1994 …2020

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2020

Beyond heat stress: Intestinal integrity disruption and mechanism-based intervention strategies

Lian, P., Braber, S., Garssen, J., Wichers, H. J., Folkerts, G., Fink-Gremmels, J. & Varasteh, S., 1 Mar 2020, In : Nutrients. 12, 3, 734.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
Open Access

Heat treatment of β-lactoglobulin affects its digestion and translocation in the upper digestive tract

Deng, Y., Govers, C., Tomassen, M., Hettinga, K. & Wichers, H. J., 15 Nov 2020, In : Food Chemistry. 330, 127184.

Research output: Contribution to journalArticleAcademicpeer-review

Identification and in silico bioinformatics analysis of PR10 proteins in cashew nut

Bastiaan-Net, S., Pina-Pérez, M. C., Dekkers, B. J. W., Westphal, A. H., America, A. H. P., Ariëns, R. M. C., de Jong, N. W., Wichers, H. J. & Mes, J. J., Jul 2020, In : Protein Science. 29, 7, p. 1581-1595

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method

Bastiaan-Net, S., Batstra, M. R., Aazamy, N., Savelkoul, H. F. J., Van Der Valk, J. P. M., Gerth Van Wijk, R., Schreurs, M. W. J., Wichers, H. J. & De Jong, N. W., 14 Feb 2020, In : Clinical Chemistry and Laboratory Medicine.

Research output: Contribution to journalArticleAcademicpeer-review

Phenylthiourea binding to human tyrosinase-related protein 1

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 1 Feb 2020, In : International Journal of Molecular Sciences. 21, 3, 915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Specific Polyunsaturated Fatty Acids Can Modulate in vitro Human moDC2s and Subsequent Th2 Cytokine Release

Hoppenbrouwers, T., Fogliano, V., Garssen, J., Pellegrini, N., Willemsen, L. E. M. & Wichers, H. J., 4 May 2020, In : Frontiers in Immunology. 11, 748.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

The effect of low vs. high temperature dry heating on solubility and digestibility of cow's milk protein

Zenker, H. E., Raupbach, J., Boeren, S., Wichers, H. J. & Hettinga, K. A., Dec 2020, In : Food Hydrocolloids. 109, 106098.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2019

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

Lozano-Ojalvo, D., Benedé, S., Antunes, C. M., Bavaro, S. L., Bouchaud, G., Costa, A., Denery-Papini, S., Díaz-Perales, A., Garrido-Arandia, M., Gavrovic-Jankulovic, M., Hayen, S., Martínez-Blanco, M., Molina, E., Monaci, L., Pieters, R. H. H., Villemin, C., Wichers, H. J., Wróblewska, B., Willemsen, L. E. M., Roggen, E. L. & 1 others, van Bilsen, J. H. M., 1 Mar 2019, In : Trends in Food Science and Technology. 85, p. 307-319

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients

Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J. & Masereeuw, R., Oct 2019, In : Toxicology in Vitro. 60, p. 1-11

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)
Open Access
3 Citations (Scopus)
Open Access
5 Citations (Scopus)

IgE Cross-Reactivity of Cashew Nut Allergens

Bastiaan-Net, S., Reitsma, M., Cordewener, J. H. G., van der Valk, J. P. M., America, T. A. H. P., Dubois, A. E. J., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 2019, In : International Archives of Allergy and Immunology. 178, 1, p. 19-32

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)

Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity

Lacroix, I. M. E., Dávalos Terán, I., Fogliano, V. & Wichers, H. J., Mar 2019, In : International Journal of Food Science and Technology. 54, 3, p. 696-704 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
7 Citations (Scopus)

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Hoppenbrouwers, T., Cvejić Hogervorst, J. H., Garssen, J., Wichers, H. J. & Willemsen, L. E. M., 22 May 2019, In : Frontiers in Immunology. 10, 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
5 Citations (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)
2018

Consumption of β-glucans to spice up T cell treatment of tumors: a review

de Graaff, P., Govers, C., Wichers, H. J. & Debets, R., 3 Oct 2018, In : Expert Opinion on Biological Therapy. 18, 10, p. 1023-1040

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
9 Citations (Scopus)
Open Access
6 Citations (Scopus)

Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses

Lépine, A. F. P., de Wit, N., Oosterink, E., Wichers, H., Mes, J. & de Vos, P., 2 Jul 2018, In : Frontiers in Microbiology. 9, 1439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

van der Valk, J. P. M., Berends, I., van Wijk, R. G., Arends, N. J. T., van Maaren, M. S., de Groot, H., Wichers, H. J., Emons, J. A. M., Dubois, A. E. J. & de Jong, N. W., Mar 2018, In : Annals of Allergy, Asthma and Immunology. 120, 3, p. 300-303

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2 Jan 2018, In : Chemistry - A European Journal. 24, 1, p. 47-55

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

The Effect of Tomatine on Gene Expression and Cell Monolayer Integrity in Caco-2

Arena, M., Govers, C. C. F. M., Lotti, C., Ricciardi, L., Wichers, H. J. & Mes, J. J., 13 Mar 2018, In : Molecules. 23, 3, 644.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)
2017

