1994 …2020

Research output per year

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Research Output

Article

Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase

Toopcham, T., Mes, J. J., Wichers, H. J. & Yongsawatdigul, J., 2017, In : Food Chemistry. 224, p. 320-328

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Immunomodulatory capacity of fungal proteins on the cytokine production of human peripheral blood mononuclear cells

Jeurink, P. V., Lull Noguera, C., Savelkoul, H. F. J. & Wichers, H. J., 2008, In : International Immunopharmacology. 8, 8, p. 1124-1133

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Scopus)

Immuunmodulatie door voeding "Van black box naar toolbox"

Wolthuis, A. & Wichers, H. J., 2013, In : Immuun. 2, 2, p. 30-31

Research output: Contribution to journalArticlePopular

Immuunmodulatie door voedsel : rol bij allergie?

Wichers, H. J., 2010, In : Nederlands Tijdschrift voor Allergie en Astma. 10, 2, p. 48-55

Research output: Contribution to journalArticleProfessional

Open Access

Impact of (bio)chemical and physical procedures on food allergen stability

Soler Rivas, C. & Wichers, H. J., 2001, In : Allergy. 56, Suppl. 67, p. 52-55

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Impact of Maillard Reaction on Immunoreactivity and Allergenicity of the Hazelnut Allergen Cor a 11

Iwan, M., Vissers, Y. M., Fiedorowicz, E., Kostyra, H., Savelkoul, H. F. J. & Wichers, H. J., 2011, In : Journal of Agricultural and Food Chemistry. 59, 13, p. 7163-7171

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)

Improvement of lipoxygenase inhibition by octapeptides

Schurink, M., van Berkel, W. J. H., Wichers, H. J. & Boeriu, C. G., 2007, In : Peptides. 28, 12, p. 2268-2275

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Influence of processing and in vitro digestion on the allergic cross-reactivity of three mealworm species

Van Broekhoven, S., Bastiaan-Net, S., De Jong, N. W. & Wichers, H. J., 2016, In : Food Chemistry. 196, p. 1075-1083

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)

Inhibition of mushroom polyphenol oxidase by agaritine

Espín, J. C., Jolivet, S. & Wichers, H. J., 1998, In : Journal of Agricultural and Food Chemistry. 46, 8, p. 2976-2980

Research output: Contribution to journalArticleAcademicpeer-review

46 Citations (Scopus)

Intrahepatic CD8+ lymphocyte trapping during tolerance induction using mushroom derived formulations: A possible role for liver in tolerance induction

Shuvy, M., Hershcovici, T., Lull-Noguera, C. & Wichers, H. J., 2008, In : World Journal of Gastroenterology. 14, 24, p. 3872-3878

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)

Investigation into the potential of commercially available lesser mealworm (A. diaperinus) protein to serve as sources of peptides with DPP-IV inhibitory activity

Lacroix, I. M. E., Dávalos Terán, I., Fogliano, V. & Wichers, H. J., Mar 2019, In : International Journal of Food Science and Technology. 54, 3, p. 696-704 9 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
8 Citations (Scopus)

Kinetics of Activation of Latent Mushroom (Agaricus bisporus) Tyrosinase by Benzyl Alcohol

Espin, J. C. & Wichers, H. J., 1999, In : Journal of Agricultural and Food Chemistry. 47, 9, p. 3503-3508

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Scopus)

Kinetic Study of the Oxidation of .gamma.-L-Glutaminyl-4- hydroxybenzene Catalyzed by Mushroom (Agaricus bisporus) Tyrosinase

Espin, J. C., Jolivet, S. & Wichers, H. J., 1999, In : Journal of Agricultural and Food Chemistry. 47, 9, p. 3495-3502

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Lactobacillus acidophilus attenuates Salmonella-induced stress of epithelial cells by modulating tight-junction genes and cytokine responses

Lépine, A. F. P., de Wit, N., Oosterink, E., Wichers, H., Mes, J. & de Vos, P., 2 Jul 2018, In : Frontiers in Microbiology. 9, 1439.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen allergic patients

Vissers, Y. M., Snel, J., Zuurendonk, P. F., Kleerebezem, M., Wichers, H. J. & Savelkoul, H. F. J., 2011, In : FEMS Immunology and Medical Microbiology. 61, 1, p. 28-40

Research output: Contribution to journalArticleAcademicpeer-review

20 Citations (Scopus)

Large-scale recombinant expression and purificatoin of human tyrosinase suitabel for structural studies

Lai, X., Soler-Lopez, M., Wichers, H. J. & Dijkstra, B., 2016, In : PLoS ONE. 11, 8, 16 p., e0161697.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
26 Citations (Scopus)

Ligninolytic enzymes activities of Oyster mushrooms cultivated on OMW (olive mill waste) supplemented media, spawn and substrates

Ruiz-Rodrigues, A., Polonia, I., Soler-Rivas, C. & Wichers, H. J., 2011, In : International Biodeterioration and Biodegradation. 65, 2, p. 285-293

