1994 …2020

Research output per year

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Research Output

2017

Endurance exercise increases intestinal uptake of the peanut allergen Ara h 6 after peanut consumption in humans

Janssen Duijghuijsen, L. M., Van Norren, K., Grefte, S., Koppelman, S. J., Lenaerts, K., Keijer, J., Witkamp, R. F. & Wichers, H. J., 2017, In : Nutrients. 9, 1, 84.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Het behandelen van koemelkallergie... met koemelk

Hettinga, K. A., Wichers, H. J. & De Jong, N. W., 2017, In : VoedingsMagazine. 1, p. 10-12

Research output: Contribution to journalArticleProfessional

Open Access

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase

Toopcham, T., Mes, J. J., Wichers, H. J. & Yongsawatdigul, J., 2017, In : Food Chemistry. 224, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

van der Valk, J. P. M., el Bouche, R., Gerth van Wijk, R., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Translational Allergy. 7, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype

Tang, Y., Govers, C., Wichers, H. J. & Mes, J. J., 2017, In : Journal of Functional Foods. 36, p. 280-289

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes claudin 7

Janssen Duijghuijsen, L. M., Grefte, S., de Boer, V. C. J., Zeper, L., van Dartel, D. A. M., van der Stelt, I., Bekkenkamp-Grovenstein, M., van Norren, K., Wichers, H. J. & Keijer, J., 11 Oct 2017, In : Frontiers in Physiology. 8, 13 p., 794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
25 Citations (Scopus)

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
14 Citations (Scopus)

Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 2017, In : Angewandte Chemie-International Edition. 56, 33, p. 9812-9815

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
43 Citations (Scopus)

Voeding en immuniteit: Kan voeding bijdragen aan het voorkomen van allergie, infectie en ontsteking?

van Neerven, R. J. J., Albers, R., Wichers, H. J., Garssen, J. & Savelkoul, H. F. J., Mar 2017, In : Nederlands Tijdschrift voor Allergie en Astma. 17, p. 21-28

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Water-soluble polysaccharide extracts from the oyster culinary-medicinal mushroom pleurotus ostreatus (Agaricomycetes) with HMGCR inhibitory activity

Gil-Ramírez, A., Smiderle, F. R., Morales, D., Govers, C., Synytsya, A., Wichers, H. J., Iacomini, M. & Soler-Rivas, C., 2017, In : International Journal of Medicinal Mushrooms. 19, 10, p. 879-892

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
2016

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution

Lai, X., Soler-Lopez, M., Ismaya, W. T., Wichers, H. J. & Dijkstra, B. W., 2016, In : Acta Crystallographica Section F. Structural Biology and Crystallization Communications. 72, 3, p. 244-250

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)
11 Citations (Scopus)

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

Van Broekhoven, S., Bastiaan-Net, S., De Jong, N. W. & Wichers, H. J., 2016, In : Food Chemistry. 196, p. 1075-1083

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Intestinal epithelial integrity depends on mitochondrial energy production

Janssen Duijghuijsen, L. M., Grefte, S., van Norren, K., de Boer, V. C. J., van Dartel, D. A. M., Witkamp, R. F., Wichers, H. J. & Keijer, J., 24 Nov 2016.

Research output: Contribution to conferencePosterAcademic

Intestinal epithelial integrity depends on mitochondrial energy production

Janssen Duijghuijsen, L. M., Grefte, S., van Norren, K., de Boer, V. C. J., van Dartel, D. A. M., Witkamp, R. F., Wichers, H. J. & Keijer, J., 24 Nov 2016.

Research output: Contribution to conferenceAbstractAcademic

Large-scale recombinant expression and purificatoin of human tyrosinase suitabel for structural studies

Lai, X., Soler-Lopez, M., Wichers, H. J. & Dijkstra, B., 2016, In : PLoS ONE. 11, 8, 16 p., e0161697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

Mitochondrial ATP production and intestinal epithelial permeability - An in vitro model

Janssen Duijghuijsen, L. M., Grefte, S., Wichers, H. J., van Norren, K. & Keijer, J., 2016.