Adaptation of exercise-induced stress in well-trained healthy young men

Janssen Duijghuijsen, L. M., Keijer, J., Mensink, M. R., Lenaerts, K., Ridder, L. O., Nierkens, S., Kartaram, S., Verschuren, M. C. M., Pieters, R., Bas, R., Witkamp, R. F., Wichers, H. J. & van Norren, K., 2017, In : Experimental Physiology. 102, 1, p. 86-99

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Van Bilsen, J. H. M., Sienkiewicz-Szłapka, E., Lozano-Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., Ladics, G. S., Pieters, R. H. H., Denery-Papini, S., Vissers, Y. M., Bavaro, S. L., Larré, C., Verhoeckx, K. C. M. & Roggen, E. L., 2017, In : Clinical and Translational Allergy. 7, 1, 13.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
11 Citations (Scopus)

Bioavailability of angiotensin I-converting enzyme (ACE) inhibitory peptides derived from Virgibacillus halodenitrificans SK1-3-7- proteinases hydrolyzed tilapia muscle proteins

Toopcham, T., Mes, J. J., Wichers, H. J., Roytrakul, S. & Jirawat, Y., 2017, In : Food Chemistry. 220, p. 190-197

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

Janssen Duijghuijsen, L. M., Wichers, H. J., van Norren, K., Keijer, J., Baumert, J. L., De Jong, G. A. H., Witkamp, R. F. & Koppelman, S. J., 2017, In : Journal of Immunological Methods. 440, p. 52-57

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Dietary Protein: Key to Feeding th 10 Billion

Wichers, H. J., Sep 2017, In : World of Food Ingredients. september, p. 70-72

Research output: Contribution to journalArticleProfessional

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase

Toopcham, T., Mes, J. J., Wichers, H. J. & Yongsawatdigul, J., 2017, In : Food Chemistry. 224, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

van der Valk, J. P. M., el Bouche, R., Gerth van Wijk, R., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Translational Allergy. 7, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype

Tang, Y., Govers, C., Wichers, H. J. & Mes, J. J., 2017, In : Journal of Functional Foods. 36, p. 280-289

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes claudin 7

Janssen Duijghuijsen, L. M., Grefte, S., de Boer, V. C. J., Zeper, L., van Dartel, D. A. M., van der Stelt, I., Bekkenkamp-Grovenstein, M., van Norren, K., Wichers, H. J. & Keijer, J., 11 Oct 2017, In : Frontiers in Physiology. 8, 13 p., 794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
10 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
23 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2017, In : Angewandte Chemie-International Edition. 56, 33, p. 9812-9815

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
39 Citations (Scopus)

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity

Gil-Ramírez, A., Smiderle, F. R., Morales, D., Govers, C., Synytsya, A., Wichers, H. J., Iacomini, M. & Soler-Rivas, C., 2017, In : International Journal of Medicinal Mushrooms. 19, 10, p. 879-892

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2016

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution

Lai, X., Soler-Lopez, M., Ismaya, W. T., Wichers, H. J. & Dijkstra, B. W., 2016, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 72, 3, p. 244-250

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
10 Citations (Scopus)

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

Van Broekhoven, S., Bastiaan-Net, S., De Jong, N. W. & Wichers, H. J., 2016, In : Food Chemistry. 196, p. 1075-1083

Research output: Contribution to journalArticleAcademicpeer-review

37 Citations (Scopus)

Large-scale recombinant expression and purificatoin of human tyrosinase suitabel for structural studies

Lai, X., Soler-Lopez, M., Wichers, H. J. & Dijkstra, B., 2016, In : PLoS ONE. 11, 8, 16 p., e0161697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

Multicentre double-blind placebo-controlled food challenge study in children sensitised to cashew nut

van der Valk, J. P. M., Gerth van Wijk, R., Dubois, A. E. J., de Groot, H., Reitsma, M., Vlieg-Boerstra, B. J., Savelkoul, H. F. J., Wichers, H. J. & de Jong, N. W., 2016, In : PLoS ONE. 11, 3, 12 p., e0151055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial

van der Valk, J. P. M., Gerth van Wijk, R., Flokstra-de Blok, B. M. J., van der Velde, J. L., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2016, In : Pediatric Allergy and Immunology. 27, 8, p. 812-817

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3

Reitsma, M., Bastiaan-Net, S., Sforza, S., Van Der Valk, J. P. M., Van Gerth Van Wijk, R., Savelkoul, H. F. J., De Jong, N. W. & Wichers, H. J., 2016, In : Journal of Agricultural and Food Chemistry. 64, 5, p. 1191-1201

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
Open Access
20 Citations (Scopus)

The effect of endurance exercise on intestinal integrity in well-trained healthy men

Janssen Duijghuijsen, L., Mensink, M., Lenaerts, K., Fiedorowicz, E., van Dartel, D. A. M., Mes, J. J., Luiking, Y. C., Keijer, J., Wichers, H. J., Witkamp, R. F. & van Norren, K., 1 Oct 2016, In : Physiological Reports. 4, 20, e12994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)