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy

Hoppenbrouwers, T., Cvejić Hogervorst, J. H., Garssen, J., Wichers, H. J. & Willemsen, L. E. M., 22 May 2019, In : Frontiers in Immunology. 10, 1118.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
6 Citations (Scopus)

Low percentage of clinically relevant pistachio nut and mango co-sensitisation in cashew nut sensitised children

van der Valk, J. P. M., el Bouche, R., Gerth van Wijk, R., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Translational Allergy. 7, 1, 8.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
13 Citations (Scopus)

Macrophages treated with non-digestible polysaccharides reveal a transcriptionally unique phenotype

Tang, Y., Govers, C., Wichers, H. J. & Mes, J. J., 2017, In : Journal of Functional Foods. 36, p. 280-289

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
4 Citations (Scopus)
13 Citations (Scopus)

Melanin biosynthesis pathway in Agaricus bisporus mushrooms

Weijn, A., Bastiaan-Net, S., Wichers, H. J. & Mes, J. J., 2013, In : Fungal Genetics and Biology. 55, p. 42-53

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Microbiological effects of olive mill waste addition to substrates for Pleurotus pulmonarius cultivation

Soler-Rivas, C., Garcia-Rosado, A., Polonia, I., Junca-Blanch, G., Marin, F. R. & Wichers, H. J., 2006, In : International Biodeterioration and Biodegradation. 57, 1, p. 37-44

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)

Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes claudin 7

Janssen Duijghuijsen, L. M., Grefte, S., de Boer, V. C. J., Zeper, L., van Dartel, D. A. M., van der Stelt, I., Bekkenkamp-Grovenstein, M., van Norren, K., Wichers, H. J. & Keijer, J., 11 Oct 2017, In : Frontiers in Physiology. 8, 13 p., 794.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
12 Citations (Scopus)

Multicentre double-blind placebo-controlled food challenge study in children sensitised to cashew nut

van der Valk, J. P. M., Gerth van Wijk, R., Dubois, A. E. J., de Groot, H., Reitsma, M., Vlieg-Boerstra, B. J., Savelkoul, H. F. J., Wichers, H. J. & de Jong, N. W., 2016, In : PLoS ONE. 11, 3, 12 p., e0151055.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
24 Citations (Scopus)

Mushrooms: more than just taste (in Dutch)

Leguijt, C., van der Valk, H. C. P. M., Sanders, M. G., Termeer, A. G. W., van der Vuurst de Vries, R. G., Yüksel, D. & Wichers, H. J., 1997, In : De Champignoncultuur. 41, 8, p. 277-285

Research output: Contribution to journalArticleProfessional

No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial

van der Valk, J. P. M., Gerth van Wijk, R., Flokstra-de Blok, B. M. J., van der Velde, J. L., de Groot, H., Wichers, H. J., Dubois, A. E. J. & de Jong, N. W., 2016, In : Pediatric Allergy and Immunology. 27, 8, p. 812-817

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Novel foods and allergy: Regulations and risk-benefit assessment

van Putten, M. C., Kleter, G. A., Gilissen, L. J. W. J., Gremmen, H. G. J., Wichers, H. J. & Frewer, L. J., 2011, In : Food Control. 22, 2, p. 143-157

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Novel foods and food allergies: A review of the issues

van Putten, M. C., Frewer, L. J., Gilissen, L. J. W. J., Gremmen, B., Peijnenburg, A. A. C. M. & Wichers, H. J., 2006, In : Trends in Food Science and Technology. 17, 6, p. 289-299

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Novel peptides with tyrosinase inhibitory activity

Schurink, M., van Berkel, W. J. H., Wichers, H. J. & Boeriu, C. G., 2007, In : Peptides. 28, 3, p. 485-495

Research output: Contribution to journalArticleAcademicpeer-review

115 Citations (Scopus)

Oleuropein and related compounds

Soler-Rivas, C., Espin, J. C. & Wichers, H. J., 2000, In : Journal of the Science of Food and Agriculture. 80, 7, p. 1013-1023

Research output: Contribution to journalArticleAcademicpeer-review

292 Citations (Scopus)

Optimized triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

Teodorowicz, M., Perdijk, O., Verhoek, I., Govers, C., Savelkoul, H. F. J., Tang, Y., Wichers, H. & Broersen, K., 2017, In : PLoS ONE. 12, 3, e0173778.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
25 Citations (Scopus)

Origin and Processing Methods Slightly Affect Allergenic Characteristics of Cashew Nuts (Anacardium occidentale)

Reitsma, M., Bastiaan-Net, S., Sijbrandij, L., de Weert, E., Sforza, S., Gerth van Wijk, R., Savelkoul, H. F. J., de Jong, N. W. & Wichers, H. J., 1 Apr 2018, In : Journal of Food Science. 83, 4, p. 1153-1164

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Partial purification and characterization of pectin methylesterase from green beans (Phaseolus vulgaris L.).

