol Monooxygenase
Zinc
Proteins
Ions
Melanin

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Language
5 Citations (Scopus)

Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity

Gil-Ramírez, A., Smiderle, F. R., Morales, D., Govers, C., Synytsya, A., Wichers, H. J., Iacomini, M. & Soler-Rivas, C., 2017, In : International Journal of Medicinal Mushrooms. 19, 10, p. 879-892

Research output: Contribution to journalArticleAcademicpeer-review

Pleurotus
Ostreidae
Agaricales
Glucans
Polysaccharides
2016
8 Citations (Scopus)

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution

Lai, X., Soler-Lopez, M., Ismaya, W. T., Wichers, H. J. & Dijkstra, B. W., 2016, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 72, 3, p. 244-250

Research output: Contribution to journalArticleAcademicpeer-review

Monophenol Monooxygenase
Agaricales
Lectins
Carrier Proteins
Crystal structure
8 Citations (Scopus)
glycation
Lactose
whey protein
lactose
Digestion
30 Citations (Scopus)

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

Van Broekhoven, S., Bastiaan-Net, S., De Jong, N. W. & Wichers, H. J., 2016, In : Food Chemistry. 196, p. 1075-1083

Research output: Contribution to journalArticleAcademicpeer-review

Tenebrio
dust mites
in vitro digestion
cross reaction
Pyroglyphidae
18 Citations (Scopus)

Large-scale recombinant expression and purificatoin of human tyrosinase suitabel for structural studies

Lai, X., Soler-Lopez, M., Wichers, H. J. & Dijkstra, B., 2016, In : PLoS ONE. 11, 8, 16 p., e0161697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Monophenol Monooxygenase
melanin
albino
skin (animal)
Melanins
21 Citations (Scopus)

Multicentre double-blind placebo-controlled food challenge study in children sensitised to cashew nut

van der Valk, J. P. M., Gerth van Wijk, R., Dubois, A. E. J., de Groot, H., Reitsma, M., Vlieg-Boerstra, B. J., Savelkoul, H. F. J., Wichers, H. J. & de Jong, N. W., 2016, In : PLoS ONE. 11, 3, 12 p., e0151055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Anacardium
cashew nuts
Nuts
placebos
Allergies
6 Citations (Scopus)

No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial

van der Valk, J. P. M., Gerth van Wijk, R., Flokstra-de Blok, B. M. J., van der Velde, J. L., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2016, In : Pediatric Allergy and Immunology. 27, 8, p. 812-817

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Nuts
Quality of Life
Clinical Trials
Food Hypersensitivity
13 Citations (Scopus)

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3

Reitsma, M., Bastiaan-Net, S., Sforza, S., Van Der Valk, J. P. M., Van Gerth Van Wijk, R., Savelkoul, H. F. J., De Jong, N. W. & Wichers, H. J., 2016, In : Journal of Agricultural and Food Chemistry. 64, 5, p. 1191-1201

Research output: Contribution to journalArticleAcademicpeer-review

Anacardium
Anacardium occidentale
cashew nuts
Anas
Globulins
16 Citations (Scopus)
Open Access
Maillard Reaction
binding capacity
Maillard reaction
whey protein
Heating
10 Citations (Scopus)

The effect of endurance exercise on intestinal integrity in well-trained healthy men

Janssen Duijghuijsen, L., Mensink, M., Lenaerts, K., Fiedorowicz, E., van Dartel, D. A. M., Mes, J. J., Luiking, Y. C., Keijer, J., Wichers, H. J., Witkamp, R. F. & van Norren, K., 1 Oct 2016, In : Physiological Reports. 4, 20, e12994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Exercise
Lactulose
Rhamnose
Permeability
Glucagon-Like Peptide 2

The Mutual influences of man-made pollutants and allergic manifestations

Jeurink, P. V., Damialis, A., Wichers, H. J. & Savelkoul, H. F. J., 2016, In : APSTRACT: Applied Studies in Agribusiness and Commerce. 10, 2-3, p. 97-106

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
pollution
pollutant
atmospheric pollution
soil pollution
cardiovascular disease

Voedselallergie: mosterd na de maaltijd?