Research output: Contribution to conferencePosterAcademic

Multicentre double-blind placebo-controlled food challenge study in children sensitised to cashew nut

van der Valk, J. P. M., Gerth van Wijk, R., Dubois, A. E. J., de Groot, H., Reitsma, M., Vlieg-Boerstra, B. J., Savelkoul, H. F. J., Wichers, H. J. & de Jong, N. W., 2016, In : PLoS ONE. 11, 3, 12 p., e0151055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial

van der Valk, J. P. M., Gerth van Wijk, R., Flokstra-de Blok, B. M. J., van der Velde, J. L., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2016, In : Pediatric Allergy and Immunology. 27, 8, p. 812-817

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3

Reitsma, M., Bastiaan-Net, S., Sforza, S., Van Der Valk, J. P. M., Van Gerth Van Wijk, R., Savelkoul, H. F. J., De Jong, N. W. & Wichers, H. J., 2016, In : Journal of Agricultural and Food Chemistry. 64, 5, p. 1191-1201

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
Open Access
22 Citations (Scopus)

The effect of endurance exercise on intestinal integrity in well-trained healthy men

Janssen Duijghuijsen, L., Mensink, M., Lenaerts, K., Fiedorowicz, E., van Dartel, D. A. M., Mes, J. J., Luiking, Y. C., Keijer, J., Wichers, H. J., Witkamp, R. F. & van Norren, K., 1 Oct 2016, In : Physiological Reports. 4, 20, e12994.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

The Mutual influences of man-made pollutants and allergic manifestations

Jeurink, P. V., Damialis, A., Wichers, H. J. & Savelkoul, H. F. J., 2016, In : APSTRACT: Applied Studies in Agribusiness and Commerce. 10, 2-3, p. 97-106

Research output: Contribution to journalArticleAcademicpeer-review

Open Access

Voedselallergie: mosterd na de maaltijd?

Wichers, H. J., 27 May 2016, In : Voedingsmiddelentechnologie. 7, p. 29 1 p.

Research output: Contribution to journalArticleAcademicpeer-review

2015

Anti-inflammatory activity of the basolateral fraction of Caco-2 cells exposed to a rosemary supercritical extract

Arranz, E., Mes, J. J., Wichers, H. J., Jaime, L., Reglero, G. & Santoyo, S., 2015, In : Journal of Functional Foods. 13, 1, p. 384-390

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)

Comprehensive clinical study on cashew nut allergy: preliminary results

van der Valk, J. P. M., Gerth van Wijk, R., Wichers, H. J., Dubois, A. E. J., de Groot, H. & de Jong, N. W., 2015, p. 1-1.

Research output: Contribution to conferenceAbstractAcademic

Food Processing and Allergenicity

Verhoeckx, K., Vissers, Y., Baumert, J. L., Faludi, R., Fleys, M., Flanagan, S., Herouet-Guicheney, C., Holzhauser, T., Shimojo, R., van der Bolt, N., Wichers, H. J. & Kimber, I., Apr 2015, In : Food and Chemical Toxicology. 80, p. 223-240

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
193 Citations (Scopus)

Multi-center study in cashew nut sensitized children: prelimary results

van der Valk, J. P. M., Gerth van Wijk, R., Wichers, H. J., Dubois, A. E. J., de Groot, H. & de Jong, N. W., Jun 2015.

Research output: Contribution to conferencePosterAcademic

Real-time pcr analysis of pru av 1 and pru av 3 allergens

Verschuren, M. C. M., Bastiaan-Net, S., Depoortere, D., Foetisch, K., Scheurer, S., Wichers, H. J. & Noij, T., 2015.

Research output: Contribution to conferencePosterAcademic

Specificity of anti-pru av 1 antibodies for the detection of pru av 1 isoallergens

Verschuren, M. C. M., Bastiaan-Net, S., van Uden, N. M. E., Vandenberghe, K., Foetisch, K., Scheurer, S., Wichers, H. J. & Noij, T., 2015.

Research output: Contribution to conferencePosterAcademic

The Impact of Food Bioactives on Health: in vitro and ex vivo models

Verhoeckx, K. (ed.), Cotter, P. (ed.), Lopez-Exposito, I. (ed.), Lea, T. (ed.), Mackie, A. (ed.), Requena, T. (ed.), Swiatecka, D. (ed.) & Wichers, H. J. (ed.), 2015, Zeist: Springer International Publishing. 338 p.

Research output: Book/ReportBook editingAcademic

Open Access
49 Citations (Scopus)

The sensitivity of mealworm Tropomyosin to in vitro digestion is influenced by heat treatment

van Broekhoven, S., Bastiaan-Net, S., de Jong, N. W. & Wichers, H. J., Apr 2015.

Research output: Contribution to conferencePosterAcademic

THP-1 and U937 cells

Chanput, W., Peters, V. & Wichers, H., 2015, The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models. Springer International Publishing, p. 147-159

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

22 Citations (Scopus)
2014

Chitinase-digested chitin particles might show elevated receptor binding activity in HEK Blue TLR2 reporter cells

Koper, J. E. B., Bastiaan-Net, S. & Wichers, H. J., 2014.