Laats, M. M., Grosdenis, F., Recourt, K., Voragen, A. G. J. & Wichers, H. J., 1997, In : Journal of Agricultural and Food Chemistry. 45, p. 572-577

Research output: Contribution to journalArticleAcademicpeer-review

18 Citations (Scopus)
Open Access
1 Citation (Scopus)

Phenylthiourea binding to human tyrosinase-related protein 1

Lai, X., Wichers, H. J., Soler-Lopez, M. & Dijkstra, B. W., 1 Feb 2020, In : International Journal of Molecular Sciences. 21, 3, 915.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
2 Citations (Scopus)

Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells

Smiderle, F. R., Ruthes, A. C., van Arkel, J., Chanput, W., Lacomini, M., Wichers, H. J. & van Griensven, L. J. L. D., 2011, In : BMC Complementary & alternative medicine. 11, 11 p., 58.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
73 Citations (Scopus)

Postharvest Morphogenesis of Agaricus Bisporus: Influence of Plant Hormones

Donkers, J. W., Mooibroek, A., Braaksma, A. & Wichers, H. J., 1996, In : Acta botanica neerlandica. 45, 4, p. 574

Research output: Contribution to journalArticleAcademicpeer-review

Prediction of cashew nut allergy in sensitized children

van der Valk, J. P. M., Vergouwe, Y., van Wijk, R. G., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & De Jong, N. W., 2017, In : Pediatric Allergy and Immunology. 28, 5, p. 487-490

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Protein transport across the small intestine in food hypersensitivity

Reitsma, M., Westerhout, J., Wichers, H. J., Wortelboer, H. & Verhoeckx, K. C. M., 2014, In : Molecular Nutrition & Food Research. 58, 1, p. 194-205

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Purification and Characterization of Anacardium occidentale (Cashew) Allergens Ana o 1, Ana o 2, and Ana o 3

Reitsma, M., Bastiaan-Net, S., Sforza, S., Van Der Valk, J. P. M., Van Gerth Van Wijk, R., Savelkoul, H. F. J., De Jong, N. W. & Wichers, H. J., 2016, In : Journal of Agricultural and Food Chemistry. 64, 5, p. 1191-1201

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Purification and characterization of natural Bet v 1 from birch pollen and related allergens from carrot and celery

Bollen, M. A., Garcia, A., Cordewener, J. H. G., Wichers, H. J., Helsper, J. P. F. G., Savelkoul, H. F. J. & van Boekel, M. A. J. S., 2007, In : Molecular Nutrition & Food Research. 51, 12, p. 1527-1536

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)

Release of major peanut allergens from their matrix under various pH and simulated saliva conditions—Ara h2 and ara h6 are readily bio-accessible

Koppelman, S. J., Smits, M., Tomassen, M., De Jong, G. A. H., Baumert, J., Taylor, S. L., Witkamp, R., Veldman, R. J., Pieters, R. & Wichers, H., 11 Sep 2018, In : Nutrients. 10, 9, 1281.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
1 Citation (Scopus)

Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Torano, J. S., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B. & Masereeuw, R., 6 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 16105-16110 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
16 Citations (Scopus)

Screening of free radical scavenging capacity and antioxidant activities of Rosmarinus officinalis extracts with focus on location and harvesting times

Yesil Celiktas, O., Girgin, G., Orhan, H., Wichers, H. J., Bedir, E. & Vardar Sukan, F., 2007, In : European Food Research and Technology. 224, 4, p. 443-451

Research output: Contribution to journalArticleAcademicpeer-review

59 Citations (Scopus)

Sensory evaluation plays a pivotal role in the quality improvement of processed agricultural products (in Dutch)

Wichers, H. J., Yuksel, D., van der Vuurst, R. G. & Leguijt, T., 1995, In : Voedingsmiddelentechnologie. 28, 11, p. 12-14

Research output: Contribution to journalArticleProfessional

Sequence and structural features of plant and fungal tyrosinases (review article number 120)

van Gelder, C. W. G., Flurkey, W. H. & Wichers, H. J., 1997, In : Phytochemistry. 45, 7, p. 1309-1323

Research output: Contribution to journalArticleAcademicpeer-review

380 Citations (Scopus)

sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitized to cashew nuts

van der Valk, J. P. M., Gerth van Wijk, R., Vergouwe, Y., Steyerberg, E. W., Reitsma, M., Wichers, H. J., Savelkoul, H. F. J., Vlieg-Boerstra, B., de Groot, H., Dubois, A. E. J. & de Jong, N. W., 2017, In : Clinical and Experimental Allergy. 47, 1, p. 113-120

Research output: Contribution to journalArticleAcademicpeer-review

Open Access
15 Citations (Scopus)

Slow-binding inhibition of mushroom (Agaricus bisporus) tyrosinase isoforms by tropolone

Espin, J. C. & Wichers, H. J., 1999, In : Journal of Agricultural and Food Chemistry. 47, 7, p. 2638-2644

Research output: Contribution to journalArticleAcademicpeer-review

96 Citations (Scopus)

Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children

van der Valk, J. P. M., Berends, I., van Wijk, R. G., Arends, N. J. T., van Maaren, M. S., de Groot, H., Wichers, H. J., Emons, J. A. M., Dubois, A. E. J. & de Jong, N. W., Mar 2018, In : Annals of Allergy, Asthma and Immunology. 120, 3, p. 300-303

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)