Wichers, H. J., 27 May 2016, In : Voedingsmiddelentechnologie. 7, p. 29 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015
14 Citations (Scopus)

Anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract

Arranz, E., Mes, J. J., Wichers, H. J., Jaime, L., Reglero, G. & Santoyo, S., 2015, In : Journal of Functional Foods. 13, 1, p. 384-390

Research output: Contribution to journalArticleAcademicpeer-review

Caco-2 Cells
rosemary
anti-inflammatory activity
Anti-Inflammatory Agents
Cytokines
153 Citations (Scopus)

Food Processing and Allergenicity

Verhoeckx, K., Vissers, Y., Baumert, J. L., Faludi, R., Fleys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., van der Bolt, N., Wichers, H. J. & Kimber, I., Apr 2015, In : Food and Chemical Toxicology. 80, p. 223-240

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
allergenicity
Food processing
Food Handling
food processing
Food
2014
32 Citations (Scopus)

Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

Boers, I., Muskiet, F. A. J., Berkelaar, E., Schut, E., Penders, R., Hoenderdos, K., de Jong, M. C. & Wichers, H. J., 2014, In : Lipids in Health and Disease. 13, 13 p., 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Nutrition
Blood Pressure
Blood pressure
Hydrocortisone
Weight Loss
50 Citations (Scopus)

House dust mite (Der p 10) and crustacean allergic patients may react to food containing Yellow mealworm proteins

Verhoeckx, K., van Broekhoven, S., den Hartog-Jager, C. F., Gaspari, M., de Jong, G. A. H., Wichers, H. J., van Hoffen, E., Houben, G. F. & Knulst, A. C., 2014, In : Food and Chemical Toxicology. 65, p. 364-373

Research output: Contribution to journalArticleAcademicpeer-review

Tenebrio
dust mites
Pyroglyphidae
Tenebrio molitor
Dust
5 Citations (Scopus)

Hydrolysates of glycated and heat treated peanut 7S globulin (Ara h 1) modulate human gut microbiota proliferation, survival and adhesion

Teodorowicz, M., Swiatecka, D., Savelkoul, H. F. J., Wichers, H. J. & Kostyra, E., 2014, In : Journal of Applied Microbiology. 116, 2, p. 424-434

Research output: Contribution to journalArticleAcademicpeer-review

Globulins
Hot Temperature
Enterococcus faecalis
Enterococcus
Lactobacillus
2013
53 Citations (Scopus)

Agaricus bisporus and Agaricus brasiliensis (1 ¿ 6)-ß-d-glucans show immunostimulatory activity on human THP-1 derived macrophages

Smiderle, F. R., Alquini, G., Tadra-Sfeir, M. Z., Lacomini, M., Wichers, H. J. & van Griensven, L. J. L. D., 2013, In : Carbohydrate Polymers. 94, 1, p. 91-99

Research output: Contribution to journalArticleAcademicpeer-review

Glucans
Macrophages
Genes
Immune system
Polysaccharides
22 Citations (Scopus)

Biochemical and functional characterization of recombinant fungal immunomodulatory proteins (rFIPs)

Bastiaan-Net, S., Chanput, W., Hertz, A., Zwittink, R. D., Mes, J. J. & Wichers, H. J., 2013, In : International Immunopharmacology. 15, 1, p. 167-175

Research output: Contribution to journalArticleAcademicpeer-review

Fungal Proteins
Recombinant Proteins
Lectins
Erythrocytes
Electric Impedance
43 Citations (Scopus)

Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds

Chanput, W., Mes, J. J., Savelkoul, H. F. J. & Wichers, H. J., 2013, In : Food & Function. 4, 2, p. 266-276

Research output: Contribution to journalArticleAcademicpeer-review

macrophages
Macrophages
Lentinan
Food
cholecalciferol
22 Citations (Scopus)

Effect of Maillard reaction on biochemical properties of peanut 7S globulin (Ara h 1) and its interaction with a human colon cancer cell line (Caco-2)

Teodorowicz, M., Fiedorowicz, E., Kostyra, H., Wichers, H. J. & Kostyra, E., 2013, In : European Journal of Nutrition. 52, 8, p. 1927-1938

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Maillard Reaction
Globulins
Colonic Neoplasms
Interleukin-8
Caco-2 Cells

Groente blijkt ook in de schappen nog een dag-en-nachtritme te hebben. Spinazie bij groenteboer leeft nog

Keulemans, M. & Wichers, H. J., 2013, In : De Volkskrant. p. 5-5 1 p.

Research output: Contribution to journalArticlePopular

Immuunmodulatie door voeding "Van black box naar toolbox"

Wolthuis, A. & Wichers, H. J., 2013, In : Immuun. 2, 2, p. 30-31

Research output: Contribution to journalArticlePopular