Research output: Contribution to conferencePosterProfessional

Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study

Boers, I., Muskiet, F. A. J., Berkelaar, E., Schut, E., Penders, R., Hoenderdos, K., de Jong, M. C. & Wichers, H. J., 2014, In : Lipids in Health and Disease. 13, 13 p., 160.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
38 Citations (Scopus)

House dust mite (Der p 10) and crustacean allergic patients may react to food containing Yellow mealworm proteins

Verhoeckx, K., van Broekhoven, S., den Hartog-Jager, C. F., Gaspari, M., de Jong, G. A. H., Wichers, H. J., van Hoffen, E., Houben, G. F. & Knulst, A. C., 2014, In : Food and Chemical Toxicology. 65, p. 364-373

Research output: Contribution to journalArticleAcademicpeer-review

60 Citations (Scopus)

Hydrolysates of glycated and heat treated peanut 7S globulin (Ara h 1) modulate human gut microbiota proliferation, survival and adhesion

Teodorowicz, M., Swiatecka, D., Savelkoul, H. F. J., Wichers, H. J. & Kostyra, E., 2014, In : Journal of Applied Microbiology. 116, 2, p. 424-434

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Influence of processing and in vitro digestion on the allergenicity of three mealworm species

van Broekhoven, S., de Jong, N., Bastiaan-Net, S. & Wichers, H. J., 2014.

Research output: Contribution to conferencePosterProfessional

Intensive Exercise Hampers the Postprandial Citrulline Bioavailability Following Casein Bolus Feeding

Janssen Duijghuijsen, L., Mensink, M. G. J., Witkamp, R. F., Keijer, J., Wichers, H. J., Luiking, Y. & van Norren, K., 2014, Abstracts of the 36th ESPEN Congress. Elsevier, Vol. 33. p. S11-S12

Research output: Chapter in Book/Report/Conference proceedingAbstract

Open Access

In vitro digestion of heat treated cashew nut

Reitsma, M., Bastiaan-Net, S. & Wichers, H. J., 2014.

Research output: Contribution to conferencePosterProfessional

Is the basophil activation test (BAT) a reliable tool in the diagnosis of soy allergy?

Teodorowicz, M., Breedveld, A. C., Ruinemans-Koerts, J., Jansen, A. P. H., Savelkoul, H. F. J. & Wichers, H. J., 2014.

Research output: Contribution to conferencePosterProfessional

Nutritional intervention study in fast ageing Ercc1- 7mice

van Beek, A. A., Sovran, B., Meijer, B., Leenen, P. J., Wichers, H. J. & Savelkoul, H. F. J., 2014.

Research output: Contribution to conferenceAbstractAcademic

Probiotic intervention in fast ageing Ercc1-/ 7 mice affects mucosal and systemic immunity

van Beek, A. A., Sovran, B., Meijer, B., de Vos, P., Dekker, J., Wells, J. M., Wichers, H. J., Leenen, P. J. & Savelkoul, H. F. J., 2014.

Research output: Contribution to conferenceAbstractAcademic

Protein transport across the small intestine in food hypersensitivity

Reitsma, M., Westerhout, J., Wichers, H. J., Wortelboer, H. & Verhoeckx, K. C. M., 2014, In : Molecular Nutrition & Food Research. 58, 1, p. 194-205

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Systematic review on cashew nut allergy

van der Valk, J. P. M., Dubois, A. E. J., Wichers, H. J., de Jong, N. W. & van Wijk, R., 2014, In : Allergy. 69, p. 692-698

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

THP-1 cell line: an in vitro cell model for immune-modulation approach : Review

Chanput, W., Mes, J. J. & Wichers, H. J., 2014, In : International Immunopharmacology. 23, 1, p. 37-45

Research output: Contribution to journalArticleAcademicpeer-review

299 Citations (Scopus)
2013

Agaricus bisporus and Agaricus brasiliensis (1 ¿ 6)-ß-d-glucans show immunostimulatory activity on human THP-1 derived macrophages

Smiderle, F. R., Alquini, G., Tadra-Sfeir, M. Z., Lacomini, M., Wichers, H. J. & van Griensven, L. J. L. D., 2013, In : Carbohydrate Polymers. 94, 1, p. 91-99

Research output: Contribution to journalArticleAcademicpeer-review

65 Citations (Scopus)